Karolina Louvanto, Lisanne Verhoef, Ville Pimenoff, Tiina Eriksson, Siiri Leppälä, Camilla Lagheden, Penelope Gray, Dorota Scibior-Bentkowska, Elizabeth Sumiec, Pekka Nieminen, Joakim Dillner, Johannes Berkhof, Chris J L M Meijer, Matti Lehtinen, Belinda Nedjai, Daniëlle A M Heideman
Cervical cancer screening programs, including triage tests, need redesigning as human papillomavirus (HPV)-vaccinated women are entering the programs. Methylation markers offer a potential solution to reduce false-positive rates by identifying clinically relevant cervical lesions with progressive potential. In a nested case-control study, 9242 women who received the three-dose HPV16/18-vaccine at ages 12-15 or 18 in a community-randomized trial were included. Subsequently, they were re-randomized for either frequent or infrequent cervical cancer screening trials...
May 27, 2024: International Journal of Cancer. Journal International du Cancer