Chen Wang, Jianling Ji, Wanting Wang, Yujie Wang
OBJECTIVE: To investigate morphological predictors of neurological deterioration (ND) in patients with acute isolated pontine infarct. METHODS: Acute isolated pontine infarct patients within 7 days after onset of stroke symptoms were included retrospectively and classified into ND and non-ND groups. Morphological phenotypes (paramedian pontine infarct [PPI], atypical PPI, small deep infarct, and other types), topographical location, and lesion size were evaluated on axial diffusion-weighted imaging...
March 19, 2023: Acta Neurologica Belgica
Marta Fernandes, Aidan Cardall, Jin Jing, Wendong Ge, Lidia M V R Moura, Claire Jacobs, Christopher McGraw, Sahar F Zafar, M Brandon Westover
OBJECTIVES: Unstructured data present in electronic health records (EHR) is a rich source of medical information, however its abstraction is labor intensive. Automated EHR phenotyping (AEP) can reduce the need for manual chart review. We present an AEP model that is designed to automatically identify patients diagnosed with epilepsy. METHODS: The ground truth for model training and evaluation was captured from a combination of structured questionnaires filled out by physicians for a subset of patients and manual chart review using customized software...
March 19, 2023: Epilepsia
Laetitia Lebrun, Sacha Allard-Demoustiez, Nathalie Gilis, Claude Van Campenhout, Marine Rodesch, Celine Roman, Pierluigi Calò, Valentina Lolli, Philippe David, Christophe Fricx, Olivier De Witte, Fabienne Escande, Claude-Alain Maurage, Isabelle Salmon
Central Nervous System (CNS) embryonal tumors represent a heterogeneous group of highly aggressive tumors occurring preferentially in children but also described in adolescents and adults. In 2021, the CNS World Health Organization (WHO) classification drastically changed the diagnosis of the other CNS embryonal tumors including new histo-molecular tumor types. Here, we report a pediatric case of a novel tumor type among the other CNS embryonal tumors classified within the methylation class "CNS Embryonal Tumor with BRD4-LEUTX Fusion"...
March 18, 2023: Acta Neuropathologica Communications
Daniel Perez-Marcos, Roberta Ronchi, Arthur Giroux, Fanny Brenet, Andrea Serino, Tej Tadi, Olaf Blanke
BACKGROUND: Unilateral spatial neglect (USN) is a debilitating neuropsychological syndrome that often follows brain injury, in particular a stroke affecting the right hemisphere. In current clinical practice, the assessment of neglect is based on old-fashioned paper-and-pencil and behavioral tasks, and sometimes relies on the examiner's subjective judgment. Therefore, there is a need for more exhaustive, objective and ecological assessments of USN. METHODS: In this paper, we present two tasks in immersive virtual reality to assess peripersonal and extrapersonal USN...
March 18, 2023: Journal of Neuroengineering and Rehabilitation
Ryan K Shahidehpour, Abraham S Nelson, Lydia G Sanders, Chloe R Embry, Peter T Nelson, Adam D Bachstetter
New histological techniques are needed to examine protein distribution in human tissues, which can reveal cell shape and disease pathology connections. Spatial proteomics has changed the study of tumor microenvironments by identifying spatial relationships of immunomodulatory cells and proteins and contributing to the discovery of new cancer immunotherapy biomarkers. However, the fast-expanding toolkit of spatial proteomic approaches has yet to be systematically applied to investigate pathological alterations in the aging human brain in health and disease states...
March 18, 2023: Acta Neuropathologica Communications
Yanruo Huang, Qihang Wang, Yunsong Peng, Wenjie Du, Qi Wang, Jiangtao Qi, Zijian Hao, Yingwei Wang
Neuronal voltage changes which are dependent on chloride transporters and channels are involved in forming neural functions during early development and maintaining their stability until adulthood. The intracellular chloride concentration maintains a steady state, which is delicately regulated by various genes coding for chloride transporters and channels (GClTC) on the plasmalemma; however, the synergistic effect of these genes in central nervous system disorders remains unclear. In this study, we first defined 10 gene clusters with similar temporal expression patterns, and identified 41 GClTC related to brain developmental process...
