Giovanna Fico, Gerard Anmella, Michele De Prisco, Vincenzo Oliva, Chiara Possidente, Lorenzo Bracco, Marta Bort, Tabatha Fernandez-Plaza, Anna Giménez-Palomo, Eduard Vieta, Andrea Murru
Predominant Polarity (PP) is an established specifier of Bipolar Disorder (BD), holding significant clinical implications. Nevertheless, there exists no consensus on how to incorporate mixed states into PP, leaving patients prone to mixed recurrences that are unclassified. In a comprehensive study involving 701 euthymic BD patients, we sought to redefine PP by introducing a novel metric, the "mixed tendency", and establish a practical threshold to identify patients with a "mixed phenotype". Furthermore, we investigated potential associations between the mixed phenotype and specific PP categories...
November 29, 2023: Journal of Clinical Medicine