keyword
https://read.qxmd.com/read/38535271/bone-regeneration-and-repair-materials
#1
EDITORIAL
Marcio Mateus Beloti, Adalberto Luiz Rosa
Bone tissue has a remarkable ability to regenerate following injury and trauma [...].
March 21, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534621/fabrication-and-characterization-of-quad-component-bioinspired-hydrogels-to-model-elevated-fibrin-levels-in-central-nervous-tissue-scaffolds
#2
JOURNAL ARTICLE
Ana M Diaz-Lasprilla, Meagan McKee, Andrea C Jimenez-Vergara, Swathisri Ravi, Devon Bellamy, Wendy Ortega, Cody O Crosby, Jennifer Steele, Germán Plascencia-Villa, George Perry, Dany J Munoz-Pinto
Multicomponent interpenetrating polymer network (mIPN) hydrogels are promising tissue-engineering scaffolds that could closely resemble key characteristics of native tissues. The mechanical and biochemical properties of mIPNs can be finely controlled to mimic key features of target cellular microenvironments, regulating cell-matrix interactions. In this work, we fabricated hydrogels made of collagen type I (Col I), fibrin, hyaluronic acid (HA), and poly (ethylene glycol) diacrylate (PEGDA) using a network-by-network fabrication approach...
March 17, 2024: Gels
https://read.qxmd.com/read/38523973/in-vitro-biocompatibility-assessment-of-a-novel-membrane-containing-magnesium-chitosan-carboxymethyl-cellulose-and-alginate-intended-for-bone-tissue-regeneration
#3
JOURNAL ARTICLE
Deepika Subramaniam, Saravanan Sekaran
Bone tissue engineering (BTE) is an emerging interdisciplinary field that aims to develop new strategies and materials for repairing, regenerating, or replacing damaged bone tissues. This field combines engineering, biology, and medicine principles to create functional bone tissues in the laboratory and in vivo. The main goal of BTE is to create biological substitutes that mimic the structure, function, and properties of natural bone tissue, thereby promoting the regeneration of bone defects caused by trauma, disease, or aging...
February 2024: Curēus
https://read.qxmd.com/read/38516171/a-review-on-gold-nanoparticles-as-an-innovative-therapeutic-cue-in-bone-tissue-engineering-prospects-and-future-clinical-applications
#4
JOURNAL ARTICLE
Dae Hyeok Yang, Haram Nah, Donghyun Lee, Sung Jun Min, Seulki Park, Sang-Hyun An, Jianxin Wang, Huining He, Kyu-Sun Choi, Wan-Kyu Ko, Jae Seo Lee, Il Keun Kwon, Sang Jin Lee, Dong Nyoung Heo
Bone damage is a complex orthopedic problem primarily caused by trauma, cancer, or bacterial infection of bone tissue. Clinical care management for bone damage remains a significant clinical challenge and there is a growing need for more advanced bone therapy options. Nanotechnology has been widely explored in the field of orthopedic therapy for the treatment of a severe bone disease. Among nanomaterials, gold nanoparticles (GNPs) along with other biomaterials are emerging as a new paradigm for treatment with excellent potential for bone tissue engineering and regenerative medicine applications...
June 2024: Materials today. Bio
https://read.qxmd.com/read/38513723/an-injectable-cartilage-coating-composite-with-long-term-protection-effective-lubrication-and-chondrocyte-nourishment-for-osteoarthritis-treatment
#5
JOURNAL ARTICLE
Hongfu Cao, Siyan Deng, Xi Chen, Xiaolin Cui, Tun Yuan, Jie Liang, Xingdong Zhang, Yujiang Fan, Qiguang Wang
The osteoarthritic (OA) environment within articular cartilage poses significant challenges, resulting in chondrocyte dysfunction and cartilage matrix degradation. While intra-articular injections of anti-inflammatory drugs, biomaterials, or bioactive agents have demonstrated some effectiveness, they primarily provide temporary relief from OA pain without arresting OA progression. This study presents an injectable cartilage-coating composite, comprising hyaluronic acid and decellularized cartilage matrix integrated with specific linker polymers...
