Angela B Deutschlander, Takuya Konno, Alexandra I Soto-Beasley, Ronald L Walton, Jay A van Gerpen, Ryan J Uitti, Michael G Heckman, Zbigniew K Wszolek, Owen A Ross
OBJECTIVE: To determine whether distinct microtubule-associated protein tau MAPT H1 subhaplotypes are associated with clinical and demographic features in Parkinson's disease. METHODS: A retrospective cohort study included 855 unrelated Caucasian patients with Parkinson's disease who were seen by Movement Disorder specialists at the Mayo Clinic Florida between 1998 and 2016. The primary outcome measures were specific demographic and clinical features of Parkinson's disease, including age at onset, disease progression, survival, motor signs, dementia, dystonia, dyskinesia, autonomic dysfunction, impulse control disorder, psychiatric features, REM sleep behavior disorder, restless legs syndrome, and Parkinson's disease subtype...
August 7, 2020: Annals of Clinical and Translational Neurology
Bibiana Restrepo, Kathleen Angkustsiri, Sandra L Taylor, Sally J Rogers, Jacqueline Cabral, Brianna Heath, Alexa Hechtman, Marjorie Solomon, Paul Ashwood, David G Amaral, Christine Wu Nordahl
Gastrointestinal (GI) symptoms are frequently reported in children with autism spectrum disorder (ASD). We evaluated the frequency and severity of GI symptoms in preschool-aged children with ASD compared to participants with typical development (TD). Our goal was to ascertain whether GI symptoms are associated with differences in sex or developmental and behavioral measures. Participants were between 2 and 3.5 years of age and included 255 children with ASD (184 males/71 females) and 129 age-matched TD controls (75 males/54 females)...
August 6, 2020: Autism Research: Official Journal of the International Society for Autism Research
Ching-Hsiang Lai, Ren-Jing Huang, James Kok-Suh Wong, Shen-Wen Chang, Ai-Hui Chung, Yung-Chun Chi, Yi-Chen Yu, Shin-Da Lee, Hua Ting
Sleep-disordered breathing (SDB) causes hypoxic stress and can trigger uric acid (UA) overproduction. We comprehensively investigated whether SDB, interacting with components of metabolic syndrome, hepatic and renal dysfunctions, low physical fitness, sedentary lifestyle, disrupted sleep, and chronic systemic inflammation (CSI), is directly associated with hyperuricaemia. In 528 community-based males (mean [SD] age 46.2 [7.4] years), we cross-sectionally analysed measures of anthropometry; self-reported lifestyle habits; overnight sleep polysomnography data; cardiopulmonary exercise tests; and biomarkers of cardiometabolic, hepatic, and renal functions; and CSI, using structural equation modelling...
August 6, 2020: Journal of Sleep Research
L H Messer, K Campbell, L Pyle, G Forlenza
AIM: To describe patient-reported outcomes of the Basal-IQ predictive low-glucose-suspend system (Tandem Diabetes Care, San Diego, CA, USA) in real-world use. METHODS: Adults with type 1 diabetes/caregivers of minors with type 1 diabetes completed the Diabetes Impact and Device Satisfaction questionnaire (11 items scored on 10-point Likert scales) prior to Basal-IQ system initiation, and at 2, 4 and 6 months post-initiation. Analysis was stratified by previous insulin treatment method...
August 7, 2020: Diabetic Medicine: a Journal of the British Diabetic Association
Johanna Gudmundsdottir, Josefine Lindgren, Malin Thorpö, Helena Johansson, Johan Hellgren, Gunnhildur Gudnadottir
PURPOSE: Sleep-disordered breathing, SDB, in children is associated with morbidity that can result in caregivers having to stay at home from work. The aim of this study was to investigate whether the number of days when caregivers are reimbursed, temporary parental benefit (TPB) to stay at home from work to care for their sick child is increased among children with SDB before and after tonsil surgery. METHODS: This is a retrospective, cross-sectional study of children (n = 440), aged 2-11 years, that underwent tonsil surgery for SDB in day surgery at Sahlgrenska University Hospital in 2014 and 2015...
August 7, 2020: European Archives of Oto-rhino-laryngology
Yo-Ichiro Kuma, Jun Hosomichi, Hideyuki Maeda, Shuji Oishi, Risa Usumi-Fujita, Yasuhiro Shimizu, Sawa Kaneko, Jun-Ichi Suzuki, Ken-Ichi Yoshida, Takashi Ono
PURPOSE: Chronic intermittent hypoxia (IH) plays a pivotal role in the consequences of obstructive sleep apnea (OSA). It has been demonstrated that IH impairs nasomaxillary complex growth to reduce nasal airway cavity size in rodent models. Although turbinate dysfunction with inflammatory mucosal hypertrophy is related to OSA, the role of IH in turbinate hypertrophy with inflammation-driven fibrosis is unknown. Here, we aimed to clarify the pathogenesis of inflammatory mucosal hypertrophy and epithelial-mesenchymal transition (EMT) in the nasal turbinate under IH...
