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Cardiac amyloid | Page 3

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https://read.qxmd.com/read/32417331/molecular-imaging-of-amyloid-deposits-for-early-diagnosis-of-cardiac-amyloidosis-and-monitoring-treatment-response
#41
EDITORIAL
Wengen Chen, Vasken Dilsizian
No abstract text is available yet for this article.
June 2020: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/32417330/diagnostic-accuracy-of-11-c-pib-positron-emission-tomography-for-detection-of-cardiac-amyloidosis
#42
Sara Rosengren, Tor Skibsted Clemmensen, Lars Tolbod, Sven-Olof Granstam, Hans Eiskjær, Gerhard Wikström, Ola Vedin, Tanja Kero, Mark Lubberink, Hendrik J Harms, Frank A Flachskampf, Tomasz Baron, Kristina Carlson, Fabian Mikkelsen, Gunnar Antoni, Niels Frost Andersen, Steen Hvitfeldt Poulsen, Jens Sörensen
OBJECTIVES: This dual-site study evaluated the diagnostic accuracy of the method. BACKGROUND: Pittsburgh compound ([11 C]PIB) positron emission tomography (PIB-PET) has shown promise as a specific and noninvasive method for the diagnosis of cardiac amyloidosis (CA). METHODS: The study had 2 parts. In the initial study, 51 subjects were included, 36 patients with known CA and increased wall thickness (15 immunoglobulin light chain [AL] and 21 transthyretin [ATTR] amyloidosis) and 15 control patients (7 were nonamyloid hypertrophic and 8 healthy volunteers)...
May 8, 2020: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/32408830/diffusion-tensor-cardiovascular-magnetic-resonance-in-cardiac-amyloidosis
#43
Zohya Khalique, Pedro F Ferreira, Andrew D Scott, Sonia Nielles-Vallespin, Ana Martinez-Naharro, Marianna Fontana, Phillip Hawkins, David N Firmin, Dudley J Pennell
Background Cardiac amyloidosis (CA) is a disease of interstitial myocardial infiltration, usually by light chains or transthyretin. We used diffusion tensor cardiovascular magnetic resonance (DT-CMR) to noninvasively assess the effects of amyloid infiltration on the cardiac microstructure. Methods DT-CMR was performed at diastole and systole in 20 CA, 11 hypertrophic cardiomyopathy, and 10 control subjects with calculation of mean diffusivity, fractional anisotropy, and sheetlet orientation (secondary eigenvector angle)...
May 2020: Circulation. Cardiovascular Imaging
https://read.qxmd.com/read/32408301/cardiac-care-of-patients-with-cardiac-amyloidosis
#44
REVIEW
Osnat Itzhaki Ben Zadok, Ran Kornowski
Cardiac amyloidosis, the majority of cases of which are due to immunoglobulin light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR), affects different aspects of the heart and cardiovascular system. Amyloid-induced cardiomyopathy, clinically manifesting with heart failure and electrophysiological abnormalities, has distinct characteristics compared to non-amyloid cardiomyopathies. Accordingly, specific management strategies are required. This paper will review the cardiovascular manifestations of patients with cardiac amyloidosis and their suggested treatment strategies, emphasizing the importance of multidisciplinary care...
May 14, 2020: Acta Haematologica
https://read.qxmd.com/read/32407731/the-unraveling-cardiac-and-musculoskeletal-defects-and-their-role-in-common-alzheimer-disease-morbidity-and-mortality
#45
REVIEW
Vidyani Suryadevara, Michael Kluppel, Federica Del Monte, Monte S Willis
Alzheimer disease (AD), characterized by deterioration of cognitive capabilities, is prevalent among 44 million people worldwide. Beyond memory deficits, the most common AD co-morbidities include swallowing defects (muscle), fractures (bone, muscle), and heart failure. The underlying causes of these co-morbidities and their role in AD pathophysiology are currently unknown. This review is the first to summarize the emerging picture of the cardiac and musculoskeletal deficits in human AD. We present the involvement of the heart, characterized by diastolic heart failure, the presence of amyloid deposits, and electrophysiological changes compared to age-matched controls...
