Domingo J Quintana-Hernández, Jaime Rojas-Hernández, Angelo Santana-Del Pino, Carmen Céspedes Suárez, Mónica Pellejero Silva, María Teresa Miró-Barrachina, Ignacio Ibáñez Fernández, José Antonio Estupiñán López, Lucas F Borkel
BACKGROUND: This longitudinal study addressed whether mindfulness practice prevents psychological and behavioral symptoms, especially mood disorders, in Alzheimer's disease (AD). OBJECTIVE: To assess the incidence of depression in the course of AD and to determine which non-pharmacological treatment (NPT) is most effective in preventing psychopathological symptoms. METHODS: We conducted a longitudinal, non-inferiority and equivalence randomized clinical trial, repeated-measures design, with a control group and three experimental treatments: mindfulness, cognitive stimulation, and relaxation...
November 24, 2022: Journal of Alzheimer's Disease: JAD
Ping Li, Junyu Wu, Shujie Liu, Ruiqing Lu, Hualian Jiang, Niu Wang, Manhui Luo, Liping Guo, Jingshu Xiao, Lang Bu, Lihong Liu, Fan Xing, Hong Peng, Chunmei Li, Lan Ma, Bo Zhao, Zhongwei Zhou, Deyin Guo
Zika virus (ZIKV) targets the neural progenitor cells (NPCs) in brain during intrauterine infections and consequently causes severe neurological disorders, such as microcephaly in neonates. Although replicating in the cytoplasm, ZIKV dysregulates the expression of thousands of host genes, yet the detailed mechanism remains elusive. Herein, we report that ZIKV encodes a unique DNA-binding protein to regulate host gene transcription in the nucleus. We found that ZIKV NS5, the viral RNA polymerase, associates tightly with host chromatin DNA through its methyltransferase domain and this interaction could be specifically blocked by GTP...
December 6, 2022: Proceedings of the National Academy of Sciences of the United States of America
Georgina Spies, Melanie Deist, Sharain Suliman, Soraya Seedat
BACKGROUND: The HIV Neurobehavioral Research Center International Neurobehavioral Battery is a culturally valid battery sensitive to the neurocognitive (NC) effects of HIV-infection. However, its lengthy administration time makes the battery impractical in resource-limited settings, like South Africa, which are often faced with an overwhelming disease burden, a lack of neurological and neuropsychological (NP) expertise, and staff shortages. The present study therefore sought to develop an abbreviated version of the HNRC Battery and validate this battery in a sample of people with HIV (PWH) in South Africa...
November 28, 2022: Neuropsychology
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2022: Journal of Neurophysiology
David W Allison, Justin W Silverstein, Shanti S Thirumalai, Randy S D'Amico
The rate at which stimulation is applied to peripheral nerves is critical to generating high-quality intraoperative somatosensory evoked potentials (SSEPs) in a timely manner. Guidelines based on a limited study and anecdotal evidence present differing, incorrect, or incomplete stimulation rate recommendations. We examined the effect stimulating the ulnar and tibial nerves at 1.05, 2.79, 5.69, and 8.44 Hz had on cortical, subcortical, and peripheral response amplitude and latency in 10 subjects with neuromuscular blockade (NMB) and 10 without NMB in the operating room under general anesthesia...
November 28, 2022: Neurodiagnostic Journal
Priya Pallavi, Neeti Jariwala, Niravkumar Patel, Manasi Kanetkar, Shraddha Diwan, Uttama Lahiri
Fear of Fall (FoF) is often associated with postural and gait abnormalities leading to decreased mobility in individuals with Parkinson's Disease (PD). The variability in knee flexion (postural index) during heel-strike and toe-off events while walking can be related to one's FoF. Depending on the progression of the disease, gait abnormality can be manifested as start/turn/stop hesitation, etc. adversely affecting one's cadence along with an inability to transfer weight from one leg to the other. Also, task demands can have implications on one's gait and posture...
