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JOURNAL ARTICLE
Md Saydur Rahman, Mohammad Maruf Billah, Victor Rangel, Esmirna Cantu
Global warming is one of the greatest threats to living organisms. Among them, marine invertebrates are severely impacted on reproductive fitness by rising seawater surface temperatures due to climate change (e.g., massive heat waves). In this study, we used highly sensitive radioimmunoassay, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), in situ TUNEL assay, luminescence assay, and colorimetric assay techniques to investigate the impacts of high temperatures on global DNA methylation, cellular apoptosis, and nitrative stress in gonads of Atlantic sea urchin (Arbacia punctulata, a commercially important species)...
September 4, 2023: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
#42
Reem Abdel-Haq, Johannes C M Schlachetzki, Joseph C Boktor, Thaisa M Cantu-Jungles, Taren Thron, Mengying Zhang, John W Bostick, Tahmineh Khazaei, Sujatha Chilakala, Livia H Morais, Greg Humphrey, Ali Keshavarzian, Jonathan E Katz, Matthew Thomson, Rob Knight, Viviana Gradinaru, Bruce R Hamaker, Christopher K Glass, Sarkis K Mazmanian
No abstract text is available yet for this article.
August 31, 2023: ELife
#43
JOURNAL ARTICLE
Ann C McKee, Jesse Mez, Bobak Abdolmohammadi, Morgane Butler, Bertrand Russell Huber, Madeline Uretsky, Katharine Babcock, Jonathan D Cherry, Victor E Alvarez, Brett Martin, Yorghos Tripodis, Joseph N Palmisano, Kerry A Cormier, Caroline A Kubilus, Raymond Nicks, Daniel Kirsch, Ian Mahar, Lisa McHale, Christopher Nowinski, Robert C Cantu, Robert A Stern, Daniel Daneshvar, Lee E Goldstein, Douglas I Katz, Neil W Kowall, Brigid Dwyer, Thor D Stein, Michael L Alosco
IMPORTANCE: Young contact sport athletes may be at risk for long-term neuropathologic disorders, including chronic traumatic encephalopathy (CTE). OBJECTIVE: To characterize the neuropathologic and clinical symptoms of young brain donors who were contact sport athletes. DESIGN, SETTING, AND PARTICIPANTS: This case series analyzes findings from 152 of 156 brain donors younger than 30 years identified through the Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) Brain Bank who donated their brains from February 1, 2008, to September 31, 2022...
August 28, 2023: JAMA Neurology
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JOURNAL ARTICLE
Ana Georgina Cobián Güemes, Tram Le, Maria Isabel Rojas, Nicole E Jacobson, Helena Villela, Katelyn McNair, Shr-Hau Hung, Lili Han, Lance Boling, Jessica Claire Octavio, Lorena Dominguez, Vito Adrian Cantú, Sinéad Archdeacon, Alejandro A Vega, Michelle A An, Hamza Hajama, Gregory Burkeen, Robert A Edwards, Douglas J Conrad, Forest Rohwer, Anca M Segall
Achromobacter species colonization of Cystic Fibrosis respiratory airways is an increasing concern. Two adult patients with Cystic Fibrosis colonized by Achromobacter xylosoxidans CF418 or Achromobacter ruhlandii CF116 experienced fatal exacerbations. Achromobacter spp. are naturally resistant to several antibiotics. Therefore, phages could be valuable as therapeutics for the control of Achromobacter . In this study, thirteen lytic phages were isolated and characterized at the morphological and genomic levels for potential future use in phage therapy...
July 30, 2023: Viruses
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JOURNAL ARTICLE
Yanko Castro-Govea, Jorge A García-Garza, Sergio E Vázquez-Lara, Cynthia M González-Cantú, Hernán Chacón-Moreno, Víctor H Cervantes-Kardasch
It is undeniable that a significant number of patients who want to improve their facial appearance is increasingly interested in nonsurgical procedures. Without a doubt, the use of autologous fat could not be left out as a magnificent alternative for nasal modeling simply because of four influential factors: ease of collection, compatibility, the temporality of the results, and safety. This work describes an innovative alternative technique for nasal modeling using micrografts enriched with adipose-derived mesenchymal stem cells (ASCs)...
July 2023: Archives of Plastic Surgery
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JOURNAL ARTICLE
Jordan H Driskill, Miguel Dario Cantu, Jessica Garcia, Kathryn E Dickerson, Weina Chen
No abstract text is available yet for this article.