May 11, 2020: American Journal of Pathology
https://read.qxmd.com/read/32405093/the-role-of-biomarkers-in-diagnosis-of-covid-19-a-systematic-review
#46
REVIEW
Muhammed Kermali, Raveena Kaur Khalsa, Kiran Pillai, Zahra Ismail, Amer Harky
Aims: As of the 28th April 2020, the COVID-19 pandemic has infiltrated over 200 countries and affected over three million confirmed people. We review different biomarkers to evaluate if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease. Methods: A systematic review of the literature was carried out to identify relevant articles using six different databases. Keywords to refine the search included 'COVID-19', 'SARS-CoV2', 'Biomarkers', among others...
May 13, 2020: Life Sciences
https://read.qxmd.com/read/32400202/quantification-of-cardiac-amyloid-with-18-f-flutemetamol-in-patients-with-v30m-hereditary-transthyretin-amyloidosis
#47
Sofia Möckelind, Jan Axelsson, Björn Pilebro, Per Lindqvist, Ole B Suhr, Torbjörn Sundström
Background: Hereditary transthyretin amyloid (ATTRv) is a systemic amyloidosis with mainly neurological and cardiac symptoms. The aim of this study was to evaluate the outcome of [18 F]Flutemetamol PET/CT-scan of the heart in long-term survivors with ATTRV30M amyloidosis. Methods: Twenty-one patients with ATTRV30M amyloidosis and predominantly neurological symptoms, mainly negative on cardiac 99m technetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD)-scintigraphy, were examined with a dynamic [18 F]Flutemetamol PET/CT-scan...
May 13, 2020: Amyloid: the International Journal of Experimental and Clinical Investigation
https://read.qxmd.com/read/32388447/cardiac-aa-amyloidosis-in-a-patient-with-obstructive-hypertrophic-cardiomyopathy
#48
Boyangzi Li, Monica Ahluwalia, Navneet Narula, Andre L Moreira, Daniel G Swistel, Daniele Massera, Mark V Sherrid
Cardiac amyloid A (AA) amyloidosis is rare. We present the case of a 72-year-old woman with obstructive hypertrophic cardiomyopathy (HCM) and biopsy-proven renal AA amyloidosis whose dyspnea and exercise intolerance had worsened over the previous year. Her AA amyloidosis was suspected to be secondary to chronic diverticulitis for which she had undergone hemicolectomy and sigmoidectomy 3 years prior. Echocardiographic findings were consistent with worsening left ventricular outflow tract obstruction at rest...
March 7, 2020: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/32387068/outcomes-in-patients-with-cardiac-amyloidosis-undergoing-heart-transplantation
#49
Christopher D Barrett, Kevin M Alexander, Hongyu Zhao, Francois Haddad, Paul Cheng, Ronglih Liao, Matthew T Wheeler, Michaela Liedtke, Stanley Schrier, Sally Arai, Dana Weisshaar, Ronald M Witteles
OBJECTIVES: The purpose of this study is to report outcomes after heart transplantation in patients with cardiac amyloidosis based on a large single-center experience. BACKGROUND: Cardiac amyloidosis causes significant morbidity and mortality, often leading to restrictive cardiomyopathy, progressive heart failure, and death. Historically, heart transplantation outcomes have been worse in patients with cardiac amyloidosis compared with other heart failure populations, in part due to the systemic nature of the disease...
May 4, 2020: JACC. Heart Failure
https://read.qxmd.com/read/32368992/emerging-molecular-targets-for-imaging-of-atherosclerotic-plaque-using-positron-emission-tomography
#50
Rudolf A Werner, Frank M Bengel, Thorsten Derlin
BACKGROUND: Positron-emission-tomography (PET) using the radiopharmaceutical 18F-fluorodeoxyglucose (FDG) has become an established and validated molecular imaging modality for characterization of the inflammatory activity of atherosclerotic plaque. In the latest years, new innovative radiopharmaceuticals and applications have emerged, providing specific information on atherosclerotic plaque biology, particularly focused on inflammatory processes. OBJECTIVE: To review and highlight recent evidence on the role of PET for atherosclerosis imaging using emerging radiotracers...
