Jasper Holleman, Makrina Daniilidou, Ingemar Kåreholt, Malin Aspö, Göran Hagman, Chinedu T Udeh-Momoh, Gabriela Spulber, Miia Kivipelto, Alina Solomon, Anna Matton, Shireen Sindi
BACKGROUND: Neuroinflammation is a hallmark of the Alzheimer's disease (AD) pathogenic process. Cortisol dysregulation may increase AD risk and is related to brain atrophy. This cross-sectional study aims to examine interactions of cortisol patterns and neuroinflammation markers in their association with neuroimaging correlates. METHOD: 134 participants were recruited from the Karolinska University Hospital memory clinic (Stockholm, Sweden). Four visual rating scales were applied to magnetic resonance imaging or computed tomography scans: medial temporal lobe atrophy (MTA), global cortical atrophy (GCA), white matter lesions (WML), and posterior atrophy...
March 17, 2024: Brain, Behavior, and Immunity