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JOURNAL ARTICLE
Lawrence Chun-Man Lau, Wai-Wang Chau, Randy Ng, Jonathan Patrick Ng, Elvis Chun-Sing Chui, Michael Tim-Yun Ong, James Francis Griffith, Patrick Shu-Hang Yung
BACKGROUND: Glenoid bone loss is a risk factor leading to the failure of arthroscopic Bankart repair. While 20-25% glenoid bone loss has long been considered the level to necessitate bony augmentation, recent studies indicate that 13.5% has a "subcritical" glenoid bone loss level, which is associated with decreased short- and medium-term functional scores. Few researchers worked on the long-term effect of "subcritical" or even less severe degrees of glenoid bone loss on redislocation rates and functional outcomes after arthroscopic Bankart repair...
2024: Advances in Orthopedics
#22
JOURNAL ARTICLE
Online behavioural interventions for children and young people with eczema: Quantitative evaluation.
Kate Greenwell, Taeko Becque, Katy Sivyer, Mary Steele, James Denison-Day, Mary Steele, Laura M Howells, Matthew J Ridd, Amanda Roberts, Sandra Lawton, Sinéad M Langan, Julie Hooper, Sylvia Wilczynska, Gareth Griffiths, Tracey H Sach, Paul Little, Hywel Williams, Kim S Thomas, Lucy Yardley, Ingrid Muller, Miriam Santer, Beth Stuart
BACKGROUND: Two online behavioural interventions (Eczema Care Online; one website for parents/carers of children with eczema; one for young people with eczema) have been shown in randomised controlled trials to facilitate a sustained improvement in eczema severity. AIM: To describe intervention use and examine potential mediators of intervention outcomes and contextual factors that may influence intervention delivery and outcomes. DESIGN AND SETTING: Quantitative process evaluation; UK primary care...
February 5, 2024: British Journal of General Practice
#23
JOURNAL ARTICLE
Abdullah Almaatouq, Thomas L Griffiths, Jordan W Suchow, Mark E Whiting, James Evans, Duncan J Watts
Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of the solution, with accompanying discussions of its implementation in existing work and its potential for other domains. Collectively, the commentaries enhance our confidence in the promise and viability of integrative experiment design, while highlighting important considerations about how it is used...
February 5, 2024: Behavioral and Brain Sciences
#24
Alice Horisberger, Alec Griffith, Joshua Keegan, Arnon Arazi, John Pulford, Ekaterina Murzin, Kaitlyn Howard, Brandon Hancock, Andrea Fava, Takanori Sasaki, Tusharkanti Ghosh, Jun Inamo, Rebecca Beuschel, Ye Cao, Katie Preisinger, Maria Gutierrez-Arcelus, Thomas M Eisenhaure, Joel Guthridge, Paul J Hoover, Maria Dall'Era, David Wofsy, Diane L Kamen, Kenneth C Kalunian, Richard Furie, Michael Belmont, Peter Izmirly, Robert Clancy, David Hildeman, E Steve Woodle, William Apruzzese, Maureen A McMahon, Jennifer Grossman, Jennifer L Barnas, Fernanda Payan-Schober, Mariko Ishimori, Michael Weisman, Matthias Kretzler, Celine C Berthier, Jeffrey B Hodgin, Dawit S Demeke, Chaim Putterman, Michael B Brenner, Jennifer H Anolik, Soumya Raychaudhuri, Nir Hacohen, Judith A James, Anne Davidson, Michelle A Petri, Jill P Buyon, Betty Diamond, Fan Zhang, James A Lederer, Deepak A Rao
Lupus nephritis (LN) is a frequent manifestation of systemic lupus erythematosus, and fewer than half of patients achieve complete renal response with standard immunosuppressants. Identifying non-invasive, blood-based pathologic immune alterations associated with renal injury could aid therapeutic decisions. Here, we used mass cytometry immunophenotyping of peripheral blood mononuclear cells in 145 patients with biopsy-proven LN and 40 healthy controls to evaluate the heterogeneity of immune activation in patients with LN and to identify correlates of renal parameters and treatment response...
March 9, 2024: bioRxiv
#25
JOURNAL ARTICLE
Joel S Burma, James K Griffiths, Jonathan D Smirl
To compare the construct validity and between-day reliability of projection pursuit regression (PPR) from oscillatory lower body negative pressure (OLBNP) and squat-stand maneuvers (SSMs). Nineteen participants completed 5 min of OLBNP and SSMs at driven frequencies of 0.05 and 0.10 Hz across two visits. Autoregulatory plateaus were derived at both point-estimates and across the cardiac cycle. Between-day reliability was assessed with intraclass correlation coefficients (ICCs), Bland-Altman plots with 95% limits of agreement (LOA), coefficient of variation (CoV), and smallest real differences...
