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JOURNAL ARTICLE
Omer Faruk Cetiner, Mehmet Hora, Ibrahim Halil Kafadar, Aysegul Ulu Kilic, Aycan Gundogdu
Prosthetic joint infection (PJI) and aseptic loosening (AL) are common complications of total joint arthroplasty. An accumulation of evidence indicates the presence of microbial communities on prosthetic implants, but the overall microbial profile is unclear. In this study, we aimed to investigate the differences in the microbial composition of prosthetic implants obtained from PJI and AL patients using the 16S rRNA sequencing method. Patients who underwent revision hip, knee, or shoulder arthroplasty caused by PJI (n = 20) or AL (n = 10) were enrolled in the study...
April 15, 2024: Acta Microbiologica et Immunologica Hungarica
#42
JOURNAL ARTICLE
Hideto Kameda, Keiichiro Nishida, Toshihiro Nanki, Akira Watanabe, Yukiya Oshima, Shigeki Momohara
OBJECTIVES: To report up to 3-year safety and effectiveness of certolizumab pegol (CZP) in Japanese patients with rheumatoid arthritis from a postmarketing surveillance study. METHODS: Patients enrolled previously completed 24 weeks of CZP in the 24-week postmarketing surveillance study. Adverse drug reactions (ADRs) were recorded for patients who received ≥1 CZP dose. Effectiveness outcomes were 28-joint Disease Activity Score with erythrocyte sedimentation rate and European Alliance of Associations for Rheumatology response...
March 29, 2024: Modern Rheumatology
#43
JOURNAL ARTICLE
Weidong Liu, Qi Jiang, Shenglong Xue, Wenjia Hui, Wenjie Kong, Mengxia Zhang, Feng Gao
UNLABELLED: There has been a suggestion of a potential protective effect of Helicobacter pylori ( H. pylori ) in the development of ulcerative colitis (UC). Virulence factor is an important factor in H. pylori , but little is known about the clinical characteristics of ulcerative colitis. In this retrospective study, a total of 322 patients with UC were analyzed. They were divided into three groups based on H. pylori antibody typing classification: type I H. pylori infection group, type II H...
April 15, 2024: Microbiology Spectrum
#44
JOURNAL ARTICLE
Victoria Starnes, Joan Duggan, Caitlyn Hollingshead
INTRODUCTION: Fungal prosthetic joint infections comprise less than 1% of prosthetic joint infections. Thus, little is known regarding optimal management. This study aims to characterize the microbiology, surgical and medical management, and outcomes for these complex infections. The objectives of this study were to assess the impact of surgical approach, antifungal treatment, fungal species, and time to onset of infection from initial surgery on patient outcomes. METHODS: A retrospective record review over 12 years was performed in two health systems that included patients with a deep culture positive for a fungal isolate and the presence of a prosthetic joint...
April 13, 2024: Infectious Diseases and Therapy
#45
REVIEW
Michele Mercurio, Giorgio Gasparini, Erminia Cofano, Andrea Zappia, Filippo Familiari, Olimpio Galasso
The aim of this systematic review was to investigate the outcomes of knee arthrodesis (KA) after periprosthetic joint infection (PJI) of the knee. Differences in clinical outcomes and complication rates among the intramedullary nailing (IMN), external fixation (EF), and compression plating (CP) procedures were compared. A total of 23 studies were included. Demographics, microbiological data, types of implants, surgical techniques with complications, reoperations, fusion, and amputation rates were reported. A total of 787 patients were evaluated, of whom 601 (76...
April 7, 2024: Healthcare (Basel, Switzerland)
#46
REVIEW
Donato Di Gennaro, Giannantonio Coletta, Enrico Festa, Domenico De Mauro, Maria Rizzo, Luca Diana, Giovanni Balato, Massimo Mariconda
BACKGROUND: The gold standard treatment for periprosthetic joint infections is the two-stage revision that includes the spacer placement before definitive reimplantation. The management of PJI affects patients' joint function and, subsequently, their mental health. Even though significant advances have been achieved, little to no attention has been paid to the psychological implications. So, based on standardized patient-reported outcome measures (PROMs), this study aimed to clarify the effect of spacer treatment of infected hip and knee arthroplasties on patients' mental health...
