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REVIEW
Georgios Sidiropoulos, Antonios Antoniadis, Athanasios Saplaouras, Georgios Bazoukis, Κonstantinos P Letsas, Theodoros D Karamitsos, Georgios Giannopoulos, Nikolaos Fragakis
Baseline RV function potentially determines response to Cardiac Resynchronization Therapy (CRT) but is not included in the current selection criteria for CRT. In this meta-analysis, we examine the value of echocardiographic indices of RV function as potential predictors of CRT outcomes in patients with standard indications for CRT. Baseline tricuspid annular plane systolic excursion (TAPSE) was consistently higher in CRT responders, and this association appears independent of age, sex, ischemic etiology of HF, and baseline left-ventricular ejection fraction (LVEF)...
March 11, 2023: Hellenic Journal of Cardiology: HJC
#22
REVIEW
Konstantinos Vlachos, Konstantinos P Letsas, Neil T Srinivasan, Antonio Frontera, Michael Efremidis, Stelios Dragasis, Claire A Martin, Ruaridh Martin, Takashi Nakashima, George Bazoukis, Takeshi Kitamura, Panagiotis Mililis, Athanasios Saplaouras, Stamatios Georgopoulos, Stamatios Sofoulis, Ourania Kariki, Stavroula Koskina, Masateru Takigawa, Frédéric Sacher, Pierre Jais, Pasquale Santangeli
In the setting of structural heart disease, ventricular tachycardia (VT) is typically associated with a re-entrant mechanism. In patients with hemodynamically tolerated VTs, activation and entrainment mapping remain the gold standard for the identification of the critical parts of the circuit. However, this is rarely accomplished, as most VTs are not hemodynamically tolerated to permit mapping during tachycardia. Other limitations include noninducibility of arrhythmia or nonsustained VT. This has led to the development of substrate mapping techniques during sinus rhythm, eliminating the need for prolonged periods of mapping during tachycardia...
February 2023: Heart rhythm O2
#23
JOURNAL ARTICLE
Alexander C Perino, Paul J Wang, Michael Lloyd, Francesco Zanon, Katsuhito Fujiu, Faizel Osman, Sem Briongos-Figuero, Toshiaki Sato, Tolga Aksu, Marek Jastrzebski, Skevos Sideris, Praveen Rao, Krzysztof Boczar, Xu Yuan-Ning, Michael Wu, Narayanan Namboodiri, Rodrigue Garcia, Vikas Kataria, Jan De Pooter, Oliver Przibille, Anil K Gehi, Oscar Cano, Grigorios Katsouras, Binni Cai, Klaus Astheimer, Tanyanan Tanawuttiwat, Tomas Datino, Jacques Rizkallah, Mohammad Alasti, Gregory Feld, Maria Teresa Barrio-Lopez, Mark Gilmore, Sergio Conti, Satoshi Yanagisawa, Julia H Indik, Jiangang Zou, Sandeep A Saha, Daniel Rodriguez-Munoz, Kuan-Cheng Chang, Dmitry S Lebedev, Miguel A Leal, Andreas Haeberlin, Alexander R J Dal Forno, Michael Orlov, Manuel Frutos, Pilar Cabanas-Grandio, Jonathan Lyne, Francisco Leyva, Jose Maria Tolosana, Pierre Ollitrault, Pasquale Vergara, Cristina Balla, Subodh R Devabhaktuni, Giovanni Forleo, Konstantinos P Letsas, Atul Verma, Jeffrey P Moak, Abhijeet B Shelke, Karol Curila, Edmond M Cronin, Piotr Futyma, Elaine Y Wan, Pietro Enea Lazzerini, Felipe Bisbal, Michela Casella, Gioia Turitto, Lawrence Rosenthal, T Jared Bunch, Artur Baszko, Nicolas Clementy, Yong-Mei Cha, Huang-Chung Chen, Vincent Galand, Robert Schaller, Julian W E Jarman, Masahide Harada, Yong Wei, Kengo Kusano, Constanze Schmidt, Marco Antonio Arguello Hurtado, Niyada Naksuk, Tadashi Hoshiyama, Krishna Kancharla, Yoji Iida, Mashiro Mizobuchi, Daniel P Morin, Serkan Cay, Gabriele Paglino, Tillman Dahme, Sharad Agarwal, Pugazhendhi Vijayaraman, Parikshit S Sharma
BACKGROUND: Adoption and outcomes for conduction system pacing (CSP), which includes His bundle pacing (HBP) or left bundle branch area pacing (LBBAP), in real-world settings are incompletely understood. We sought to describe real-world adoption of CSP lead implantation and subsequent outcomes. METHODS: We performed an online cross-sectional survey on the implantation and outcomes associated with CSP, between November 15, 2020, and February 15, 2021. We described survey responses and reported HBP and LBBAP outcomes for bradycardia pacing and cardiac resynchronization CRT indications, separately...