January 2024: Physiological Reports
#26
JOURNAL ARTICLE
Bradley A Erickson, James W Griffith, Guo Wensheng, You Mengying, Ted Herman, Catherine S Bradley, J Quentin Clemens, John T Farrar, Priyanka Gupta, Karl J Kreder, H Henry Lai, Bruce D Naliboff, Diane K Newman, Larissa V Rodriguez, Theresa Spitznagle, Siobhan Sutcliffe, Suzette E Sutherland, Bayley J Taple, J Richard Landis
PURPOSE: This study tested the hypothesis that ecological momentary assessment (EMA) of pelvic pain (PP) and urinary urgency (UU) would reveal unique Urologic Chronic Pelvic Pain Syndrome (UCPPS) phenotypes that would be associated with disease specific quality of life (QOL) and illness impact metrics (IIM). MATERIALS AND METHODS: A previously validated smart phone app (M-app) was provided to willing Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) participants...
January 22, 2024: Neurourology and Urodynamics
#27
JOURNAL ARTICLE
James B Kirkbride, Deidre M Anglin, Ian Colman, Jennifer Dykxhoorn, Peter B Jones, Praveetha Patalay, Alexandra Pitman, Emma Soneson, Thomas Steare, Talen Wright, Siân Lowri Griffiths
People exposed to more unfavourable social circumstances are more vulnerable to poor mental health over their life course, in ways that are often determined by structural factors which generate and perpetuate intergenerational cycles of disadvantage and poor health. Addressing these challenges is an imperative matter of social justice. In this paper we provide a roadmap to address the social determinants that cause mental ill health. Relying as far as possible on high-quality evidence, we first map out the literature that supports a causal link between social determinants and later mental health outcomes...
February 2024: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
#28
JOURNAL ARTICLE
Paul Little, Katherine Bradbury, Beth Stuart, Jane Barnett, Adele Krusche, Mary Steele, Elena Heber, Steph Easton, Kirsten Ailsa Smith, Joanna Slodkowska-Barabasz, Liz Payne, Teresa Corbett, Guiqing Yao, Sebastien Pollet, Jazzine Smith, Judith Joseph, Megan Lawrence, Dankmar Bohning, Tara Cheetham-Blake, Diana Eccles, Claire Foster, Adam W A Geraghty, Geraldine Leydon, Andre Muller, Richard Neal, Richard Osborne, Shanaya Rathod, Alison Richardson, Chloe Grimmett, Geoff Sharman, Roger Bacon, Lesley Turner, Richard Stephens, Tamsin Burford, Laura Wilde, Karen Middleton, Megan Liddiard, Kirsty Rogers, James Raftery, Shihua Zhu, Fran Webley, Gareth Griffiths, Jaqui Nutall, Trudie Chalder, Clare E Wilkinson, Eila Watson, Lucy Yardley
BACKGROUND: Many cancer survivors following primary treatment have prolonged poor quality of life. AIM: To determine the effectiveness of a bespoke digital intervention to support cancer survivors. DESIGN: Pragmatic parallel open randomised trial. SETTING: UK general practices. METHODS: People having finished primary treatment (<= 10 years previously) for colo-rectal, breast or prostate cancers, with European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30 score <85, were randomised by online software to: 1)detailed 'generic' digital NHS support ('LiveWell';n=906), 2) a bespoke complex digital intervention ('Renewed';n=903) addressing symptom management, physical activity, diet, weight loss, distress, or 3) 'Renewed-with-support' (n=903): 'Renewed' with additional brief email and telephone support...
December 20, 2023: British Journal of General Practice
#29
JOURNAL ARTICLE
James Hennegan, Aled H Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J M Bartley, Joanna J Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas, Christos S Bartsocas, Margarita Markouri, Eleni Antoniadou, Ioanna Laina, Owain W Howell, Meng Li, Yuqin Wang, William J Griffiths, Emma L Lane, Mariah J Lelos, Spyridon Theofilopoulos
Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25 R )26-dihydroxycholesterol (7α,26-diHC), was significantly elevated in the cerebrospinal fluid of patients with Parkinson's disease (PD). In this study we investigated the role of 7α,26-diHC in midbrain dopamine (mDA) neuron development and survival. We report that 7α,26-diHC induces apoptosis and reduces the number of mDA neurons in hESC-derived cultures and in mouse progenitor cultures...