September 2023: British Journal of Haematology
#47
JOURNAL ARTICLE
Madeline Huff, Shuchita V Jhaveri, Ayesha Khan, Lina Pedraza, Maria Pesantez Borja, Daniela Santos Cantu, Chelsea Chang
PURPOSE: The Rio Grande Valley in South Texas comprises 5% percent of Texas's population yet 17%of Texas's COVID-19 deaths. We aimed to address underlying mistrust and systemic racism in our Hispanic community that contributes to health inequities by developing a cultural competence guide for public health messaging. METHODS: We employed a mixed method design (e.g., focus groups, surveys, interviews) to develop and implement a cultural competence guide in an iterative community-informed process...
June 2023: Curēus
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JOURNAL ARTICLE
Roxane Labrosse, Julia Chu, Myriam Armant, John K Everett, Danilo Pellin, Niharika Kareddy, Andrew L Frelinger, Lauren A Henderson, Amy E O'Connell, Amlan Biswas, Jet Coenen-van der Spek, Alexandra Marina Miggelbrink, Claudia Fiorini, Hriju Adhikari, Charles C Berry, Vito Adrian Cantu, Johnson Fong, Jason Roy Jaroslavsky, Derin F Karadeniz, Quan-Zhen Li, Shantan Reddy, Aoife M Roche, Chengsong Zhu, Jennifer S Whangbo, Colleen Dansereau, Brenda L Mackinnon, Emily Morris, Stephanie M Koo, Wendy B London, Safa Baris, Ahmet Ozen, Elif Karakoc-Aydiner, Jenny McDade Despotovic, Lisa R Forbes Satter, Akihiko Saitoh, Yuta Aizawa, Alejandra King, Mai Anh T Nguyen, Vy Do Uyen Vu, Scott B Snapper, Anne Galy, Luigi D Notarangelo, Frederic D Bushman, David A Williams, Sung-Yun Pai
Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder characterized by combined immunodeficiency, eczema, microthrombocytopenia, autoimmunity, and lymphoid malignancies. Gene therapy (GT) to modify autologous CD34+ cells is an emerging alternative treatment with advantages over standard allogeneic hematopoietic stem cell transplant for patients who lack well-matched donors, avoiding graft-versus-host-disease. We report the outcomes of a phase I/II clinical trial in which 5 patients with severe WAS underwent GT using a self-inactivating lentiviral (SIN-LV) vector expressing the human WAS cDNA under the control of a 1...
July 21, 2023: Blood
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JOURNAL ARTICLE
Benjamin T Caswell, Thomas J Summers, Gerra L Licup, David C Cantu
The mutation space of spatially conserved (MSSC) amino acid residues is a protein structural quantity developed and described in this work. The MSSC quantifies how many mutations and which different mutations, i.e., the mutation space, occur in each amino acid site in a protein. The MSSC calculates the mutation space of amino acids in a target protein from the spatially conserved residues in a group of multiple protein structures. Spatially conserved amino acid residues are identified based on their relative positions in the protein structure...
July 11, 2023: ACS Omega
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JOURNAL ARTICLE
Daniel A Salmon, Matthew Z Dudley, Janesse Brewer, Jana Shaw, Holly B Schuh, Tina M Proveaux, Amelia M Jamison, Amanda Forr, Michelle Goryn, Robert F Breiman, Walter A Orenstein, Lee-Sien Kao, Robina Josiah Willcock, Michelle Cantu, Tori Decea, Robin Mowson, Kate Tsubata, Lucie Marisa Bucci, Jaqueline Lawler, James D Watkins, Jamie W Moore, James H Fugett, Adriele Fugal, Yazmine Tovar, Marie Gay, Aleen M Cary, Iulia Vann, Lee B Smith, Lilly Kan, Magda Mankel, Sumayya Beekun, Victoria Smith, Stephanie D Adams, Steven A Harvey, Peter Z Orton
INTRODUCTION: Vaccine hesitancy is a global health threat undermining control of many vaccine-preventable diseases. Patient-level education has largely been ineffective in reducing vaccine concerns and increasing vaccine uptake. We built and evaluated a personalized vaccine risk communication website called LetsTalkShots in English, Spanish and French (Canadian) for vaccines across the lifespan. LetsTalkShots tailors lived experiences, credible sources and informational animations to disseminate the right message from the right messenger to the right person, applying a broad range of behavioral theories...
