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JOURNAL ARTICLE
Chirag Ram, Sameh Yousef, Wei-Guo Ma, Ishani Vallabhajosyula, Saket Singh, Ritu Agarwal, Rita K Milewski, Roland Assi, Prakash A Patel, Matthew Williams, Arnar Geirsson, Prashanth Vallabhajosyula
To investigate the association between area deprivation index (ADI) and aortic valve replacement (AVR) in patients with severe aortic stenosis (AS). Patients aged 40-95 years with severe AS confirmed by echocardiography were included. The 9-digit zip code of patient residence address was used to identify the ADI ranking, based on which patients were divided into 5 groups (with Group E being most deprived). The rates of AV intervention were compared among 5 groups using competing risks analysis, with death as a competing event...
February 28, 2024: Scientific Reports
#2
JOURNAL ARTICLE
Silvia Pomella, Matteo Cassandri, Lucrezia D'Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R Vakoc, Enrico Velardi, Beat W Schafer, Ernesto Guccione, Susanne A Gatz, Ajla Wasti, Marielle Yohe, Myron Ignatius, Concetta Quintarelli, Janet Shipley, Lucio Miele, Javed Khan, Peter J Houghton, Francesco Marampon, Berkley E Gryder, Biagio De Angelis, Franco Locatelli, Rossella Rota
Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS with frequent RAS pathway mutations. RMS express the master myogenic transcription factor MYOD that, whilst essential for survival, cannot support differentiation. Here we discover SKP2, an oncogenic E3-ubiquitin ligase, as a critical pro-tumorigenic driver in FN-RMS. We show that SKP2 is overexpressed in RMS through the binding of MYOD to an intronic enhancer...
December 15, 2023: Nature Communications
#3
JOURNAL ARTICLE
Julie E Mangino, Michael S Firstenberg, Rita K C Milewski, William Rhys-Williams, James P Lees, Aaron Dane, William G Love, Jesus Gonzalez Moreno
We studied 83 cardiac-surgery patients with nasal S. aureus carriage who received 4 intranasal administrations of XF-73 nasal gel or placebo <24 hours before surgery. One hour before surgery, patients exhibited a S. aureus nasal carriage reduction of 2.5 log10 with XF-73 compared to 0.4 log10 CFU/mL for those who received placebo (95% CI, -2.7 to -1.5; P < .0001).
March 23, 2023: Infection Control and Hospital Epidemiology
#4
JOURNAL ARTICLE
Rita Carrie Karianna Milewski, Andreas Habertheuer, Joseph E Bavaria, Maham Suhail, Mary Siki, Robert Hu, Melanie A Freas, Chirag Ram, Ananya Nanduri, Wilson Y Szeto, Prashanth Vallabhajosyula
OBJECTIVE: Surgery for ascending aneurysms in bicuspid aortic valve syndrome primarily includes Bentall root replacement, aortic valve replacement with supracoronary ascending aorta replacement (AVRSCAAR), and valve-sparing root reimplantation (VSRR). Comparative analysis of long-term clinical and functional outcomes of these procedures is detailed. METHODS: From 1997 to 2017, 635 patients with bicuspid aortic valve undergoing root complex-focused procedures electively were stratified by valvulopathy (ie, aortic stenosis vs aortic insufficiency) and substratified into ascending or root aneurysm phenotype...
November 24, 2022: Journal of Thoracic and Cardiovascular Surgery
#5
JOURNAL ARTICLE
Rita C Milewski, Subhasis Chatterjee, HelenMari Merritt-Genore, J W Awori Hayanga, Michael C Grant, Nathalie Roy, Hitoshi Hirose, Rainer Moosdorf, Glenn J Whitman, Jonathan W Haft, Brett Hiebert, Christine Stead, Peter Rycus, Rakesh C Arora
BACKGROUND: The Society of Thoracic Surgeons Workforce on Critical Care and the Extracorporeal Life Support Organization sought to identify how the coronavirus disease 2019 (COVID-19) pandemic has changed the practice of venoarterial (VA) and venovenous (VV) extracorporeal membrane oxygenation (ECMO) programs across North America. METHODS: A 26-question survey covering 6 categories (ECMO initiation, cannulation, management, anticoagulation, triage/protocols, and credentialing) was emailed to 276 North American Extracorporeal Life Support Organization centers...
