Lakshmi Kant Pathak, Walaa Dabbas
Collapsing glomerulopathy is a distinct and aggressive clinicopathologic variant of focal segmental glomerulosclerosis (FSGS). Here we present a 46-year-old man with acute renal failure from biopsy-proven collapsing FSGS and nephrotic syndrome in the setting of a diagnosis of hemophagocytic lymphohistiocytosis secondary to acute Epstein-Barr virus infection. This rare association has not been well described previously.
June 30, 2020: Proceedings of the Baylor University Medical Center
Sadichhya Lohani, Mohanraj Sadasivam, Hamid Rabb, Mohamed G Atta
Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis associated with persistently high levels of interferon gamma produced by T-cell receptor αβ (+), CD4- CD8- (double negative) T lymphocytes that progressed despite treatment and improvement of other cytokine levels. Double negative T cells are elevated and activated in autoimmune lymphoproliferative syndrome (ALPS)...
October 15, 2020: Nephron
Gajapathiraju Chamarthi, William L Clapp, Saraswathi Gopal
Collapsing glomerulopathy (CG) is a distinct podocytopathy characterized by the global or segmental collapse of glomerular capillary tuft with overlying podocyte hypertrophy and hyperplasia. CG has been associated with numerous etiologies, including infections, autoimmune disorders, drugs, and malignancies. Anecdotal reports of CG in patients with mixed connective tissue disease (MCTD) have been reported in the literature. We report a case of a 53-year-old female who presented to us with acute kidney injury and proteinuria...
October 14, 2020: CEN Case Reports
Elham Ahmadian, Seyed Mahdi Hosseiniyan Khatibi, Saiedeh Razi Soofiyani, Sima Abediazar, Mohammadali M Shoja, Mohammadreza Ardalan, Sepideh Zununi Vahed
The novel coronavirus (SARS-CoV-2) has turned into a life-threatening pandemic disease (Covid-19). About 5% of patients with Covid-19 have severe symptoms including septic shock, acute respiratory distress syndrome, and the failure of several organs, while most of them have mild symptoms. Frequently, the kidneys are involved through direct or indirect mechanisms. Kidney involvement mainly manifests itself as proteinuria and acute kidney injury (AKI). The SARS-CoV-2-induced kidney damage is expected to be multifactorial; directly it can infect the kidney podocytes and proximal tubular cells and based on an angiotensin-converting enzyme 2 (ACE2) pathway it can lead to acute tubular necrosis, protein leakage in Bowman's capsule, collapsing glomerulopathy and mitochondrial impairment...
October 6, 2020: Reviews in Medical Virology
Yannick M Nlandu, Jean-Robert R Makulo, Nestor M Pakasa, Ernest K Sumaili, Clarisse N Nkondi, Justine B Bukabau, François K Beya, Nazaire M Nseka, François B Lepira
Although the lungs remain the main target of SARS-CoV-2, other organs, such as kidneys, can be affected, which has a negative impact on the outcomes of COVID-19 patients. Although previous studies of kidney disease in COVID-19 reported mainly SARS-CoV-2-induced tubular and interstitial injury, there is growing evidence coming out of Africa of glomerular involvement, especially collapsing glomerulopathy seen particularly in people of African descent. We report a case of collapsing glomerulopathy revealed by acute kidney injury and a new onset of full blown nephrotic syndrome in a black Congolese patient coinfected with COVID-19 and malaria...
2020: Case Reports in Nephrology
Elizabeth Soria-Castro, Verónica Guarner-Lans, María Elena Soto, María Del Carmen Avila-Casado, Linaloe Manzano Pech, Israel Pérez-Torres
Patients with collapsing glomerulopathy (CG) have marked proteinuria that rapidly progresses to chronic renal failure. In this study, we investigated if the nephropathy produced in a rat model by the injection of serum from CG patients induced alterations in fatty acid (FA) metabolism. Twenty-four female Sprague-Dawley rats were divided into four groups of six rats each: Group I, control rats (C); Group II, rats that received injections of 1 mL of 0.9% NaCl saline solution (SS); Group III, rats injected with 25 mg/mL of serum from healthy subjects (HS); and Group IV, rats injected with 25 mg/mL of serum from CG patients...
September 29, 2020: Biomedicines
Rebecca Noble, Mei Ying Tan, Thomas McCulloch, Mohamed Shantier, Catherine Byrne, Matthew Hall, Mark Jesky
Since the emergency of novel coronavirus COVID-19 (SARS-CoV-2) in December 2019, infections have spread rapidly across the world. The reported incidence of acute kidney injury (AKI) in the context of COVID-19 is variable, and its mechanism is not well understood. Data are emerging about possible mechanisms of AKI including virus-induced cytopathic effect and cytokine storm-induced injury. To date, there have been few reports of kidney biopsy findings in the context of AKI in COVID-19 infection. This article describes 2 cases of collapsing glomerulopathy, 1 in a native kidney and, for the first time, 1 in a kidney transplant...
