Leticia Benítez, Sara Castro-Barquero, Fàtima Crispi, Lina Youssef, Francesca Crovetto, Ute Fischer, Ersen Kameri, Clara Bueno, Mireia Camos, Pablo Menéndez, Merja Heinäniemi, Arndt Borkhardt, Eduard Gratacós
Acute leukemia is the most common pediatric cancer, with an incidence peak at 2-5 years of age. Despite the medical advances improving survival rates, children suffer from significant side-effects of treatments as well as its high social and economic impact. The frequent prenatal origin of this developmental disease follows the two-hit carcinogenesis model established in the 70s: a first hit in prenatal life with the creation of genetic fusion lesions or aneuploidy in hematopoietic progenitor/stem cells, and usually a second hit in pediatric age that converts the preleukemic clone into clinical leukemia...
May 6, 2024: Fetal Diagnosis and Therapy