March 2023: Ann Thorac Surg Short Rep
#6
JOURNAL ARTICLE
Sameh Yousef, Andrea Amabile, Chirag Ram, Saket Singh, Ritu Agarwal, Rita Milewski, Roland Assi, Prakash A Patel, Markus Krane, Arnar Geirsson, Prashanth Vallabhajosyula
OBJECTIVE: Current guidelines recommend intervention in subjects with severe symptomatic aortic stenosis (AS), even though any degree of AS is associated with a higher risk of mortality. We investigated the association between the degree of AS, delineated by transvalvular flow velocity, and patient morbidity and mortality. METHODS: Medically managed patients aged 40-95 years with maximum flow velocity (Vmax ) by echocardiography between 2013 and 2018 were stratified into five groups (A-E) based on the 75th, 90th, 97...
November 15, 2022: Journal of Cardiac Surgery
#7
JOURNAL ARTICLE
Sameh Yousef, Andrea Amabile, Chirag Ram, Huang Huang, Varun Korutla, Saket Singh, Ritu Agarwal, Roland Assi, Rita K Milewski, Yawei Zhang, Prakash A Patel, Markus Krane, Arnar Geirsson, Prashanth Vallabhajosyula
(1) Background: The clinical burden of aortic stenosis (AS) remains high in Western countries. Yet, there are no screening algorithms for this condition. We developed a risk prediction model to guide targeted screening for patients with AS. (2) Methods: We performed a cross-sectional analysis of all echocardiographic studies performed between 2013 and 2018 at a tertiary academic care center. We included reports of unique patients aged from 40 to 95 years. A logistic regression model was fitted for the risk of moderate and severe AS, with readily available demographics and comorbidity variables...
July 28, 2022: Journal of Clinical Medicine
#8
JOURNAL ARTICLE
Sameh Yousef, Andrea Amabile, Huang Huang, Ritu Agarwal, Saket Singh, Chirag Ram, Rita K Milewski, Roland Assi, Yawie Zhang, Markus Krane, Arnar Geirsson, Prashanth Vallabhajosyula
(1) Background: Our goal was to develop a risk prediction model for mortality in patients with moderate and severe aortic stenosis (AS). (2) Methods: All patients aged 40-95 years, with echocardiographic evidence of moderate and severe AS at a single institution, were studied over a median of 2.8 (1.5-4.8) years, between 2013-2018. Patient characteristics and mortality were compared using Chi-squares, t-tests, and Kaplan-Meier (KM) curves, as appropriate. The risk calculation for mortality was derived using the Cox proportional hazards model...
May 23, 2022: Journal of Clinical Medicine
#9
JOURNAL ARTICLE
Kathryn W Holmes, Sheila Markwardt, Kim A Eagle, Richard B Devereux, Jonathan W Weinsaft, Federico M Asch, Scott A LeMaire, Cheryl L Maslen, Howard K Song, Dianna M Milewicz, Siddharth K Prakash, Dongchuan Guo, Shaine A Morris, Reed E Pyeritz, Rita C Milewski, William J Ravekes, H C Dietz, Ralph V Shohet, Michael Silberbach, Mary J Roman
BACKGROUND: The GenTAC (Genetically Triggered Thoracic Aortic Aneurysm and Cardiovascular Conditions) Registry enrolled patients with genetic aortopathies between 2007 and 2016. OBJECTIVES: The purpose of this study was to compare age distribution and probability of elective surgery for proximal aortic aneurysm, any dissection surgery, and cardiovascular mortality among aortopathy etiologies. METHODS: The GenTAC study had a retrospective/prospective design...