August 6, 2020: Sleep & Breathing
Liana S Lianov, Grace Caroline Barron, Barbara L Fredrickson, Sean Hashmi, Andrea Klemes, Janani Krishnaswami, Jenny Lee, Noémie Le Pertel, Jessica A Matthews, Rachel A Millstein, Edward M Phillips, Deepa Sannidhi, Patty Purpur de Vries, Anne Wallace, Sandra J Winter
Lifestyle-related diseases have common risk factors: physical inactivity, poor diet, inadequate sleep, high stress, substance use, and social isolation. Evidence is mounting for the benefits of incorporating effective methods that promote healthy lifestyle habits into routine health care treatments. Research has established that healthy habits foster psychological and physiological health and that emotional well-being is central to achieving total well-being. The Happiness Science and Positive Health Committee of the American College of Lifestyle Medicine aims to raise awareness about strategies for prioritizing emotional well-being...
August 7, 2020: Translational Behavioral Medicine
A Targa, F Dakterzada, I Benítez, R López, M Pujol, M Dalmases, A Arias, M Sánchez-de-la-Torre, H Zettenberg, K Blennow, R Pamplona, M Jové, F Barbé, G Piñol-Ripoll
STUDY OBJECTIVES: The majority of studies investigating the association between sleep and Alzheimer's disease (AD) biomarkers have been performed in healthy subjects. Our objective was to investigate the association between sleep and several biomarkers that reflect distinct aspects of AD physiopathology. METHODS: The cohort included 104 individuals with mild-moderate AD. The subjects were submitted to one-night polysomnography, and cerebrospinal fluid was collected in the following morning to measure the selected biomarkers associated with amyloid deposition, tau pathology, neurodegeneration, axonal damage, synaptic integrity, neuroinflammation, and oxidative damage...
August 7, 2020: Sleep
Emily K Scott, Stephen M Downs, Amy K Pottenger, James P Bien, Michele S Saysana
Background: Approximately, 3,500 infants die annually from sleep-related infant deaths in the United States. We sought to improve pediatricians' counseling on safe sleep from birth through 6 months of age through a virtual quality improvement learning collaborative (QILC). Our aim was appropriate screening, counseling, and documentation of safe sleep advice in 75% of eligible patient encounters after the QILC. Methods: We formed a 9-month QILC for inpatient and outpatient pediatricians...
July 2020: Pediatric Quality & Safety
Maliheh Abootalebi, Mansoureh Dehghani, Marzieh Akbarzadeh
BACKGROUND: Mental health is one of the major determinants of a person's health which has a significant impact on the quality of life. Implementing of mental health training programs for promotion of health affected teenage girls to premenstrual syndrome (PMS) in Shiraz, southern Iran: a community-based study. MATERIALS AND METHODS: This study is randomized controlled trial done on 100 teenage girls affected to PMS in Shiraz-Iran (selected from400 girls). Multistage cluster sampling method was used f or sampling...
2020: Journal of Education and Health Promotion
Alireza Najimi, Yousef Veisani, Sanaz Azami, Arman Azadi
INTRODUCTION: Sexual problems in elder people are considered as a public health concern and can affect their overall health and quality of life. This study aimed to investigate the sexual quality of life and its relationship with general health in older men in the west of Iran. METHODS: This was a cross-sectional study among 362 older men aged 60 years or older attending Comprehensive Health Care Centers in Ilam, Iran. Samples selected through Quota sampling method and simple random sampling...
2020: Journal of Education and Health Promotion
Carlos Martın Ardila, Ángela Marıa Gómez-Restrepo
BACKGROUND: Ethnic minorities are underrepresented in health sciences programs in various nations. Furthermore, there is no known research studying the occurrence of physical inactivity (PI) and insufficient sleep (IS), and their effects on academic achievement (AA) in ethnic minority students (EMS) in higher education. OBJECTIVE: The objective of this study is to explore the occurrence of PI and IS, and their independent and mixed effects on AA in EMS of a dental school...
2020: Journal of Education and Health Promotion
Nejmiye Akkus, Betul Kilic, Pelin Ozyavuz Cubuk
As a multisystemic congenital mental retardation disorder/anomaly, Smith-Magenis syndrome (SMS) is commonly aroused from de novo interstitial deletion of the 17p11.2 chromosome. The deletion of this chromosome results with haploinsufficiency for the retinoic acid-induced 1 ( RAI1 ) gene. In this article, we present three cases, who were diagnosed with SMS with mental retardation and behavioral problems such as self-hugging and sleeping disturbances. During the evaluation of the patients, it has been found that there was a 3...
