Julie Lerond, Bertrand Mathon, Mélina Scopin, Lucia Nichelli, Justine Guégan, Céline Bertholle, Brigitte Izac, Muriel Andrieu, Thomas Gareau, Florian Donneger, Badreddine Mohand Oumoussa, Franck Letourneur, Suzanne Tran, Mathilde Bertrand, Isabelle Le Roux, Mehdi Touat, Sophie Dupont, Jean Christophe Poncer, Vincent Navarro, Franck Bielle
OBJECTIVE: Mesial Temporal Lobe Epilepsy-associated Hippocampal Sclerosis (MTLE-HS) is a syndrome associated with various aetiologies. We previously identified CD34-positive extravascular stellate cells (CD34+ cells) possibly related to BRAFV600E oncogenic variant in a subset of MTLE-HS. We aimed to identify the BRAFV600E oncogenic variants and characterise the CD34+ cells. METHODS: We analysed BRAFV600E oncogenic variant by digital droplet Polymerase Chain Reaction in 53 MTLE-HS samples (25 with CD34+ cells) and 9 non-expansive neocortical lesions resected during epilepsy surgery (5 with CD34+ cells)...
September 23, 2023: Neuropathology and Applied Neurobiology
Ana Carolina De Campos, Álvaro Hidalgo-Robles, Egmar Longo, Claire Shrader, Ginny Paleg
No abstract text is available yet for this article.
September 23, 2023: Developmental Medicine and Child Neurology
Marganit Benish, Shai Shrot, Assaf Barg, Iris Kventsel, Ronit Elhasid, Gili Kenet, Sarina Levy-Mendelovich
Retinal vein occlusion (RVO) and superior ophthalmic vein thrombosis (SOVT) are rare diseases in the pediatric population; however, the ophthalmic and neurologic morbidity are significant. As published data are scarce for these conditions, we present our experience with pediatric ocular venous thrombosis in four patients, and discuss recommended management for evaluation and treatment. We suggest performing thrombophilia workup for all pediatric patients with RVO or SOVT. In patients with thrombophilia risk factors or patients with additional thrombi, we highly recommend initiating anticoagulation therapy...
September 23, 2023: Pediatric Blood & Cancer
Domingo Palacios-Ceña, Javier Güeita-Rodríguez, Antonio Gil-Nagel, Carmen Jimenez-Antona, Cristina García-Bravo, Juan Francisco Velarde-García, Juan Nicolas Cuenca-Zaldivar, Ángel Aledo-Serrano
No abstract text is available yet for this article.
September 23, 2023: Developmental Medicine and Child Neurology
Karin Fast, Elisabet Wentz, Josefine Roswall, Maxwell Strandberg, Stefan Bergman, Jovanna Dahlgren
AIM: To investigate the prevalence of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in a population-based birth cohort and correlate the findings with prenatal and perinatal factors. We hypothesized that children born preterm, having experienced preeclampsia or maternal overweight, would have an increased risk of ADHD or ASD. METHOD: A Swedish cohort of 2666 children (1350 males, 1316 females) has been followed from birth with parental and perinatal data...
September 22, 2023: Developmental Medicine and Child Neurology
Chuan Qin, Man Chen, Ming-Hao Dong, Sheng Yang, Hang Zhang, Yun-Fan You, Luo-Qi Zhou, Yun-Hui Chu, Yue Tang, Xiao-Wei Pang, Long-Jun Wu, Dai-Shi Tian, Wei Wang
Microglia-mediated neuroinflammation contributes to acute demyelination in neuromyelitis optica spectrum disorders (NMOSD). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in the cerebrospinal fluid (CSF) has been associated with microglial activation in several neurodegenerative diseases. However, the basis for this immune-mediated attack and the pathophysiological role of sTREM2 in NMOSD remain to be elucidated. Here, we performed Mendelian randomization analysis and identified a genetic association between increased CSF sTREM2 and NMOSD risk...
September 22, 2023: Brain
Juan Shi, Kai-Xuan He, Yan-Bo Dong, Yu-He Liu, Cheng Lu, Wan-Xin Li
OBJECTIVE: Brachial plexus schwannoma (BPS) is a rare clinical entity that poses a significant challenge for head and neck surgeons due to its neuroanatomical complexity and potential severe complications, such as major motor or sensory neurological deficits or pain of the corresponding upper extremity. This article summarizes our experience in its diagnosis and intracapsular enucleation with intraoperative neuromonitoring (INM). METHODS: A retrospective review of BPS cases treated at our tertiary medical institution was conducted between April 2020 and May 2023...
