Jasmohan S Bajaj, I Jane Cox, Naga S Betrapally, Douglas M Heuman, Mitchell L Schubert, Maiyuran Ratneswaran, Phillip B Hylemon, Melanie B White, Kalyani Daita, Nicole A Noble, Masoumeh Sikaroodi, Roger Williams, Mary M E Crossey, Simon D Taylor-Robinson, Patrick M Gillevet
Proton pump inhibitors (PPI) have been associated with infectious complications in cirrhosis, but their impact on distal gut microbiota composition and function is unclear. We aimed to evaluate changes in stool microbiota composition and function in patients with cirrhosis and healthy controls after omeprazole therapy. Both 15 compensated cirrhotic patients and 15 age-matched controls underwent serum gastrin measurement, stool microbiota profiling with multitagged pyrosequencing, and urinary metabolic profiling with NMR spectroscopy to assess microbial cometabolites before/after a 14-day course of 40 mg/day omeprazole under constant diet conditions...
November 15, 2014: American Journal of Physiology. Gastrointestinal and Liver Physiology