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REVIEW
Shuangshuang Wang, Siwang Hu, Yuping Pan
Vascular calcification is a common accompanying pathological change in many chronic diseases, which is caused by calcium deposition in the blood vessel wall and leads to abnormal blood vessel function. With the progress of medical technology, the diagnosis rate of vascular calcification has explosively increased. However, due to its mechanism's complexity, no effective drug can relieve or even reverse vascular calcification. Irisin is a myogenic cytokine regulating adipose tissue browning, energy metabolism, glucose metabolism, and other physiological processes...
2024: Frontiers in Endocrinology
#22
JOURNAL ARTICLE
Qi Sun, Fang Liu, Jiakang Fang, Qiangqiang Lian, Yunpeng Hu, Xinyu Nan, Fa-Ming Tian, Guochuan Zhang, Dianwen Qi, Liu Zhang, Jingwen Zhang, Yang Luo, Zuzhuo Zhang, Zhuang Zhou
OBJECTIVES: Adjacent segment disc degeneration (ASDD) is one of the long-term sequelae of spinal fusion, which is more susceptible with osteoporosis. As an anti-osteoporosis drug, strontium ranelate (SR) has been reported to not only regulate bone metabolism but also cartilage matrix formation. However, it is not yet clear whether SR has a reversal or delaying effect on fusion-induced ASDD in a model of osteoporosis. MATERIALS AND METHODS: Fifth three-month-old female Sprague-Dawley rats that underwent L4-L5 posterolateral lumbar fusion (PLF) with spinous-process wire fixation 4 weeks after bilateral ovariectomy (OVX) surgery...
March 2024: Bone Reports
#23
JOURNAL ARTICLE
Justin C Weissberg, Kshitij A Desai, Michael C Stoner
OBJECTIVES: Transcarotid artery revascularization (TCAR), using interoperative flow reversal is a unique, hybrid operation utilized in treating critical carotid artery stenosis. Over the past decade, TCAR has been increasingly used to treat asymptomatic carotid artery disease and has a similar risk profile to traditional carotid endarterectomy (CEA). Postoperative length of stay (LOS) has a significant impact on cost-effectiveness as well as quality outcomes in this expanded setting. The objective of this study is to develop a multivariate regression model to identify key preoperative variables and their impact factor on LOS after TCAR for asymptomatic carotid artery stenosis...
February 21, 2024: Annals of Vascular Surgery
#24
JOURNAL ARTICLE
Weicheng Lu, Jianfei Yan, Chenyu Wang, Wenpin Qin, Xiaoxiao Han, Zixuan Qin, Yu Wei, Haoqing Xu, Jialu Gao, Changhe Gao, Tao Ye, Franklin R Tay, Lina Niu, Kai Jiao
Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary injury. Inflammasome-related proteins encapsulated in brain-derived extracellular vesicles can cross the blood‒brain barrier to reach distal tissues. These proteins initiate inflammatory dysfunction, such as neurogenic heterotopic ossification. This recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention strategies...
February 22, 2024: Bone Research
#25
JOURNAL ARTICLE
Marianna Ranieri, Ines Angelini, Mariagrazia D'Agostino, Annarita Di Mise, Mariangela Centrone, Maria Venneri, Angela Ferrulli, Maria Mastrodonato, Grazia Tamma, Itsuro Endo, Seiji Fukumoto, Toshio Matsumoto, Giovanna Valenti
High concentrations of urinary calcium counteract vasopressin action via the activation of the Calcium-Sensing Receptor (CaSR) expressed in the luminal membrane of the collecting duct cells, which impairs the trafficking of aquaporin-2 (AQP2). In line with these findings, we provide evidence that, with respect to wild-type mice, CaSR knock-in (KI) mice mimicking autosomal dominant hypocalcaemia, display a significant decrease in the total content of AQP2 associated with significantly higher levels of AQP2 phosphorylation at Ser261, a phosphorylation site involved in AQP2 degradation...