2023: Frontiers in Public Health
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JOURNAL ARTICLE
Carlo Sposito, Marianna Maspero, Valeria Conalbi, Andrea Magarotto, Michele Altomare, Carlo Battiston, Paolo Cantù, Vincenzo Mazzaferro
BACKGROUND: Indocyanine green (ICG)-guided lymphadenectomy using near-infrared visualization (NIR) may increase nodal yield during gastrectomy. The purpose of this study was to evaluate the clinical benefit of NIR visualization on the quality of D2 lymphadenectomy during laparoscopic distal gastrectomy. METHODS: This single-arm, open-label, Simon's two-stage, adaptive, phase 2 trial included patients who underwent laparoscopic distal gastrectomy for gastric adenocarcinoma...
October 2023: Annals of Surgical Oncology
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JOURNAL ARTICLE
R Abbasi, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, J M Alameddine, A A Alves, N M Amin, K Andeen, T Anderson, G Anton, C Argüelles, Y Ashida, S Athanasiadou, S Axani, X Bai, A Balagopal V, S W Barwick, V Basu, S Baur, R Bay, J J Beatty, K-H Becker, J Becker Tjus, J Beise, C Bellenghi, S Benda, S BenZvi, D Berley, E Bernardini, D Z Besson, G Binder, D Bindig, E Blaufuss, S Blot, M Boddenberg, F Bontempo, J Y Book, J Borowka, S Böser, O Botner, J Böttcher, E Bourbeau, F Bradascio, J Braun, B Brinson, S Bron, J Brostean-Kaiser, R T Burley, R S Busse, M A Campana, E G Carnie-Bronca, C Chen, Z Chen, D Chirkin, K Choi, B A Clark, K Clark, L Classen, A Coleman, G H Collin, A Connolly, J M Conrad, P Coppin, P Correa, D F Cowen, R Cross, C Dappen, P Dave, C De Clercq, J J DeLaunay, D Delgado López, H Dembinski, K Deoskar, A Desai, P Desiati, K D de Vries, G de Wasseige, T DeYoung, A Diaz, J C Díaz-Vélez, M Dittmer, H Dujmovic, M Dunkman, M A DuVernois, T Ehrhardt, P Eller, R Engel, H Erpenbeck, J Evans, P A Evenson, K L Fan, A R Fazely, A Fedynitch, N Feigl, S Fiedlschuster, A T Fienberg, C Finley, L Fischer, D Fox, A Franckowiak, E Friedman, A Fritz, P Fürst, T K Gaisser, J Gallagher, E Ganster, A Garcia, S Garrappa, L Gerhardt, A Ghadimi, C Glaser, T Glauch, T Glüsenkamp, N Goehlke, A Goldschmidt, J G Gonzalez, S Goswami, D Grant, T Grégoire, S Griswold, C Günther, P Gutjahr, C Haack, A Hallgren, R Halliday, L Halve, F Halzen, M Ha Minh, K Hanson, J Hardin, A A Harnisch, A Haungs, K Helbing, F Henningsen, E C Hettinger, S Hickford, J Hignight, C Hill, G C Hill, K D Hoffman, K Hoshina, W Hou, F Huang, M Huber, T Huber, K Hultqvist, M Hünnefeld, R Hussain, K Hymon, S In, N Iovine, A Ishihara, M Jansson, G S Japaridze, M Jeong, M Jin, B J P Jones, D Kang, W Kang, X Kang, A Kappes, D Kappesser, L Kardum, T Karg, M Karl, A Karle, U Katz, M Kauer, M Kellermann, J L Kelley, A Kheirandish, K Kin, J Kiryluk, S R Klein, A Kochocki, R Koirala, H Kolanoski, T Kontrimas, L Köpke, C Kopper, S Kopper, D J Koskinen, P Koundal, M Kovacevich, M Kowalski, T Kozynets, E Krupczak, E Kun, N Kurahashi, N Lad, C