December 2020: Journal of Pediatric Genetics
Nihit Kumar, Yuri A Zarate
SATB2 -associated syndrome is an autosomal dominant, multisystemic disorder with associated sleep and behavioral abnormalities. Evidence is limited on appropriate management strategies in this population. We describe the medical management of a four-year-old child with poor sleep and significant behavioral problems. After failing initial treatment with melatonin, we initiated treatment clonidine along with high doses of trazodone for sleep. Daytime treatment with quetiapine was added to successfully manage behavioral issues...
2020: Case Reports in Genetics
N Belloumi, S Maalej Bellaj, I Bachouche, F Chermiti Ben Abdallah, S Fenniche
Background: Preservation of sleep quality is a modifiable and treatable factor, which may enhance the patient's adherence to other supportive and palliative care procedures. The outcome of sleep disturbances in lung cancer patients before and after treatment aren't reported. The aim of this study was to investigate changes in sleep quality before and after chemotherapy in locally advanced or metastatic NSCLC patients. Methods: It was a prospective study including 64 patients with stage III or IV nonsmall-cell lung cancer...
2020: Sleep Disorders
Lili Huang, Jiajun Lyu, Zichong Long, Yuanqing Xia, Yiting Chen, Xiuxia Ye, Shenghui Li
Purpose: We conducted this study to add the evidence regarding the gender-specific association between sleep duration and blood pressure (BP) in children. Methods: A secondary analysis was performed among 1000 children aged 7-13 years, who had at least two rounds of survey records in China Health and Nutrition Survey through 2004-2015. Generalized estimating equation was used to explore the gender-specific association of sleep duration with BP. The subgroup analysis was applied in those participants with normal weight...
2020: International Journal of Hypertension
Fabienne Langlois, Gabriela M Suarez, Maria Fleseriu
Acromegaly is a complex disease with excessive growth hormone and insulin-like growth factor 1 (IGF-1) causing multisystem effects, particularly cardiovascular, respiratory, and metabolic. Psychological concerns and poor quality of life (QoL) are also major disease consequences. This review is intended for clinicians and focuses on the latest developments related to respiratory and QoL effects of long-term growth hormone excess. Along with biochemical disease control, patient treatment satisfaction and outcomes have become major treatment objectives; current knowledge and tools to evaluate and manage this aspect of the disease are described...
2020: F1000Research
Denholm J Aspy
The International Lucid Dream Induction Study (ILDIS) investigated and compared the effectiveness of five different combinations of lucid dream induction techniques including reality testing (RT), Wake Back to Bed (WBTB), the Mnemonic Induction of Lucid Dreams (MILD) technique, the Senses Initiated Lucid Dream (SSILD) technique, and a hybrid technique combining elements of both MILD and SSILD. Participants with an interest in lucid dreaming ( N = 355) completed a pre-test questionnaire and then a baseline sleep and dream recall logbook for 1 week before practicing the lucid dream induction techniques for another week...
2020: Frontiers in Psychology
Lei Xia, Feng Jiang, Jeffrey Rakofsky, Yulong Zhang, Kai Zhang, Tingfang Liu, Yuanli Liu, Huanzhong Liu, Yi-Lang Tang
Objectives: Mental health professionals (MHPs) play an important role in treating patients with nicotine addiction. However, data on MHPs' cigarette smoking habits are scarce. This survey aimed to collect such data and to examine the correlates of smoking among MHPs working in China. Methods: A cross-sectional survey was conducted in all 41 provincial, tertiary psychiatric hospitals, and MHPs from these hospitals were targeted. An anonymous questionnaire was designed to collect socio-demographic and occupational factors, and the Maslach Burnout Inventory-Human Service Survey was used to assess burnout...
2020: Frontiers in Psychiatry
Yinzhi Kang, Shuai Liu, Lulu Yang, Bixia Xu, Lianhong Lin, Likai Xie, Wanling Zhang, Jihui Zhang, Bin Zhang
Background: Mobile phone addiction behaviors (MPAB) are extensively associated with several mental and sleep problems. Only a limited number of bidirectional longitudinal papers have focused on this field. This study aimed to examine the bidirectional associations of MPAB with mental distress, sleep disturbances, and sleep patterns. Methods: A total of 940 and 902 (response rate: 95.9%) students participated at baseline and one-year follow-up, respectively. Self-reported severity of mobile phone addiction was measured using Mobile Phone Involvement Questionnaire (MPIQ)...
2020: Frontiers in Psychiatry
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