February 17, 2024: Journal of Physiology
#26
JOURNAL ARTICLE
Y K Shi, K H Yuan, Z M Fu, R R Hu, H Wang
The previous observational studies could not overcome the effects of confounding variables and reverse causality. We aimed to determine whether there is a causal relationship between systemic lupus erythematosus and osteoporosis in East Asian and European populations, respectively, by two-sample Mendelian Randomization analysis. We obtained and downloaded data from publicly available genome-wide association study databases and analyses for East Asian and European populations, including systemic lupus erythematosus (SLE), osteoporosis (OP), multisite bone mineral density (BMD), and OP with fracture...
February 14, 2024: Calcified Tissue International
#27
JOURNAL ARTICLE
Jinyi Zhou, Jinting Wu, Fangda Fu, Sai Yao, Wenbiao Zheng, Weibin Du, Huan Luo, Hongting Jin, Peijian Tong, Chengliang Wu, Hongfeng Ruan
α-Solanine has been shown to exhibit anti-inflammatory and anti-tumour properties; however, its efficacy in treating osteoarthritis (OA) remains ambiguous. The study aimed to evaluate the therapeutic effects of α-solanine on OA development in a mouse OA model. The OA mice were subjected to varying concentrations of α-solanine, and various assessments were implemented to assess OA progression. We found that α-solanine significantly reduced osteophyte formation, subchondral sclerosis and OARSI score...
February 2024: Journal of Cellular and Molecular Medicine
#28
REVIEW
Jimil Shah, Abhirup Chatterjee, Truptesh H Kothari
Chronic pancreatitis (CP) is an irreversible and progressive inflammation of the pancreas that can involve both pancreatic parenchyma and the pancreatic duct. CP results in morphological changes in the gland in the form of fibrosis and calcification along with functional impairment in the form of exocrine and endocrine insufficiency. Studies on the natural history of CP reveal the irreversibility of the condition and the resultant plethora of complications, of which pancreatic adenocarcinoma is the most dreaded one...
January 30, 2024: Diagnostics
#29
JOURNAL ARTICLE
Chien-Liang Chen, En-Shao Liou, Ming-Ting Wu
INTRODUCTION: Denosumab preceding elective surgery is an alternative option when parathyroidectomy is not immediately possible. Denosumab (an osteoprotegerin mimic) may play a role in the cardiovascular system, which is reflected in the features of epicardial adipose tissue (EAT) and coronary artery calcification (CAC). METHODS: We investigated the effects of denosumab on EAT attenuation (EATAT) and CAC in dialysis patients with secondary hyperparathyroidism (SHPT)...
February 7, 2024: Cardiorenal Medicine
#30
JOURNAL ARTICLE
Roberto Castricini, Olimpio Galasso, Michele Mercurio, Luca Dei Giudici, Alessandro Massarini, Marco De Gori, Davide Castioni, Giorgio Gasparini
BACKGROUND: The medium-term results of reverse shoulder arthroplasty (RSA) that has been performed by a single surgeon have been previously reported. The purpose of this study was to investigate the minimum 10-year clinical and radiographic outcomes of these patients. METHODS: In this prospective cohort study, 27 patients were evaluated after RSA for massive rotator cuff tear with or without eccentric osteoarthritis (OA) or concentric OA with the Constant-Murley Score (CMS), range of motion (ROM), and a radiologic assessment...
January 2024: JSES international
#31
JOURNAL ARTICLE
Paul Rothenberg, Santiago Joaquin Lopez, Dylan Thibault, Lakshmikumar Pillai, Samantha Danielle Minc
OBJECTIVE: Carotid artery stent (CAS) occlusion is a rare complication not well studied. We used a national dataset to assess real world CAS experience to determine the rate of stent occlusion. The purpose of this study was to: 1) Identify risk factors associated with CAS occlusion on long-term follow-up (LTFU) and 2) Determine the adjusted odds of death/transient ischemic attack (TIA)/stroke (CVA) in patients with occlusion. METHODS: The national VQI CAS dataset (2016-2021) comprised the sample...
January 31, 2024: Annals of Vascular Surgery
#32
JOURNAL ARTICLE
Vishal Singh Guleria, Neha Quadri, Keshava Prasad, Ranajit Das, Priyanka Upadhyai
BACKGROUND: Spondyloepimetaphyseal dysplasia with joint laxity type 3 (SEMDJL3) is a rare skeletal dysplasia associated with EXOC6B, a component of the exocyst complex, involved in vesicle tethering and exocytosis at the plasma membrane. So far, EXOC6B and the pathomechanisms underlying SEMDJL3 remain obscure. METHODS AND RESULTS: Exoc6b was detected largely at the perinuclear regions and the primary cilia base in ATDC5 prechondrocytes. Its shRNA lentiviral knockdown impeded primary ciliogenesis...