April 6, 2024: Healthcare (Basel, Switzerland)
#47
JOURNAL ARTICLE
Domenico De Mauro, Enrico Festa, Donato Di Gennaro, Tiziana Ascione, Giannantonio Coletta, Massimo Mariconda, Giovanni Balato
Periprosthetic joint infections (PJIs) are a prominent subject of discussion in orthopedics and are frequently debated at conferences and congresses. In the context of PJIs affecting the knee, the decision between following a one-stage or two-stage treatment approach has historically been a pivotal consideration. The first option is limited by indications and potentially devastating complications in case of failure, whereas the second is widely accepted as the gold standard. Initially, the spacer was conceived solely to restore and maintain knee space after removal of the implant...
March 28, 2024: Healthcare (Basel, Switzerland)
#48
JOURNAL ARTICLE
Yujiang Liu, Junxin Lin
BACKGROUND: Periprosthetic infection is a serious complication after arthroplasty and is characterized by a long duration, recurrence, and a low cure rate. Although fungal infections are infrequent, they are often catastrophic, with an insidious onset, a long duration, atypical clinical symptoms, and imaging features in the early stage. They are easily misdiagnosed, or the diagnosis is missed, resulting in wrong treatment approaches. CASE PRESENTATION: This paper reports a case involving a 62-year-old female patient of Korean ethnicity with a periprosthetic infection after knee arthroplasty who underwent joint debridement...
April 13, 2024: Journal of Medical Case Reports
#49
JOURNAL ARTICLE
Luca Barberis, Luigi Sabatini, Andrea Pellegrino, Claudia Galletta, Salvatore Risitano, Marcello Capella, Alessandro Massè, Marco Schiraldi, Pier Francesco Indelli
BACKGROUND: Bicruciate-retaining (BCR) total knee arthroplasty (TKA) has seen renewed interest due to the potential for more natural knee kinematics with anterior cruciate ligament (ACL) retention. OBJECTIVE: The present study attempts to determine differences in the 2-year survivorship and patient-reported outcomes between two surgical strategies (traditional instrumentation versus robotics) applied to the extensive use of a modern, 2nd generation BCR TKA design...
March 28, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
#50
MULTICENTER STUDY
Natalia Mena-Vázquez, Rocío Redondo-Rodriguez, Marta Rojas-Gimenez, Carmen María Romero-Barco, Clara Fuego-Varela, Nair Perez-Gómez, Isabel Añón-Oñate, Patricia Castro Pérez, Aimara García-Studer, Ana Hidalgo-Conde, Rocío Arnedo Díez de Los Ríos, Eva Cabrera-César, Maria Luisa Velloso-Feijoo, Sara Manrique-Arija, Jerusalem Calvo-Gutiérrez, Myriam Gandía-Martínez, Pilar Morales-Garrido, Francisco Javier Godoy-Navarrete, Coral Mouriño-Rodriguez, Francisco Espildora, María Carmen Aguilar-Hurtado, Antonio Fernández-Nebro
OBJECTIVE: To describe severe infection, foci of infection, microorganisms, associated factors, and impact on mortality in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). PATIENTS AND METHODS: The study was based on a multicenter prospective cohort of patients with RA-ILD followed up from 2015 to 2023. The main outcome measures were incident severe infection and fatal infection. We evaluated infectious foci, etiologic agents, vaccination status, variables associated with lung function, and clinical-therapeutic variables in RA...
2024: Frontiers in Immunology
#51
JOURNAL ARTICLE
Ryan D Freshman, Jacob L Kotlier, Cory K Mayfield, Amir Fathi, Aamir Ahmad, Christian Cruz, Joseph N Liu, Frank A Petrigliano
BACKGROUND: Perioperative intravenous (IV) dexamethasone is commonly used in lower extremity total joint arthroplasty to manage postoperative pain and nausea/vomiting, and recent studies have demonstrated that its use may lower rates of acute postoperative medical complications. However, there is limited information regarding the safety and efficacy of IV dexamethasone in patients undergoing total shoulder arthroplasty (TSA). Additionally, there is concern surrounding corticosteroid use prior to surgery as preoperative corticosteroid injections have been associated with adverse outcomes after TSA, including periprosthetic joint infection (PJI) and revision surgery...