May 4, 2020: Current Radiopharmaceuticals
https://read.qxmd.com/read/32356182/disease-specific-biomarkers-in-transthyretin-cardiac-amyloidosis
#51
REVIEW
Nicholas S Hendren, Lori R Roth, Justin L Grodin
PURPOSE OF REVIEW: Transthyretin amyloidosis is an increasingly recognized cause of restrictive cardiomyopathy related to amyloid fibril deposition in cardiac tissues. As treatment therapies have emerged for transthyretin amyloidosis (ATTR), so has interest in using biomarkers to identify disease prior to advanced presentation. RECENT FINDINGS: Lower levels of transthyretin and retinol binding protein-4 have been demonstrated in patients with pathogenic mutations of transthyretin either with or without clinical disease...
April 30, 2020: Current Heart Failure Reports
https://read.qxmd.com/read/32342909/lethal-cardiac-amyloidosis-microscopic-differential-diagnosis-with-microfibrillar-cardiomyopathy-in-a-forensic-case
#52
Stefano Tambuzzi, Salvatore Andreola, Michele Boracchi, Paolo Fociani, Guendalina Gentile, Riccardo Zoja
In a previous study, we presented a case of an elderly woman's sudden death, in which microscopic examinations showed intramyocardial eosinophilic material suspected for amyloid, but not definable as such to the classic Congo Red staining. To overcome the arisen interpretative and diagnostic difficulties, we experimentally modified the classic Congo Red staining, using a specific one for corpse. The finding of a low-intensity positivity allowed us to formulate a very likely diagnosis of occult lethal cardiac amyloidosis...
April 2020: Journal of Forensic and Legal Medicine
https://read.qxmd.com/read/32338497/structural-characterization-of-cardiac-ex-vivo-transthyretin-amyloid-insight-into-transthyretin-misfolding-pathway-in-vivo
#53
Anvesh K R Dasari, Ivan Hung, Brian Michael, Zhehong Gan, Jeffery W Kelly, Lawreen H Connors, Robert G Griffin, Kwang Hun Lim
Structural characterization of misfolded protein ag-gregates is essential to understanding molecular mechanism of protein aggregation associated with various protein misfolding disorders. Here, we re-port structural analyses of ex vivo transthyretin ag-gregates extracted from human cardiac tissue. Comparative structural analyses of in vitro and ex vivo transthyretin aggregates using various bio-physical techniques revealed that cardiac transthy-retin amyloid has similar structural features to those of in vitro transthyretin amyloid...
April 27, 2020: Biochemistry
https://read.qxmd.com/read/32337388/an-autopsy-case-of-cardiac-amyloidosis-with-heterogeneous-deposition-of-amyloid-protein-a-possible-mechanism-for-relative-apical-sparing-of-longitudinal-strain
#54
Naoko Sawada, Masao Daimon, Hiroyuki Abe, Tetsuo Ushiku, Tomoko S Kato, Hiroyuki Morita, Issei Komuro
No abstract text is available yet for this article.
April 2020: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/32328845/advances-in-the-treatment-of-cardiac-amyloidosis
#55
REVIEW
Ariane Vieira Scarlatelli Macedo, Pedro Vellosa Schwartzmann, Breno Moreno de Gusmão, Marcelo Dantas Tavares de Melo, Otávio Rizzi Coelho-Filho
Cardiac amyloidosis is associated with a high mortality rate, a long delay between the first signs and the diagnosis but a short interval between diagnosis and death. This scenario has changed recently due to improved disease awareness among doctors and significant progress in diagnosis thanks to multimodal imaging and a multidisciplinary approach. Therefore, during the last few years, we have had access to specific therapies for those patients. Those therapies are quite different depending on the type of amyloidosis, but there has been real progress...
April 23, 2020: Current Treatment Options in Oncology
https://read.qxmd.com/read/32317158/clinical-profile-and-outcome-of-cardiac-amyloidosis-in-a-spanish-referral-center
#56
Ángela López-Sainz, Aitor Hernandez-Hernandez, Esther Gonzalez-Lopez, Fernando Domínguez, Maria Alejandra Restrepo-Cordoba, Marta Cobo-Marcos, Manuel Gómez-Bueno, Francisco Jose Hernandez-Perez, Juan Francisco Oteo, Jesus G Mirelis, Miguel Angel Cavero, Vanessa Moñivas, Susana Mingo Santos, F Javier de Haro-Del Moral, Isabel Krsnik, Clara Salas, Belén Bornstein, Ana Briceño, Juan Antonio López, Jesús Vázquez, Luis Alonso-Pulpón, Javier Segovia, Pablo Garcia-Pavia
INTRODUCTION AND OBJECTIVES: Cardiac amyloidosis (CA) is produced by amyloid fiber deposition in the myocardium. The most frequent forms are those caused by light chains (AL) and transthyretin (ATTR). Our objective was to describe the diagnosis, treatment and outcomes of CA in a specialized Spanish center. METHODS: We included all patients diagnosed with CA in Hospital Universitario Puerta de Hierro Majadahonda from May 2008 to September 2018. We analyzed their clinical characteristics, outcomes, and survival...
