keyword
https://read.qxmd.com/read/38537203/68ga-dotanoc-pet-ct-in-2-siblings-with-von-hippel-lindau-disease
#1
JOURNAL ARTICLE
Priyanka G B, Nishikant Avinash Damle, Ravindranath Reddy K, Nikhil Tandon, Priyanka Naranje, Devasenathipathy Kandasamy, Kishan Subudhi
Von Hippel-Lindau disease is a rare multisystem disorder that shows autosomal dominant inheritance. It is a cancer syndrome that is characterized by the development of a variety of benign and malignant tumors-CNS hemangioblastomas, retinal angiomas, endolymphatic sac tumors, renal cysts and tumors, pancreatic cysts and tumors, adrenal pheochromocytomas, and epididymal cystadenomas. Here we present the 68Ga-labeled DOTANOC scans of 2 siblings who show an interesting spectrum of findings consistent with Von Hippel-Lindau disease...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537161/serum-hsp70-and-vegf-levels-are-effective-predictive-factors-of-chemoradiosensitivity-and-prognosis-of-pancreatic-cancer-patients
#2
JOURNAL ARTICLE
Liumei Xiong, Danming Li, Gui Xiao, Sipin Tan, Jianbo Wen, Guiliang Wang
AIM: To evaluate the value of serum HSP70 and VEGF levels for predicting the chemoradiosensitivity of the pancreatic cancer patients. METHODS: A total of 255 patients with pancreatic cancer and 60 healthy subjects were enrolled in this study. Serum levels of HSP70 and VEGF were measured using enzyme-linked immunosorbent assay (ELISA) for the pre-treatment, during-treatment and post- chemoradiotherapy time-points. The results were analyzed to evaluate the potential of serum HSP70 and VEGF levels for predicting the chemoradiosensitivity of pancreatic cancer patients...
March 27, 2024: Pancreas
https://read.qxmd.com/read/38537071/metabolic-tumor-burden-as-a-prognostic-indicator-after-neoadjuvant-chemotherapy-in-pancreatic-cancer
#3
JOURNAL ARTICLE
Woohyung Lee, Minyoung Oh, Jae Seung Kim, Minkyu Sung, Kwangpyo Hong, Bong Jun Kwak, Yejong Park, Eunsung Jun, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Changhoon Yoo, Kyu-Pyo Kim, Inkeun Park, Jae Ho Jeong, Heung-Moon Chang, Baek-Yeol Ryoo, Jung Bok Lee, Song Cheol Kim
BACKGROUND: There is no standardized assessment for evaluating response although neoadjuvant chemotherapy (NAT) is widely accepted for borderline resectable or locally advanced pancreatic cancer (BRPC or LAPC). This study was aimed to evaluate NAT response using positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG-PET/CT) parameters alongside carbohydrate antigen (CA) 19-9 levels. METHODS: Patients who underwent surgery after NAT for BRPC and LAPC between 2017 and 2021 were identified...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537056/perioperative-outcomes-and-long-term-survival-of-cryosurgery-on-unresectable-pancreatic-cancer-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Kang Xue, Xiaofeng Liu, Xiaolin Xu, Li Wang, Bole Tian
BACKGROUND: Pancreatic cancer (PC) continues to rank as one of the deadliest forms of cancer, with the majority of patients being diagnosed with unresectable disease. The implementation of cryoablation-based comprehensive treatment is expected to lead to a reduction in tumor size and potentially achieve complete resection. However, the availability of systematic and evidence-based treatment guidelines for cryoablation in pancreatic cancer is currently limited. MATERIALS AND METHODS: A computerized search was conducted in the Medline, Embase, Cochrane Library databases, and Clinicaltrials to retrieve studies published from August 1987 to June 2023...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536927/activation-of-endogenous-retroviruses-and-induction-of-viral-mimicry-by-mek1-2-inhibition-in-pancreatic-cancer
#5
JOURNAL ARTICLE
Alice Cortesi, Francesco Gandolfi, Fabiana Arco, Pierluigi Di Chiaro, Emanuele Valli, Sara Polletti, Roberta Noberini, Francesco Gualdrini, Sergio Attanasio, Francesca Citron, I-Lin Ho, Rutvi Shah, Er-Yen Yen, Mara Cetty Spinella, Simona Ronzoni, Simona Rodighiero, Nico Mitro, Tiziana Bonaldi, Serena Ghisletti, Silvia Monticelli, Andrea Viale, Giuseppe Riccardo Diaferia, Gioacchino Natoli
While pancreatic ductal adenocarcinomas (PDACs) are addicted to KRAS-activating mutations, inhibitors of downstream KRAS effectors, such as the MEK1/2 kinase inhibitor trametinib, are devoid of therapeutic effects. However, the extensive rewiring of regulatory circuits driven by the attenuation of the KRAS pathway may induce vulnerabilities of therapeutic relevance. An in-depth molecular analysis of the transcriptional and epigenomic alterations occurring in PDAC cells in the initial hours after MEK1/2 inhibition by trametinib unveiled the induction of endogenous retroviruses (ERVs) escaping epigenetic silencing, leading to the production of double-stranded RNAs and the increased expression of interferon (IFN) genes...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536650/ifit1-modulates-the-proliferation-migration-and-invasion-of-pancreatic-cancer-cells-via-wnt-%C3%AE-catenin-signaling
#6
JOURNAL ARTICLE
Tian-Hao Li, Bang-Bo Zhao, Cheng Qin, Yuan-Yang Wang, Ze-Ru Li, Hong-Tao Cao, Xiao-Ying Yang, Xing-Tong Zhou, Wei-Bin Wang
OBJECTIVES: Previously, Interferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) has been shown to promote cancer development. Here, we aimed to explore the role of IFIT1 in the development and progression of pancreatic cancer, including the underlying mechanisms. METHODS: We explored IFIT1 expression in pancreatic cancer samples using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. Cell Counting Kit-8 (CCK8), colony formation, scratch wound-healing and Transwell assays were performed to assess the proliferation, migration and invasion abilities of pancreatic cancer cells...
