Qin Yang, Jingyun Guo, Jiehuang Zheng, Yan Chen, Binhua Zou, Ruopeng Li, Zongbao Ding, Yiyuan Wang, Lihong Li, Ziye Chen, Lixia Mo, Qinghe Liang, Fengsheng Chen, Xiaojuan Li
Bone is a preferred metastatic site of advanced breast cancer and the 5-year overall survival rate of breast cancer patients with bone metastasis is only 22.8%. Targeted inhibition of osteoclasts can treat skeletal-related events (SREs) in breast cancer patients. Polyphyllin VII (PP7), a pennogenyl saponin isolated from traditional Chinese herb Paris polyphylla, exhibits strong anti-inflammatory and anti-cancer activities. In this study, we evaluated the effect of PP7 on metastatic breast cancer-induced bone destruction in vivo and the underlying mechanisms...
May 28, 2023: International Immunopharmacology