Michael J Balsan, Jeanne Burns, Fred Kimock, Emily Hirsch, Andrew Unger, Richard Telesco, Elisabeth Bloch-Salisbury
BACKGROUND: Loud noises in the neonatal intensive care unit (NICU) exacerbate patient cardiac and respiratory activity, disrupt sleep, and may contribute to hearing deficits, speech and language disorders, and neurodevelopmental delays among NICU graduates. AIMS: This study evaluated infant-patient tolerance and nurse ease of use of a novel frequency-selective hearing protection device, DREAMIES (NEATCap Medical, LLC). STUDY DESIGN AND SUBJECTS: Fifty neonates receiving care in a Level III NICU participated in a 2-phase prospective study...
March 26, 2021: Early Human Development
Viktor Haellman, Tobias Strittmatter, Adrian Bertschi, Pascal Stücheli, Martin Fussenegger
Current molecular cloning strategies generally lack inter-compatibility, are not strictly modular, or are not applicable to engineer multi-gene expression vectors for transient and stable integration. A standardized molecular cloning platform would advance research, for example, by promoting exchange of vectors between groups. Here, we present a versatile plasmid architecture for mammalian synthetic biology, which we designate VAMSyB, consisting of a three-tier vector family. Tier-1 is designed for easy engineering of fusion constructs, as well as easy swapping of genes and modules to tune the functionality of the vector...
April 12, 2021: Metabolic Engineering
Antonio M Persico, Arianna Ricciardello, Marco Lamberti, Laura Turriziani, Francesca Cucinotta, Claudia Brogna, Benedetto Vitiello, Celso Arango
Autism Spectrum Disorder (ASD) is a severe and lifelong neurodevelopmental disorder, with high social costs and a dramatic burden on the quality of life of patients and family members. Despite its high prevalence, reaching 1/54 children and 1/45 adults in the United States, no pharmacological treatment is still directed to core symptoms of ASD, encompassing social and communication deficits, repetitive behaviors, restricted interests, and abnormal sensory processing. The purpose of this review is to provide an overview of the state-of-the-art of psychopharmacological therapy available today for ASD in children and adolescents, in order to foster best practices and to organize new strategies for future research...
April 12, 2021: Progress in Neuro-psychopharmacology & Biological Psychiatry
M Panagiotou, S Michel, J H Meijer, T Deboer
Aging is a multifactorial process likely stemming from damage accumulation and/or a decline in maintenance and repair mechanisms in the organisms that eventually determine their lifespan. In our review, we focus on the morphological and functional alterations that the aging brain undergoes affecting sleep and the circadian clock in both human and rodent models. Although both species share mammalian features, differences have been identified on several experimental levels, which we outline in this review. Additionally, we delineate some challenges on the preferred analysis and we suggest that a uniform route is followed so that findings can be smoothly compared...
April 12, 2021: Biochemical Pharmacology
Stuart Batterman, Sydni C Warner, Tian Xia, Simone Sagovac, Benjamin Roberts, Bridget Vial, Chris Godwin
Noise exposure can affect sleep, health and cognitive performance, and it disproportionately affects communities of color. This study has the objective of evaluating both conventional and supplemental noise metrics in a community noise survey examining Southwest Detroit, Michigan, a densely populated and industrialized area with extensive truck traffic on residential streets. Sound pressure level (SPL) monitors were deployed at 21 residential sites within 900 m of a major interstate highway. With assistance from youth volunteers, continuous SPL measurements were obtained for 1...
April 12, 2021: Environmental Research
Tanya Dimitrov, Mingjian He, Robert Stickgold, Michael J Prerau
STUDY OBJECTIVES: Sleep spindles are defined based on expert observations of waveform features in the electroencephalogram traces. This is a potentially limiting characterization, as transient oscillatory bursts like spindles are easily obscured in the time-domain by higher amplitude activity at other frequencies or by noise. It is therefore highly plausible that many relevant events are missed by current approaches based on traditionally-defined spindles. Given their oscillatory structure, we reexamine spindle activity from first principles, using time-frequency activity in comparison to scored spindles...
April 15, 2021: Sleep
Jun Chen, Guoqiang Sang, Yu Zhang, Aifeng Jiang
BACKGROUND: The World Health Organization has declared the Corona Virus Disease 2019 (COVID-19) epidemic as a public health emergency of international concern. Given the sudden infection from and extensive dispersion of COVID-19 and the absence of specific drugs, those infected are in danger if they are not treated in time. Consequently, COVID-19 has become an important factor influencing adolescents' mental health. The purpose of this study is to explore the intervention effect of the integration model on the negative emotions of adolescents during the COVID-19 epidemic...
