Bismark Gatica-Garcia, Michael J Bannon, Irma Alicia Martínez-Dávila, Luis O Soto-Rojas, David Reyes-Corona, Lourdes Escobedo, Minerva Maldonado-Berny, M E Gutierrez-Castillo, Armando J Espadas-Alvarez, Manuel A Fernandez-Parrilla, Juan U Mascotte-Cruz, C P Rodríguez-Oviedo, Irais E Valenzuela-Arzeta, Claudia Luna-Herrera, Francisco E Lopez-Salas, Jaime Santoyo-Salazar, Daniel Martinez-Fong
JOURNAL/nrgr/04.03/01300535-202409000-00039/figure1/v/2024-01-16T170235Z/r/image-tiff Parkinsonism by unilateral, intranigral β-sitosterol β-D-glucoside administration in rats is distinguished in that the α-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time, thus replicating several clinical features of Parkinson's disease, a typical α-synucleinopathy. As Nurr1 represses α-synuclein, we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateral β-sitosterol β-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection...
September 1, 2024: Neural Regeneration Research