keyword
https://read.qxmd.com/read/38536048/mixed-connective-tissue-disease-presenting-with-psychosis-a-case-report
#21
JOURNAL ARTICLE
Nikhil Tondehal, Arnab Sengupta, Kavya Mohankumar, Chintan Trivedi, Zeeshan Mansuri, Shailesh Jain
Mixed connective tissue disease (MCTD) is a systemic autoimmune disease with features overlapping multiple autoimmune disorders. One study found that over 55% of patients with MCTD experienced neuropsychiatric symptoms, the most common of which was an "aseptic meningitis-like syndrome." We present a case of a 17-year-old adolescent girl presenting with abnormal speech and behavior, auditory hallucinations, and paranoid delusions after an isolated episode of fever. She was treated for her psychotic symptoms but later developed symptoms resembling neuroleptic malignant syndrome...
April 1, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38536047/restoring-trust-for-people-with-psychosis-through-psychotherapy
#22
JOURNAL ARTICLE
Jeremy M Ridenour, Jay A Hamm, Courtney N Wiesepape, Benjamin Buck
Mistrust is a significant problem for people with psychosis and can interfere with their capacity to engage in psychosocial treatment. In this article, the developmental trajectory of mistrust is outlined, including the impact that attachment disruption, childhood trauma, attributional biases, internalized stigma, and discrimination can have on the person's capacity to form trusting bonds with others. After this review, three elements are described that may allow for the restoration of trust: the therapist's openness to understanding the patient's experience and agenda for therapy, the therapist's effort to honestly disclose their thoughts to encourage dialogue and mutual reflection, and therapist's attempt to promote metacognition through helping the patient develop more complex representations of the minds of others...
April 1, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38536046/what-happens-next-maintenance-of-gains-after-discharge-from-va-residential-ptsd-treatment
#23
JOURNAL ARTICLE
Peter P Grau, Ilan Harpaz-Rotem, Mark A Ilgen, Dara Ganoczy, Rebecca K Sripada
Residential posttraumatic stress disorder (PTSD) treatment in the Department of Veterans Affairs is helpful for many Veterans, yet the majority experience symptom rebound after discharge. This study examined a national cohort of Veterans (n = 1872) who completed VA residential PTSD treatment and identified factors associated with maintenance of gains from discharge to 4-month follow-up. We generated three logistic regression models based on response profiles during residential treatment. In the "marginal responders" group, 1-3 "booster" sessions of PTSD treatment were associated with decreased odds of maintenance of gains (odds ratio [OR], 0...
April 1, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38536041/neurotic-disorders-in-children-and-adults-under-social-stress-neurosis-in-kids-and-adults-social-stress
#24
JOURNAL ARTICLE
Sergii Boltivets, Tymur Gonchar, Oleksiy Gonchar, Lyudmila Uralova, Yuliya Chelyadyn
The relevance of the research subject is to explore the neurotic disorders that arise in people affected by the Russian-Ukrainian war and who witness violence and war crimes. The purpose of the research is to reflect the specific features of the mental reaction of children and adults to military actions as an example of global social stress. Bibliographic, bibliosemantic, and statistical research methods were used in the research. Since the beginning of the full-scale invasion, the number of patients with prolonged depression and schizophrenia has increased, and neurotic disorders has become more severe and acute...
March 13, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38536039/the-nature-of-combat-stress-development-during-military-operations-and-psychotherapy-in-extreme-situations
#25
JOURNAL ARTICLE
Yanina Ovsyannikova, Diana Pokhilko, Mykola Krasnokutskyi, Valentyn Kerdyvar, Kateryna Kreshchuk
The purpose of the research work is the theoretical and empirical analysis of the study of the nature of combat stress in military personnel and the assessment of psychotherapeutic methods of providing psychological assistance in extreme situations. The authors used the following methods to achieve this goal: method of analysis and synthesis, hermeneutic method, testing method, comparative method, and generalization method. The results of the research work have revealed the meaning of traumatic stress, psychological trauma, and combat mental trauma, and explained the concept of combat stress and the dynamics of its growth...
March 13, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38535979/understanding-multiple-sclerosis-as-a-disease-spectrum-above-and-below-the-clinical-threshold
#26
JOURNAL ARTICLE
Stephen Krieger, Karin Cook, Carrie M Hersh
PURPOSE OF REVIEW: Research in multiple sclerosis (MS) has long been predicated on clinical groupings that do not reflect the underlying biologic heterogeneity apparent within patient populations. This review explicates the various levels of explanation through which the spectrum of disease is described and investigated both above and below the clinical threshold of detection, as framed by the topographical model of MS, to help advance a cogent mechanistic framework. RECENT FINDINGS: Contemporary evidence has amended the view of MS as consisting of sequential disease phases in favor of a spectrum of disease with an admixture of interdependent and dynamic pathobiological axes driving tissue injury and progression...
