Yu Li, Haiting Huang, Cuijin Gu, Wenyi Huang, Xianxian Chen, Xiaoting Lu, Aijia You, Sen Ye, Jun Zhong, Yao Zhao, Yu Yan, Chun Li
Pressure ulcer (PU) is a worldwide problem that is difficult to address because of the related inflammatory response, local hypoxia, and repeated ischaemia/reperfusion, causing great suffering and financial burden to patients. Traditional Chinese medicine turtle plate powder can treat skin trauma, but its composition is complex and inconvenient to use. Here, we combined cholesterol myristate (S8) with berberine (BBR), with anti-inflammatory and antibacterial effects, as a drug and used hydroxypropyl methylcellulose and polyvinylpyrrolidone K30 as carriers to construct a novel film-forming polymeric solution (S8 + BBR FFPS), comprehensively study its reparative effect on PU and explore the potential mechanism in rat PU models...
February 14, 2024: Wound Repair and Regeneration