March 19, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38495742/implants-coating-strategies-for-antibacterial-treatment-in-fracture-and-defect-models-a-systematic-review-of-animal-studies
#6
REVIEW
Baoqi Li, Pascal Thebault, Béatrice Labat, Guy Ladam, Volker Alt, Markus Rupp, Christoph Brochausen, Jonathan Jantsch, Margaret Ip, Ning Zhang, Wing-Hoi Cheung, Shui Yee Sharon Leung, Ronald Man Yeung Wong
OBJECTIVE: Fracture-related infection (FRI) remains a major concern in orthopaedic trauma. Functionalizing implants with antibacterial coatings are a promising strategy in mitigating FRI. Numerous implant coatings have been reported but the preventive and therapeutic effects vary. This systematic review aimed to provide a comprehensive overview of current implant coating strategies to prevent and treat FRI in animal fracture and bone defect models. METHODS: A literature search was performed in three databases: PubMed, Web of Science and Embase, with predetermined keywords and criteria up to 28 February 2023...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38488327/a-nontoxic-strontium-nanoparticle-that-holds-the-potential-to-act-upon-osteocompetent-cells-an-in-vitro-and-in-vivo-characterization
#7
JOURNAL ARTICLE
Larwsk Hayann, Vitor Freire da Rocha, Marina Ferreira Cândido, Raphael Martini Vicente, Luiz H S Andrilli, Sandra Y Fukada, María Sol Brassesco, Pietro Ciancaglini, Edgard Eduard Engel, Ana Paula Ramos
Estrogen deficiency, long-term immobilization, and/or aging are commonly related to bone mass loss, thus increasing the risk of fractures. One option for bone replacement in injuries caused by either traumas or pathologies is the use of orthopedic cement based on polymethylmethacrylate (PMMA). Nevertheless, its reduced bioactivity may induce long-term detachment from the host tissue, resulting in the failure of the implant. In view of this problem, we developed an alternative PMMA-based porous cement (pPMMA) that favors cell invasion and improves osteointegration with better biocompatibility...
March 15, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38460171/harnessing-mechanical-stress-with-viscoelastic-biomaterials-for-periodontal-ligament-regeneration
#8
JOURNAL ARTICLE
Jiu-Jiu Zhang, Xuan Li, Yi Tian, Jie-Kang Zou, Dian Gan, Dao-Kun Deng, Chen Jiao, Yuan Yin, Bei-Min Tian, Rui-Xin Wu, Fa-Ming Chen, Xiao-Tao He
The viscoelasticity of mechanically sensitive tissues such as periodontal ligaments (PDLs) is key in maintaining mechanical homeostasis. Unfortunately, PDLs easily lose viscoelasticity (e.g., stress relaxation) during periodontitis or dental trauma, which disrupt cell-extracellular matrix (ECM) interactions and accelerates tissue damage. Here, Pluronic F127 diacrylate (F127DA) hydrogels with PDL-matched stress relaxation rates and high elastic moduli are developed. The hydrogel viscoelasticity is modulated without chemical cross-linking by controlling precursor concentrations...
March 9, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38457904/in-vitro-development-and-optimization-of-cell-laden-injectable-bioprinted-gelatin-methacryloyl-gelma-microgels-mineralized-on-the-nanoscale
#9
JOURNAL ARTICLE
Mauricio Gonçalves da Costa Sousa, Gabriela de Souza Balbinot, Ramesh Subbiah, Rahul Madathiparambil Visalakshan, Anthony Tahayeri, Maria Elisa Lima Verde, Avathamsa Athirasala, Genevieve Romanowicz, Robert E Guldberg, Luiz E Bertassoni
Bone defects may occur in different sizes and shapes due to trauma, infections, and cancer resection. Autografts are still considered the primary treatment choice for bone regeneration. However, they are hard to source and often create donor-site morbidity. Injectable microgels have attracted much attention in tissue engineering and regenerative medicine due to their ability to replace inert implants with a minimally invasive delivery. Here, we developed novel cell-laden bioprinted gelatin methacrylate (GelMA) injectable microgels, with controllable shapes and sizes that can be controllably mineralized on the nanoscale, while stimulating the response of cells embedded within the matrix...
March 2, 2024: Biomater Adv
https://read.qxmd.com/read/38431865/kaolin-loaded-gelatin-sponges-for-rapid-and-effective-hemostasis-and-accelerated-wound-healing
#10
JOURNAL ARTICLE
Jing Zhou, Ming Li, Jing Chang, Bo Chen, Tianbing Wang, Wei Guo, Yanhua Wang
Severe trauma with massive active blood loss, including liver and spleen rupture, arterial bleeding and pelvic fracture, will lead disability, malformation and even death. Therefore, it is very important to develop new, fast and efficient hemostatic materials. In this study, a novel Gelatin/Kaolin (GE/KA) composite sponge was developed. Meanwhile, to further investigate the effect of kaolin content on sponge properties, we prepared four types of sponges: GE/5% KA, GE/10% KA, GE/15% KA and GE/20% KA. The results of coagulation test in vitro showed that compared to the other groups, there were more activated adhered platelets and red blood cells on the surface of GE/15% KA...