February 2, 2024: Molecular Biology Reports
#33
JOURNAL ARTICLE
Arun H S Kumar
BACKGROUND: Sortilin1 (SORT1) is a ubiquitously expressed transporter involved in sorting or clearing proteins and is pathologically linked to tissue fibrosis and calcification. Targeting SORT1 may have potential clinical efficacy in controlling or reversing cardiovascular fibrosis and/or calcification. Hence, this study assessed the protein-protein network of human SORT1 and its targetability using known nutra-/pharmaceuticals. MATERIAL AND METHODS: Network proteins of human SORT1 were identified using the String database, and the affinity of the protein-protein interaction of this network was analysed using Chimera software (Chimera-1...
January 18, 2024: Life
#34
JOURNAL ARTICLE
Jieyu He, Yanjiao Wang, Junkun Zhan, Shuang Li, Yuqing Ni, Wu Huang, Limin Long, Pan Tan, Yi Wang, Youshuo Liu
OBJECTIVE: To investigate the relationship between icariin and the osteoblastic differentiation of vascular smooth muscle cells (VSMCs) and the signal pathway involved. METHODS: We applied a universally accepted calcification model of VSMCs induced by β glycerophosphate. Then the VSMCs calcification was observed by treatment with icariin and/or inhibitors of estrogen receptors (ERs) and p38-mitogen-activated protein kinase (MAPK) signaling. RESULTS: Icariin inhibited osteoblastic differentiation and mineralization of VSMCs due to decreased ALP activity and Runx2 expression...
December 2023: Aging medicine
#35
JOURNAL ARTICLE
André Luiz Cerqueira Almeida, Marcelo Dantas Tavares de Melo, David Costa de Souza Le Bihan, Marcelo Luiz Campos Vieira, José Luiz Barros Pena, José Maria Del Castillo, Henry Abensur, Renato de Aguiar Hortegal, Maria Estefania Bosco Otto, Rafael Bonafim Piveta, Maria Rosa Dantas, Jorge Eduardo Assef, Adenalva Lima de Souza Beck, Thais Harada Campos Espirito Santo, Tonnison de Oliveira Silva, Vera Maria Cury Salemi, Camila Rocon, Márcio Silva Miguel Lima, Silvio Henrique Barberato, Ana Clara Rodrigues, Arnaldo Rabschkowisky, Daniela do Carmo Rassi Frota, Eliza de Almeida Gripp, Rodrigo Bellio de Mattos Barretto, Sandra Marques E Silva, Sanderson Antonio Cauduro, Aurélio Carvalho Pinheiro, Salustiano Pereira de Araujo, Cintia Galhardo Tressino, Carlos Eduardo Suaide Silva, Claudia Gianini Monaco, Marcelo Goulart Paiva, Cláudio Henrique Fisher, Marco Stephan Lofrano Alves, Cláudia R Pinheiro de Castro Grau, Maria Veronica Camara Dos Santos, Isabel Cristina Britto Guimarães, Samira Saady Morhy, Gabriela Nunes Leal, Andressa Mussi Soares, Cecilia Beatriz Bittencourt Viana Cruz, Fabio Villaça Guimarães Filho, Bruna Morhy Borges Leal Assunção, Rafael Modesto Fernandes, Roberto Magalhães Saraiva, Jeane Mike Tsutsui, Fábio Luis de Jesus Soares, Sandra Nívea Dos Reis Saraiva Falcão, Viviane Tiemi Hotta, Anderson da Costa Armstrong, Daniel de Andrade Hygidio, Marcelo Haertel Miglioranza, Ana Cristina Camarozano, Marly Maria Uellendahl Lopes, Rodrigo Julio Cerci, Maria Eduarda Menezes de Siqueira, Jorge Andion Torreão, Carlos Eduardo Rochitte, Alex Felix
Central Illustration : Position Statement on the Use of Myocardial Strain in Cardiology Routines by the Brazilian Society of Cardiology's Department Of Cardiovascular Imaging - 2023 Proposal for including strain in the integrated diastolic function assessment algorithm, adapted from Nagueh et al.67 Am: mitral A-wave duration; Ap: reverse pulmonary A-wave duration; DD: diastolic dysfunction; LA: left atrium; LASr: LA strain reserve; LVGLS: left ventricular global longitudinal strain; TI: tricuspid insufficiency...