September 7, 2020: Nephron
Juan Carlos Q Velez, Tiffany Caza, Christopher P Larsen
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
August 11, 2020: Nature Reviews. Nephrology
Yuvraj Sharma, Samih H Nasr, Christopher P Larsen, Amy Kemper, Adrian H Ormsby, Sean R Williamson
Collapsing glomerulopathy is an aggressive form of focal segmental glomerulosclerosis with diverse causes. The presence of the apolipoprotein L1 ( APOL1 ) high-risk genotype is a major risk factor for collapsing glomerulopathy in African Americans. Coronavirus disease 2019 (COVID-19) is an emerging pandemic with predominant respiratory manifestations. However, kidney involvement is being frequently noted and is associated with higher mortality. Currently, kidney pathology data for COVID-19 are scant and mostly come from postmortem findings...
July 2020: Kidney medicine
Sandeep Magoon, Prasad Bichu, Varun Malhotra, Fatema Alhashimi, Yanglin Hu, Siddharth Khanna, Kabaye Berhanu
Coronavirus disease 19 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with acute kidney injury, presumably due to acute tubular injury. However, this does not explain proteinuria, sometimes severe, and hematuria often observed. We present 2 African American patients with glomerulopathy demonstrated by kidney biopsy in the setting of acute kidney injury and COVID-19 infection. Kidney biopsy specimens showed a collapsing variant of focal segmental glomerulosclerosis in addition to acute tubular injury...
July 2020: Kidney medicine
Juan Carlos Q Velez, Tiffany Caza, Chirstopher P Larsen
No abstract text is available yet for this article.
August 4, 2020: Nature Reviews. Nephrology
Rajib K Gupta, Ramya Bhargava, Al-Aman Shaukat, Emily Albert, John Leggat
BACKGROUND: Coronavirus disease-2019 (COVID-19) is an ongoing pandemic which has affected over 12 million people across the globe. Manifestations in different organs systems are being reported regularly. Renal biopsy findings in hospitalized COVID-19 patients presenting solely with acute kidney injury (AKI) have recently been described in published literature in few case reports. The findings include diffuse acute tubular injury (ATI) along with the glomerular lesion of collapsing glomerulopathy (CG)...
August 4, 2020: BMC Nephrology
Sol Carriazo, Mehmet Kanbay, Alberto Ortiz
COVID-19 is a global pandemic fuelled in some countries by government actions. The current issue of Clinical Kidney Journal presents 15 articles on COVID-19 and kidney disease from three continents, providing a global perspective of the impact of severe acute respiratory syndrome coronavirus 2 on electrolytes and different kidney compartments (glomeruli, tubules and vascular compartments) and presenting clinically as a syndrome of inappropriate antidiuretic hormone secretion, acute kidney injury, acute kidney disease, collapsing glomerulopathy and thrombotic microangiopathy, among others, in the context of a brand-new cardiorenal syndrome...
June 2020: Clinical Kidney Journal
Aymeric Couturier, Sophie Ferlicot, Kévin Chevalier, Matthieu Guillet, Marie Essig, Stéphane Jauréguiberry, Rocco Collarino, Mathilde Dargelos, Alice Michaut, Guillaume Geri, Anne-Marie Roque-Afonso, Mohamad Zaidan, Ziad A Massy
Among patients hospitalized for novel coronavirus disease (COVID-19), between 10 and 14% develop an acute kidney injury and around half display marked proteinuria and haematuria. Post-mortem analyses of COVID-19 kidney tissue suggest that renal tubular cells and podocytes are affected. Here we report two cases of collapsing glomerulopathy and tubulointerstitial lesions in living COVID-19 patients. Despite our use of sensitive reverse transcription polymerase chain reaction techniques in this study, we failed to detect the virus in blood, urine and kidney tissues...