March 27, 2024: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/38536602/endoscopic-loco-regional-treatment-in-controlling-pancreatic-neuroendocrine-tumors-pnets-behavior-a-case-series-and-literature-review
#7
JOURNAL ARTICLE
Cosmas Rinaldi Adithya Lesmana
Pancreatic neuroendocrine tumors (PNETs) are considered rare pancreatic neoplasms, and it is a challenging disease entity due to its indolent behavior and is difficult to manage. Diagnostic challenge is usually found in the imaging-based approach, such as transabdominal ultrasound, abdominal CT scan, and abdominal MRI. Surgery is still the main key player in controlling the disease. The main problems in clinical practice are the early detection of small PNETs lesion and non-functional PNET (NF-PNET) cases. Most cases usually come with large tumor size or metastatic disease...
March 27, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38536586/prevalence-of-and-factors-associated-with-financial-toxicity-after-pancreatectomy-and-gastrectomy
#8
JOURNAL ARTICLE
Yuki Hirata, Connie To, Heather Lyu, Grace L Smith, Joyce P Samuel, Hop S Tran Cao, Brian D Badgwell, Matthew H G Katz, Naruhiko Ikoma
BACKGROUND: Financial toxicity (FT) refers to the adverse impact of cancer treatment costs on patients' experiences, potentially leading to poor adherence to treatment and outcomes. However, the prevalence of FT among patients undergoing major upper gastrointestinal cancer operations, as well as factors associated with FT, remain unclear. METHODS: We conducted a cross-sectional study by sending the Comprehensive Score for financial Toxicity (COST) survey and Surgery-Q (a survey specifically developed for this study) to patients who underwent gastrectomy or pancreatectomy for malignant disease at our institution in 2019-2021...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38535623/a-multiomics-assessment-of-preoperative-exercise-in-pancreatic-cancer-survivors-receiving-neoadjuvant-therapy-a-case-series
#9
JOURNAL ARTICLE
Travis Nemkov, Francesca Cendali, Monika Dzieciatkowska, Daniel Stephenson, Kirk C Hansen, Catherine M Jankowski, Angelo D'Alessandro, Ryan J Marker
To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before and after a personalized exercise intervention. Consisting of personalized aerobic and resistance exercises, this intervention was associated with significant molecular changes that correlated with improvements in lean mass, appendicular skeletal muscle index (ASMI), and performance in the 400-m walk test (MWT) and sit-to-stand test...
March 20, 2024: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/38535308/diagnostic-and-prognostic-performance-of-metabolic-signatures-in-pancreatic-ductal-adenocarcinoma-the-clinical-application-of-quantitative-nextgen-mass-spectrometry
#10
JOURNAL ARTICLE
Paulo D'Amora, Ismael D C G Silva, Steven S Evans, Adam J Nagourney, Katharine A Kirby, Brett Herrmann, Daniela Cavalheiro, Federico R Francisco, Paula J Bernard, Robert A Nagourney
With 64,050 new diagnoses and 50,550 deaths in the US in 2023, pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of all human malignancies. Early detection and improved prognostication remain critical unmet needs. We applied next-generation metabolomics, using quantitative tandem mass spectrometry on plasma, to develop biochemical signatures that identify PDAC. We first compared plasma from 10 PDAC patients to 169 samples from healthy controls. Using metabolomic algorithms and machine learning, we identified ratios that incorporate amino acids, biogenic amines, lysophosphatidylcholines, phosphatidylcholines and acylcarnitines that distinguished PDAC from normal controls...
