Pieter Vancamp, Lucile Butruille, Anni Herranen, Anita Boelen, Jean-Baptiste Fini, Barbara A Demeneix, Sylvie Remaud
Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia throughout adulthood. We previously demonstrated that a postnatal thyroid hormone (TH) peak orchestrates this remodelling, rendering this process vulnerable to endocrine disruption. We exposed mice to 2 or 200 µg/kg bw/day of the bisphenol A-replacement and suspected TH-disruptor bisphenol F (BPF) in the drinking water, from embryonic day 15 to postnatal day 21 (P21). In parallel, one group was exposed to the TH-synthesis blocker propylthiouracil (0...
January 21, 2023: Environment International
Asra Nayab, Muhammad Hammad Malik, Ajay A Madhavan, James Glockner, Douglas A Collins, Doris E Wenger
Ganglioneuromas are benign neuroblastic tumors seen most in pediatric population. The most common locations are mediastinal, retroperitoneal and adrenal regions. Ganglioneuromas rarely occur in presacral space. We present one such case of an incidentally diagnosed presacral ganglioneuroma in an asymptomatic 71-year-old male who initially presented with hematuria.
March 2023: Radiology Case Reports
Sarah J Meller, Lexie Hernandez, Eduardo Martin-Lopez, Zachary A Kloos, Teresa Liberia, Charles A Greer
Microglia invade the neuroblast migratory corridor of the rostral migratory stream (RMS) early in development. The early postnatal RMS does not yet have the dense astrocyte and vascular scaffold that helps propel forward migrating neuroblasts, which led us to consider if microglia help regulate conditions permissive to neuroblast migration in the RMS. GFP-labeled microglia in CX3CR-1GFP/+ mice assemble primarily along the outer borders of the RMS during the first postnatal week, where they exhibit predominantly an ameboid morphology and associate with migrating neuroblasts...
January 25, 2023: ENeuro
Jian-Ching Wu, Chao-Cheng Huang, Pei-Wen Wang, Ting-Ya Chen, Wen-Ming Hsu, Jiin-Haur Chuang, Hui-Ching Chuang
Neuroblastoma (NB) is characterized by several malignant phenotypes that are difficult to treat effectively without combination therapy. The therapeutic implication of mitochondrial ClpXP protease ClpP and ClpX has been verified in several malignancies, but is unknown in NB. Firstly, we observed a significant increase in ClpP and ClpX expression in immature and mature ganglion cells as compared to more malignant neuroblasts and less malignant Schwannian-stroma-dominant cell types in human neuroblastoma tissues...
January 13, 2023: International Journal of Molecular Sciences
Candela Caballero-Eraso, Olaia Colinas, Verónica Sobrino, Rafaela González-Montelongo, José María Cabeza, Lin Gao, Ricardo Pardal, José López-Barneo, Patricia Ortega-Sáenz
KEY POINTS: Obstructive sleep apnea is a frequent condition in the human population that predisposes to severe cardiovascular and metabolic alterations. Activation of the carotid body, the main arterial oxygen-sensing chemoreceptor, by repeated episodes of hypoxemia induces exacerbation of the carotid body-mediated chemoreflex and contributes to sympathetic overflow characteristic of sleep apnea patients. In rats, chronic intermittent hypoxemia induces fast neurogenesis in the carotid body with rapid activation of neuroblasts, which enter in a process of proliferation and maturation into O2 -sensing chemoreceptor glomus cells...
January 17, 2023: Journal of Physiology
João Costa, Manuel Jácome, Pedro Souteiro, Catarina Santos, Ana Luísa Cunha
Composite pheochromocytoma (CP) is a rare adrenal tumor, composed of ordinary pheochromocytoma and neuroblastic components. There is a paucity of information in the literature regarding this entity. We report the case of a 56-year-old woman with a CP of the left adrenal gland with a ganglioneuroma component. A review of the published literature found 110 cases of CP. The median age was 51.5 (5.86) years, and 59/110 (53.6%) were female. Association with genetic predisposition syndromes was found in 22/110 (20%), the most common of which was neurofibromatosis type 1, in 15/110 (13...
January 16, 2023: Virchows Archiv: An International Journal of Pathology
Irene Donato, Kiran K Velpula, Andrew J Tsung, Jack A Tuszynski, Consolato M Sergi
PURPOSE: Neuroblastoma is a pediatric solid tumor with a prognosis associated with histology and age of the patient, which are the parameters of the well-established current classification (Shimada classification). Despite the development of new treatment options, the prognosis of high-risk neuroblastoma patients is still poor. Therefore, there is a continuous need to stratify the children suffering from this tumor. A mathematical and computational approach is proposed to enable automatic and precise cancer diagnosis on the histological slide...