March 28, 2024: Current Opinion in Neurology
https://read.qxmd.com/read/38535959/single-nucleotide-polymorphisms-associated-with-mercury-levels-and-neurological-symptoms-an-overview
#27
REVIEW
Jamila Alessandra Perini, Jessica Vilarinho Cardoso, Alana de Oliveira Knesse, Felipe Oliveira Pessoa-Silva, Ana Claudia Santiago de Vasconcellos, Daniel Escorsim Machado, Paulo Cesar Basta
Mercury (Hg) pollution is a global public health concern because of its adverse effects on the environment and health. Single-nucleotide polymorphisms (SNPs) have been associated with Hg levels and outcomes. The aim of this review was to describe the research and discuss the evidence on the genetic susceptibility of Hg-exposed individuals to the development of neurocognitive disorders. A systematic review was performed to identify the genes/SNPs associated with Hg toxicokinetics and that, therefore, affect neurological function in exposed populations...
March 20, 2024: Toxics
https://read.qxmd.com/read/38535945/long-term-environmental-methylmercury-exposure-is-associated-with-peripheral-neuropathy-and-cognitive-impairment-among-an-amazon-indigenous-population
#28
JOURNAL ARTICLE
Bruno H Rebouças, Gabriel T Kubota, Rogério A A Oliveira, Bruna D Pinto, Roberta M Cardoso, Ana C S Vasconcellos, Paulo C Basta
Widespread contamination of the Amazon basin with mercury has been reported to occur since at least the mid-80s due to heavy gold mining activity. Although initial studies have indicated that this may lead to deleterious neurological consequences to the indigenous populations living in the region, further research is needed to better characterize the neurological burden of such long-term exposure. With this aim, a cross-sectional exploratory study has been conducted with the Yanomami indigenous population residing in a northern Amazon region...
March 12, 2024: Toxics
https://read.qxmd.com/read/38535862/surgical-outcomes-of-laminectomy-durotomy-and-a-non-synthetic-dura-substitute-application-in-ten-dogs-with-a-spinal-subarachnoid-diverticulum
#29
JOURNAL ARTICLE
Michał Mól, Ricardo Fernandes, Simon Wheeler, Massimo Mariscoli
This retrospective study aimed to report the surgical treatment and outcomes of laminectomies followed by durotomy and the application of a non-synthetic collagen matrix dura substitute (DurepairTM ) in ten dogs with a spinal subarachnoid diverticulum (SAD). The medical records of these ten client-owned dogs with SAD diagnosed by magnetic resonance imaging (MRI) were reviewed. All patients had chronic and progressive deficits. At presentation, common neurological signs were proprioceptive ataxia, ambulatory spastic paraparesis or tetraparesis, and faecal incontinence...
March 14, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535789/real-life-treatment-outcome-of-botulinum-toxin-a-injection-on-overactive-bladder-and-voiding-dysfunction-in-patients-with-central-nervous-system-lesions
#30
JOURNAL ARTICLE
Yuan-Hong Jiang, Jia-Fong Jhang, Sheng-Fu Chen, Hann-Chorng Kuo
PURPOSE: Neurogenic lower urinary tract dysfunction (NLUTD) is common in patients with neurological lesions in the central nervous system (CNS). Medical treatment usually cannot adequately relieve NLUTD. This study reported the real-life treatment outcome of botulinum toxin A (BoNT-A) for overactive bladders (OAB) and voiding dysfunction in patients with CNS lesions. METHODS: We retrospectively analyzed the first-time treatment outcome of 74 patients who received detrusor 100 U BoNT-A for OAB and 45 patients who received a urethral sphincter 100 U BoNT-A injection for voiding dysfunction...