December 2023: Arquivos Brasileiros de Cardiologia
#36
JOURNAL ARTICLE
Guangyu Zhou, Chen Zhang, Hui Peng, Xuesong Su, Qun Huang, Zixia Zhao, Guangyi Zhao
BACKGROUND: Medial vascular calcification is commonly identified in chronic kidney disease (CKD) patients and seriously affects the health and life quality of patients. This study aimed to investigate the effects of protein arginine methyltransferase 3 (PRMT3) on vascular calcification induced by CKD. METHODS: A mice model of CKD was established with a two-step diet containing high levels of calcium and phosphorus. Vascular smooth muscle cells (VSMCs) were subjected to β-glycerophosphate (β-GP) treatment to induce the osteogenic differentiation as an in vitro CKD model...
January 10, 2024: Molecular Medicine
#37
JOURNAL ARTICLE
Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
BACKGROUND: Glucagon-like peptide-1 receptor agonist (GLP-1RA), which is a therapeutic agent for the treatment of type 2 diabetes mellitus, has a beneficial effect on the cardiovascular system. METHODS: To examine the protective effects of GLP-1RAs on proliferation and migration of vascular smooth muscle cells (VSMCs), A-10 cells exposed to angiotensin II (Ang II) were treated with either exendin-4, liraglutide, or dulaglutide. To examine the effects of GLP-1RAs on vascular calcification, cells exposed to high concentration of inorganic phosphate (Pi) were treated with exendin-4, liraglutide, or dulaglutide...
January 3, 2024: Diabetes & Metabolism Journal
#38
JOURNAL ARTICLE
Qing-Qing Dong, Yu-Chi Tu, Pan Gao, Qian-Qian Liao, Peng Zhou, Hui Zhang, Hua-Pan Shu, Lu-Lu Sun, Li Feng, Li-Jun Yao
Rationale: Vascular calcification (VC) is a life-threatening complication in patients with chronic kidney disease (CKD) caused mainly by hyperphosphatemia. However, the regulation of VC remains unclear despite extensive research. Although serum- and glucocorticoid-induced kinase 3 (SGK3) regulate the sodium-dependent phosphate cotransporters in the intestine and kidney, its effect on VC in CKD remains unknown. Additionally, type III sodium-dependent phosphate cotransporter-1 (Pit-1) plays a significant role in VC development induced by high phosphate in vascular smooth muscle cells (VSMCs)...
2024: Theranostics
#39
JOURNAL ARTICLE
Yujing Wang, Min Xiao, Feng Cai, Yang Li, Tianli Shi, Xiaoyan Zhou, Shuhong Tian, Denggao Huang
Vascular calcification (VC) is a common complication of chronic kidney disease (CKD). VC is a gene-regulated process similar to osteogenic differentiation. There are still no convincing schemes to prevent and reduce the development of VC. It has been reported that hypoxia-inducing factor 1α (HIF-1α) and endothelin-1(ET-1) are related to VC. In this study, we found that the expression of ET-1 and HIF-1α was enhanced after VC, the interaction between HIF-1α and ET-1 was confirmed by CO-IP and luciferase experiments...
December 29, 2023: Environmental Toxicology
#40
JOURNAL ARTICLE
Joseph V Madrid, Madeline K M Vera-Colón, Nicole I Zur Nieden
Tobacco smoke contains between 7000 and 10,000 constituents, and only an evanescently low number of which have been identified, let alone been evaluated for their toxicity. Recently, the Food and Drug Administration has published a list of 93 chemical tobacco constituents that are harmful or potentially harmful to a number of cellular processes. However, their effect on developing skeletal cells is unknown. In this study, we used ToxPI, a computational tool, to prioritize constituents on this list for screening in osteogenically differentiating human embryonic stem cells and fibroblasts...
December 7, 2023: Toxics
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