Adline Rahmoune, Marion F Winkler, Richa Saxena, Charlene Compher, Hassan S Dashti
BACKGROUND: Patients receiving home parenteral nutrition (HPN) frequently report disrupted sleep. However, there are often inconsistencies between objectively measured and questionnaire-derived sleep measures. We compared sleep measures estimated from wrist actigraphy and self-report in adults receiving HPN. METHODS: In this secondary analysis, we pooled data from two sleep-related studies enrolling adults receiving habitual HPN. We compared measures from 7-day averages of wrist actigraphy against comparable responses to a sleep questionnaire...
October 1, 2023: Nutrition in Clinical Practice
Fabrizio Lombardi, Hans J Herrmann, Liborio Parrino, Dietmar Plenz, Silvia Scarpetta, Anna Elisabetta Vaudano, Lucilla de Arcangelis, Oren Shriki
Alpha oscillations are a distinctive feature of the awake resting state of the human brain. However, their functional role in resting-state neuronal dynamics remains poorly understood. Here we show that, during resting wakefulness, alpha oscillations drive an alternation of attenuation and amplification bouts in neural activity. Our analysis indicates that inhibition is activated in pulses that last for a single alpha cycle and gradually suppress neural activity, while excitation is successively enhanced over a few alpha cycles to amplify neural activity...
September 29, 2023: Cell Reports
Nidhi Sukul, Junhui Zhao, Ronald L Pisoni, Sebastian Walpen, Thilo Schaufler, Elham Asgari, Fitsum Guebre-Egziabher, Li Zho, Mohammed Abdulrahman Al-Ghonaim, Kosaku Nitta, Bruce M Robinson, Angelo Karaboyas
RATIONALE & OBJECTIVE: Cross-sectional studies have reported an association of chronic kidney disease-associated pruritus (CKD-aP) with adverse clinical events and patient-reported outcomes (PROs). We studied the longitudinal associations between changes in CKD-aP and clinical outcomes among patients receiving maintenance hemodialysis. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: 7,976 hemodialysis recipients across 21 countries in phases 4-6 (2009-2018) of the Dialysis Outcomes and Practice Patterns Study (DOPPS) who had 2 CKD-aP assessments approximately 12 months apart...
August 16, 2023: American Journal of Kidney Diseases
Henri Lahti, Markus Kulmala, Lauri Hietajärvi, Nelli Lyyra, Dorota Kleszczewska, Meyran Boniel-Nissim, Jana Furstova, Regina van den Eijnden, Gorden Sudeck, Leena Paakkari
PURPOSE: Social media use has increased rapidly during the past decade, raising concerns about adolescents who display problematic social media use (PSMU), as indicated by addiction-like symptoms (e.g., preoccupation, tolerance). We aimed to assess the extent to which an individual resource (health literacy), and social resources (friend support and family support), moderated the association between a range of individual characteristics (gender, age, family affluence, and depressive feelings) and PSMU; also the association between PSMU and health outcomes (self-rated health, life satisfaction, and sleep difficulties), both cross-nationally and nationally...
September 29, 2023: Journal of Adolescent Health
S Chouhan, S M Hulke, S Wakode, R Parasar, S Pandey
In an attempt to deal with their workload and stressful atmosphere, medical students often cut down on their sleep. Sleep not only has an impact on cognitive functions, but it is also essential for stress recovery and tiredness removal. The study was done to determine the quality of sleep using the Pittsburgh Sleep Quality Index (PSQI) among medical students in Bhopal. This cross-sectional descriptive questionnaire study of 408 medical (MBBS or MD) students from AIIMS and GMC, Bhopal, was undertaken from June 2020 to September 2020...
October 2023: Mymensingh Medical Journal: MMJ
Astrid Junge, Anja Hauschild
BACKGROUND: Mental health problems cover a wide spectrum. Depression and anxiety disorders are the most frequent mental health problem in the general population and in elite athletes. The aim of the present study was to assess the prevalence of symptoms of depression, generalised anxiety disorder and eating disorders in professional dancers, to compare the results between genders and to the general population and to analyse potential determinants. METHODS: During a pre-season health screening, professional dancers of six German companies answered a comprehensive questionnaire on personal and dancer-specific characteristics, medical history and the Patient Health Questionnaire (PHQ-9), Generalised Anxiety Disorder Questionnaire (GAD-7) and Eating-Disorder-Examination-Questionnaire (EDE-QS)...
