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https://read.qxmd.com/read/30724174/advancements-in-maxillofacial-trauma-a-historical-perspective
#1
REVIEW
Patrick J Louis, Anthony B Morlandt
For the 75th anniversary of the Journal of Oral and Maxillofacial Surgery, the authors were asked to review the past and examine advancements in the management of facial trauma. Several important advances in the management of maxillofacial trauma have resulted in improved outcomes. These include the development of high-resolution computed tomography, improved classification schemes, rigid fixation techniques, improved biomaterials, soft tissue resuspension, and primary bone grafting. Further advances in outcomes have occurred with the use of microsurgical techniques, free tissue transfer techniques, virtual surgical planning, endoscopic techniques, and surgical navigation...
November 2018: Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/30691075/particulated-extracted-human-teeth-characterization-by-sem%C3%A2-edx-evaluation-as-a-biomaterial-for-socket-preservation-an-in-vitro-study
#2
José Luis Calvo-Guirado, Alvaro Ballester-Montilla, Piedad N De Aza, Manuel Fernández-Domínguez, Sergio Alexandre Gehrke, Pilar Cegarra-Del Pino, Lanka Mahesh, André Antonio Pelegrine, Juan Manuel Aragoneses, José Maté-Sánchez de Val
The aim of the study was to evaluate the chemical composition of crushed, extracted human teeth and the quantity of biomaterial that can be obtained from this process. A total of 100 human teeth, extracted due to trauma, decay, or periodontal disease, were analyzed. After extraction, all the teeth were classified, measured, and weighed on a microscale. The human teeth were crushed immediately using the Smart Dentin Grinder machine (KometaBio Inc., Cresskill, NJ, USA), a device specially designed for this procedure...
January 25, 2019: Materials
https://read.qxmd.com/read/30685477/decorin-supplemented-collagen-hydrogels-for-the-co-delivery-of-bone-morphogenetic-protein-2-and-microvascular-fragments-to-a-composite-bone-muscle-injury-model-with-impaired-vascularization
#3
Marissa A Ruehle, Mon-Tzu Alice Li, Albert Cheng, Laxminarayanan Krishnan, Nick J Willett, Robert E Guldberg
Traumatic musculoskeletal injuries that result in bone defects or fractures often affect both bone and the surrounding soft tissue. Clinically, these types of multi-tissue injuries have increased rates of complications and long-term disability. Vascular integrity is a key clinical indicator of injury severity, and revascularization of the injury site is a critical early step of the bone healing process. Our lab has previously established a pre-clinical model of composite bone-muscle injury that exhibits impaired bone healing; however, the vascularization response in this model had not yet been investigated...
January 25, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30678893/a-review-of-emerging-bone-tissue-engineering-via-peg-conjugated-biodegradable-amphiphilic-copolymers
#4
REVIEW
Jiang-Ze Wang, Ming-Liang You, Zhen-Qi Ding, Wen-Bin Ye
Defects in bones can be caused by a plethora of reasons, such as trauma or illness, and in many cases, it poses challenges to the current treatment approaches for bone repair. With increasing demand of bone bioengineering in tissue transplant, there is a need to source for sustainable solutions to induce bone regeneration. Polymeric biomaterials have been identified as a promising approach due to its excellent biocompatibility and controllable biodegradability. Specifically, poly(ethylene glycol) (PEG) is one of the most commonly investigated polymer for use in bio-related application due to its bioinertness and versatility...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30667561/recommendations-for-design-and-conduct-of-preclinical-in-vivo-studies-of-orthopedic-device-related-infection
#5
REVIEW
Moriarty T Fintan, Harris G Llinos, Mooney A Robert, Wenke C Joseph, Riool Martijn, Zaat Aj Sebastian, Moter Annette, Schaer P Thomas, Khanna Nina, Kuehl Richard, Alt Volker, Montali Andrea, Liu Jianfeng, Zeiter Stephan, Busscher HenkJ, Grainger W David, Richards R Geoff
Orthopedic device-related infection (ODRI), including both fracture-related infection (FRI) and periprosthetic joint infection (PJI), remain amongst the most challenging complications in orthopedic and musculoskeletal trauma surgery. ODRI has been convincingly shown to delay healing, worsen functional outcome and incur significant socio-economic costs. To address this clinical problem, ever more sophisticated technologies targeting the prevention and/or treatment of ODRI are being developed and tested in vitro and in vivo...
