Rong Tang, Jin Xu, Wei Wang, Qingcai Meng, Chenghao Shao, Yiyin Zhang, Yubin Lei, Zifeng Zhang, Yuan Liu, Qiong Du, Xiangjie Sun, Di Wu, Chen Liang, Jie Hua, Bo Zhang, Xianjun Yu, Si Shi
The molecular dynamics of pancreatic ductal adenocarcinoma (PDAC) under chemotherapy remain incompletely understood. The widespread use of neoadjuvant chemotherapy (NAC) provides a unique opportunity to investigate PDAC samples post-chemotherapy. Leveraging a cohort from Fudan University Shanghai Cancer Center, encompassing PDAC samples with and without exposure to neoadjuvant albumin-bound paclitaxel and gemcitabine (AG), we have compiled data from single-cell and spatial transcriptomes, proteomes, bulk transcriptomes, and metabolomes, deepening our comprehension of the molecular changes in PDACs in response to chemotherapy...
October 17, 2023: Cell reports medicine