November 28, 2022: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Ali M Alam, Conor S Gillespie, Jack Goodall, Tina Damodar, Lance Turtle, Ravi Vasanthapuram, Tom Solomon, Benedict D Michael
BACKGROUND: Scrub typhus has become a leading cause of central nervous system (CNS) infection in endemic regions. As a treatable condition, prompt recognition is vital. However, few studies have focused on describing the symptomology and outcomes of neurological scrub typhus infection. We conducted a systematic review and meta-analysis to report the clinical features and case fatality ratio (CFR) in patients with CNS scrub typhus infection. METHODS: A search and analysis plan was published in PROSPERO [ID 328732]...
November 28, 2022: PLoS Neglected Tropical Diseases
Jianquan Chen, Xinyuan Lin, Zhouming Lv, Maoshui Chen, Taosheng Huang
BACKGROUND: Percutaneous vertebroplasty (PVP) has been used widely to treat osteoporotic vertebral compression fractures (OVCFs). However, it has many disadvantages, such as excessive radiation exposure, long operation times, and high cement leakage rates. This study was conducted to explore the clinical effects and safety of the use of a three-dimensional (3D)-printed body-surface guide plate to aid PVP for the treatment of OVCFs. METHODS: This prospective cohort study was conducted with patients with OVCFs presenting between October 2020 and June 2021...
2022: PloS One
Huseyin Kilic, Sezgin Sahin, Mekiya Filiz Toprak, Gokce Hale Hatay, Kubra Yilmaz, Amra Adrovic, Kenan Barut, Esin Ozturk Isik, Erdem Tuzun, Osman Kizilkilic, Sema Saltik, Ozgur Kasapcopur
OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterised by the presence of various autoantibodies. Mild cognitive impairment developing in patients without significant neuropsychiatric (NP) symptoms was thought to be the result of immune-mediated myelinopathy. We aimed to determine the role of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in the neurological manifestations of childhood-onset SLE (cSLE) and if there is a correlation between various metabolite peaks in magnetic resonance spectroscopy (MRS) and myelinopathy...
November 24, 2022: Clinical and Experimental Rheumatology
Nevsun Inanc, Belchin Kostov, Roberta Priori, Alejandra Flores-Chavez, Francesco Carubbi, Antónia Szántó, Valeria Valim, Hendrika Bootsma, Sonja Praprotnik, Virginia Fernandes Moça Trevisani, Gabriela Hernández-Molina, Benedikt Hofauer, Sandra G Pasoto, Miguel López-Dupla, Elena Bartoloni, Maureen Rischmueller, Valerie Devauchelle-Pensec, Kerem Abacar, Federico Giardina, Alessia Alunno, Ildikó Fanny Horváth, Liseth de Wolff, Laura Caldas, Soledad Retamozo, Manuel Ramos-Casals, Pilar Brito-Zerón
OBJECTIVES: To investigate the safety and efficacy of SARS-Cov-2 vaccination in patients with primary Sjögren syndrome (pSS) due to scarcity of data in this population. METHODS: By the first week of May 2021, all Big Data SS Consortium centres patients who had received at least one dose of any SARS-CoV-2 vaccine were included in the study. The in-charge physician asked patients about local and systemic reactogenicity to collect SARS-CoV-2 vaccination data. RESULTS: The vaccination data of 1237 patients were received...
November 17, 2022: Clinical and Experimental Rheumatology
Alberto J Espay, Michael S Okun
No abstract text is available yet for this article.
November 28, 2022: JAMA Neurology
Prasad Shirvalkar, Lawrence Poree
No abstract text is available yet for this article.
November 28, 2022: JAMA Neurology
Josep Dalmau, Francesc Graus
No abstract text is available yet for this article.
November 28, 2022: JAMA Neurology
Sanket S Dhruva, Jaime Murillo, Omid Ameli, Pamela E Morin, Donna L Spencer, Rita F Redberg, Ken Cohen
IMPORTANCE: Spinal cord stimulators (SCSs) are increasingly used for the treatment of chronic pain. There is a need for studies with long-term follow-up. OBJECTIVE: To determine the comparative effectiveness and costs of SCSs compared with conventional medical management (CMM) in a large cohort of patients with chronic pain. DESIGN, SETTING, AND PARTICIPANTS: This was a 1:5 propensity-matched retrospective comparative effectiveness research analysis of insured individuals from April 1, 2016, to August 31, 2018...