January 22, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30654212/implantable-antimicrobial-biomaterials-for-local-drug-delivery-in-bone-infection-models
#6
Jeremy D Caplin, Andrés J García
Increased use of implantable biomedical devices demonstrates their potential in treating a wide variety of ailments and disorders in bone trauma and orthopaedic, reconstructive, and craniofacial applications. However, the number of cases involving implant failure or malfunction due to bacterial infection have also increased in recent years. Implanted devices can facilitate the growth of bacteria as these micro-organisms have the potential to adhere to the implant and grow and develop to form biofilms. In an effort to better understand and mitigate these occurrences, biomaterials containing antimicrobial agents that can be released or presented within the local microenvironment have become an important area of research...
January 14, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30652939/histopathological-evaluation-of-orthopedic-medical-devices-the-state-of-the-art-in-animal-models-imaging-and-histomorphometry-techniques
#7
Nicolette Jackson, Michel Assad, Derick Vollmer, James Stanley, Madeleine Chagnon
Orthopedic medical devices are continuously evolving for the latest clinical indications in craniomaxillofacial, spine, trauma, joint arthroplasty, sports medicine, and soft tissue regeneration fields, with a variety of materials from new metallic alloys and ceramics to composite polymers, bioresorbables, or surface-treated implants. There is great need for qualified medical device pathologists to evaluate these next generation biomaterials, with improved biocompatibility and bioactivity for orthopedic applications, and a broad range of knowledge is required to stay abreast of this ever-changing field...
January 17, 2019: Toxicologic Pathology
https://read.qxmd.com/read/30642917/thromboinflammation-challenges-of-therapeutically-targeting-coagulation-and-other-host-defence-mechanisms
#8
Shaun P Jackson, Roxane Darbousset, Simone M Schoenwaelder
Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a broad range of human disorders. It is well recognized clinically in the context of superficial thrombophlebitis (thrombosis and inflammation of superficial veins), however it is more dangerous when it develops in the microvasculature of injured tissues and organs. Microvascular thrombosis with associated inflammation is well recognized in the context of sepsis and ischemia-reperfusion injury, however it also occurs in organ transplant rejection, major trauma, severe burns, the antiphospholipid syndrome, preeclampsia, sickle cell disease and biomaterial-induced thromboinflammation...
January 14, 2019: Blood
https://read.qxmd.com/read/30604468/biomaterial-and-stem-cell-based-strategies-for-skeletal-muscle-regeneration
#9
REVIEW
Andrew Dunn, Muhamed Talovic, Krishna Patel, Anjali Patel, Madison Marcinczyk, Koyal Garg
Adult skeletal muscle can regenerate effectively after mild physical or chemical insult. Muscle trauma or disease can overwhelm this innate capacity for regeneration and result in heightened inflammation and fibrotic tissue deposition resulting in loss of structure and function. Recent studies have focused on biomaterial and stem cell-based therapies to promote skeletal muscle regeneration following injury and disease. Many stem cell populations besides satellite cells are implicated in muscle regeneration...
January 3, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30496865/the-chondrocyte-cell-proliferation-of-a-chitosan-silk-fibroin-egg-shell-membrane-hydrogels
#10
Terin Adali, Rasime Kalkan, Leila Karimizarandi
Articular cartilage is a poorly cellularized, non-vascularized connective tissue that undergoes alterations due to trauma and osteoarthritis. Tissue engineering strategies involving the combination of cells, biomaterials and bioactive agents have been of interest notably for the repair of damaged articular cartilage. The aim of this study was to design Chitosan/Silk Fibroin/Egg Shell Membrane (CHI/SF/ESM) hydrogels and analyse the cell proliferation activity of human chondrocyte cells. The FTIR spectrophotometer, XRD analysis, ICP-MS, SEM analysis, swelling kinetics and biodegradation tests with protease enzyme, and antibacterial activity test with Escherichia coli, Candida albicans have been used for characterization of hydrogels...
