Munire Maimaiti, Chenhui Li, Mingxing Cheng, Ziwei Zhong, Jiameng Hu, Lei Yang, Lele Zhang, Ze Hong, Jinyi Song, Mingyu Pan, Xiaonan Ma, Shufang Cui, Peng Zhang, Haiping Hao, Chen Wang, Haiyang Hu
BACKGROUND: Ischemic stroke is a major cause of worldwide death and disability, with recombinant tissue plasminogen activator being the sole effective treatment, albeit with a limited treatment window. The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway is emerging as the major DNA-sensing pathway to invoke immune responses in neuroinflammatory disorders. METHODS: By performing a series of neurobehavioral assessments, electrophysiological analysis, high-throughput sequencing, and cell-based assays based on the transient middle cerebral artery occlusion (tMCAO) mouse stroke model, we examined the effects and underlying mechanisms of genetic and pharmacological inhibition of the cGAS-STING pathway on long-term post-stroke neurological functional outcomes...
April 16, 2024: Med