Lagunas Gualda, J L Lanfranchi, M J Larson, F Lauber, J P Lazar, J W Lee, K Leonard, A Leszczyńska, Y Li, M Lincetto, Q R Liu, M Liubarska, E Lohfink, C J Lozano Mariscal, L Lu, F Lucarelli, A Ludwig, W Luszczak, Y Lyu, W Y Ma, J Madsen, K B M Mahn, Y Makino, S Mancina, I C Mariş, I Martinez-Soler, R Maruyama, S McCarthy, T McElroy, F McNally, J V Mead, K Meagher, S Mechbal, A Medina, M Meier, S Meighen-Berger, Y Merckx, J Micallef, D Mockler, T Montaruli, R W Moore, K Morik, R Morse, M Moulai, T Mukherjee, R Naab, R Nagai, R Nahnhauer, U Naumann, J Necker, L V Nguyen, H Niederhausen, M U Nisa, S C Nowicki, D Nygren, A Obertacke Pollmann, M Oehler, B Oeyen, A Olivas, E O'Sullivan, H Pandya, D V Pankova, N Park, G K Parker, E N Paudel, L Paul, C Pérez de Los Heros, L Peters, J Peterson, S Philippen, S Pieper, A Pizzuto, M Plum, Y Popovych, A Porcelli, M Prado Rodriguez, B Pries, G T Przybylski, C Raab, J Rack-Helleis, A Raissi, M Rameez, K Rawlins, I C Rea, Z Rechav, A Rehman, P Reichherzer, R Reimann, G Renzi, E Resconi, S Reusch, W Rhode, M Richman, B Riedel, E J Roberts, S Robertson, G Roellinghoff, M Rongen, C Rott, T Ruhe, D Ryckbosch, D Rysewyk Cantu, I Safa, J Saffer, D Salazar-Gallegos, P Sampathkumar, S E Sanchez Herrera, A Sandrock, M Santander, S Sarkar, S Sarkar, K Satalecka, M Schaufel, H Schieler, S Schindler, T Schmidt, A Schneider, J Schneider, F G Schröder, L Schumacher, G Schwefer, S Sclafani, D Seckel, S Seunarine, A Sharma, S Shefali, N Shimizu, M Silva, B Skrzypek, B Smithers, R Snihur, J Soedingrekso, A Sogaard, D Soldin, C Spannfellner, G M Spiczak, C Spiering, M Stamatikos, T Stanev, R Stein, J Stettner, T Stezelberger, B Stokstad, T Stürwald, T Stuttard, G W Sullivan, I Taboada, S Ter-Antonyan, J Thwaites, S Tilav, F Tischbein, K Tollefson, C Tönnis, S Toscano, D Tosi, A Trettin, M Tselengidou, C F Tung, A Turcati, R Turcotte, C F Turley, J P Twagirayezu, B Ty, M A Unland Elorrieta, N Valtonen-Mattila, J Vandenbroucke, N van Eijndhoven, D Vannerom, J van Santen, J Veitch-Michaelis, S Verpoest, C Walck, W Wang, T B Watson, C Weaver, P Weigel, A Weindl, M J Weiss, J Weldert, C Wendt, J Werthebach, M Weyrauch, N Whitehorn, C H Wiebusch, N Willey, D R Williams, M Wolf, G Wrede, J Wulff, X W Xu, J P Yanez, E Yildizci, S Yoshida, S Yu, T Yuan, Z Zhang, P Zhelnin
The origin of high-energy cosmic rays, atomic nuclei that continuously impact Earth's atmosphere, is unknown. Because of deflection by interstellar magnetic fields, cosmic rays produced within the Milky Way arrive at Earth from random directions. However, cosmic rays interact with matter near their sources and during propagation, which produces high-energy neutrinos. We searched for neutrino emission using machine learning techniques applied to 10 years of data from the IceCube Neutrino Observatory. By comparing diffuse emission models to a background-only hypothesis, we identified neutrino emission from the Galactic plane at the 4...
