Michael Guger, Robert Hatschenberger, Fritz Leutmezer
BACKGROUND AND PURPOSE: Randomized controlled trials and observational studies of nabiximols oromucosal spray in patients with multiple sclerosis (MS) spasticity have shown improvement in a range of associated symptoms (pain, spasms, fatigue, bladder dysfunction, and sleep disturbances). This study evaluated the effectiveness and tolerability of add-on nabiximols in the routine management of patients with MS spasticity in Austria, with a focus on spasticity-associated symptoms. METHODS: This was an open, prospective, multicenter, observational, non-interventional study of patients with MS spasticity receiving add-on treatment with nabiximols oromucosal spray...
March 19, 2023: Brain and Behavior
Takanori Hayashi, Nobuhiro Wada, Tetsuya Kubota, Chie Koizumi, Yoshitaka Sakurai, Masakazu Aihara, Satoshi Usami, Toshimasa Yamauchi, Naoto Kubota
AIMS/INTRODUCTION: Patients with type 2 diabetes mellitus are reported to be at a high risk for sarcopenia, and are known to have a poorer sleep quality. However, the association between sleep quality and skeletal muscle in patients with type 2 diabetes mellitus is not yet precisely understood. MATERIALS AND METHODS: A total of 110 inpatients with type 2 diabetes mellitus aged 40-90 years were enrolled. The sleep quality was assessed using the Pittsburgh sleep quality index (PSQI)...
March 19, 2023: Journal of Diabetes Investigation
Rebecca Evans, Haruhide Kimura, Masato Nakashima, Takashi Ishikawa, Hiroshi Yukitake, Motohisa Suzuki, James Hazel, Hélène Faessel, Jingtao Wu, Yaming Hang, Robert Alexander, Laura Rosen, Deborah S Hartman, Emiliangelo Ratti
The orexin 2 receptor-selective agonist danavorexton (TAK-925) has been shown to produce wake-promoting effects in wild-type mice, narcolepsy-model mice, and individuals with narcolepsy type 1 and type 2. Here, we report wake-promoting effects of danavorexton in non-human primates and healthy men during their sleep phase. Electroencephalogram analyses revealed that subcutaneous administration of danavorexton significantly increased wakefulness in common marmosets (p < 0.05 at 0.1 mg kg-1 , and p < 0...
March 19, 2023: Journal of Sleep Research
Qiang Han, Wei Hu, Na Sun, Jiadong Chu, Xuanli Chen, Tongxing Li, Qida He, Zhaolong Feng, Yueping Shen
BACKGROUND: Although studies have demonstrated associations between sleep quality (SQ) and grip strength (GS) in older adults, the direction and underlying mechanisms of this relationship are yet to be better delineated. We aimed to longitudinally investigate the bidirectional association between SQ and GS and the mediating role of depression in this association. METHODS: Based on two nationally representative samples with people aged ≥ 50 years from the China Health and Retirement Longitudinal Study (CHARLS; 4,200 participants) and English Longitudinal Study of Ageing (ELSA; 5,922 participants), cross-lagged panel models were employed to examine the potential bidirectional relationships between objectively measured GS and self-reported SQ...
March 19, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Shunta Hori, Kazumasa Torimoto, Mitsuru Tomizawa, Tatsuo Yoneda, Kuniaki Inoue, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Nobumichi Tanaka, Kiyohide Fujimoto
BACKGROUND: To investigate the quality of life (QOL) of patients with nocturia after kidney transplantation (KT) and the association between nocturnal polyuria and sleep quality. METHODS: In a cross-sectional study, a patient who consented was evaluated using the following items: international prostate symptom QOL score, nocturia-quality of life score, overactive bladder symptom score, Pittsburgh sleep quality index, bladder diary, uroflowmetry, and bioimpedance analysis...
March 16, 2023: Transplantation Proceedings
Ying Song, Beibei Wang, Wenjun Wang, Qiwen Shi
Orexin (OX)A and OXB are a pair of neuropeptides secreted by orexin-producing neurons in the lateral hypothalamus. The orexin system can regulate many physiological processes through these two receptor pathways, such as feeding behavior, sleep/wake state, energy homeostasis, reward, and the coordination of emotion. Mammalian target of rapamycin (mTOR) can coordinate upstream signals with downstream effectors, thereby regulating fundamental cellular processes and also plays an essential role in the signaling network downstream of the orexin system...