March 3, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38405945/a-biodegradable-microgrooved-and-tissue-mechanocompatible-citrate-based-scaffold-improves-bladder-tissue-regeneration
#11
Madeleine Goedegebuure, Matthew Bury, Xinlong Wang, Pasquale San Felice, Federico Cammarata, Larry Wang, Tiffany Sharma, Nachiket Rajinikanth, Vikram Karra, Vidhika Siddha, Arun Sharma, Guillermo Ameer
Chronic bladder dysfunction due to bladder disease or trauma is detrimental to affected patients as it can lead to increased risk of upper urinary tract dysfunction. Current treatment options include surgical intervention that enlarge the bladder with autologous bowel tissue to alleviate pressure on the upper urinary tract. This highly invasive procedure, termed bladder augmentation enterocystoplasty (BAE), significantly increases risk of patient morbidity and mortality due to the incompatibility between the bowel and bladder tissue...
February 18, 2024: bioRxiv
https://read.qxmd.com/read/38401185/characterization-of-degradation-kinetics-of-additively-manufactured-plga-under-variable-mechanical-loading-paradigms
#12
JOURNAL ARTICLE
Anna N Smith, Joseph B Ulsh, Richa Gupta, My My Tang, Ana P Peredo, Tim D Teinturier, Rob L Mauck, Sarah Gullbrand, Michael W Hast
Controlled degradation of biodegradable poly-lactic-co-glycolic acid (PLGA) trauma implants may increase interfragmentary loading which is known to accelerate fracture healing. Additive manufacturing allows us to tune the mechanical properties of PLGA scaffolds; however, little is known about this novel approach. The purpose of this study was to use in vitro and in vivo models to determine the degradative kinetics of additively manufactured test coupons fabricated with PLGA. We hypothesized that 1) increases in infill density would lead to improved initial mechanical properties, and 2) loss of mechanical properties would be constant as a function of time, regardless of implant design...
February 18, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38369464/biomaterial-based-mechanical-regulation-facilitates-scarless-wound-healing-with-functional-skin-appendage-regeneration
#13
REVIEW
Ying-Ying Li, Shuai-Fei Ji, Xiao-Bing Fu, Yu-Feng Jiang, Xiao-Yan Sun
Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration, promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic transitions. The field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical properties...
February 18, 2024: Military Medical Research
https://read.qxmd.com/read/38364815/3d-bioprinted-xanthan-hydrogels-with-dual-antioxidant-and-chondrogenic-functions-for-post-traumatic-cartilage-regeneration
#14
JOURNAL ARTICLE
Yuting Chen, Yiguan Le, Junxu Yang, Yifeng Yang, Xianjing Feng, Jihong Cai, Yifeng Shang, Sigit Sugiarto, Qingjun Wei, Dan Kai, Li Zheng, Jinmin Zhao
Intra-articular trauma typically initiates the overgeneration of reactive oxidative species (ROS), leading to post-traumatic osteoarthritis and cartilage degeneration. Xanthan gum (XG), a branched polysaccharide, has shown its potential in many biomedical fields, but some of its inherent properties, including undesirable viscosity and poor mechanical stability, limit its application in 3D printed scaffolds for cartilage regeneration. In this project, we developed 3D bioprinted XG hydrogels by modifying XG with methacrylic (MA) groups for post-traumatic cartilage therapy...
February 16, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38353052/film-forming-polymer-solutions-containing-cholesterol-myristate-and-berberine-mediate-pressure-ulcer-repair-via-the-wnt-%C3%AE-catenin-pathway
#15
JOURNAL ARTICLE
Yu Li, Haiting Huang, Cuijin Gu, Wenyi Huang, Xianxian Chen, Xiaoting Lu, Aijia You, Sen Ye, Jun Zhong, Yao Zhao, Yu Yan, Chun Li
Pressure ulcer (PU) is a worldwide problem that is difficult to address because of the related inflammatory response, local hypoxia, and repeated ischaemia/reperfusion, causing great suffering and financial burden to patients. Traditional Chinese medicine turtle plate powder can treat skin trauma, but its composition is complex and inconvenient to use. Here, we combined cholesterol myristate (S8) with berberine (BBR), with anti-inflammatory and antibacterial effects, as a drug and used hydroxypropyl methylcellulose and polyvinylpyrrolidone K30 as carriers to construct a novel film-forming polymeric solution (S8 + BBR FFPS), comprehensively study its reparative effect on PU and explore the potential mechanism in rat PU models...