April 9, 2024: Journal of Shoulder and Elbow Surgery
#52
JOURNAL ARTICLE
Jason E Hsu, Frederick A Matsen, Anastasia J Whitson, Adam Waalkes, Jared Almazan, Lori A Bourassa, Stephen J Salipante, Dustin R Long
BACKGROUND: Cutibacterium acnes is the bacterium most commonly responsible for shoulder periprosthetic joint infection (PJI) and is often cultured from samples obtained at the time of revision for failed shoulder arthroplasty. We sought to determine whether these bacteria originate from the patient or from exogenous sources. We also sought to identify which C. acnes genetic traits were associated with the development of shoulder PJI. METHODS: We performed bacterial whole-genome sequencing of C...
April 9, 2024: Journal of Shoulder and Elbow Surgery
#53
JOURNAL ARTICLE
Emily A Treu, Jeffrey J Frandsen, Graham J DeKeyser, Brenna E Blackburn, Michael J Archibeck, Lucas A Anderson, Jeremy M Gililland
INTRODUCTION: Femoral neck fractures (FNF) in elderly patients are associated with major morbidity and mortality. The influence of postoperative discharge location on recovery and outcomes after arthroplasty for hip fractures is not well understood. METHODS: A multi-site retrospective cohort from nine academic centers identified patients who had FNF treated with hemiarthroplasty (HA) or total hip arthroplasty (THA) between 2010 and 2019. Patients who had diagnoses of dementia, stroke, age > 80 years, or high energy fracture were excluded...
April 9, 2024: Journal of Arthroplasty
#54
JOURNAL ARTICLE
Bryan D Springer, Carlos Higuera-Rueda, Brian de Beaubien, Kevin Warner, Andrew Glassman, Hari Parvataneni, Nicolas Piuzzi
INTRODUCTION: Systemic intravenous antimicrobials yield poor outcomes during the treatment of periprosthetic joint infection because systemic therapy is unable to obtain the minimum biofilm eradication concentration. Therefore, this study evaluated the safety of a novel method of optimized local delivery of intra-articular antibiotics (IAA) when compared to two-stage exchange arthroplasty. METHODS: This was a Phase II, multicenter, prospective randomized clinical trial of the safety of a seven-day two-stage exchange arthroplasty with IAA irrigation compared to a standard two-stage exchange...
April 9, 2024: Journal of Arthroplasty
#55
JOURNAL ARTICLE
Stéphanie Pascual, Brooklyn Noble, Nusreen Ahmad-Saeed, Catherine Aldridge, Simone Ambretti, Sharon Amit, Rachel Annett, Shaan Ashk O'Shea, Anna Maria Barbui, Gavin Barlow, Lucinda Barrett, Mario Berth, Alessandro Bondi, Nicola Boran, Sara E Boyd, Catarina Chaves, Martin Clauss, Peter Davies, Ileana T Dianzo-Delgado, Jaime Esteban, Stefan Fuchs, Lennart Friis-Hansen, Daniel Goldenberger, Andrej Golle, Juha O Groonroos, Ines Hoffmann, Tomer Hoffmann, Harriet Hughes, Marina Ivanova, Peter Jezek, Gwennan Jones, Zeynep Ceren Karahan, Cornelia Lass-Flörl, Frédéric Laurent, Laura Leach, Matilde Lee Horsbøll Pedersen, Caroline Loiez, Maureen Lynch, Robert J Maloney, Martin Marsh, Olivia Milburn, Shanine Mitchell, Luke S P Moore, Lynn Moffat, Marianna Murdjeva, Michael E Murphy, Deepa Nayar, Giacomo Nigrisoli, Fionnuala O'Sullivan, Büşra Öz, Teresa Peach, Christina Petridou, Mojgan Prinz, Mitja Rak, Niamh Reidy, Gian Maria Rossolini, Anne-Laure Roux, Patricia Ruiz-Garbajosa, Kordo Saeed, Llanos Salar-Vidal, Carlos Salas Venero, Mathyruban Selvaratnam, Eric Senneville, Peter Starzengruber, Ben Talbot, Vanessa Taylor, Rihard Trebše, Deborah Wearmouth, Birgit Willinger, Marjan Wouthuyzen-Bakker, Brianne Couturier, Florence Allantaz
Introduction : The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). Methods : A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel. Results : A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88...