September 30, 2023: Sports Medicine—Open
Maen Zreaqat, Rozita Hassan, A R Samsudin, Sahal Alforaidi
UNLABELLED: Twin-block appliance had been advocated as a potential treatment option in paediatric obstructive sleep apnoea (OSA) due to their favourable effect in enhancing upper airway parameters and improving OSA symptoms. The aim of this study was to evaluate the effect of twin-block appliance therapy on upper airway parameters/dimensions and the apnoea-hypopnea indexes (AHIs) in OSA children with class II mandibular retrognathic skeletal malocclusion using cone-beam computed tomography...
September 30, 2023: European Journal of Pediatrics
Elizabeth Smith Khoury, Ruchit V Patel, Caroline O'Ferrall, Amanda Fowler, Nirnath Sah, Anjali Sharma, Siddharth Gupta, Susanna Scafidi, Joshua S Kurtz, Sarah J Olmstead, Sapna R Kudchadkar, Rangaramanujam M Kannan, Mary E Blue, Sujatha Kannan
Rett syndrome is an X-linked neurodevelopmental disorder caused by mutation of Mecp2 gene and primarily affects females. Glial cell dysfunction has been implicated in in Rett syndrome (RTT) both in patients and in mouse models of this disorder and can affect synaptogenesis, glial metabolism and inflammation. Here we assessed whether treatment of adult (5-6 months old) symptomatic Mecp2-heterozygous female mice with N-acetyl cysteine conjugated to dendrimer (D-NAC), which is known to target glia and modulate inflammation and oxidative injury, results in improved behavioral phenotype, sleep and glial inflammatory profile...
September 30, 2023: Journal of Neurochemistry
Rebecca C Cox, Alivia B Blumenstein, Tina M Burke, Christopher M Depner, Molly K Guerin, Emily Hay-Arthur, Janine Higgins, Oliver A Knauer, Shannon M Lanza, Rachel R Markwald, Edward L Melanson, Andrew W McHill, Sarah J Morton, Hannah K Ritchie, Mark R Smith, Alexandra N Smits, Kate E Sprecher, Ellen R Stothard, Dana Withrow, Kenneth P Wright
OBJECTIVES: Dim light melatonin onset, or the rise in melatonin levels representing the beginning of the biological night, is the gold standard indicator of circadian phase. Considerably less is known about dim light melatonin offset, or the decrease in melatonin to low daytime levels representing the end of the biological night. In the context of insufficient sleep, morning circadian misalignment, or energy intake after waketime but before dim light melatonin offset, is linked to impaired insulin sensitivity, suggesting the need to characterize dim light melatonin offset and identify risk for morning circadian misalignment...
September 28, 2023: Sleep Health
Rashad Hussain, Uschi Graham, Alison Elder, Maiken Nedergaard
Epidemiological evidence demonstrates a link between air pollution exposure and the onset and progression of cognitive impairment and Alzheimer's disease (AD). However, current understanding of the underlying pathophysiological mechanisms is limited. This opinion article examines the hypothesis that air pollution-induced impairment of glymphatic clearance represents a crucial etiological event in the development of AD. Exposure to airborne particulate matter (PM) leads to systemic inflammation and neuroinflammation, increased metal load, respiratory and cardiovascular dysfunction, and sleep abnormalities...
September 28, 2023: Trends in Neurosciences
A L D'Rozario, C Kao, C L Phillips, A E Mullins, N Memarian, B J Yee, S L Duffy, G Cho, K K Wong, K Kremerskothen, J Chapman, C Haroutonian, D J Bartlett, S L Naismith, R R Grunstein
STUDY OBJECTIVES: Limited channel electroencephalography (EEG) investigations in obstructive sleep apnea (OSA) have revealed deficits in slow wave activity (SWA) and spindles during sleep and increased EEG slowing during resting wakefulness. High-density EEG (Hd-EEG) has also detected local parietal deficits in SWA (delta power) during NREM. It is unclear whether effective continuous positive airway pressure (CPAP) treatment reverses regional SWA deficits, and other regional sleep and wake EEG abnormalities, and whether any recovery relates to improved overnight memory consolidation...
September 30, 2023: Sleep
Diane C Lim, Arezu Najafi, Lamia Afifi, Claudio LA Bassetti, Daniel J Buysse, Fang Han, Birgit Högl, Yohannes Adama Melaku, Charles M Morin, Allan I Pack, Dalva Poyares, Virend K Somers, Peter R Eastwood, Phyllis C Zee, Chandra L Jackson
Healthy sleep is essential for physical and mental health, and social wellbeing; however, across the globe, and particularly in developing countries, national public health agendas rarely consider sleep health. Sleep should be promoted as an essential pillar of health, equivalent to nutrition and physical activity. To improve sleep health across the globe, a focus on education and awareness, research, and targeted public health policies are needed. We recommend developing sleep health educational programmes and awareness campaigns; increasing, standardising, and centralising data on sleep quantity and quality in every country across the globe; and developing and implementing sleep health policies across sectors of society...