May 31, 2022: Journal of the American College of Cardiology
#10
EDITORIAL
J W Awori Hayanga, Subhasis Chatterjee, Bo Soo Kim, HelenMari Merritt-Genore, Rita Carrie Karianna Milewski, Jonathan W Haft, Rakesh C Arora
No abstract text is available yet for this article.
October 12, 2021: Journal of Thoracic and Cardiovascular Surgery
#11
REVIEW
HelenMari Merritt-Genore, Rainer Moosdorf, Erin Gillaspie, Sylvain Lother, Daniel Engelman, Shahnur Ahmed, Frank A Baciewicz, Michael C Grant, Rita Milewski, Kelly Cawcutt, J Awori Hayanga, Subhasis Chatterjee, Rakesh C Arora
Cardiothoracic surgical patients are at risk of increased coronavirus disease severity. Several important factors influence the administration of the coronavirus disease vaccine in the perioperative period. This guidance statement outlines current information regarding vaccine types, summarizes recommendations regarding appropriate timing of administration, and provides information regarding side effects in the perioperative period for cardiac and thoracic surgical patients.
November 2021: Annals of Thoracic Surgery
#12
JOURNAL ARTICLE
Gabe Weininger, Makoto Mori, Michael Shang, Ellelan Degife, Michael Amick, Sameh Yousef, Roland Assi, Rita Milewski, Arnar Geirsson, Prashanth Vallabhajosyula
BACKGROUND: Ascending aortic aneurysms (AsAA) remain a silent killer for which timely intervention and surveillance intervals are critical. Despite this, little is known about the follow-up care patients receive after incidental detection of an AsAA. We examined the pattern of surveillance and follow-up care for these high-risk patients. METHODS: We identified patients at our institution with incidentally detected AsAAs (≥37 mm) between 2013 and 2016. We collected information on patients' aneurysms and clinical follow-up...
January 2022: Annals of Thoracic Surgery
#13
JOURNAL ARTICLE
Rita C Milewski
No abstract text is available yet for this article.
March 2021: Journal of Thoracic and Cardiovascular Surgery
#14
JOURNAL ARTICLE
Silvia Pomella, Prethish Sreenivas, Berkley E Gryder, Long Wang, David Milewski, Matteo Cassandri, Kunal Baxi, Nicole R Hensch, Elena Carcarino, Young Song, Hsien-Chao Chou, Marielle E Yohe, Benjamin Z Stanton, Bruno Amadio, Ignazio Caruana, Cristiano De Stefanis, Rita De Vito, Franco Locatelli, Yidong Chen, Eleanor Y Chen, Peter Houghton, Javed Khan, Rossella Rota, Myron S Ignatius
Rhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN)-RMS commonly with RAS pathway mutations. RMS express myogenic master transcription factors MYOD and MYOG yet are unable to terminally differentiate. Here, we report that SNAI2 is highly expressed in FN-RMS, is oncogenic, blocks myogenic differentiation, and promotes growth. MYOD activates SNAI2 transcription via super enhancers with striped 3D contact architecture...
January 8, 2021: Nature Communications
#15
JOURNAL ARTICLE
Markian M Bojko, Andreas Habertheuer, Joseph E Bavaria, Maham Suhail, Robert W Hu, Joey Harmon, Nimesh D Desai, Rita K Milewski, Matthew L Williams, Wilson Y Szeto, Jana Mossey, Prashanth Vallabhajosyula
OBJECTIVE: Patients with acute type A aortic dissection demonstrate a wide range of aortic insufficiency. Outcomes after valve resuspension and root repair are not well studied in the long term. We evaluated the long-term effects of preoperative aortic insufficiency in patients undergoing emergency root-preserving surgery for acute type A aortic dissection. METHODS: From 2002 to 2017, 558 of 776 patients with acute type A aortic dissection underwent native aortic valve resuspension and root reconstruction...