November 26, 2018: International Journal of Biological Macromolecules
https://read.qxmd.com/read/30488014/chondrogenic-differentiation-of-adipose-derived-mesenchymal-stem-cells-induced-by-l-ascorbic-acid-and-platelet-rich-plasma-on-silk-fibroin-scaffold
#11
Anggraini Barlian, Hermawan Judawisastra, Nayla M Alfarafisa, Untung A Wibowo, Imam Rosadi
Articular cartilage is an avascular tissue with limited regenerative property. Therefore, a defect or trauma in articular cartilage due to disease or accident can lead to progressive tissue deterioration. Cartilage tissue engineering, by replacing defective cartilage tissue, is a method for repairing such a problem. In this research, three main aspects-cell, biomaterial scaffold, and bioactive factors-that support tissue engineering study were optimized. Adipose-derived mesenchymal stem cells (ADSC) that become cartilage were grown in an optimized growth medium supplemented with either platelet rich plasma (PRP) or L-ascorbic acid (LAA)...
2018: PeerJ
https://read.qxmd.com/read/30481915/-national-experts-consensus-on-clinical-application-of-collagen-based-wound-biomaterials-2018-version
#12
Guozhong Lyu
Collagen, as the main structural protein in human body, plays an important role in the wound healing process. Due to their inherent hemostatic characteristics, good biocompatibility, low immunogenicity, as well as controllable biodegradability, collagen-based materials have attracted much attention. In this article, we mainly introduce the characteristics of collagen-based wound biomaterials and the application mechanism as scaffold and wound dressing. And the standard and unified experts' consensus formed on the clinical indications, recommended applications, contraindications, and matters needing attention...
November 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/30471041/bioartificial-esophagus-where-are-we-now
#13
Eun-Jae Chung
The current treatments for esophageal diseases, such as carcinomas, trauma or congenital malformations, require surgical intervention and esophageal reconstruction using redundant parts of the gastrointestinal tract. However, the use of gastrointestinal segments can cause various surgical morbidities and mortality because additional abdominal surgery may be required at the expense of other anatomic structures. Therefore, tissue engineering using various biomaterial or cell sources has emerged as an alternative strategy of biomimicking the native esophageal tissue that could be implanted as an artificial graft...
2018: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30443837/characterization-and-cytotoxicity-evaluation-of-a-marine-sponge-biosilica
#14
P R Gabbai-Armelin, H W Kido, M A Cruz, J P S Prado, I R Avanzi, M R Custódio, A C M Renno, R N Granito
Bone fractures characterize an important event in the medical healthcare, being related to traumas, aging, and diseases. In critical conditions, such as extensive bone loss and osteoporosis, the tissue restoration may be compromised and culminate in a non-union consolidation. In this context, the osteogenic properties of biomaterials with a natural origin have gained prominence. Particularly, marine sponges are promising organisms that can be exploited as biomaterials for bone grafts. Thus, the objectives of this study were to study the physicochemical and morphological properties of biosilica (BS) from sponges by using scanning electron microscopy, Fourier-transform infrared, X-ray diffraction (SEM, FTIR and XRD respectively), mineralization, and pH...
November 16, 2018: Marine Biotechnology
https://read.qxmd.com/read/30440145/-national-experts-consensus-on-clinical-application-of-collagen-based-wound-biomaterials-2018-version
#15
G Z Lyu
Collagen, as the main structural protein in human body, plays an important role in the wound healing process. Due to their inherent hemostatic characteristics, good biocompatibility, low immunogenicity, as well as controllable biodegradability, collagen-based materials have attracted much attention. In this article, we mainly introduce the characteristics of collagen-based wound biomaterials and the application mechanism as scaffold and wound dressing. And the standard and unified experts' consensus formed on the clinical indications, recommended applications, contraindications, and matters needing attention...
