Justyna Godos, Giovanni Luca Romano, Lucia Gozzo, Samuele Laudani, Nadia Paladino, Irma Dominguez Azpíroz, Nohora Milena Martínez López, Francesca Giampieri, José L Quiles, Maurizio Battino, Fabio Galvano, Filippo Drago, Giuseppe Grosso
Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained particular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for modulating the biological activities of phenolic metabolites in humans...
2024: Frontiers in Pharmacology