January 16, 2023: Tumori
Ze-Fu Chen, Li-Zhen Wu, Ze-Ting Chen, Liang-Ju Su, Ce-Jun Fu
BACKGROUND: In recent years, miRNAs have become a research hotspot, which is related to the occurrence and development of a variety of malignant tumors, but there are few studies in neuroblastoma. In this study, the differentially expressed microRNAs (miRNAs) in neuroblastoma were identified and analyzed using bioinformatics, and their biological functions and related signaling pathways were examined. METHODS: The neuroblastoma miRNA chip GSE121513 was obtained from the Gene Expression Omnibus (GEO) database and the data of 95 neuroblastoma samples and normal fetal adrenal neuroblastoma samples were analyzed to screen the differential miRNAs...
December 2022: Translational Pediatrics
Ana Domingo-Muelas, Jose Manuel Morante-Redolat, Verónica Moncho-Amor, Antonio Jordán-Pla, Ana Pérez-Villalba, Pau Carrillo-Barberà, Germán Belenguer, Eva Porlan, Martina Kirstein, Oriol Bachs, Sacri R Ferrón, Robin Lovell-Badge, Isabel Fariñas
Cell differentiation involves profound changes in global gene expression that often has to occur in coordination with cell cycle exit. Because cyclin-dependent kinase inhibitor p27 reportedly regulates proliferation of neural progenitor cells in the subependymal neurogenic niche of the adult mouse brain, but can also have effects on gene expression, we decided to molecularly analyze its role in adult neurogenesis and oligodendrogenesis. At the cell level, we show that p27 restricts residual cyclin-dependent kinase activity after mitogen withdrawal to antagonize cycling, but it is not essential for cell cycle exit...
January 11, 2023: Cellular and Molecular Life Sciences: CMLS
Luo-Dan Qian, Li-Juan Feng, Shu-Xin Zhang, Jun Liu, Jia-Liang Ren, Lei Liu, Hui Zhang, Jigang Yang
BACKGROUND: The aim of this study was to evaluate the effect of a model combining a 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT)-based radiomics signature with clinical factors in the preoperative prediction of the International Neuroblastoma Pathology Classification (INPC) type of pediatric peripheral neuroblastic tumor (pNT). METHODS: A total of 106 consecutive pediatric pNT patients confirmed by pathology were retrospectively analyzed...
January 1, 2023: Quantitative Imaging in Medicine and Surgery
Asmaa' Mohd Satar, Farah Amna Othman, Suat Cheng Tan
BACKGROUND: Ischemic stroke is a condition in which an occluded blood vessel interrupts blood flow to the brain and causes irreversible neuronal cell death. Transplantation of regenerative stem cells has been proposed as a novel therapy to restore damaged neural circuitry after ischemic stroke attack. However, limitations such as low cell survival rates after transplantation remain significant challenges to stem cell-based therapy for ischemic stroke in the clinical setting. In order to enhance the therapeutic efficacy of transplanted stem cells, several biomaterials have been developed to provide a supportable cellular microenvironment or functional modification on the stem cells to optimize their reparative roles in injured tissues or organs...
December 26, 2022: World Journal of Stem Cells
Dmitrii S Vasilev, Anastasiia D Shcherbitskaia, Natalia L Tumanova, Anastasiia V Mikhel, Yulia P Milyutina, Anna A Kovalenko, Nadezhda M Dubrovskaya, Daria B Inozemtseva, Irina V Zalozniaia, Alexander V Arutjunyan
Maternal hyperhomocysteinemia causes the disruption of placental blood flow and can lead to serious disturbances in the formation of the offspring's brain. In the present study, the effects of prenatal hyperhomocysteinemia (PHHC) on the neuronal migration, neural tissue maturation, and the expression of signaling molecules in the rat fetal brain were described. Maternal hyperhomocysteinemia was induced in female rats by per os administration of 0.15% aqueous methionine solution in the period of days 4-21 of pregnancy...
January 3, 2023: Cells
Na Wu, Xiaochuan Sun, Chao Zhou, Jin Yan, Chongjie Cheng
BACKGROUND: Traumatic brain injury (TBI) is a disease with high mortality and morbidity, which leads to severe neurological dysfunction. Neurogenesis has provided therapeutic options for treating TBI. Brain derived neurotrophic factor (BDNF) plays a key role in neuroblasts migration. We aimed to investigate to the key regulating principle of BDNF in endogenous neuroblasts migration in a mouse TBI model. METHODS: In this study, controlled cortical impact (CCI) mice (C57BL/6J) model was established to mimic TBI...
January 5, 2023: Stem Cell Research & Therapy
Jose Erik Alvarez-Contino, Estela Díaz-Sánchez, Marina Mirchandani-Duque, Jose Andrés Sánchez-Pérez, Miguel A Barbancho, Alexander López-Salas, Natalia García-Casares, Kjell Fuxe, Dasiel O Borroto-Escuela, Manuel Narváez
Dysregulation of adult hippocampal neurogenesis is linked to major depressive disorder (MDD), with more than 300 million people diagnosed and worsened by the COVID-19 pandemic. Accumulating evidence for neuropeptide Y (NPY) and galanin (GAL) interaction was shown in various limbic system regions at molecular-, cellular-, and behavioral-specific levels. The purpose of the current work was to evaluate the proliferating role of GAL2 receptor (GALR2) and Y1R agonists interaction upon intranasal infusion in the ventral hippocampus...