April 18, 2020: Revista Española de Cardiología
https://read.qxmd.com/read/32280403/incidentally-detected-cardiac-amyloidosis-on-99m-tc-mdp-bone-scintigraphy
#57
Ahmed Fathala
Cardiac amyloidosis (CA) is an important cause of restrictive cardiomyopathy and heart failure with preserved ejection fraction (HFpEF). At present, 3 bone-seeking tracers, 99m Tc-diphosphono-1,2-propanodicarboxylic acid (99m Tc-DPD), 99m Tc-pyrophosphate (99m Tc-PYP), and 99m Tc-hydroxymethylene diphosphonate (99m Tc-HMDP), have been evaluated for detecting CA, but they are not widely available. In contrast, methylene diphosphate (MDP) is widely available. However, only sporadic case reports have shown that MDP can accumulate in patients with CA...
June 2020: Radiology Case Reports
https://read.qxmd.com/read/32267922/prevalence-and-outcome-of-dual-aortic-stenosis-and-cardiac-amyloid-pathology-in-patients-referred-for-transcatheter-aortic-valve-implantation
#58
Paul R Scully, Kush P Patel, Thomas A Treibel, George D Thornton, Rebecca K Hughes, Sucharitha Chadalavada, Michail Katsoulis, Neil Hartman, Marianna Fontana, Francesca Pugliese, Nikant Sabharwal, James D Newton, Andrew Kelion, Muhiddin Ozkor, Simon Kennon, Michael Mullen, Guy Lloyd, Leon J Menezes, Philip N Hawkins, James C Moon
AIMS: Cardiac amyloidosis is common in elderly patients with aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI). We hypothesized that patients with dual aortic stenosis and cardiac amyloid pathology (AS-amyloid) would have different baseline characteristics, periprocedural and mortality outcomes. METHODS AND RESULTS: Patients aged ≥75 with severe AS referred for TAVI at two sites underwent blinded bone scintigraphy prior to intervention (Perugini Grade 0 negative, 1-3 increasingly positive)...
April 8, 2020: European Heart Journal
https://read.qxmd.com/read/32266575/diagnosis-of-transthyretin-amyloid-cardiomyopathy
#59
REVIEW
Adam S Hafeez, Anthony A Bavry
Transthyretin amyloid cardiomyopathy (ATTR-CM) continues to be an easily overlooked, life-threatening, yet treatable cause of heart failure. Furthermore, its elusive diagnosis leads to late or misdiagnosis. As therapeutic advancements such as tafamidis usher in a promising new era in the management of ATTR-CM, the need for disease awareness and efficient diagnostic evaluation is crucial. With newer inexpensive imaging modalities and techniques, such as longitudinal strain imaging, T1 mapping on cardiac magnetic resonance imaging, and cardiac scintigraphy, the diagnosis of ATTR-CM no longer requires invasive evaluation with tissue biopsy...
April 7, 2020: Cardiology and Therapy
https://read.qxmd.com/read/32265209/isolated-cardiovascular-involvement-in-light-chain-amyloidosis
#60
Ahamed Shaheer Ahmed, Sampath Kumar, Gautam Sharma, Sudheer Arava
A 50-year-old woman presented with complaints of palpitations and breathlessness of 6 months' duration. She was being treated elsewhere as a case of dilated cardiomyopathy. On evaluation she had racoon eyes, poor progression of R wave on ECG and low-voltage complexes in the limb leads. Echocardiography revealed biventricular hypertrophy, diastolic dysfunction and moderate systolic dysfunction. Cardiac MRI showed features suggestive of amyloidosis. Bone marrow biopsy revealed raised plasma cell count, and endomyocardial biopsy showed amyloid deposits in the myocardium...
April 6, 2020: BMJ Case Reports
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