Ioannis N Petropoulos, Karen John, Fatima Al-Shibani, Georgios Ponirakis, Adnan Khan, Hoda Gad, Ziyad R Mahfoud, Heba Altarawneh, Muhammad Hassan Rehman, Dhabia Al-Merekhi, Pooja George, Faiza Ibrahim, Reny Francis, Beatriz Canibano, Dirk Deleu, Ahmed El-Sotouhy, Surjith Vattoth, Mark Stettner, Ahmed Own, Ashfaq Shuaib, Naveed Akhtar, Saadat Kamran, Rayaz A Malik
BACKGROUND: Corneal immune cells (ICs) are antigen-presenting cells that are known to increase ocular and systemic inflammatory conditions. OBJECTIVE: We aimed to assess longitudinal changes in corneal IC in patients with multiple sclerosis (MS) and relation to disability and ongoing treatment. DESIGN: Prospective observational study conducted between September 2016 and February 2020. METHODS: Patients with relapsing-remitting MS (RRMS) ( n = 45) or secondary progressive MS (SPMS) ( n = 15) underwent corneal confocal microscopy (CCM) at baseline and 2-year follow-up for estimation of corneal IC density [dendritic cells with (DCF) (cells/mm2 ) or without nerve fiber contact (DCP); and non-dendritic cells with (NCF) or without nerve fiber contact (NCP)]...
2023: Therapeutic Advances in Neurological Disorders