January 4, 2023: Journal of Cellular Physiology
Jia-Lei Yang, Hong Fan, Fan-Fan Fu, Bao-Lin Guo, Ying Huang, Li Sun, Wen-Ting Wang, Jun-Ling Xing, Xin-Tian Hu, Yu-Qiang Ding, Kun Zhang, Ying-Zhou Hu, Ya-Zhou Wang
The adult cortex has long been regarded as non-neurogenic. Whether injury can induce neurogenesis in the adult cortex is still controversial. Here, we report that focal ischemia stimulates a transient wave of local neurogenesis. Using 5'-bromo-2'-deoxyuridine labeling, we demonstrated a rapid generation of doublecortin-positive neuroblasts that died quickly in mouse cerebral cortex following ischemia. Nestin-CreER -based cell ablation and fate mapping showed a small contribution of neuroblasts by subventricular zone neural stem cells...
July 2023: Neural Regeneration Research
Sipin Zhu, Xiaoyong Hu, Samuel Bennett, Oscar Charlesworth, Shengnan Qin, Yuliang Mai, Haicheng Dou, Jiake Xu
Galanin is a neurohormone as well as a neurotransmitter and plays versatile physiological roles for the neuroendocrine axis, such as regulating food intake, insulin level and somatostatin release. It is expressed in the central nervous system, including hypothalamus, pituitary, and the spinal cord, and colocalises with other neuronal peptides within neurons. Structural analyses reveal that the human galanin precursor is 104 amino acid (aa) residues in length, consisting of a mature galanin peptide (aa 33-62), and galanin message-associated peptide (GMAP; aa 63-104) at the C-terminus...
2022: Frontiers in Endocrinology
Kang Li, Ke Song, Yuli Hou, Yuan Tian, Huijuan Wang, Libo Sun, Ang Li, Yonghong Zhang
Neuroblast differentiation-associated protein AHNAK, a large structural scaffold protein, remains mysterious in biological processes. AHNAK plays a suppressive or progressive role in different types of cancers. To investigate the role of the AHNAK in hepatocellular carcinoma (HCC), cell viability assays were performed to determine the cell proliferation of the stable AHNAK-knockdown HepG2 cell line; co-immunoprecipitation (Co-IP) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) were performed on HCC and matched paracancerous (MPC) tissues...
December 8, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Claudio Montante, Francesco Fabozzi, Maria Felicia Villani, Maria Luisa D'Andrea, Alessandra Stracuzzi, Gian Luigi Natali, Giada Del Baldo, Francesca Del Bufalo, Maria Carmen Garganese, Annalisa Serra, Paolo Tomà, Rita Alaggio, Sabina Vennarini, Giovanna Stefania Colafati, Angela Mastronuzzi, Maria Antonietta De Ioris
Neuroblastic tumors (NTs) represent the most common extracranial neoplasm occurring in childhood. Although ganglioneuroblastoma intermixed (GNBI) and ganglioneuroma (GN) are classified as very low-risk tumors, neuroblastoma (NB) and ganglioneuroblastoma-nodular (GNBN) may represent a serious risk to survival. Unfortunately, areas of GNBI and GNBN can coexist in the same mass, leading to incorrect risk staging when only biopsy is performed. Herein, we describe a case of multifocal NT (thoracic and abdominal localization) occurring in a 4-year-old male...
December 19, 2022: Diagnostics
Elena Ţarcă, Elena Cojocaru, Laura Mihaela Trandafir, Alina Costina Luca, Alina Sinziana Melinte Popescu, Lăcrămioara Ionela Butnariu, Marian George Melinte Popescu, Dana Teodora Anton Păduraru, Mihaela Moscalu, Daniela Rusu, Viorel Ţarcă
Neurofibromatosis type 1 (NF1) is a genetic disease, with autosomal dominant transmission, related to pathogenic variant of the tumor suppressor gene NF1 (17q11.2), predisposing affected subjects to a variety of benign (neurofibromas and plexiform neurofibromas) and malignant tumors. The lack of the NF1-neurofibromin gene product can cause uncontrolled cell proliferation in the central or peripheral nervous system and multisystemic involvement, and so the disease includes a heterogeneous group of clinical manifestations...
December 12, 2022: Diagnostics
Brandt Warecki, Ian Bast, Matthew Tajima, William Sullivan
The complete separation of sister chromatids during anaphase is a fundamental requirement for successful mitosis. Therefore, divisions with either persistent DNA-based connections or lagging chromosome fragments threaten aneuploidy if unresolved. Here, we demonstrate the existence of an anaphase mechanism in normally dividing cells in which pervasive connections between telomeres of segregating chromosomes aid in rescuing lagging chromosome fragments. We observe that in a large proportion of Drosophila melanogaster neuronal stem cell divisions, early anaphase sister and non-sister chromatids remain connected by thin telomeric DNA threads...
December 9, 2022: Current Biology: CB
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