March 16, 2023: Trends in Endocrinology and Metabolism: TEM
Chiung-Yu Huang, Chun-I Chen, Yung-Chuan Lu, Yu-Ching Lin, Chu-Yun Lu
BACKGROUND: Sleep disturbances are more prevalent in diabetic patients than in the general population and may consequently be comorbid with hyperglycaemia. OBJECTIVE: The two study aims were to (1) verify the factors associated with sleep disturbances and glycaemic control and (2) further understand the mediation effects of coping and social support in the relationship among stress, sleep disturbances, and glycaemic control. METHODS: A cross-sectional study design was used...
April 2023: Applied Nursing Research: ANR
Juan J Madrid-Valero, Alice M Gregory
During the last decade quantitative and molecular genetic research on sleep has increased considerably. New behavioural genetics techniques have marked a new era for sleep research. This paper provides a summary of the most important findings from the last ten years, on the genetic and environmental influences on sleep and sleep disorders and their associations with health-related variables (including anxiety and depression) in humans. In this review we present a brief summary of the main methods in behaviour genetic research (such as twin and genome-wide association studies)...
February 28, 2023: Sleep Medicine Reviews
Susanne Grylka-Baeschlin, Antonia N Mueller
OBJECTIVES: To gain a deeper understanding of primiparous women's preparation for early labour as well as their expectations and experiences of symptoms of onset of labour. METHODS: A qualitative study using focus group discussion was conducted with n = 18 first-time mothers within the first six months of giving birth. Discussions were transcribed verbatim and coded and summarised into themes by two researchers using qualitative content analysis. RESULTS: The statements of the participants revealed four themes: 'Preparing for the unpredictable', 'Expectations and reality', 'Perception and wellbeing' and 'Experiencing the beginning of birth'...
March 11, 2023: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
Danielle R Glick, Samuel A Abariga, Irine Thomas, Andrea G Shipper, Brian C Gunia, Michael A Grandner, Elliot Rosenberg, Stella E Hines, Vincent Capaldi, Jacob Collen, Emerson M Wickwire
OBJECTIVE: Insufficient and disturbed sleep are associated with significant morbidity among working-age adults. Poor sleep results in negative health outcomes and increases economic costs to employers. The current systematic review surveyed the peer-reviewed scientific literature and aggregated scientific evidence of sleep-related economic burdens borne by employers. METHODS: A systematic review was performed to identify peer-reviewed, English language studies evaluating the economic impact of insufficient and disturbed sleep among adult employee populations...
March 18, 2023: PharmacoEconomics
Kirsten Barnes, Emily Babbage, Jessica Barker, Natasha Jain, Kate Faasse
Open label placebos (OLPs) appear generally efficacious among clinical samples, but the empirical evidence regarding their use in non-clinical and sub-clinical samples, as well as when administered independent of a convincing rationale, is mixed. Healthy participants (N = 102) were randomised to either a 6-day course of OLP pills with information provision (OLP-plus: N = 35), without information provision (OLP-only: N = 35), or no-treatment control group (N = 32)...
March 18, 2023: Applied Psychology. Health and Well-being
Marijke Proesmans, Francois Vermeulen, Mieke Boon
INTRODUCTION: Patients with neurocognitive impairment (NI) have multiple medical needs, with respiratory problems leading to an important reduction in quality of life and life expectancy. We aimed to explain that the origin of chronic respiratory symptoms in patients with NI is multifactorial. AREAS COVERED: In people with NI there is a high prevalence of swallowing dysfunction and hypersalivation inducing aspiration; cough efficacy is decreased resulting in chronic lung infection; sleep-disordered breathing is frequent and muscle mass is abnormal due to malnutrition...
March 18, 2023: Expert Review of Respiratory Medicine
Muhammad Taha Abid, Mudassir Abbas, Syed Hamza Haider
No abstract text is available yet for this article.
March 2023: JPMA. the Journal of the Pakistan Medical Association
Shubhada N Joshi, Aditya N Joshi, Narendra D Joshi
Neuronal up and down states have long been known to exist both in vitro and in vivo. A variety of functions and mechanisms have been proposed for their generation, but there has not been a clear connection between the functions and mechanisms. We explore the potential contribution of cellular-level biochemistry to the network-level mechanisms thought to underlie the generation of up and down states. We develop a neurochemical model of a single tripartite synapse, assumed to be within a network of similar tripartite synapses, to investigate possible function-mechanism links for the appearance of up and down states...