2021: Psychiatria Danubina
Romain Kirszenblat, Paul Edouard
BACKGROUND: A decrease in the pulse oxygen saturation (SpO2) level is an indicator of hypoxemia that may occur in various respiratory diseases such as chronic obstructive pulmonary disease (COPD), sleep apnea syndrome (SAS) and COVID-19. There is currently no mass-market wrist-worn SpO2 monitor meeting the medical standards for pulse oximeters. OBJECTIVE: The main objective of this monocentric and prospective clinical study with single-blind analysis was to test and validate the accuracy of the Withings ScanWatch's reflective pulse oximeter function to measure SpO2 levels at different stages of hypoxia...
April 11, 2021: Journal of Medical Internet Research
Muhammad Awais, Xi Long, Bin Yin, Saadullah Farooq Abbasi, Saeed Akhbarzadeh, Chunmei Lu, Xinhua Wang, Laishuan Wang, Jiong Zhang, Jeroen Dudink, Wei Chen
Sleep is a natural phenomenon controlled by the central nervous system. The sleep-wake pattern, which functions as an essential indicator of neurophysiological organization in the neonatal period, has profound meaning in the prediction of cognitive diseases and brain maturity. In recent years, unobtrusive sleep monitoring and automatic sleep staging have been intensively studied for adults, but much less for neonates. This work aims to investigate a novel video-based unobtrusive method for neonatal sleep-wake classification by analyzing the behavioral changes in the neonatal facial region...
April 15, 2021: IEEE Journal of Biomedical and Health Informatics
Surobhi Chatterjee, Sujita Kumar Kar
Background : Smartphone is an indispensable miracle of artificial intelligence in the hands of global netizens. Medical students overburdened and sleep-deprived due to the curricular demands can have serious health effects due to further sleep deprivation caused by problematic smartphone use, affecting their work proficiency as practicing physicians. This study aimed to evaluate the association of smartphone addiction and quality of sleep among medical students across all semesters, along with other background variables...
April 15, 2021: Psychiatry
Grace E Vincent, Katya Kovac, Madeline Sprajcer, Sarah M Jay, Amy C Reynolds, Jill Dorrian, Matthew J W Thomas, Sally A Ferguson
OBJECTIVE: The sleep of individuals who provide unpaid care for children with medical needs is likely to be significantly impacted by this role. Sleep may be affected by the practical tasks undertaken during the night (e.g., administering medication), in addition to the emotional impact (e.g., worry, rumination). The aim of this systematic review was to examine the available literature on the impact of caregiving for children with medical needs on caregivers' sleep. METHOD: Electronic databases, including PubMed, Medline, and Web of Science, were searched using predetermined criteria...
April 2021: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Stina Oftedal, Anna T Rayward, Sasha Fenton, Mitch J Duncan
OBJECTIVE: The prospective relationships between poor sleep health, poor diet quality, and physical inactivity with self-rated health (SRH) are not well described. The aim of this study was to assess individual and joint associations between high-risk health behaviors and incident poor SRH. METHOD: Participants from the Household Income and Labor Dynamics in Australia longitudinal cohort reporting "good" SRH in 2013 were included (n = 8,853) in 2020 data analysis...
April 2021: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Lilly Derby, Ian M Kronish, Dallas Wood, Ying Kuen K Cheung, Elizabeth Cohn, Naihua Duan, Tara St Onge, Joan Duer-Hefele, Karina W Davidson, Nathalie Moise
OBJECTIVE: Personalized trials have the potential to improve the precision of treatment selection and foster patient involvement in clinical decision making. Little is known about the attitudes of patients with multimorbidities. To address this, stakeholders designed and conducted a national survey that determined general attitudes and features of personalized trials that may increase their use among patients with multimorbidities in clinical and research practice. METHOD: A multistakeholder collaboratory of patients, clinicians, scientists, methodologists, statisticians, and research disseminators designed a survey to determine the conditions, symptoms, and design attributes most applicable to personalized trials according to patients...