February 29, 2024: Metabolites
https://read.qxmd.com/read/38535087/identification-and-validation-of-t-cell-exhaustion-signature-for-predicting-prognosis-and-immune-response-in-pancreatic-cancer-by-integrated-analysis-of-single-cell-and-bulk-rna-sequencing-data
#11
JOURNAL ARTICLE
Yaowu Zhu, Li Tan, Danju Luo, Xiong Wang
PURPOSE: Pancreatic cancer (PACA) is one of the most fatal malignancies worldwide. Immunotherapy is largely ineffective in patients with PACA. T-cell exhaustion contributes to immunotherapy resistance. We investigated the prognostic potential of T-cell exhaustion-related genes (TEXGs). METHODS: A single-cell RNA (scRNA) sequencing dataset from Tumor Immune Single-Cell Hub (TISCH) and bulk sequencing datasets from the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were used to screen differentially expressed TEXGs...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38535071/a-simple-clinical-scoring-system-to-determine-the-risk-of-pancreatic-cancer-in-the-general-population
#12
JOURNAL ARTICLE
Dai Yoshimura, Mitsuharu Fukasawa, Yoshioki Yoda, Masahiko Ohtaka, Tadao Ooka, Shinichi Takano, Satoshi Kawakami, Yoshimitsu Fukasawa, Natsuhiko Kuratomi, Shota Harai, Naruki Shimamura, Hiroyuki Hasegawa, Naoto Imagawa, Yuichiro Suzuki, Takashi Yoshida, Shoji Kobayashi, Mitsuaki Sato, Tatsuya Yamaguchi, Shinya Maekawa, Nobuyuki Enomoto
This study aimed to develop and validate a simple scoring system to determine the high-risk group for pancreatic cancer (PC) in the asymptomatic general population. The scoring system was developed using data from PC cases and randomly selected non-PC cases undergoing annual medical checkups between 2008 and 2013. The performance of this score was validated for participants with medical checkups between 2014 and 2016. In the development set, 45 PC cases were diagnosed and 450 non-PC cases were identified. Multivariate analysis showed three changes in clinical data from 1 year before diagnosis as independent risk factors: ΔHbA1c ≥ 0...
March 20, 2024: Diagnostics
https://read.qxmd.com/read/38535043/determination-of-l-asparaginase-activity-and-its-therapeutic-monitoring-in-children-with-hematological-malignancies-in-a-single-croatian-center
#13
JOURNAL ARTICLE
Jasna Lenicek Krleza, Ana Katusic Bojanac, Gordana Jakovljevic
BACKGROUND: Among malignant diseases which develop during childhood, hematological cancers, such as leukemias and lymphomas, are the most common. Outcomes have greatly improved due to the refinement of multiagent chemotherapy regimens that include enhanced asparaginase therapy. In this study, we aimed to evaluate our experiences related to the analytical and clinical significance of determining l-Asparaginase activity. METHODS: Since 2016, the Laboratory of the Children's Hospital Zagreb has routinely measured l-Asparaginase activity and to date, has measured more than 280 examples of activity in a total of 57 children with hematological malignancy treated at the Pediatric Oncology Department of the Children's Hospital Zagreb...
March 15, 2024: Diagnostics
https://read.qxmd.com/read/38535034/lifestyle-medicine-for-the-prevention-and-treatment-of-pancreatitis-and-pancreatic-cancer
#14
REVIEW
Sruthi Kapliyil Subramanian, Bhaumik Brahmbhatt, Jennifer M Bailey-Lundberg, Nirav C Thosani, Pritesh Mutha
The incidence of pancreatitis and pancreatic cancer is on the upswing in the USA. These conditions often lead to higher healthcare costs due to the complex nature of diagnosis and the need for specialized medical interventions, surgical procedures, and prolonged medical management. The economic ramification encompasses direct healthcare expenses and indirect costs related to productivity losses, disability, and potential long-term care requirements. Increasing evidence underscores the importance of a healthy lifestyle in preventing and managing these conditions...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534992/analysis-of-ivim-perfusion-fraction-improves-detection-of-pancreatic-ductal-adenocarcinoma
#15
JOURNAL ARTICLE
Katarzyna Nadolska, Agnieszka Białecka, Elżbieta Zawada, Wojciech Kazimierczak, Zbigniew Serafin
The purpose of this study was to evaluate whether intravoxel incoherent motion (IVIM) parameters can enhance the diagnostic performance of MRI in differentiating normal pancreatic parenchyma from solid pancreatic adenocarcinomas. This study included 113 participants: 66 patients diagnosed with pancreatic adenocarcinoma and 47 healthy volunteers. An MRI was conducted at 1.5 T MR unit, using nine b-values. Postprocessing involved analyzing both conventional monoexponential apparent diffusion coefficient (ADC) and IVIM parameters (diffusion coefficient D-pure molecular diffusion coefficient, perfusion-dependent diffusion coefficient D*-pseudodiffusion coeffitient, and perfusion fraction coefficient (f)) across four different b-value selections...
