Cláudio Quintino, Milene R Malheiros-Lima, Poliana Peres Ghazale, Pedro Paulo Pereira Braga, Octávio A C Maia, Carlos Eduardo Gonçalves de Oliveira, Felipe Waks Andrade, Guus H Schoorlemmer, Thiago S Moreira, David Henriques da Matta, Diego Basile Colugnati, Aline Priscila Pansani
OSA is known to increase the risk for SUDEP in persons with epilepsy, but the relationship between these two factors is not clear. Also, there is no study showing the acute responses to obstructive apnea in a chronic epilepsy model. Therefore, this study aimed to characterize cardiorespiratory responses to obstructive apnea and chemoreceptor stimulation in rats. In addition, we analyzed respiratory centers in the brain stem by immunohistochemistry. Epilepsy was induced with pilocarpine. About 30-60 days after the first spontaneous seizure, tracheal and thoracic balloons, and electrodes for recording the electroencephalogram, electromyogram, and electrocardiogram were implanted...
May 31, 2024: Epilepsy & Behavior: E&B