Eyra Marien, Michael Meister, Thomas Muley, Steffen Fieuws, Sergio Bordel, Rita Derua, Jeffrey Spraggins, Raf Van de Plas, Jonas Dehairs, Jens Wouters, Muralidhararao Bagadi, Hendrik Dienemann, Michael Thomas, Philipp A Schnabel, Richard M Caprioli, Etienne Waelkens, Johannes V Swinnen
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death globally. To develop better diagnostics and more effective treatments, research in the past decades has focused on identification of molecular changes in the genome, transcriptome, proteome, and more recently also the metabolome. Phospholipids, which nevertheless play a central role in cell functioning, remain poorly explored. Here, using a mass spectrometry (MS)-based phospholipidomics approach, we profiled 179 phospholipid species in malignant and matched non-malignant lung tissue of 162 NSCLC patients (73 in a discovery cohort and 89 in a validation cohort)...
October 1, 2015: International Journal of Cancer. Journal International du Cancer