September 22, 2023: Ear, Nose, & Throat Journal
Yin-Qiong Huang, Zhe Wu, Shu Lin, Xiang-Rong Chen
Traumatic encephalopathy syndrome (TES) is used to describe the clinical manifestations of chronic traumatic encephalopathy (CTE). However, effective treatment and prevention strategies are lacking. Increasing evidence has shown that rehabilitation training could prevent cognitive decline, enhance brain plasticity, and effectively improve neurological function in neurodegenerative diseases. Therefore, the mechanisms involved in the effects of rehabilitation exercise therapy on the prognosis of CTE are worth exploring...
September 22, 2023: Molecular Medicine
Meghan M Caylor, R Loch Macdonald
BACKGROUND: Causes of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH) include early brain injury and delayed neurologic deterioration, which may result from delayed cerebral ischemia (DCI). Complex pathophysiological mechanisms underlie DCI, which often includes angiographic vasospasm (aVSP) of cerebral arteries. METHODS: Despite the study of many pharmacological therapies for the prevention of DCI in aSAH, nimodipine-a dihydropyridine calcium channel blocker-remains the only drug recommended universally in this patient population...
September 22, 2023: Neurocritical Care
Heather Wood
No abstract text is available yet for this article.
September 22, 2023: Nature Reviews. Neurology
Jafar Sadeghzadeh, Leila Hosseini, Ahmad Mobed, Hamid Soltani Zangbar, Jaber Jafarzadeh, Jamshid Pasban, Parviz Shahabi
Cerebral ischemia and subsequent reperfusion, leading to reduced blood supply to specific brain areas, remain significant contributors to neurological damage, disability, and mortality. Among the vulnerable regions, the subcortical areas, including the hippocampus, are particularly susceptible to ischemia-induced injuries, with the extent of damage influenced by the different stages of ischemia. Neural tissue undergoes various changes and damage due to intricate biochemical reactions involving free radicals, oxidative stress, inflammatory responses, and glutamate toxicity...
September 22, 2023: Cellular and Molecular Neurobiology
Madigan M Reid, Ludmila Belayev, Larissa Khoutorova, Pranab K Mukherjee, Andre Obenaus, Kierany Shelvin, Stacey Knowles, Sung-Ha Hong, Nicolas G Bazan
Despite efforts to identify modulatory neuroprotective mechanisms of damaging ischemic stroke cascade signaling, a void remains on an effective potential therapeutic. The present study defines neuroprotection by very long-chain polyunsaturated fatty acid (VLC-PUFA) Elovanoid (ELV) precursors C-32:6 and C-34:6 delivered intranasally following experimental ischemic stroke. We demonstrate that these precursors improved neurological deficit, decreased T2WI lesion volume, and increased SMI-71 positive blood vessels and NeuN positive neurons, indicating blood-brain barrier (BBB) protection and neurogenesis modulated by the free fatty acids (FFAs) C-32:6 and C-34:6...
September 22, 2023: Scientific Reports
Rakesh Kumar, Rajan Kumar, Neha Sharma, Navneet Khurana, Sachin Kumar Singh, Saurabh Satija, Meenu Mehta, Manish Vyas
No abstract text is available yet for this article.
September 20, 2023: Neurotoxicology
Kathleen E Cullen
The vestibular cerebellum plays an essential role in maintaining our balance and ensuring perceptual stability during activities of daily living. Here I examine three key regions of the vestibular cerebellum: the floccular lobe, anterior vermis (lobules I-V), and nodulus and ventral uvula (lobules X-IX of the posterior vermis). These cerebellar regions encode vestibular information and combine it with extravestibular signals to create internal models of eye, head, and body movements, as well as their spatial orientation with respect to gravity...
September 20, 2023: Trends in Neurosciences
Mélanie Nguyen Ky, Adrien Duran, Iris Hasantari, Agnès Bru, Mathilde Deloire, Bruno Brochet, Aurélie Ruet, Nathalie Schmitt
BACKGROUND AND OBJECTIVES: Natalizumab, a monoclonal humanized antibody targeting integrin α4, inhibits the transmigration of lymphocytes into the CNS by preventing the interaction of integrin α4β1 with V-CAM expressed on brain vascular endothelial cells. Although natalizumab treatment reduces the clinical relapse rate in patients with relapsing-remitting MS, its discontinuation after reactivation of the JC virus is associated with a rebound of the disease in 20% of patients...
