Maddalena Conte, Laura Petraglia, Serena Cabaro, Vincenza Valerio, Paolo Poggio, Emanuele Pilato, Emilio Attena, Vincenzo Russo, Adele Ferro, Pietro Formisano, Dario Leosco, Valentina Parisi
Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases with age. AF is strongly associated with an increased risk of stroke, heart failure and cardiovascular mortality. Among the risk factors associated with AF onset and severity, obesity and inflammation play a prominent role. Numerous recent evidence suggested a role of epicardial adipose tissue (EAT), the visceral fat depot of the heart, in the development of AF. Several potential arrhythmogenic mechanisms have been attributed to EAT, including myocardial inflammation, fibrosis, oxidative stress, and fat infiltration...
2022: Frontiers in Cardiovascular Medicine