March 1, 2024: Toxins
https://read.qxmd.com/read/38535458/using-constellation-pharmacology-to-characterize-a-novel-%C3%AE-conotoxin-from-conus-ateralbus
#31
JOURNAL ARTICLE
Jorge L B Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J Hone, David Morgenstern, Victor M Chua, Iris Bea L Ramiro, Julita S Imperial, Lee S Leavitt, Jasmine Phan, Fernando A Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O Tun, Beatrix M Ueberheide, J Michael McIntosh, Vitor Vasconcelos, Baldomero M Olivera, Joanna Gajewiak
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating the structure and function of the various nAChR subtypes. By studying how conotoxins interact with nAChRs, we can improve our understanding of these receptors, leading to new insights into neurological diseases associated with nAChRs. Here, we describe the discovery and characterization of a novel conotoxin from Conus ateralbus , αCtx-AtIA, which has an amino acid sequence homologous to the well-described αCtx-PeIA, but with a different selectivity profile towards nAChRs...
February 29, 2024: Marine Drugs
https://read.qxmd.com/read/38535457/new-forms-of-neuroactive-phospholipids-for-dha-enrichment-in-brain
#32
JOURNAL ARTICLE
Romina Gomes, Inês Mendes, Maria Paula Duarte, Narcisa M Bandarra, Ana Gomes-Bispo
Low levels of docosahexaenoic acid (DHA) in the brain have been related to neurological disorders, like Alzheimer's disease (AD). After ingestion, dietary DHA must cross the blood-brain barrier, where it is absorbed as lysophosphatidylcholine (LPC), due to its role as a preferential DHA carrier in the brain. This work aimed at the production of LPC-DHA extracts to be used in supplementation/food fortification intended neural enrichment in DHA. As it is rich in DHA, especially its phospholipids (PL), Atlantic mackerel ( Scomber scombrus , caught in Spring/2022) was used as a raw material...
February 29, 2024: Marine Drugs
https://read.qxmd.com/read/38535312/integrating-genome-sequencing-and-untargeted-metabolomics-in-monozygotic-twins-with-a-rare-complex-neurological-disorder
#33
Rulan Shaath, Aljazi Al-Maraghi, Haytham Ali, Jehan AlRayahi, Adam D Kennedy, Karen L DeBalsi, Sura Hussein, Najwa Elbashir, Sujitha S Padmajeya, Sasirekha Palaniswamy, Sarah H Elsea, Ammira A Akil, Noha A Yousri, Khalid A Fakhro
Multi-omics approaches, which integrate genomics, transcriptomics, proteomics, and metabolomics, have emerged as powerful tools in the diagnosis of rare diseases. We used untargeted metabolomics and whole-genome sequencing (WGS) to gain a more comprehensive understanding of a rare disease with a complex presentation affecting female twins from a consanguineous family. The sisters presented with polymicrogyria, a Dandy-Walker malformation, respiratory distress, and multiorgan dysfunctions. Through WGS, we identified two rare homozygous variants in both subjects, a pathogenic variant in ADGRG1 (p...
March 4, 2024: Metabolites
https://read.qxmd.com/read/38535293/integrative-analysis-of-cytokine-and-lipidomics-datasets-following-mild-traumatic-brain-injury-in-rats
#34
JOURNAL ARTICLE
Alexis N Pulliam, Alyssa F Pybus, David A Gaul, Samuel G Moore, Levi B Wood, Facundo M Fernández, Michelle C LaPlaca
Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary injury phase, TBI is characterized by complex secondary cascades that involve altered homeostasis and metabolism, faulty signaling, neuroinflammation, and lipid dysfunction. The objectives of the present study were to (1) assess potential correlations between lipidome and cytokine changes after closed-head mild TBI (mTBI), and (2) examine the reproducibility of our acute lipidomic profiles following TBI...
February 21, 2024: Metabolites
https://read.qxmd.com/read/38535283/membranes-and-synaptosomes-used-to-investigate-synaptic-gabaergic-currents-in-epileptic-patients
#35
JOURNAL ARTICLE
Alessandro Gaeta, Lilian Juliana Lissner, Veronica Alfano, Pierangelo Cifelli, Alessandra Morano, Cristina Roseti, Angela Di Iacovo, Eleonora Aronica, Eleonora Palma, Gabriele Ruffolo
Among the most prevalent neurological disorders, epilepsy affects about 1% of the population worldwide. We previously found, using human epileptic tissues, that GABAergic neurotransmission impairment is a key mechanism that drives the pathological phenomena that ultimately lead to generation and recurrence of seizures. Using both a "microtransplantation technique" and synaptosomes preparations from drug-resistant temporal lobe epilepsies (TLEs), we used the technique of two-electrode voltage clamp to record GABA-evoked currents, focusing selectively on the synaptic "fast inhibition" mediated by low-affinity GABAA receptors...