June 2021: Journal of Thoracic and Cardiovascular Surgery
#16
JOURNAL ARTICLE
Markian M Bojko, Maham Suhail, Joseph E Bavaria, Alex Bueker, Robert W Hu, Joey Harmon, Andreas Habertheuer, Rita K Milewski, Wilson Y Szeto, Prashanth Vallabhajosyula
OBJECTIVE: The incidence of elderly patients with acute type A aortic dissection is increasing. A recent analysis of the International Registry of Acute Aortic Dissection failed to show a mortality benefit with surgery compared with medical management in octogenarians. Therefore, we compared our institutional outcomes of emergency surgery for acute type A aortic dissection in octogenarians versus septuagenarians to understand the outcomes of surgical intervention in elderly patients. METHODS: From 2002 to 2017, 70 octogenarians (aged ≥80 years) and 165 septuagenarians (70-79 years) underwent surgery for acute type A aortic dissection (N = 235, total)...
January 2022: Journal of Thoracic and Cardiovascular Surgery
#17
COMPARATIVE STUDY
Markian M Bojko, Roland Assi, Joseph E Bavaria, Maham Suhail, Andreas Habertheuer, Robert W Hu, Joey Harmon, Rita K Milewski, Nimesh D Desai, Wilson Y Szeto, Prashanth Vallabhajosyula
OBJECTIVE: The durability of root repair for acute type A aortic dissection is not well studied in the context of aortic insufficiency and stability of the sinuses of Valsalva. We compared clinical and functional outcomes in patients undergoing root repair and replacement for acute type A aortic dissection. METHODS: Of 716 patients undergoing surgery for acute type A aortic dissection, 585 (81.7%) underwent root repair and 131 (18.3%) underwent root replacement...
March 2022: Journal of Thoracic and Cardiovascular Surgery
#18
EDITORIAL
Jason J Han, John J Kelly, Rita Karianna Milewski
No abstract text is available yet for this article.
May 1, 2020: Journal of Thoracic and Cardiovascular Surgery
#19
JOURNAL ARTICLE
Fate of the Preserved Sinuses of Valsalva After Emergency Repair for Acute Type A Aortic Dissection.
Markian M Bojko, Maham Suhail, Joseph E Bavaria, Andreas Habertheuer, Robert W Hu, Joey Harmon, Nimesh D Desai, Rita K Milewski, Matthew L Williams, Wilson Y Szeto, Prashanth Vallabhajosyula
BACKGROUND: Patients with acute type A aortic dissection (ATAAD) present with heterogeneous involvement of the aortic root complex. Despite this variation, the aortic root can usually be preserved the majority of the time by Teflon (WL Gore, Newark, DE) inlay patch reconstruction of the dissected sinuses of Valsalva (SOV). In this study, we report the long term anatomic, functional, and clinical outcomes associated with the preserved SOV after surgery for ATAAD. METHODS: From 2002-2017, of 776 emergency ATAAD operations at a single institution, 558 (71...
November 2020: Annals of Thoracic Surgery
#20
JOURNAL ARTICLE
Mary A Siki, Andreas Habertheuer, Joseph E Bavaria, Caroline Komlo, Maxwell Hunt, Melanie A Freas, Rita K Milewski, Nimesh D Desai, Wilson Y Szeto, Prashanth Vallabhajosyula
OBJECTIVE: Bicuspid aortic valve (BAV) represents 2 cusps oriented along a spectrum of equal (180°/180°) or unequal (150°/210°) leaflet surface area distribution along the aortic annular plane. We have taken the approach of respecting the native geometric orientation of the repaired BAV leaflets when creating the aortic neoroot during valve-sparing root reimplantation (VSRR) procedures. We investigated midterm outcomes with this 2-prong approach for VSRR in BAV syndrome. METHODS: Of 72 patients in a prospectively maintained BAV repair database, 68 met inclusion criteria: 36 patients had 180°/180° neoroot geometry, and 32 patients had 150°/210° orientation...
July 2020: Journal of Thoracic and Cardiovascular Surgery
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