June 30, 2023: Science
#53
JOURNAL ARTICLE
Umberto Granziol, Mark D Griffiths, Liye Zou, Peiying Yang, Hannah K Herschel, Annika Junker, Takayuki Akimoto, Oliver Stoll, Merve Alpay, Zeynep Aydın, Thomas Zandonai, Laura Di Lodovico, Mia Beck Lichtenstein, Mike Trott, Robert M Portman, Melanie Schipfer, Brian Cook, Silvia Cerea, Aleksei Y Egorov, Abril Cantù-Berrueto, Ricardo de la Vega Marcos, Paula Texeira Fernandes, Emilio Landolfi, Zsolt Demetrovics, Eliza E Tóth, Marco Solmi, Attila Szabo
Exercise addiction (EA) refers to excessive exercise, lack of control, and health risks. The Exercise Addiction Inventory (EAI) is one of the most widely used tools in its assessment. However, the cross-cultural psychometric properties of the EAI could be improved because it misses three pathological patterns, including guilt, exercise despite injury, and experienced harm. Therefore, the present study tested the psychometric properties of the expanded EAI (EAI-3) in a large international sample. The EAI-3 was administered to 1931 physically active adult exercisers speaking five languages (Chinese, German, Italian, Japanese, and Turkish) and other measures for obsessive-compulsive behavior, eating disorders, and personality traits...
May 10, 2023: International Journal of Mental Health and Addiction
#54
REVIEW
Daniel H Daneshvar, Evan S Nair, Zachary H Baucom, Abigail Rasch, Bobak Abdolmohammadi, Madeline Uretsky, Nicole Saltiel, Arsal Shah, Johnny Jarnagin, Christine M Baugh, Brett M Martin, Joseph N Palmisano, Jonathan D Cherry, Victor E Alvarez, Bertrand R Huber, Jennifer Weuve, Christopher J Nowinski, Robert C Cantu, Ross D Zafonte, Brigid Dwyer, John F Crary, Lee E Goldstein, Neil W Kowall, Douglas I Katz, Robert A Stern, Yorghos Tripodis, Thor D Stein, Michael D McClean, Michael L Alosco, Ann C McKee, Jesse Mez
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI), but the components of RHI exposure underlying this relationship are unclear. We create a position exposure matrix (PEM), composed of American football helmet sensor data, summarized from literature review by player position and level of play. Using this PEM, we estimate measures of lifetime RHI exposure for a separate cohort of 631 football playing brain donors. Separate models examine the relationship between CTE pathology and players' concussion count, athletic positions, years of football, and PEM-derived measures, including estimated cumulative head impacts, linear accelerations, and rotational accelerations...
June 20, 2023: Nature Communications
#55
JOURNAL ARTICLE
M Encarna Micó-Amigo, Tecla Bonci, Anisoara Paraschiv-Ionescu, Martin Ullrich, Cameron Kirk, Abolfazl Soltani, Arne Küderle, Eran Gazit, Francesca Salis, Lisa Alcock, Kamiar Aminian, Clemens Becker, Stefano Bertuletti, Philip Brown, Ellen Buckley, Alma Cantu, Anne-Elie Carsin, Marco Caruso, Brian Caulfield, Andrea Cereatti, Lorenzo Chiari, Ilaria D'Ascanio, Bjoern Eskofier, Sara Fernstad, Marcel Froehlich, Judith Garcia-Aymerich, Clint Hansen, Jeffrey M Hausdorff, Hugo Hiden, Emily Hume, Alison Keogh, Felix Kluge, Sarah Koch, Walter Maetzler, Dimitrios Megaritis, Arne Mueller, Martijn Niessen, Luca Palmerini, Lars Schwickert, Kirsty Scott, Basil Sharrack, Henrik Sillén, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Alison J Yarnall, Lynn Rochester, Claudia Mazzà, Silvia Del Din
BACKGROUND: Although digital mobility outcomes (DMOs) can be readily calculated from real-world data collected with wearable devices and ad-hoc algorithms, technical validation is still required. The aim of this paper is to comparatively assess and validate DMOs estimated using real-world gait data from six different cohorts, focusing on gait sequence detection, foot initial contact detection (ICD), cadence (CAD) and stride length (SL) estimates. METHODS: Twenty healthy older adults, 20 people with Parkinson's disease, 20 with multiple sclerosis, 19 with proximal femoral fracture, 17 with chronic obstructive pulmonary disease and 12 with congestive heart failure were monitored for 2...