February 2023: Physical Review. E
Matthieu Gilson, Enzo Tagliazucchi, Rodrigo Cofré
Consciousness is supported by complex patterns of brain activity which are indicative of irreversible nonequilibrium dynamics. While the framework of stochastic thermodynamics has facilitated the understanding of physical systems of this kind, its application to infer the level of consciousness from empirical data remains elusive. We faced this challenge by calculating entropy production in a multivariate Ornstein-Uhlenbeck process fitted to Functional magnetic resonance imaging brain activity recordings. To test this approach, we focused on the transition from wakefulness to deep sleep, revealing a monotonous relationship between entropy production and the level of consciousness...
February 2023: Physical Review. E
Virginia A Aparicio, Nuria Marín-Jiménez, Marta Flor-Alemany, Pedro Acosta-Manzano, Irene Coll-Risco, Laura Baena-García
OBJECTIVE: The aim of the present study was to explore the influence of a concurrent exercise (aerobic+resistance) training program, from the 17th gestational week (g.w.) until birth on low back and sciatic pain, and pain disability. A total of 93 pregnant women divided into exercise (n=49) and control (n=44) groups followed a 60-min, 3 days/week, concurrent exercise training. METHODS: Low back and sciatic pain were measured with a Visual Analogic Scale (VAS)...
March 17, 2023: Scandinavian Journal of Medicine & Science in Sports
Michael H Berry, Michael Moldavan, Tavita Garrett, Marc Meadows, Olga Cravetchi, Elizabeth White, Joseph Leffler, Henrique von Gersdorff, Kevin M Wright, Charles N Allen, Benjamin Sivyer
Visual input to the hypothalamus from intrinsically photosensitive retinal ganglion cells (ipRGCs) influences several functions including circadian entrainment, body temperature, and sleep. ipRGCs also project to nuclei such as the supraoptic nucleus (SON), which is involved in systemic fluid homeostasis, maternal behavior, social behaviors, and appetite. However, little is known about the SON-projecting ipRGCs or their relationship to well-characterized ipRGC subtypes. Using a GlyT2Cre mouse line, we show a subtype of ipRGCs restricted to the dorsal retina that selectively projects to the SON...
March 17, 2023: Nature Communications
Rita Gomes, Bebiana Sousa, Diana Gonzaga, Catarina Prior, Marta Rios, Inês Vaz Matos
INTRODUCTION: Sleep problems are frequent in children with attention-deficit/hyperactivity disorder (ADHD). Some authors have tried to characterize paediatric sleep habits in Portugal, but none has focused on preschool-age children nor attempted to establish their association with ADHD. We aimed to assess the prevalence of ADHD symptoms in preschool-age children and to study their association with sleep habits. MATERIAL AND METHODS: We conducted a cross-sectional study...
March 15, 2023: Anales de pediatría
Lisa Bransby, Emily Rosenich, Rachel F Buckley, Nawaf Yassi, Matthew P Pase, Paul Maruff, Yen Ying Lim
OBJECTIVE: Studies of modifiable dementia risk factors (MDRFs) generally consider MDRFs individually, despite strong evidence that they co-occur in adult populations. In a large sample of middle-aged adults, this study aimed to determine the frequency and co-occurrence of MDRFs, spanning five domains (mood symptomatology, risky lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology). The relationship between number of domains in which MDRFs were reported with cognitive performance and subjective cognitive concerns was then determined...
March 16, 2023: Neuropsychology
Yves Dauvilliers, Michel Lecendreux, Gert Jan Lammers, Patricia Franco, Mikhail Poluektov, Christian Caussé, Isabelle Lecomte, Jeanne Marie Lecomte, Philippe Lehert, Jean Charles Schwartz, Giuseppe Plazzi
BACKGROUND: Narcolepsy is a life-long disorder characterised by excessive daytime sleepiness and cataplexy, often arising in childhood or adolescence. Pitolisant, a selective histamine H3 receptor inverse agonist, has been approved in Europe and USA for adults with narcolepsy with or without cataplexy, with a favourable safety profile. This phase 3 study aimed to assess the safety and efficacy of pitolisant in children with narcolepsy with or without cataplexy. METHODS: For this double-blind, randomised, placebo-controlled, multisite study, we recruited patients aged 6-17 years with narcolepsy with or without cataplexy in 11 sleep centres in five countries (Italy, France, Netherlands, Russia, and Finland)...
April 2023: Lancet Neurology
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