Ronghua Yu, Yongmei Xiao, Wuhen Xu, Ting Zhang, Yizhong Wang, Hui Hu
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare X-linked recessive immunodeficiency caused by mutations in the forkhead box protein 3 ( FOXP3 ) gene. IPEX is characterized by the onset of intractable diarrhea, type 1 diabetes mellitus (T1DM), and eczema in the early stages of life. The typical clinic triad for IPEX is not always seen. Here, we report a 15-year-old male patient with atypical IPEX syndrome complicated with severe eosinophilic gastritis (EG) and pyloric stenosis...
2022: Frontiers in Pediatrics
Li Wang, Zu-Qiang Liu, Jing-Zheng Liu, Li-Yun Ma, Xiao-Qing Li, Lu Yao, Quan-Lin Li, Ping-Hong Zhou
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) for anastomotic lesions is technically challenging due to severe fibrosis, deformity, staples, and limited space for procedure. We aimed to characterize the clinicopathological characteristics, feasibility, and effectiveness of ESD for anastomotic lesions of the upper gastrointestinal tract. METHODS: We retrospectively investigated 43 patients with lesions involving the anastomoses of the upper GI tract who underwent ESD from April 2007 to February 2021...
December 7, 2022: Surgical Endoscopy
Balakrishnan Kamaraj, Ruthwik Duvuru, Mohammed Afsharhussain Hithayathulla, Kaargil Puliyadi Rishi, Gowthami Sai Kogilatota Jagirdhar
Gastrointestinal stromal tumors (GISTs) are uncommon GI tract cancers that develop from immature mesenchymal cells. It might be difficult to get an early diagnosis of people with small bowel GISTs, which can cause delays in therapy. We present here a case of a 62-year-old male with an incidental finding of a small intestine GIST during the workup for umbilical hernia. He presented with swelling above the umbilicus for the past six months that was progressive in nature and not associated with pain...
November 2022: Curēus
Patrycja Sosnowska-Sienkiewicz, Karolina Michalik, Przemysław Mańkowski
<b> Introduction: </b> Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is a procedure which enables reconstruction of the continuity of the gastrointestinal track after resection of the large intestine and rectum. The most common diseases that require this type of resection include: ulcerative colitis and familial adenomatous polyposis. </br></br> <b>Aim:</b> The study aimed to determine the effectiveness of IPAA in the surgical treatment of the paediatric age group...
March 15, 2022: Polski Przeglad Chirurgiczny
Mohammad Shehab, Fatema Alrashed, Aline Charabaty, Talat Bessissow
BACKGROUND: Chronic inflammatory disorders after ileal pouch-anal anastomosis (IPAA) surgery are common. These include chronic pouchitis (CP), Crohn's disease (CD) of the pouch, prepouch ileitis (PI) and rectal cuff inflammation (cuffitis). The aim of this study was to evaluate the efficacy of biologic therapies in treating these disorders. METHOD: Systematic review of all published studies from inception to August 1, 2021 was performed to investigate the efficacy of biologic therapies for post-IPAA chronic inflammatory disorders...
December 2022: Journal of the Canadian Association of Gastroenterology
Connor Pyne, Katy L Townsend, Deborah Chong, Alejandro Alvarez-Sanchez, Ming Lu, Alexandra G Collins-Webb, Christiane V Loehr
A 5-month-old, intact male, yellow Labrador retriever was presented with a 24-hour history of anorexia and vomiting. Abdominal imaging revealed the presence of a mechanical obstruction in the jejunum and peritoneal effusion. Cytologic evaluation and culture of the effusion prior to surgery identified a suppurative exudate with bacteria consistent with septic peritonitis and suspected to be related to the intestinal lesion. An exploratory laparotomy was performed, and a segment of jejunum was circumferentially severely constricted by an off-white, fibrous band of tissue...
December 2022: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Yaning Wang, Laura Tiusaba, Shimon Jacobs, Michele Saruwatari, Bo Ning, Marc Levitt, Anthony D Sandler, So-Hyun Nam, Jin U Kang, Jaepyeong Cha
PURPOSE: Intraoperative evaluation of bowel perfusion is currently dependent upon subjective assessment. Thus, quantitative and objective methods of bowel viability in intestinal anastomosis are scarce. To address this clinical need, a conditional adversarial network is used to analyze the data from laser speckle contrast imaging (LSCI) paired with a visible-light camera to identify abnormal tissue perfusion regions. APPROACH: Our vision platform was based on a dual-modality bench-top imaging system with red-green-blue (RGB) and dye-free LSCI channels...