January 6, 2023: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
#24
REVIEW
Ourania Kariki, Konstantinos Vlachos, Stylianos Dragasis, Eleftheria-Garyfalia Tsetika, Kalliopi Perlepe, Athanasios Saplaouras, Eva Nyktari, Michael Efremidis, Konstantinos P Letsas
Atrial cardiomyopathy (AC) is an evolving pathophysiological entity that has expanded our understanding regarding the atrium and its role in arrhythmogenesis and cardiac thromboembolism. The pathological myocardium in AC promotes arrhythmogenesis through mechanical dysfunction (hypocontractility, fibrosis), adverse alterations of the endothelium and secretion of prothrombotic factors (IL-6, IL-8, TNF-a). 'Red flags', indicative of AC, can be recognized either non-invasively by electrocardiography, echocardiography and cardiac magnetic resonance imaging or invasively by high-density electroanatomical mapping as low bipolar voltage areas of the affected myocardium...
November 4, 2022: Journal of Electrocardiology
#25
REVIEW
Dimitrios Sfairopoulos, Tong Liu, Nan Zhang, Gary Tse, George Bazoukis, Konstantinos Letsas, Christos Goudis, Haralampos Milionis, Apostolos Vrettos, Panagiotis Korantzopoulos
Atrial fibrillation (AF) and atrial flutter (AFL) are associated with adverse outcomes in patients with heart failure and reduced ejection fraction (HFrEF). We investigated the effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on the incidence of AF and/or AFL in HFrEF patients. PubMed and ClinicalTrials.gov were systematically searched until March 2022 for randomized controlled trials (RCTs) that enrolled patients with HFrEF. A total of six RCTs with 9467 patients were included (N = 4731 in the SGLT2i arms; N = 4736 in the placebo arms)...
October 25, 2022: Heart Failure Reviews
#26
EDITORIAL
Konstantinos P Letsas, Athanasios Saplaouras
No abstract text is available yet for this article.
September 9, 2022: International Journal of Cardiology
#27
REVIEW
Comparing the performance of published risk scores in Brugada syndrome: a multi-center cohort study.
Sharen Lee, Jiandong Zhou, Cheuk To Chung, Rebecca On Yu Lee, George Bazoukis, Konstantinos P Letsas, Wing Tak Wong, Ian Chi Kei Wong, Ngai Shing Mok, Tong Liu, Qingpeng Zhang, Gary Tse
INTRODUCTION: The management of Brugada Syndrome (BrS) patients at intermediate risk of arrhythmic events remains controversial. The present study evaluated the predictive performance of different risk scores in an Asian BrS population and its intermediate risk subgroup. METHODS: This retrospective cohort study included consecutive patients diagnosed with BrS from January 1st , 1997 to June 20th , 2020 from Hong Kong. The primary outcome is sustained ventricular tachyarrhythmias...
September 1, 2022: Current Problems in Cardiology
#28
REVIEW
George Bazoukis, Jeremy Man Ho Hui, Yan Hiu Athena Lee, Oscar Hou In Chou, Dimitrios Sfairopoulos, Konstantinos Vlachos, Athanasios Saplaouras, Konstantinos P Letsas, Michael Efremidis, Gary Tse, Vassilios S Vassiliou, Panagiotis Korantzopoulos
Despite the strict indications for cardiac resynchronization therapy (CRT) implantation, a significant proportion of patients will fail to adequately respond to the treatment. This systematic review aims to present the existing evidence about the role of cardiac magnetic resonance (CMR) in identifying patients who are likely to respond better to the CRT. A systematic search in the MedLine database and Cochrane Library from their inception to August 2021 was performed, without any limitations, by two independent investigators...
November 2022: Heart Failure Reviews
#29
EDITORIAL
Konstantinos P Letsas, Konstantinos Vlachos
No abstract text is available yet for this article.
July 2022: JACC. Clinical Electrophysiology
#30
George Bazoukis, Elias Papasavvas, Marios Pavlou, Panagiota Georgiou, Lorentzos Kapetis, Dimitrios Patestos, Konstantinos Vlachos, Athanasios Saplaouras, Konstantinos P Letsas, Michael Efremidis, Michalis Tsielepis
Electrocardiographic findings including irregularity of the rhythm, a very rapid ventricular response, and the presence of a delta wave should raise the suspicion of pre-excited atrial fibrillation with a rapid ventricular response. Urgent cardioversion is needed due to the risk of sudden cardiac death.