January 19, 2024: IScience
#30
JOURNAL ARTICLE
Emily Hurstak, Francesca R Farina, Michael K Paasche-Orlow, Elizabeth A Hahn, Lori E Henault, Patricia Moreno, Claire Weaver, Melissa Marquez, Eloisa Serrano, Jessica Thomas, James W Griffith
We sought to analyze the relationship between health literacy, confidence in COVID-19 vaccines, and self-reported vaccination. We hypothesized that the relationship between health literacy and vaccination would be mediated by vaccine confidence. We recruited (N = 271) English- and Spanish-speaking adults in Boston and Chicago from September 2018 to September 2021. We performed a probit mediation analysis to determine if confidence in COVID-19 vaccines and health literacy predicted self-reported vaccination...
December 13, 2023: Vaccines
#31
JOURNAL ARTICLE
Burcu Celebioglu, John P Hart, Timothy Porch, Phillip Griffiths, James R Myers
Color can be an indicator of plant health, quality, and productivity, and is useful to researchers to understand plant nutritional content in their studies. Color may be related to chlorophyll content and photosynthetic activity and provides information for those studying diseases and mineral nutrition because every nutrient deficiency and many diseases produce symptoms that affect color. In order to identify significant loci related to both leaf and pod color in a snap bean ( Phaseolus vulgaris L.) diversity panel, a genome-wide association study (GWAS) was carried out...
December 18, 2023: Genes
#32
JOURNAL ARTICLE
Benedict D Michael, Cordelia Dunai, Edward J Needham, Kukatharmini Tharmaratnam, Robyn Williams, Yun Huang, Sarah A Boardman, Jordan J Clark, Parul Sharma, Krishanthi Subramaniam, Greta K Wood, Ceryce Collie, Richard Digby, Alexander Ren, Emma Norton, Maya Leibowitz, Soraya Ebrahimi, Andrew Fower, Hannah Fox, Esteban Tato, Mark A Ellul, Geraint Sunderland, Marie Held, Claire Hetherington, Franklyn N Egbe, Alish Palmos, Kathy Stirrups, Alexander Grundmann, Anne-Cecile Chiollaz, Jean-Charles Sanchez, James P Stewart, Michael Griffiths, Tom Solomon, Gerome Breen, Alasdair J Coles, Nathalie Kingston, John R Bradley, Patrick F Chinnery, Jonathan Cavanagh, Sarosh R Irani, Angela Vincent, J Kenneth Baillie, Peter J Openshaw, Malcolm G Semple, Leonie S Taams, David K Menon
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications...
December 22, 2023: Nature Communications
#33
RANDOMIZED CONTROLLED TRIAL
Guillermo Garcia-Manero, James McCloskey, Elizabeth A Griffiths, Karen W L Yee, Amer M Zeidan, Aref Al-Kali, H Joachim Deeg, Prapti A Patel, Mitchell Sabloff, Mary-Margaret Keating, Nancy Zhu, Nashat Y Gabrail, Salman Fazal, Joseph Maly, Olatoyosi Odenike, Hagop Kantarjian, Amy E DeZern, Casey L O'Connell, Gail J Roboz, Lambert Busque, Rena Buckstein, Harshad Amin, Jasleen Randhawa, Brian Leber, Aditi Shastri, Kim-Hien Dao, Aram Oganesian, Yong Hao, Harold N Keer, Mohammad Azab, Michael R Savona
BACKGROUND: The DNA methyltransferase inhibitors azacitidine and decitabine for individuals with myelodysplastic syndromes or chronic myelomonocytic leukaemia are available in parenteral form. Oral therapy with similar exposure for these diseases would offer potential treatment benefits. We aimed to compare the safety and pharmacokinetics of oral decitabine plus the cytidine deaminase inhibitor cedazuridine versus intravenous decitabine. METHODS: We did a registrational, multicentre, open-label, crossover, phase 3 trial of individuals with myelodysplastic syndromes or chronic myelomonocytic leukaemia and individuals with acute myeloid leukaemia, enrolled as separate cohorts; results for only participants with myelodysplastic syndromes or chronic myelomonocytic leukaemia are reported here...
January 2024: Lancet Haematology
#34
JOURNAL ARTICLE
David M Peng, Ryan R Davies, Kathleen E Simpson, Svetlana B Shugh, David L S Morales, Jeffrey P Jacobs, Arene Butto, Anna Joong, Jennifer Conway, Kerry Schindler, Eric R Griffiths, Devin Koehl, Ryan S Cantor, James K Kirklin, Joseph W Rossano, Iki Adachi
BACKGROUND: The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs), supported by The Society of Thoracic Surgeons, provides detailed information on pediatric patients supported with ventricular assist devices (VADs). METHODS: From September 19, 2012, to December 31, 2022, 1463 devices in 1219 patients aged <19 years were reported to the registry from 40 North American hospitals. RESULTS: Cardiomyopathy remains the most common underlying etiology (59%), followed by congenital heart disease (26%) and myocarditis (8%)...