October 2023: Lancet. Public Health
Tehreem Aftab, Ehtisham Khyzer
OBJECTIVES: To observe the smartphone addiction's prevalence and its relation to hypertension and sleep quality. METHODS: This study was carried out at the College of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia from October 2022 to March 2023. A total of 200 medical students were selected using convenience sampling. Standard procedures were used to estimate the student's height, weight, body mass, and blood pressure. Smartphone addiction was assessed using the Smartphone Addiction Scale-Short Version and sleep quality was assessed using Pittsburgh Sleep Quality Index...
October 2023: Saudi Medical Journal
Michelle J Kidd
No abstract text is available yet for this article.
October 1, 2023: Critical Care Nurse
Aila Akosua Kattner
This issue of the Biomedical Journal puts an emphasis on inflammasome subunits, the NLR protein family, and the role they play in immunity. CIITA is presented as promising tool for augmenting tumor immunogenicity. Several articles look into the involvement of NLRP3 in inflammatory bowel disease and changes of the gut microbiome, in blood glucose management, in sterile inflammation, and NLRP3's contribution to the development of hepatic encephalopathy. Furthermore, a review concerning small cell neuroendocrine carcinoma of the cervix is presented, insights are provided as to the association of knee pain and patellar malalignment, and the connection between hypoxia and sleep apnea in the case of liver injury is elucidated...
September 28, 2023: Biomedical Journal
Shunjie Liu, Su Zhang, Mengxia Guo, Qingfeng Lei, Lu He, Zhong Li
Nonpharmacological therapies for Alzheimer's disease (AD) have become a popular research topic, and acoustic stimulation during sleep is one such promising strategy for the clinical treatment of AD. Some animal experiments have illustrated that acoustic stimulation at a specific frequency can ameliorate AD-related pathology or improve cognition in mice, but these studies did not explore the effective time window of auditory stimulation. Here, we explored the effects of acoustic stimulation during wakefulness and acoustic stimulation during sleep on cognition and AD-related pathology in APP/PS1 mice and the underlying mechanisms...
September 28, 2023: Experimental Gerontology
Erik Hoff, Christian Strassberger, Ding Zou, Ludger Grote, Kaj Stenlöf, Jan Hedner
BACKGROUND: The carbonic anhydrase inhibitor sulthiame (STM) reduces obstructive sleep apnea (OSA) severity, increases overnight oxygenation and improves sleep quality. Insights into how STM modulates OSA pathophysiology (endotypic traits) adds to our understanding of the breathing disorder itself, as well as the effects of carbonic anhydrases in respiratory regulation. RESEARCH QUESTION: How does STM treatment modify endotypic traits in OSA? STUDY DESIGN AND METHODS: Per protocol tertiary analysis of a randomized controlled trial with the inclusion criteria: BMI ≥20 to ≤35 kg/m2 , age 18-75 years, apnea-hypopnea index (AHI) ≥15/h, Epworth sleepiness scale ≥6 as well as non-acceptance or non-tolerance of positive airway pressure treatment...
September 28, 2023: Chest
S Stephens, R W Motl, I Narang, S Weiss, M Finlayson, E A Yeh
BACKGROUND: Sleep, physical activity (PA) and sedentary behavior (SED) have bidirectional associations with mental health in children. The relationships among sleep, PA, SED, with depressive and fatigue symptoms have not been investigated in Pediatric Onset Multiple Sclerosis (POMS) but are needed to inform sleep and PA behavior change interventions. OBJECTIVES: (1) To describe sleep quality including: sleep efficiency, latency, total sleep time, number of awakenings, time in bed, and wake after sleep onset using actigraphy in children and adolescents ages 11 to 18 diagnosed with POMS, and to compare these sleep metrics to those of an age- and sex-matched non-MS group (2) To examine the relationship between time spent in sedentary, light (LIPA), moderate and vigorous PA (MVPA), sleep quality, with depression, fatigue, and quality of life in children and adolescents with POMS and an age and sex matched non-MS group...
September 23, 2023: Multiple Sclerosis and related Disorders
Iman Mohammadi, Mehrdad Adibparsa, Amir Najafi, Mohammad Soroush Sehat, Masoud Sadeghi
INTRODUCTION: The aim was to design a meta-analysis evaluating the positron emission tomography (PET) uptake and cerebrospinal fluid (CSF), circulating levels of amyloid-β (Aβ), and tau proteins OSA group versus control group, as well as the association of these biomarkers with the severity of OSA. MATERIAL AND METHODS: Four databases were searched until April 17, 2023, without any restrictions. The effect sizes were the standardized mean difference (SMD) along with a 95% confidence interval (CI)...
September 28, 2023: International Orthodontics
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