Ekta Pardhi, Ravindra Vasave, Vaibhavi Srivastava, Rati Yadav, Neelesh Kumar Mehra
The pharmaceutical industry is grappling with a pressing crisis in drug development, characterized by soaring R&D costs, setbacks in blockbuster drug development due to poor aqueous solubility, and patent-related limitations on new approved molecules. To combat these challenges, diverse strategies have emerged to enhance the solubility and dissolution rates of BCS II and IV drug molecules. Enter drug nanocrystals, a revolutionary nanotechnology-driven, carrier-free colloidal drug delivery system. This review provides a comprehensive insight into nanocrystal strategies, stabilizer selection criteria, preparation methods, advanced characterization techniques, the evolving nanocrystal technology landscape, current market options, and exciting clinical prospects reshaping the future of pharmaceuticals...
February 8, 2024: Drug Discovery Today