Erwei Li, Luhong Wang, Daqing Wang, Jingyi Chi, Zeran Lin, Gordon I Smith, Samuel Klein, Paul Cohen, Evan D Rosen
Oxytocin (OXT), a nine-amino-acid peptide produced in the hypothalamus and released by the posterior pituitary, has well-known actions in parturition, lactation and social behaviour1 , and has become an intriguing therapeutic target for conditions such as autism and schizophrenia2 . Exogenous OXT has also been shown to have effects on body weight, lipid levels and glucose homeostasis1,3 , suggesting that it may also have therapeutic potential for metabolic disease1,4 . It is unclear, however, whether endogenous OXT participates in metabolic homeostasis...
December 13, 2023: Nature