November 9, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/30367099/acceleration-induced-pressure-gradients-and-cavitation-in-soft-biomaterials
#16
Wonmo Kang, Marc Raphael
The transient, dynamic response of soft materials to mechanical impact has become increasingly relevant due to the emergence of numerous biomedical applications, e.g., accurate assessment of blunt injuries to the human body. Despite these important implications, acceleration-induced pressure gradients in soft materials during impact and the corresponding material response, from small deformations to sudden bubble bursts, are not fully understood. Both through experiments and theoretical analyses, we empirically show, using collagen and agarose model systems, that the local pressure in a soft sample is proportional to the square of the sample depth in the impact direction...
October 26, 2018: Scientific Reports
https://read.qxmd.com/read/30357684/modulation-of-the-osteoimmune-environment-in-the-development-of-biomaterials-for-osteogenesis
#17
Fei Wei, Yin Xiao
In spite of inherent regenerative ability of bone, large amounts of fracture patients still display delayed or compromised bone healing due to patients' age status, trauma severity or the developmental anomalies or infections, which requires therapeutic intervention. Bone regeneration involves different cells (immune cells, progenitors and mesenchymal stem cells, etc) and subsequent signaling molecules (chemokines, cytokines and growth factors, etc). The quantity and quality of immune cells influx into the site of injury and the subsequent cytokine production form a unique osteoimmune environment...
2018: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30357620/graphene-based-nanocomposites-as-promising-options-for-hard-tissue-regeneration
#18
Yong Cheol Shin, Su-Jin Song, Seung Jo Jeong, Bongju Kim, Il Keun Kwon, Suck Won Hong, Jin-Woo Oh, Dong-Wook Han
Tissues are often damaged by physical trauma, infection or tumors. A slight injury heals naturally through the normal healing process, while severe injury causes serious health implications. Therefore, many efforts have been devoted to treat and repair various tissue defects. Recently, tissue engineering approaches have attracted a rapidly growing interest in biomedical fields to promote and enhance healing and regeneration of large-scale tissue defects. On the other hand, with the recent advances in nanoscience and nanotechnology, various nanomaterials have been suggested as novel biomaterials...
2018: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30348489/intraosseous-metal-implants-in-orthopedics-a-review
#19
REVIEW
L Rony, R Lancigu, L Hubert
Metal implants are biomaterials widely used in orthopedics. They are both used in osteosynthesis and arthroplasty. Their mechanical properties, biocompatibility and resistance to corrosion make them a widely used option in orthopedics. Alloys are the most commonly used metals in orthopedics. As far as physical traumas are concerned, implants such as screws, plates and/or nails are used for osteosynthesis as they ensure the stability of the fractured area and contribute to bone healing. Prostheses are used in arthroplasty to restore joint function for as long as possible...
December 2018: Morphologie: Bulletin de L'Association des Anatomistes
https://read.qxmd.com/read/30333796/preferential-colonization-of-osteoblasts-over-co-cultured-bacteria-on-a-bifunctional-biomaterial-surface
#20
Linyang Chu, Ying Yang, Shengbing Yang, Qiming Fan, Zhifeng Yu, Xi-Le Hu, Tony D James, Xiao-Peng He, Tingting Tang
Implant-related infection is a devastating complication in clinical trauma and orthopedics. The aim of this study is to use a bifunctional biomaterial surface in order to investigate the competitive colonization between osteoblasts and bacteria, which is the cause of implant-related infection. A bone-engineering material capable of simultaneously facilitating osteoblast adhesion and inhibiting the growth of Staphylococcus aureus ( S. aureus ) was prepared. Then, three different co-cultured systems were developed in order to investigate the competitive colonization between the two cohorts on the surface...
2018: Frontiers in Microbiology
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