February 14, 2024: Wound Repair and Regeneration
https://read.qxmd.com/read/38331133/minimally-invasive-delivery-of-human-umbilical-cord-derived-mesenchymal-stem-cells-by-an-injectable-hydrogel-via-diels-alder-click-reaction-for-the-treatment-of-intrauterine-adhesions
#16
JOURNAL ARTICLE
Sentao Hu, Yangyang Dai, Liaobing Xin, Xiaowen Zheng, Zi Ye, Songying Zhang, Lie Ma
Intrauterine adhesions (IUA) are the most common cause of uterine infertility, and conventional treatments have not consistently achieved satisfactory pregnancy rates. Stem cell therapy shows promising potential for the clinical treatment of IUA. Although various advanced biomaterials have been designed for delivering stem cells to the uterine cavity, there remain significant challenges, particularly in devising therapeutic strategies for clinical application that minimize surgical incisions and conform to the intricate structure of uterine cavity...
February 6, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38329892/granular-hydrogels-improve-myogenic-invasion-and-repair-after-volumetric-muscle-loss
#17
JOURNAL ARTICLE
Gabrielle I Tanner, Leia Schiltz, Niharika Narra, Marxa L Figueiredo, Taimoor H Qazi
Skeletal muscle injuries including volumetric muscle loss (VML) lead to excessive tissue scarring and permanent functional disability. Despite high prevalence, there is currently no effective treatment for VML. Bioengineering interventions such as biomaterials that fill the VML defect to support cell and tissue growth are a promising therapeutic strategy. However, traditional biomaterials developed for this purpose lack the pore features needed to support cell infiltration. The present study investigates for the first time, the impact of granular hydrogels on muscle repair - hypothesizing that their flowability will permit conformable filling of the defect site and their inherent porosity will support the invasion of native myogenic cells, leading to effective muscle repair...
February 8, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38327823/bio-integrated-scaffold-facilitates-large-bone-regeneration-dominated-by-endochondral-ossification
#18
JOURNAL ARTICLE
Lili Sun, Haoyi Niu, Yuqiong Wu, Shiyan Dong, Xuefeng Li, Betty Y S Kim, Changsheng Liu, Yifan Ma, Wen Jiang, Yuan Yuan
Repair of large bone defects caused by severe trauma, non-union fractures, or tumor resection remains challenging because of limited regenerative ability. Typically, these defects heal through mixed routines, including intramembranous ossification (IMO) and endochondral ossification (ECO), with ECO considered more efficient. Current strategies to promote large bone healing via ECO are unstable and require high-dose growth factors or complex cell therapy that cause side effects and raise expense while providing only limited benefit...
May 2024: Bioactive Materials
https://read.qxmd.com/read/38288569/tailoring-biomaterials-ameliorate-inflammatory-bone-loss
#19
REVIEW
Shi Cheng, Kong-Huai Wang, Lu Zhou, Zhi-Jun Sun, Lu Zhang
Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease and celiac disease, disrupt the delicate balance between bone resorption and formation, leading to inflammatory bone loss. Conventional approaches to tackle this issue encompass pharmaceutical interventions and surgical procedures. Nevertheless, pharmaceutical interventions exhibit limited efficacy, while surgical treatments impose trauma and significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, and demonstrate exceptional reactivity...
January 30, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38281701/reconstruction-of-the-orbitozygomatic-framework-state-of-the-art-and-perspectives
#20
JOURNAL ARTICLE
Ségolène Reiss, Dimitri Kulker, Boris Laure, Arnaud Paré
The reconstruction of the whole orbitozygomatic framework (OZF) is complex and can be encountered in cases of congenital midface deformity, after tumor ablative surgery and in severe facial trauma. Nowadays, surgeon has a wide range of available techniques that have continually grown over the past years, optimizing the surgical management and the aesthetical outcomes. Among them, the autologous bone graft (ABG) remains one of the most suitable options : ABG is easy to harvest and has optimal biological properties for bone healing...
January 26, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
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