2024: Journal of Bone and Joint Infection
#56
JOURNAL ARTICLE
Pansachee Damronglerd, Eibhlin Higgins, Madiha Fida, Don Bambino Geno Tai, Aaron J Tande, Matthew P Abdel, Omar M Abu Saleh
Background : Periprosthetic joint infection (PJI) following total joint arthroplasty is a serious complication associated with significant morbidity. While Gram-positive cocci are the predominant causative organisms, PJIs caused by rapidly growing mycobacteria (RGM) have been reported, albeit at a lower frequency. This study aimed to investigate the characteristics and management of PJI caused by RGM. Methods : A retrospective review was conducted using an institutional PJI database to identify patients diagnosed with PJI due to RGM from January 2010 to December 2021...
2024: Journal of Bone and Joint Infection
#57
JOURNAL ARTICLE
Jesse D De Groot, Roy G B Brokelman, Bas L Fransen, Tim U Jiya, Dean F M Pakvis
Background : Antibiotic prophylaxis (AP) is considered to be the gold standard for revision total hip arthroplasty (R-THA) due to the high incidence of prosthetic joint infection (PJI). To diagnose PJI, intraoperative tissue biopsies for culture are of particular importance. However, antibiotic interference could theoretically lead to less reliable culture results. Currently, there is no consensus on whether AP should be administered before or after tissue biopsy. In this study, we aimed to investigate the effect of AP timing on culture results and PJI rates in presumed aseptic R-THA...
2024: Journal of Bone and Joint Infection
#58
JOURNAL ARTICLE
Thomas J A van Schaik, Petra J C Heesterbeek, Job L C van Susante, Wim H C Rijnen, Jon H M Goosen
Automated custom-made multiplex PCR techniques (mPCR) have become commercially available and are designed for intra-operative screening of concurrent periprosthetic joint infections (PJIs). The purpose of this study was to evaluate the value of a positive mPCR test in presumed aseptic revision total hip (THA) and knee (TKA) arthroplasties after a 1-year follow-up. In an earlier study, such an automated mPCR technique (Unyvero ITI G2; Curetis, Holzgerlingen, Germany) was tested on intra-operatively obtained synovial fluid in 200 patients with a presumed aseptic TKA or THA revision...
2024: Journal of Bone and Joint Infection
#59
JOURNAL ARTICLE
Céline Dupieux, Ghislaine Descours, Paul Verhoeven, Florence Grattard, Yvonne Benito, François Vandenesch, Céline Cazorla, Tristan Ferry, Sébastien Lustig, Bertrand Boyer, Sandrine Boisset, Anne Carricajo, Frédéric Laurent, / Pirla Investigator Group
No consensus exists about the techniques to use for microbiological diagnosis of bone and joint infections (BJIs). The objective herein was to define an algorithm to optimize BJI diagnosis in adults using various bacteriological methods on synovial fluid samples. This prospective multi-center study included 423 synovial fluids collected from adult patients with suspected BJIs. Culture (using five solid media, an enrichment broth, and blood culture bottles), universal 16S rRNA PCR followed by Sanger sequencing, and seven specific bacterial PCRs were systematically performed...
2024: Journal of Bone and Joint Infection
#60
JOURNAL ARTICLE
Michael M Kheir, Christopher G Anderson, Yu-Fen Chiu, Alberto V Carli
Introduction : The 2018 International Consensus Meeting (ICM) proposed criteria for one-stage exchange arthroplasty in treating periprosthetic joint infection (PJI). Our study aimed to determine what proportion of PJI patients met the 2018 ICM criteria and how this affected infection-free survivorship for patients. Methods : All chronic PJI patients treated with two-stage exchange within our institution between 2017-2020 were retrospectively reviewed. Included cases met 2011 Musculoskeletal Infection Society (MSIS) criteria for PJI and had a 2-year minimum follow-up...
2024: Journal of Bone and Joint Infection
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