November 28, 2022: JAMA Neurology
Eoin P Flanagan, Michael D Geschwind, A Sebastian Lopez-Chiriboga, Kyle M Blackburn, Sanchit Turaga, Sophie Binks, Jennifer Zitser, Jeffrey M Gelfand, Gregory S Day, S Richard Dunham, Stefanie J Rodenbeck, Stacey L Clardy, Andrew J Solomon, Sean J Pittock, Andrew McKeon, Divyanshu Dubey, Anastasia Zekeridou, Michel Toledano, Lindsey E Turner, Steven Vernino, Sarosh R Irani
IMPORTANCE: Autoimmune encephalitis misdiagnosis can lead to harm. OBJECTIVE: To determine the diseases misdiagnosed as autoimmune encephalitis and potential reasons for misdiagnosis. DESIGN, SETTING, AND PARTICIPANTS: This retrospective multicenter study took place from January 1, 2014, to December 31, 2020, at autoimmune encephalitis subspecialty outpatient clinics including Mayo Clinic (n = 44), University of Oxford (n = 18), University of Texas Southwestern (n = 18), University of California, San Francisco (n = 17), University of Washington in St Louis (n = 6), and University of Utah (n = 4)...
November 28, 2022: JAMA Neurology
Moeko Saito, Takao Hoshino, Kentaro Ishizuka, Shuichi Iwasaki, Sono Toi, Noriyuki Shibata, Kazuo Kitagawa
Remote ischemic conditioning (RIC) has attracted much attention as a protective strategy for the heart and brain, although the underlying mechanisms remain unclear. We hypothesized that RIC enhances collateral circulation during cerebral ischemia through endothelial function and mitigates both early ischemic change and final infarct volume. We tested the RIC and sham procedure 30 min after permanent middle cerebral artery occlusion (MCAO) in male mice. Collateral circulation was examined during the procedure with 2D color-coded ultrasound imaging...
November 28, 2022: Translational Stroke Research
Pierluigi Valente, Antonella Marte, Francesca Franchi, Bruno Sterlini, Silvia Casagrande, Anna Corradi, Pietro Baldelli, Fabio Benfenati
Proline-rich transmembrane protein 2 (PRRT2) is a neuron-specific protein implicated in the control of neurotransmitter release and neural network stability. Accordingly, PRRT2 loss-of-function mutations associate with pleiotropic paroxysmal neurological disorders, including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. PRRT2 is a negative modulator of the membrane exposure and biophysical properties of Na+ channels NaV 1.2/NaV 1.6 predominantly expressed in brain glutamatergic neurons...
November 28, 2022: Molecular Neurobiology
C U Wickramasinghe, D M G Fernando, S Wijetunge, H R S D Sumanasekara
Multiple sclerosis (MS) is a debilitating, demyelinating disease of the central nervous system, with manifestations ranging from numbness and blindness to paralysis. Typical MS is a slowly progressive demyelinating disease, causing significant morbidity spanning over many years. In contrast, "Marburg's disease" is a rare variant of MS which demonstrates a malignant monophasic disease progression leading to death within weeks to months. We present a rapidly fatal demyelinating disease with the clinicopathological findings on par with the handful of reported cases of "Marburg's disease" in the literature...
November 28, 2022: Forensic Science, Medicine, and Pathology
Faezeh Almasi, Wen Dang, Fatemeh Mohammadipanah, Ning Li
In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19 ranging from 22 to 36%. Although growing records are focusing on neurological aspects of COVID-19, the pathophysiological mechanisms and related therapeutic methods remain obscure. Considering the increased concerns of SARS-CoV-2 potential for more serious neuroinvasion conditions, the present review attempts to focus on the neuroprotective effects of natural compounds as the principle source of therapeutics inhibiting multiple steps of the SARS-CoV-2 infection cycle...
November 28, 2022: Archives of Pharmacal Research
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