Miku Miyoshi, Akihide Yoshihara, Susumu Mochizuki, Shiro Kato, Hiromi Yoshida, Tatsuhiro Matsuo, Yuka Kishimoto, Tadao Inazu, Isao Kimura, Ken Izumori, Kazuya Akimitsu
Allitol is a hexitol produced by reducing the rare sugar D-allulose with a metal catalyst under hydrogen gas. To confirm the safe level of allitol, we conducted a series of safety assessments. From the results of Ames mutagenicity assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537, Escherichia coli strain WP2uvrA, and an in vitro chromosomal aberration test on cultured Chinese hamster cells, allitol did not show any significant genotoxic effect. No significant effects on general condition, urinalysis, hematology, physiology, histopathology, or at necropsy were observed at a dose of 1,500 mg/kg body weight of allitol in the acute and 90-day sub-chronic oral-toxicity assessments for rats...
June 24, 2023: Bioscience, Biotechnology, and Biochemistry