June 14, 2023: Journal of Neuroengineering and Rehabilitation
#56
JOURNAL ARTICLE
Kathryn J Schneider, Jon S Patricios, Willem Meeuwisse, Geoff M Schneider, K Alix Hayden, Zahra Premji, Osman Hassan Ahmed, Cheri Blauwet, Steven Broglio, Robert C Cantu, Gavin A Davis, Jiri Dvorak, Ruben J Echemendia, Carolyn A Emery, Grant L Iverson, John J Leddy, Michael Makdissi, Michael McCrea, Michael McNamee, Margot Putukian, Keith Owen Yeates, Amanda M Black, Joel S Burma, Meghan Critchley, Paul H Eliason, Anu M Räisänen, Jason B Tabor, Clodagh Toomey, Paul E Ronksley, J David Cassidy
The purpose of this paper is to summarise the consensus methodology that was used to inform the International Consensus Statement on Concussion in Sport (Amsterdam 2022). Building on a Delphi process to inform the questions and outcomes from the 5th International Conference on Concussion in Sport, the Scientific Committee identified key questions, the answers to which would help encapsulate the current science in sport-related concussion and help guide clinical practice. Over 3½ years, delayed by 2 years due to the pandemic, author groups conducted systematic reviews on each selected topic...
June 2023: British Journal of Sports Medicine
#57
JOURNAL ARTICLE
Grant L Iverson, Rudolph J Castellani, J David Cassidy, Geoff M Schneider, Kathryn J Schneider, Ruben J Echemendia, Julian E Bailes, K Alix Hayden, Inga K Koerte, Geoffrey T Manley, Michael McNamee, Jon S Patricios, Charles H Tator, Robert C Cantu, Jiri Dvorak
OBJECTIVE: Concern exists about possible problems with later-in-life brain health, such as cognitive impairment, mental health problems and neurological diseases, in former athletes. We examined the future risk for adverse health effects associated with sport-related concussion, or exposure to repetitive head impacts, in former athletes. DESIGN: Systematic review. DATA SOURCES: Search of MEDLINE, Embase, Cochrane, CINAHL Plus and SPORTDiscus in October 2019 and updated in March 2022...
June 2023: British Journal of Sports Medicine
#58
Gan Zhao, Maria E Gentile, Lulu Xue, Christopher V Cosgriff, Aaron I Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P Holcomb, Maria C Basal, Kathleen M Stewart, Joseph D Planer, Edward Cantu, Jason D Christie, Maria M Crespo, Michael J Mitchell, Nuala J Meyer, Andrew E Vaughan
Inflammation upon infectious lung injury is a double-edged sword: while tissue-infiltrating immune cells and cytokines are necessary to control infection, these same factors often aggravate injury. Full appreciation of both the sources and targets of inflammatory mediators is required to facilitate strategies to maintain antimicrobial effects while minimizing off-target epithelial and endothelial damage. Recognizing that the vasculature is centrally involved in tissue responses to injury and infection, we observed that pulmonary capillary endothelial cells (ECs) exhibit dramatic transcriptomic changes upon influenza injury punctuated by profound upregulation of Sparcl1 ...
May 25, 2023: bioRxiv
#59
JOURNAL ARTICLE
F Cavalcoli, A Magarotto, M E Kelly, P Cantù, A Mancini, E Rausa, E Masci
PURPOSE: Endoscopic full-thickness resection (EFTR) is an innovative technique for the treatment of colonic lesions not feasible by conventional endoscopic resection. Here, we aimed to evaluate the efficacy and safety of a Full-Thickness Resection Device (FTRD) for colonic lesions in a high-volume tertiary referral center. METHODS: A review of a prospectively collected database on patients that underwent EFTR with FTRD for colonic lesions from June 2016 to January 2021 at our institution was performed...
May 19, 2023: Techniques in Coloproctology
#60
JOURNAL ARTICLE
Laura E Carreto-Binaghi, María Teresa Herrera, Silvia Guzmán-Beltrán, Esmeralda Juárez, Carmen Sarabia, Manuel G Salgado-Cantú, Daniel Juarez-Carmona, Cristóbal Guadarrama-Pérez, Yolanda González
Severe inflammatory responses are associated with the misbalance of innate and adaptive immunity. TLRs, NLRs, and cytokine receptors play an important role in pathogen sensing and intracellular control, which remains unclear in COVID-19. This study aimed to evaluate IL-8 production in blood cells from COVID-19 patients in a two-week follow-up evaluation. Blood samples were taken at admission (t1) and after 14 days of hospitalization (t2). The functionality of TLR2, TLR4, TLR7/8, TLR9, NOD1, and NOD2 innate receptors and IL-12 and IFN-γ cytokine receptors was evaluated by whole blood stimulation with specific synthetic receptor agonists through the quantification of IL-8, TNF-α, or IFN-γ...
April 3, 2023: Biomedicines
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