March 7, 2024: Diagnostics
https://read.qxmd.com/read/38534987/targeting-solute-carrier-transporters-slcs-as-a-therapeutic-target-in-different-cancers
#16
REVIEW
Ravi Bharadwaj, Swati Jaiswal, Erandi E Velarde de la Cruz, Ritesh P Thakare
Solute carrier (SLC) transporters constitute a vast superfamily of transmembrane proteins tasked with regulating the transport of various substances such as metabolites, nutrients, ions, and drugs across cellular membranes. SLC transporters exhibit coordinated expression patterns across normal tissues, suggesting a tightly regulated regulatory network governing normal cellular functions. These transporters are crucial for the transport of various metabolites, including carbohydrates, proteins, lipids, and nucleic acids...
March 21, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534945/chylous-ascites-associated-with-advanced-pancreatic-cancer-that-improved-with-appropriate-treatment-a-case-report
#17
Hiroo Imai, Ken Saijo, Noriko Takenaga, Keigo Komine, Kota Ouchi, Yuki Kasahara, Shiori Ishikawa, Keiju Sasaki, Yuya Yoshida, Hidekazu Shirota, Masanobu Takahashi, Chikashi Ishioka
Chylous ascites is a rare form of ascites with high triglyceride content arising from the thoracoabdominal lymph nodes in the peritoneal cavity due to various benign or malignant etiologies, including pancreatic cancer. During cancer chemotherapy, the accumulation of ascites can lead to the deterioration of the patient's general condition, making chemotherapy administration difficult, and resulting in a poor prognosis. We encountered a rare case of chylous ascites complicated by advanced pancreatic cancer. The patient presented with a discrepancy between the shrinkage of the pancreatic cancer and the accumulation of ascites...
March 12, 2024: Current Oncology
https://read.qxmd.com/read/38534482/endoscopic-hyperspectral-imaging-system-to-discriminate-tissue-characteristics-in-tissue-phantom-and-orthotopic-mouse-pancreatic-tumor-model
#18
JOURNAL ARTICLE
Na Eun Mun, Thi Kim Chi Tran, Dong Hui Park, Jin Hee Im, Jae Il Park, Thanh Dat Le, Young Jin Moon, Seong-Young Kwon, Su Woong Yoo
In this study, we developed an endoscopic hyperspectral imaging (eHSI) system and evaluated its performance in analyzing tissues within tissue phantoms and orthotopic mouse pancreatic tumor models. Our custom-built eHSI system incorporated a liquid crystal tunable filter. To assess its tissue discrimination capabilities, we acquired images of tissue phantoms, distinguishing between fat and muscle regions. The system underwent supervised training using labeled samples, and this classification model was then applied to other tissue phantom images for evaluation...
February 23, 2024: Bioengineering
https://read.qxmd.com/read/38533530/are-measures-and-related-symptoms-of-cachexia-recorded-as-outcomes-in-gastrointestinal-cancer-chemotherapy-clinical-trials
#19
JOURNAL ARTICLE
Ross Valaire, Frances Garden, Valentina Razmovski-Naumovski
BACKGROUND: Cachexia is prevalent in gastrointestinal cancers and worsens patient outcomes and chemotherapy compliance. We examined to what extent registered gastrointestinal cancer chemotherapy clinical trials record measures and related symptoms of cachexia as outcomes, and whether these were associated with trial characteristics. METHODS: Four public trial registries (2012-2022) were accessed for Phase II and/or III randomized controlled pancreatic, gastric, and colorectal cancer chemotherapy trial protocols...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533139/unraveling-proto-oncogene-erbb2-expression-in-patients-with-carcinoma-head-of-pancreas-and-chronic-pancreatitis-patients-a-case-control-study
#20
JOURNAL ARTICLE
Abhina Mohanan, Pottakkat Biju, Balasubramaniyan V, Gladwin V
Background The pre-malignant tendency of the normal, non-affected portion of the pancreas is not as well explored as the multicentricity documented in pancreatic cancer cases. In order to ascertain the expression of inflammatory markers and Erythroblastic Oncogene B ( ErbB2 ) in the non-affected pancreas in patients with pancreatic cancer, a case-control study was carried out. Materials and methods In patients who underwent pancreatoduodenectomy for pancreatic cancer (PC), pro-inflammatory genes and a tumor marker, erythroblastic oncogene 2 ( ErbB2 ) in the epidermal growth factor receptor family were analyzed in the pancreatic tissue at the cut surface of the normal pancreas using qRT-PCR...
February 2024: Curēus
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