November 2022: Journal of Medical Imaging
Stefan D van der Stel, Marco Lai, Harald C Groen, Mark Witteveen, Koert F D Kuhlmann, Brechtje A Grotenhuis, Niels F M Kok, Mark van Gastel, Benno H W Hendriks, Theo J M Ruers
INTRODUCTION: Anastomotic leakage after gastrointestinal surgery has a high impact on patient's quality of life and its origin is associated with inadequate perfusion. Imaging photoplethysmography (iPPG) is a noninvasive imaging technique that measures blood-volume changes in the microvascular tissue bed and detects changes in tissue perfusion. MATERIALS AND METHODS: Intraoperative iPPG imaging was performed in 29 patients undergoing an open segment resection of the small intestine or colon...
November 30, 2022: Journal of Surgical Research
Maher M Al-Zaiem, Rawan S Alsamli, Ethar A Alsulami, Ruba F Mohammed, Mohammad I Almatrafi
Hereditary multiple intestinal atresia (HMIA) is a rare form of intestinal atresia that affects the gastrointestinal tract from the pylorus to the rectum. A few cases have been reported in the literature. Here, we report the case of a three-day-old girl who was referred to our hospital as a case of upper intestinal obstruction. After initial resuscitation, the radiological examination revealed pyloric obstruction, multiple intra-abdominal calcifications, and rectal atresia making the diagnosis of HMIA most likely...
October 2022: Curēus
Alexander Ostapenko, Shawn Liechty, Daniel Kleiner
BACKGROUND: Endoluminal vacuum therapy has been experimentally used in patients with esophageal, rectal, and Roux-en-Y bypass surgery. Yorkshire pigs are good animal models for studying the safety and efficacy of endoluminal vacuum therapy and prior studies have employed these devices in rectal anastomotic defects, as rescue therapy for early anastomotic leaks, as well as prophylactic therapy as a means of protecting high risk anastomosis. AIM: The objective of this study is to assess the effects of a prophylactic vacuum assist device on bowel tissue surrounding an intact anastomosis at 30 days post device removal...
December 29, 2022: Journal of Clinical and Translational Research
Jin Young Cho, Mea-Young Chang, Mi Hyeon Gang, Yong Wook Lee, Jun Beom Park, Jae Young Kim, Hyun Jin Kim
PURPOSE: Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is a congenital anomaly that can cause frequent digestive and nutritional problems, even after repair. The most common complication is anastomotic stricture, for which reoperation or balloon dilatation is performed. This study aimed to evaluate the postoperative complications of EA and the role of endoscopic balloon dilatation (EBD) in cases of anastomotic stricture. METHODS: We retrospectively analyzed patients diagnosed with EA with or without TEF between January 2000 and February 2021...
November 2022: Pediatric Gastroenterology, Hepatology & Nutrition
Venkata Vinod Kumar Matli, Gazi B Zibari, Gregory Wellman, Poornima Ramadas, Sudha Pandit, James Morris
BACKGROUND: This is a unique case of a patient who was found to have two extremely rare primary malignancies synchronously, i.e. , an ampullary adenocarcinoma arising from a high-grade dysplastic tubulovillous adenoma of the ampulla of Vater (TVAoA) with a high-grade ileal gastrointestinal stromal tumor (GIST). Based on a literature review and to the best of our knowledge, this is the first report of this synchronicity. Primary ampullary tumors are extremely rare, with an incidence of four cases per million population, which is approximately 0...
November 15, 2022: World Journal of Gastrointestinal Oncology
Gülten Çiçek Okuyan, Doğukan Akkuş
BACKGROUND: Exocrine pancreatic insufficiency (EPI) can be seen after bariatric/metabolic surgery. Fecal elastase level is a simple test in diagnosing and grading EPI. Quality of life changes in patients with bariatric/metabolic surgery related to gastrointestinal complaints is debated. AIM: This study aimed to investigate rates and grades of EPI via fecal elastase levels and association between EPI and quality of life in bariatric surgery patients. METHODS: A prospective study was performed for patients with bariatric/metabolic surgery at their second-year follow-up...