March 18, 2023: Molecular Brain
Ki-Woong Nam, Hyung-Min Kwon, Yong-Seok Lee
In single subcortical infarction (SSI), changes in lesion size are a major determinant of early neurological deterioration. We evaluated the association between END and infarct growth velocity (IGV) in patients with SSI. We included consecutive patients with SSI who underwent MRI within 24 h of symptom onset between 2010 and 2020. END was defined as an increase of ≥ 2 in the total National Institutes of Health Stroke Scale (NIHSS) score or ≥ 1 in the motor NIHSS score. IGV was calculated using the following formula: IGV (mL/h) = diffusion-weighted imaging volume (mL)/time to MRI (h)...
March 18, 2023: Scientific Reports
A Farina, M Villagrán-García, J Honnorat
The use of immune checkpoint inhibitors (ICIs) has represented a major advance in cancer treatment. By enhancing endogenous immune responses to destroy cancer cells, ICIs can cause immune-related adverse events (irAEs), with possible involvement of any organ system. IrAEs are frequent, particularly those involving the skin or the endocrine system, and usually completely reversible after temporary immunosuppression, while neurological irAEs (n-irAEs) are relatively rare, often severe, and they carry a considerable risk of mortality and long-term disability...
March 16, 2023: Revue Neurologique
T Horowitz, E Tabouret, T Graillon, B Salgues, O Chinot, A Verger, E Guedj
Positron emission tomography (PET) is a powerful tool that can help physicians manage primary brain tumours at diagnosis and follow-up. In this context, PET imaging is used with three main types of radiotracers: 18 F-FDG, amino acid radiotracers, and 68 Ga conjugated to somatostatin receptor ligands (SSTRs). At initial diagnosis, 18 F-FDG helps to characterize primary central nervous system (PCNS) lymphomas and high-grade gliomas, amino acid radiotracers are indicated for gliomas, and SSTR PET ligands are indicated for meningiomas...
March 16, 2023: Revue Neurologique
E Berthouzoz, V Lazarevic, A Zekeridou, M Castro, I Debove, S Aybek, J Schrenzel, P R Burkhard, V Fleury
The suspicion of an origin of Parkinson's disease (PD) at the periphery of the body and the involvement of environmental risk factors in the pathogenesis of PD have directed the attention of the scientific community towards the microbiota. The microbiota represents all the microorganisms residing both in and on a host. It plays an essential role in the physiological functioning of the host. In this article, we review the dysbiosis repeatedly demonstrated in PD and how it influences PD symptoms. Dysbiosis is associated with both motor and non-motor PD symptoms...
March 16, 2023: Revue Neurologique
Jason A Bartos, Arianne Clare Agdamag, Rajat Kalra, Lindsay Nutting, R J Frascone, Aaron Burnett, Nik Vuljaj, Charles Lick, Peter Tanghe, Ryan Quinn, Nicholas Simpson, Bjorn Peterson, Kari Haley, Kevin Sipprell, Demetris Yannopoulos
BACKGROUND: Multiple randomized clinical trials have compared specific airway management strategies during ACLS with conflicting results. However, patients with refractory cardiac arrest died in almost all cases without the availability of extracorporeal cardiopulmonary resuscitation (ECPR). Our aim was to determine if endotracheal intubation (ETI) was associated with improved outcomes compared to supraglottic airways (SGA) in patients with refractory cardiac arrest presenting for ECPR...
March 16, 2023: Resuscitation
Meredith R Hickson, Madeline Winters, Nina H Thomas, Monique M Gardner, Matthew P Kirschen, Vinay Nadkarni, Robert Berg, Beth S Slomine, Neethi P Pinto, Alexis Topjian
BACKGROUND: Survival following pediatric out-of-hospital cardiac arrest (OHCA) has improved over the past 2 decades but data on survivors' long-term outcomes are limited. We aimed to evaluate long-term outcomes in pediatric OHCA survivors more than one year after cardiac arrest. METHODS: OHCA survivors < 18 years old who received post-cardiac arrest care in the PICU at a single center between 2008 - 2018 were included. Parents of patients <18 years and patients ≥18 years at least one year after cardiac arrest completed a telephone interview...
March 16, 2023: Resuscitation
Matthias Bergmann, Thanh N Nguyen, Christine C Segal, Bertrand L Jaber
Minimal change disease (MCD) is a well-known cause of fulminant acute nephrotic syndrome (NS) and has been associated with thrombotic complications. We report the case of a 51-year-old woman with previously biopsy-proven MCD in remission who presented with headache and encephalopathy shortly after a relapse of the NS and was diagnosed with cerebral venous thrombosis (CVT) complicated by intracranial hemorrhage and midline shift. One month prior, she had been initiated on an oral contraceptive agent during remission of the NS...
