Prachi Mehrotra Gupta, Christina Balle, Gregory K Tharp, Sydney A Nelson, Melanie A Gasper, Bryan Brown, Arghavan Alisoltani, Maricianah Onono, Thesla Palanee-Phillips, Gonsagrie Nair, Hosseana Ayele, Laura Noel-Romas, Jo-Ann S Passmore, Adam D Burgener, Renee Heffron, Heather B Jaspan, Steven E Bosinger
Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial...
September 1, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society