November 28, 2022: Obesity Surgery
Wenshuai Liu, Jiongyuan Wang, Lijie Ma, Aobo Zhuang, Jing Xu, Junyi He, Hua Yang, Yuan Fang, Weiqi Lu, Yong Zhang, Hanxing Tong
BACKGROUND: Distal duodenal resections are sometimes necessary for radical surgery, but how to restore duodenal continuity is still unclear. This study aimed at determining which style of anastomosis was more suitable for the duodenojejunostomy after resection of distal duodenum. PATIENTS AND METHODS: We retrospectively identified 34 patients who underwent distal duodenum resection at our center between January 2014 and December 2021. According to whether the end or the side of the proximal duodenum was involved in reconstruction, duodenojejunostomy were classified as End style (E-style) and Side style (S-style)...
November 24, 2022: BMC Surgery
Laura C Sahyoun, Jill K J Gaidos
PURPOSE OF REVIEW: As the incidence of inflammatory bowel disease (IBD) rises, gastroenterologists are more commonly facing management of the disease in women of childbearing age. This coincides with the development of new IBD therapies whose use in pregnancy must be considered. RECENT FINDINGS: This review provides updated recommendations for newer biologic agents and small molecules that have been approved for IBD treatment since the previous guidelines were published...
November 23, 2022: Current Gastroenterology Reports
Boyang Chen, Ping Xia, Weifeng Tang, Shijie Huang
INTRODUCTION: The optimal choice of anastomotic techniques for cervical esophagogastric anastomosis in esophagectomy remains unclear. METHODS: An electronic literature search of PubMed, Embase, and Web of Science (data up to April 2022) was conducted and screened to compare hand sewn (HS), circular stapling (CS), side-to-side linear stapling (LS), and triangulating stapling (TS) for cervical esophagogastric anastomosis. Anastomotic leak, pulmonary complications, anastomotic stricture, and reflux esophagitis of the 4 anastomotic techniques were evaluated using a Bayesian network meta-analysis by R...
November 22, 2022: Journal of Gastrointestinal Surgery
Eline A Breuking, Otis C van Varsseveld, Marc Harms, Stefaan H A J Tytgat, Jan B F Hulscher, Jetske Ruiterkamp
BACKGROUND: Although ICG-FA may be valuable in assessing anastomotic perfusion, reliable data on its use in pediatric gastrointestinal surgery is lacking. This systematic review analyzes whether ICG is useful for intestinal perfusion assessment in pediatric gastrointestinal surgery and safe to use in neonates. METHODS: Systematic searches of PubMed, EMBASE & MEDLINE and CENTRAL were performed (last conducted December 6, 2021). The main inclusion criteria were (1) use of ICG for intestinal perfusion assessment and (2) use of ICG in young infants...
October 24, 2022: Journal of Pediatric Surgery
Li Wang, Zu-Qiang Liu, Li-Yun Ma, Xiao-Qing Li, Lu Yao, Quan-Lin Li, Ping-Hong Zhou
BACKGROUND: Endoscopic submucosal dissection (ESD) for anastomotic lesions is technically challenging. We aimed to characterize the clinicopathologic characteristics, feasibility, and effectiveness of ESD for anastomotic lesions of the lower gastrointestinal tract. METHOD: We retrospectively investigated 55 patients with anastomotic lesions of the lower GI tract who underwent ESD from February 2008 to January 2021. The lesions involving one or both sides of anastomoses were classified into the unilaterally involving anastomosis (UIA) or straddling anastomosis (SA) group, respectively...
November 18, 2022: Journal of Gastroenterology and Hepatology
Y T Liu, Y Huang, Y G Hao, P F Zhang, X Yin, J F Zhang, X H Hu, B K Li, G Y Wang
The incidence of anastomotic leakage, a common and serious postoperative complication of low rectal cancer, remains high. Clarifying the risk factors for anastomotic leakage in patients with low rectal cancer after surgery can help guide clinical treatment and help patients improve their prognosis. The current literature suggests that the risk factors affecting the occurrence of anastomotic leakage after low rectal cancer include three aspects: (1) individual factors: male gender, high body mass index, malnutrition, smoking, alcoholism, and metabolic diseases; (2) tumor factors: the lower margin of tumor <5 cm from the anal verge, tumor diameter >2...
November 25, 2022: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Y L Huang, A W Wu
Defunctioning stoma is an effective method to reduce symptomatic anastomotic leakage after rectal cancer surgery. It is of concern that about 1 in 5 defunctioning stomas will not be restored, that is, becoming permanent. And that is usually beyond expectation by physicians and patients, which deserves enough attention. The causes are complex, including anastomotic complications, tumor progression, perioperative death, poor anal function and patient willingness. Possible risk factors include symptomatic anastomotic leakage, age, tumor location, neoadjuvant therapy, anal function, TNM stage, ASA score, hospital factors, etc...
November 25, 2022: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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