December 18, 2023: Annals of Thoracic Surgery
#35
JOURNAL ARTICLE
Luca Ferretti, Chris Wymant, James Petrie, Daphne Tsallis, Michelle Kendall, Alice Ledda, Francesco Di Lauro, Adam Fowler, Andrea Di Francia, Jasmina Panovska-Griffiths, Lucie Abeler-Dörner, Marcos Charalambides, Mark Briers, Christophe Fraser
How likely is it to become infected by SARS-CoV-2 after being exposed? Virtually everyone has wondered about this question during the COVID-19 pandemic. Contact tracing apps1,2 recorded measurements of proximity3 and duration between nearby smartphones. Contacts - individuals exposed to confirmed cases - were notified according to public health policies such as the 2-metre 15-minute guideline4,5 , despite limited evidence supporting this threshold. Here we analysed 7 million contacts notified by the NHS COVID-19 app6,7 in England and Wales to infer how app measurements translated to actual transmissions...
December 20, 2023: Nature
#36
JOURNAL ARTICLE
Andrew Stuart Lane, Kate E Lynch, Mark Arnold, Ilan Dar-Nimrod, James Morandini, Stefan A Gawronski, Paul E Griffiths
BACKGROUND: Knowledge of the genetic basis of health conditions can influence how the public perceives their own and others' health. When there are known genetic associations for such conditions, genetic essentialist biases facilitate deterministic thinking and an over-emphasis of genetic causality. This study investigates the role that genetic essentialist biases play in medical decision-making. METHODS: Senior postgraduate medical students (N = 102) read a scenario in which a patient presents with gastroenterological symptoms...
December 8, 2023: BMC Medical Education
#37
JOURNAL ARTICLE
Leonard L de Boer, Lesley Vanes, Serena Melgrati, Joshua Biggs O'May, Darryl Hayward, Paul C Driscoll, Jason Day, Alexander Griffiths, Renata Magueta, Alexander Morrell, James I MacRae, Robert Köchl, Victor L J Tybulewicz
Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. Here we show that signaling from the chemokine receptor CCR7 leads to activation of WNK1 and its downstream pathway at the leading edge of migrating CD4+ T cells, resulting in ion influx and water entry by osmosis. We propose that WNK1-induced water entry is required to swell the membrane at the leading edge, generating space into which actin filaments can polymerize, thereby facilitating forward movement of the cell...
December 6, 2023: Nature Communications
#38
JOURNAL ARTICLE
Sarah Clifford, Cassandra J C Wright, Peter G Miller, Ryan Baldwin, Kalinda E Griffiths, James A Smith, Michael Livingston
INTRODUCTION: Between 2017 and 2018 three major alcohol policy changes were introduced in the Northern Territory (NT): the Banned Drinker Register, an individual-level ban enforced via ID scanners at takeaway outlets; a Minimum Unit Price on alcohol; and Police Auxiliary Liquor Inspectors, who monitor takeaway outlets to prevent purchase by people who do not have a legal place to consume alcohol. We aimed to: (i) describe alcohol-involved adult sexual assault in the NT; and (ii) estimate the impacts of these alcohol policies on police-recorded adult sexual assault...
December 6, 2023: Drug and Alcohol Review
#39
JOURNAL ARTICLE
Francesca R Farina, John Regan, Melissa Marquez, Hosanna An, Patricia O'Loughlin, Pavithra Pavithra, Michelle Taddeo, Rachel C Knight, Marc Bennett, Bert Lenaert, James W Griffith
BACKGROUND: Alzheimer's disease and related dementias (ADRD) are among the most feared age-related conditions. The aim of this study was to evaluate a brief psychological intervention to promote adaptive coping in older adults experiencing heightened fear of ADRD and investigate positive downstream effects on health-related secondary outcomes, including frequency of reported memory failures, psychosocial functioning, and quality of life. METHODS: Eighty-one older adults were recruited and randomized into REFRAME or active control intervention arms...
November 29, 2023: BMC Geriatrics
#40
JOURNAL ARTICLE
Monique Reijnierse, James F Griffith
Radiography is the appropriate initial imaging modality to assess for midfoot and forefoot pathology before turning to advanced imaging techniques. While most lesions of the mid- and forefoot can be diagnosed clinically, the exact nature and severity of the pathology is often unclear. This review addresses the use of the ultrasound, as well as the added value of magnetic resonance imaging, in diagnosing conditions of the midfoot and forefoot. Ultrasound allows a dynamic assessment as well as enabling imaging-guided interventions for diagnostic and therapeutic purposes...
October 2023: Journal of Ultrasonography
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