April 2021: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Dennis J Sholler, Meghan B Moran, Sean B Dolan, Jacob T Borodovsky, Fernanda Alonso, Ryan Vandrey, Tory R Spindle
Cannabis products available for retail purchase are often marketed based on purported plant species (e.g., "indica" or "sativa"). The cannabis industry frequently claims that indica versus sativa cannabis elicits unique effects and/or is useful for different therapeutic indications. Few studies have evaluated use patterns, beliefs, subjective experiences, and situations in which individuals use indica versus sativa. A convenience sample of cannabis users ( n = 179) was surveyed via Amazon Mechanical Turk (mTurk)...
April 15, 2021: Experimental and Clinical Psychopharmacology
Madelyn E Rosenthal, M Melanie Lyons, Jessica Schweller, Vedat O Yildiz, Eugene G Chio, Meena S Khan
PURPOSE: To evaluate relationships between hypoglossal nerve stimulator (HNS) adherence and the presence of anxiety, depression, and emotional distress. METHODS: This is a cross-sectional study of subjects with moderate to severe obstructive sleep apnea (OSA), who had HNS implanted and activated at The Ohio State University Medical Center (OSUMC). Patient usage data from the previous 6 months was obtained from 33 patients. Adherence was defined as ≥28 h of use per week...
April 15, 2021: Sleep & Breathing, Schlaf & Atmung
Hoang Thi Xuan Huong, Molassiotis Alex, Chan Choi Wan, Vu Hoang Anh, Bui Thanh Phuc
PURPOSE: Current evidence for using self-acupressure to manage the cancer-related symptom cluster of insomnia, depression, and anxiety, while promising, is unknown. This study evaluated the feasibility of self-acupressure to manage this symptom cluster and to explore its potential effectiveness. METHODS: Participants were assigned randomly to three study groups, namely the true acupressure (TAP), the sham acupressure (SAP), and the enhanced standard care group (ESC)...
April 14, 2021: Sleep & Breathing
Lisa J Meltzer, Kyla L Wahlstrom, Amy E Plog, Matthew J Strand
STUDY OBJECTIVES: To examine the impact of changing school start times on sleep for primary (elementary school: ES) and secondary (middle and high school: MS/HS) students. METHODS: Students (grades 3-12) and parents (grades K-12) were surveyed annually, before and for 2 years after school start time changes (ES: 60 min earlier, MS: 40-60 min later; HS: 70 min later). Student sleep and daytime sleepiness were measured with school-administered student surveys and parent-proxy online surveys...
April 15, 2021: Sleep
Dhian Satya Rachmawati, Nursalam Nursalam, Rachmat Hargono, Bambang Widjanarko Otok
psychosocial problems that cause stress, such as loss of hope, sleep disorders and interruption in period of rest. Therefore, this study aims to analyze the Quality of Life (QoL) and Subjective Well-Being (SWB) of pulmonary TB patients and the affecting factors. DESIGN AND METHODS: An analytical observational design with a cross sectional approach was used and a total of 73 respondents were randomly selected from 89 patients with pulmonary TB. Furthermore, a questionnaire was used as study instrument and data analysis was carried out using Partial Least Square...
April 14, 2021: Journal of Public Health Research
Luigi Barrea, Giovanna Muscogiuri, Silvia Savastano, Annamaria Colao
No abstract text is available yet for this article.
April 15, 2021: Minerva endocrinology
Ambra Stefani, Alex Iranzo, Evi Holzknecht, Daniela Perra, Matilde Bongianni, Carles Gaig, Beatrice Heim, Monica Serradell, Luca Sacchetto, Alicia Garrido, Stefano Capaldi, Almudena Sánchez-Gómez, Maria Paola Cecchini, Sara Mariotto, Sergio Ferrari, Michele Fiorini, Joachim Schmutzhard, Pietro Cocchiara, Isabel Vilaseca, Lorenzo Brozzetti, Salvatore Monaco, M Jose Marti, Klaus Seppi, Eduardo Tolosa, Joan Santamaria, Birgit Högl, Werner Poewe, Gianluigi Zanusso
Isolated REM sleep behaviour disorder (RBD) is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological α-synuclein in peripheral tissues of patients with isolated RBD may identify those progressing to Parkinson's disease, dementia with Lewy bodies or multiple system atrophy, with the ultimate goal of testing preventive therapies. Real-time quaking-induced conversion (RT-QuIC) provided evidence of α-synuclein seeding activity in CSF and olfactory mucosa of patients with α-synucleinopathies...
April 14, 2021: Brain
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