November 2023: Neurology® Neuroimmunology & Neuroinflammation
Naoko Matsui, Keiko Tanaka, Mitsuyo Ishida, Yohei Yamamoto, Yuri Matsubara, Reiko Saika, Takahiro Iizuka, Koshi Nakamura, Nagato Kuriyama, Makoto Matsui, Kokichi Arisawa, Yosikazu Nakamura, Ryuji Kaji, Satoshi Kuwabara, Yuishin Izumi
BACKGROUND AND OBJECTIVES: To elucidate current epidemiologic, clinical, and immunologic profiles and treatments of stiff-person syndrome (SPS) in Japan. METHODS: A nationwide mail survey was conducted using an established method. Data processing sheets were sent to randomly selected departments of internal medicine, neurology, pediatrics, psychiatry, and neurosurgery in hospitals and clinics throughout Japan to identify patients with SPS who were seen between January 2015 and December 2017...
November 2023: Neurology® Neuroimmunology & Neuroinflammation
Joost Haarsma, Narin Deveci, Nadège Corbin, Martina F Callaghan, Peter Kok
Perception has been proposed to result from the integration of feedforward sensory signals with internally generated feedback signals. Feedback signals are believed to play an important role in driving false percepts, i.e., seeing things that are not actually there. Feedforward and feedback influences on perception can be studied using layer-specific fMRI, which we used here to interrogate neural activity underlying high confidence false percepts while healthy human participants (N=25, male and female) performed a perceptual orientation discrimination task...
September 21, 2023: Journal of Neuroscience
Darya Ryndych, Alison Sebold, Alyssa Strassburg, Yan Li, Raddy L Ramos, Gonzalo H Otazu
Individuals with mutations in a single copy of the SHANK3 gene present with social-interaction deficits. Although social behavior in mice depends on olfaction, mice with mutations in a single copy of the Shank3 gene do not have olfactory deficits in simple odor identification tasks (Drapeau et al. 2018). Here we tested olfaction in mice with mutations in a single copy of the Shank3 gene (Peça et al. 2011) using a complex odor-task and imaging in awake mice. Average glomerular responses in the olfactory bulb of Shank3B+/- were correlated with WT mice...
September 20, 2023: Journal of Neuroscience
Soumyabrata Munshi, Lucas Albrechet-Souza, Raoni Conceição Dos-Santos, Claire E Stelly, Maria E Secci, Nicholas W Gilpin, Jeffrey G Tasker
Chronic alcohol exposure leads to a neuroinflammatory response involving activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome and pro-inflammatory cytokine production. Acute ethanol (EtOH) exposure activates GABAergic synapses in the central and basolateral amygdala (BLA) ex vivo , but whether this rapid modulation of synaptic inhibition is due to an acute inflammatory response and alters anxiety-like behavior in male and female animals is not known. Here, we tested the hypotheses that acute EtOH facilitates inhibitory synaptic transmission in the BLA by activating the NLRP3 inflammasome-dependent acute inflammatory response, that the alcohol-induced increase in inhibition is cell type- and sex-dependent, and that acute EtOH in the BLA reduces anxiety-like behavior...
September 21, 2023: Journal of Neuroscience
Giorgia Coratti, Jacopo Lenkowicz, Maria Carmela Pera, Adele D'Amico, Claudio Bruno, Consolato Gullì, Noemi Brolatti, Marina Pedemonte, Laura Antonaci, Martina Ricci, Anna Capasso, Gianpaolo Cicala, Costanza Cutrona, Roberto de Sanctis, Sara Carnicella, Nicola Forcina, Michela Cateruccia, Maria Beatrice Damasio, Luca Labianca, Francesca Manfroni, Antonio Leone, Enrico Bertini, Marika Pane, Stefano Patarnello, Vincenzo Valentini, Eugenio Mercuri
BACKGROUND: Type II spinal muscular atrophy (SMA) often leads to scoliosis in up to 90% of cases. While pharmacological treatments have shown improvements in motor function, their impact on scoliosis progression remains unclear. This study aims to evaluate potential differences in scoliosis progression between treated and untreated SMA II patients. METHODS: Treatment effect on Cobb's angle annual changes and on reaching a 50° Cobb angle was analysed in treated and untreated type II SMA patients with a minimum 1...
September 22, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
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