March 2, 2024: Membranes
https://read.qxmd.com/read/38535090/machine-learning-identifies-higher-survival-profile-in-extracorporeal-cardiopulmonary-resuscitation
#36
JOURNAL ARTICLE
Ruben Crespo-Diaz, Julian Wolfson, Demetris Yannopoulos, Jason A Bartos
OBJECTIVES: Extracorporeal cardiopulmonary resuscitation (ECPR) has been shown to improve neurologically favorable survival in patients with refractory out-of-hospital cardiac arrest (OHCA) caused by shockable rhythms. Further refinement of patient selection is needed to focus this resource-intensive therapy on those patients likely to benefit. This study sought to create a selection model using machine learning (ML) tools for refractory cardiac arrest patients undergoing ECPR. DESIGN: Retrospective cohort study...
March 27, 2024: Critical Care Medicine
https://read.qxmd.com/read/38535059/ultrasound-biomicroscopy-as-a-novel-potential-modality-to-evaluate-anterior-segment-ophthalmic-structures-during-spaceflight-an-analysis-of-current-technology
#37
REVIEW
Benjamin Soares, Joshua Ong, Daniela Osteicoechea, Cihan Mehmet Kadipasaoglu, Ethan Waisberg, Prithul Sarker, Nasif Zaman, Alireza Tavakkoli, Gianmarco Vizzeri, Andrew G Lee
Ocular health is currently a major concern for astronauts on current and future long-duration spaceflight missions. Spaceflight-associated neuro-ocular syndrome (SANS) is a collection of ophthalmic and neurologic findings that is one potential physiologic barrier to interplanetary spaceflight. Since its initial report in 2011, our understanding of SANS has advanced considerably, with a primary focus on posterior ocular imaging including fundus photography and optical coherence tomography. However, there may be changes to the anterior segment that have not been identified...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38535002/the-impact-of-magnetic-resonance-imaging-findings-in-predicting-neurological-status-pre-and-post-treatment-of-spinal-dural-arteriovenous-fistulas-a-22-year-experience-in-a-neurovascular-and-spine-center
#38
JOURNAL ARTICLE
Andreas Filis, Kay Engellandt, Sergio M F Romualdo, Ibrahim El-Battrawy, Dino Podlesek, Tareq A Juratli, Ilker Y Eyüpoglu, Mido Max Hijazi
BACKGROUND: Successful treatment of spinal dural arteriovenous fistulas (SDAVF) requires prompt diagnosis with definitive fistula localization and non-delayed treatment. Magnetic resonance imaging (MRI) is used for the screening and follow-up of SDAVF, although the value of MRI signs such as myelopathy and flow voids is controversial. Therefore, we investigated the predictive value of MRI signs pre- and post-treatment and their correlation with the neurological status of SDAVF patients...
March 8, 2024: Diagnostics
https://read.qxmd.com/read/38534998/deep-learning-based-prediction-model-for-gait-recovery-after-a-spinal-cord-injury
#39
JOURNAL ARTICLE
Hyun-Joon Yoo, Kwang-Sig Lee, Bummo Koo, Chan-Woo Yong, Chae-Won Kim
Predicting gait recovery after a spinal cord injury (SCI) during an acute rehabilitation phase is important for planning rehabilitation strategies. However, few studies have been conducted on this topic to date. In this study, we developed a deep learning-based prediction model for gait recovery after SCI upon discharge from an acute rehabilitation facility. Data were collected from 405 patients with acute SCI admitted to the acute rehabilitation facility of Korea University Anam Hospital between June 2008 and December 2022...
March 8, 2024: Diagnostics
https://read.qxmd.com/read/38534977/pre-stroke-antihypertensive-therapy-affects-stroke-severity-and-3-month-outcome-of-ischemic-mca-territory-stroke
#40
JOURNAL ARTICLE
Lehel-Barna Lakatos, Manuel Bolognese, Mareike Österreich, Laura Weichsel, Martin Müller
OBJECTIVES: Whether different antihypertensive drug classes in high blood pressure (HBP) pre-stroke treatment affect dynamic cerebral autoregulation (dCA), stroke severity, and outcome. METHODS: Among 337 consecutive ischemic stroke patients (female 102; median age 71 years [interquartile range, [IQR 60; 78]; NIHSS median 3 [IQR 1; 6]) with assessment of dCA, 183 exhibited the diagnosis of HBP. dCA parameters' gain and phase were determined by transfer function analysis of spontaneous oscillations of blood pressure and cerebral blood flow velocity...
March 3, 2024: Diseases (Basel)
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