Yan Wu, Jiagui Wang, Ting Pan, Jie Lei, Yuanyuan Fan, Jingfan Wang, Changlin Xu, Qinyuan Gu, Xingxing Wang, Tianhao Xiao, Qinghuai Liu, Ping Xie, Zizhong Hu
The lens is an avascular tissue, where epithelial cells (LECs) are the primary living cells. The role of LECs-derived exosomes (LEC-exos) is largely unknown. In our study, we determined the anti-angiogenic role of LEC-exos, manifested as regressed retinal neovascularization (NV) using the oxygen-induced retinopathy (OIR), and reduced choroidal NV size and pathological vascular leakage using the laser-induced choroidal neovascularization (laser-induced CNV). Furthermore, the activation and accumulation of microglia were also restricted by LEC-exos...
February 19, 2024: Experimental Eye Research