March 16, 2023: American Journal of the Medical Sciences
Nuno A S Oliveira, Brígida R Pinho, Jorge M A Oliveira
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that leads to progressive disability and motor impairment. Existing therapies provide modest improvements in patient survival, raising a need for new treatments for ALS. Zebrafish is a promising model animal for translational and fundamental research in ALS - it is an experimentally tractable vertebrate, with high homology to humans and an ample experimental toolbox. These advantages allow high-throughput study of behavioral and pathophysiological phenotypes...
March 16, 2023: Neuroscience and Biobehavioral Reviews
Grace Pulliam, Jacob I Feldman, Tiffany G Woynaroski
Differences in sensory function have been documented for a number of neurodevelopmental conditions, including reading and language impairments. Prior studies have measured audiovisual multisensory integration (i.e., the ability to combine inputs from the auditory and visual modalities) in these populations. The present study sought to systematically review and quantitatively synthesize the extant literature on audiovisual multisensory integration in individuals with reading and language impairments. A comprehensive search strategy yielded 56 reports, of which 38 were used to extract 109 group difference and 68 correlational effect sizes...
March 16, 2023: Neuroscience and Biobehavioral Reviews
Lucas Trigo, Elisenda Eixarch, Fernanda Faig-Leite, Marta Gomez Chiari, Monica Rebollo, Mariana Dalaqua, Eduard Gratacos, Denise Lapa
BACKGROUND: Open spina bifida (OSB) is associated with Central Nervous System anomalies, as abnormal Corpus callosum (CC) and heterotopias. However, the impact of prenatal surgery over these structures remains unclear. OBJECTIVES: To describe longitudinal changes of Central Nervous System anomalies before and after prenatal OSB repair, and to evaluate their relationship with postnatal neurological outcomes. STUDY DESIGN: Retrospective cohort study of fetuses with OSB who underwent Percutaneous fetoscopic repair from January 2009 to August 2020...
March 16, 2023: American journal of obstetrics & gynecology MFM
Gonçalo Boleto, Jérôme Avouac, Bertrand Godeau, Yannick Allanore
Thrombocytopenia in the context of systemic sclerosis (SSc) is rare. It should primarily raise the possibility of scleroderma renal crisis. Immune thrombocytopenia (ITP) is another cause of low platelets that is common in systemic lupus erythematosus, but tremendously rare in patients with SSc. We herein report two cases of severe ITP in patients with SSc. The first case is a 29-year old woman with very low platelet counts (2 x 109 /L) that did not increase despite receiving corticosteroids, intravenous immunoglobulins (IVig), rituximab and romiplostim...
March 16, 2023: Joint, Bone, Spine: Revue du Rhumatisme
Yuxiao Zhang, Yan Chen, Yushi Xin, Beibei Peng, Shuai Liu
Reward learning is key to survival for individuals. Attention plays an important role in the rapid recognition of reward cues and establishment of reward memories. Reward history reciprocally guides attention to reward stimuli. However, the neurological processes of the interplay between reward and attention remain largely elusive, due to the diversity of the neural substrates that participate in these two processes. In this review, we delineate the complex and differentiated locus coeruleus norepinephrine (LC-NE) system in relation to different behavioral and cognitive substrates of reward and attention...
March 16, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
Thijs W de Vos, Maud van Zagten, Masja de Haas, Dick Oepkes, Ratna N G B Tan, C Ellen van der Schoot, Sylke J Steggerda, Linda S de Vries, Enrico Lopriore, Jeanine M M van Klink
OBJECTIVE: To evaluate the neurodevelopmental outcome at school age in children newly diagnosed with fetal neonatal alloimmune thrombocytopenia (FNAIT). STUDY DESIGN: This observational cohort study included children diagnosed with FNAIT between 2002 and 2014. Children were invited for cognitive and neurological testing. Behavioral questionnaires and school performance results were obtained. A composite outcome of neurodevelopmental impairment (NDI) was used, defined and subdivided into mild-to- moderate and severe NDI...
March 16, 2023: Journal of Pediatrics
Uyen T D Bui, Amy L Milton
Reconsolidation results in the restabilisation, and thus persistence, of a memory made labile by retrieval, and interfering with this process is thought to enable modification or weakening of the original trace. As such, reconsolidation-blockade has been a focus of research aiming to target the maladaptive memories underlying mental health disorders, including post-traumatic stress disorder and drug addiction. Current first-line therapies are not effective for all patients, and a substantial proportion of those for whom therapies are effective later relapse...
March 16, 2023: Neuroscience
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