Rachel De Barros Oliveira, Mayara Anselmi, Renata Cristina Nunes Marchette, Katiane Roversi, Guilherme Pasetto Fadanni, Luana Martins De Carvalho, Samara Damasceno, Isabella Aparecida Heinrich, Rodrigo Bainy Leal, Juliana Cavalli, Renato Elias Moreira-Júnior, Ana Lúcia Brunialti Godard, Geison Souza Izídio
Two inbred strains, Lewis (LEW) and Spontaneously Hypertensive Rats (SHR), are well-known for their contrasting behavior related to anxiety/emotionality. Studies with these two strains led to the discovery of the Quantitative Trait Loci (QTL) on chromosome 4 (Anxrr16). To better understand the influences of this genomic region, the congenic rat strain SLA16 (SHR.LEW-Anxrr16) was developed. SLA16 rats present higher hyperactivity/impulsivity, deficits in learning and memory, and lower basal blood pressure than the SHR strain, even though genetic differences between them are only in chromosome 4...
December 25, 2023: Behavioural Brain Research