June 2020: Clinical Kidney Journal
Satoru Kudose, Ibrahim Batal, Dominick Santoriello, Katherine Xu, Jonathan Barasch, Yonatan Peleg, Pietro Canetta, Lloyd E Ratner, Maddalena Marasa, Ali G Gharavi, M Barry Stokes, Glen S Markowitz, Vivette D D'Agati
BACKGROUND: Coronavirus disease 2019 (COVID-19) is thought to cause kidney injury by a variety of mechanisms. To date, pathologic analyses have been limited to patient reports and autopsy series. METHODS: We evaluated biopsy samples of native and allograft kidneys from patients with COVID-19 at a single center in New York City between March and June of 2020. We also used immunohistochemistry, in situ hybridization, and electron microscopy to examine this tissue for presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
September 2020: Journal of the American Society of Nephrology: JASN
Hélène Lazareth, Hélène Péré, Yannick Binois, Melchior Chabannes, Juliet Schurder, Thomas Bruneau, Alexandre Karras, Eric Thervet, Marion Rabant, David Veyer, Nicolas Pallet
We report a case of a kidney transplant recipient who presented with acute kidney injury and nephrotic-range proteinuria in a context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Kidney biopsy revealed collapsing glomerulopathy. Droplet-based digital PCR did not detect the presence of SARS-CoV-2 RNA in the biopsy fragment, and the virus was barely detectable in the plasma at the time of the biopsy. SARS-CoV-2 RNAemia peaked several days later, followed by a seroconversion despite the absence of circulating CD19-positive lymphocytes at admission due to rituximab-based treatment of antibody-mediated rejection 3 months earlier...
July 12, 2020: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Purva Sharma, Nupur N Uppal, Rimda Wanchoo, Hitesh H Shah, Yihe Yang, Rushang Parikh, Yuriy Khanin, Varun Madireddy, Christopher P Larsen, Kenar D Jhaveri, Vanesa Bijol
BACKGROUND: Reports show that AKI is a common complication of severe coronavirus disease 2019 (COVID-19) in hospitalized patients. Studies have also observed proteinuria and microscopic hematuria in such patients. Although a recent autopsy series of patients who died with severe COVID-19 in China found acute tubular necrosis in the kidney, a few patient reports have also described collapsing glomerulopathy in COVID-19. METHODS: We evaluated biopsied kidney samples from ten patients at our institution who had COVID-19 and clinical features of AKI, including proteinuria with or without hematuria...
September 2020: Journal of the American Society of Nephrology: JASN
Yoko Shirai, Kenichiro Miura, Tomoo Yabuuchi, Takeshi Nagasawa, Kiyonobu Ishizuka, Kazuhiro Takahashi, Sekiko Taneda, Kazuho Honda, Yutaka Yamaguchi, Hitoshi Suzuki, Yusuke Suzuki, Motoshi Hattori
Parvovirus B19 (PVB19) has been known to cause acute glomerulonephritis and nephrotic syndrome with various renal histologic patterns, such as endocapillary glomerulonephritis and collapsing glomerulopathy. Remission is achieved spontaneously or by treatment with steroid and/or immunosuppressants in most patients, except those with sickle cell anemia or two APOL1 risk alleles. In this study, we report the case of a previously healthy 5-year-old boy with infection-related glomerulonephritis (IRGN) associated with PVB19 that progressed to end-stage renal disease (ESRD)...
July 3, 2020: CEN Case Reports
Vinay Nair, Nicholas Jandovitz, Kenar D Jhaveri, David Hirschwerk, Elliot Grodstein, Vanesa Bijol, Ernesto Molmenti, Lewis Teperman
Collapsing glomerulopathy (CG) is a severe form of glomerulopathy which results in nephrotic syndrome and often ensues in rapid progression to end-stage kidney disease (ESKD). Although most commonly a result of HIV infection, other conditions such as parvovirus B19 (PB19) infection have been associated with CG. We present a case of an 18-year-old male with CG associated with PB19 infection who was heterozygous for APOL1 G1 and G2 genetic variants. In an attempt to treat, he was started on intravenous immunoglobulin (IVIg), however rapidly progressed to ESKD...
2020: Clinical Nephrology. Case Studies
Huijuan Wu, Christopher P Larsen, Cesar F Hernandez-Arroyo, Muner M B Mohamed, Tiffany Caza, Moh'd Sharshir, Asim Chughtai, Liping Xie, Juan M Gimenez, Tyler A Sandow, Mark A Lusco, Haichun Yang, Ellen Acheampong, Ivy A Rosales, Robert B Colvin, Agnes B Fogo, Juan Carlos Q Velez
BACKGROUND: Kidney involvement is a feature of COVID-19 and it can be severe in Black patients. Previous research linked increased susceptibility to collapsing glomerulopathy, including in patients with HIV-associated nephropathy, to apo L1 ( APOL1 ) variants that are more common in those of African descent. METHODS: To investigate genetic, histopathologic, and molecular features in six Black patients with COVID-19 presenting with AKI and de novo nephrotic-range proteinuria, we obtained biopsied kidney tissue, which was examined by in situ hybridization for viral detection and by NanoString for COVID-19 and acute tubular injury-associated genes...
August 2020: Journal of the American Society of Nephrology: JASN
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