Oxidative phosphorilation

Lithium (0.5--4 mM) either significantly increase, either completely normalizers the intensity of the oxidative and energy metabolism of the brain mitochondria, decreased by the influence of the blood serum of patients with manic-depressive psychosis and attack like schizophrenia. At the same time lithium gives an insignificant increase in the intensity of processes of phosphorilation in cases of an action of the blood serum of patients with a continuous development of schizophrenia. Processes of phosphorilation become normalized in a joint action on the mitochondria by lithium and antioxidants...

The authors examined the influence of the preparation metaqualone on some aspects of adrenergic metabolism-respiration, phosphorilation and ATP-ase activity of brain mitochondria of a rat in order to discover pharmacobiochemical mechanism of action. The experimental data showed that administration of metaqualon in a dose of 70 mg per kg of body weight intraperitonealy, induced a lowering of phosphorilating activity in a substrate succinate. This fact gave a foundation to suppose that in shorted respiratory chain the effect of metaqualone on the aerobic resynthesis of ATP was at a level succinat-dehydrogenase complexes...