July 2022: Clinical Case Reports
#31
JOURNAL ARTICLE
Nan Zhang, Yueying Wang, Ziliang Chen, Daiqi Liu, Gary Tse, Panagiotis Korantzopoulos, Konstantinos P Letsas, Christos A Goudis, Gregory Y H Lip, Guangping Li, Zhiwei Zhang, Tong Liu
Background and Aims: Vitamin D deficiency is a common disorder and has been linked with atrial fibrillation (AF) in several observational studies, although the causal relationships remain unclear. We conducted a Mendelian randomization (MR) analysis to determine the causal association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and AF. Methods and Results: The analyses were performed using summary statistics obtained for single-nucleotide polymorphisms (SNPs) identified from large genome-wide association meta-analyses conducted on serum 25(OH)D ( N = 79,366) and AF ( N = 1,030,836)...
2022: Frontiers in Nutrition
#32
REVIEW
George Bazoukis, Konstantinos Tyrovolas, Konstantinos P Letsas, Konstantinos Vlachos, Danny Radford, Cheuk To Chung, Tong Liu, Michael Efremidis, Gary Tse, Adrian Baranchuk
Left ventricular non-compaction cardiomyopathy (LVNC) is a congenital heart disease with autosomal dominant inheritance. This review aims to summarize the existing data about the predictors of fatal arrhythmias in patients with LVNC. Medline and Cochrane library databases were searched from inception to November 2021 for articles on LVNC. The reference lists of the relevant research studies as well as the relevant review studies and meta-analyses were also searched. Clinical symptoms and electrocardiogram findings such as left bundle branch block are significantly associated with ventricular arrhythmias...
July 1, 2022: Heart Failure Reviews
#33
REVIEW
Stylianos Dragasis, Konstantinos Vlachos, Ourania Kariki, Stavroula Koskina, Andromahi Zygouri, Ilias G Patsiotis, Aris Anastasakis, George Athanasopoulos, Konstantinos Ritsatos, Konstantinos Letsas, Michael Efremidis
Hypertrophic cardiomyopathy (HCM) represents the most common genetically inherited cardiovascular disorder and a leading cause of heart failure and sudden cardiac death. Atrial fibrillation (AF) is the most common arrhythmia encountered in HCM patients, primarily due to the process of left atrium dilatation and remodeling. Its presence typically leads to progressive functional decline, increased frequency of heart failure hospitalizations, and increased thromboembolic risk. In this mini-review, we summarize the contemporary data on AF pathophysiology, risk factors, and management in HCM patients suffering from AF...
May 15, 2022: Hellenic Journal of Cardiology: HJC
#34
EDITORIAL
Gary Tse, Nan Zhang, Wenhua Song, Konstantinos P Letsas, Tachapong Ngarmukos, Kamalan Jeevaratnam, Tong Liu
No abstract text is available yet for this article.
2022: Frontiers in Cardiovascular Medicine
#35
JOURNAL ARTICLE
Dimitrios Tachmatzidis, Anastasios Tsarouchas, Dimitrios Mouselimis, Dimitrios Filos, Antonios P Antoniadis, Dimitrios N Lysitsas, Nikolaos Mezilis, Antigoni Sakellaropoulou, Georgios Giannopoulos, Constantinos Bakogiannis, Konstantinos Triantafyllou, Nikolaos Fragakis, Konstantinos P Letsas, Dimitrios Asvestas, Michael Efremidis, Charalampos Lazaridis, Ioanna Chouvarda, Vassilios P Vassilikos
The identification of patients prone to atrial fibrillation (AF) relapse after catheter ablation is essential for better patient selection and risk stratification. The current prospective cohort study aims to validate a novel P-wave index based on beat-to-beat (B2B) P-wave morphological and wavelet analysis designed to detect patients with low burden AF as a predictor of AF recurrence within a year after successful catheter ablation. From a total of 138 consecutive patients scheduled for AF ablation, 12-lead ECG and 10 min vectorcardiogram (VCG) recordings were obtained...
March 28, 2022: Diagnostics
#36
JOURNAL ARTICLE
Cheuk To Chung, George Bazoukis, Sharen Lee, Ying Liu, Tong Liu, Konstantinos P Letsas, Antonis A Armoundas, Gary Tse
Ventricular arrhythmias (VAs) and sudden cardiac death (SCD) are significant adverse events that affect the morbidity and mortality of both the general population and patients with predisposing cardiovascular risk factors. Currently, conventional disease-specific scores are used for risk stratification purposes. However, these risk scores have several limitations, including variations among validation cohorts, the inclusion of a limited number of predictors while omitting important variables, as well as hidden relationships between predictors...
2022: International journal of arrhythmia
#37
REVIEW
Stylianos Dragasis, Konstantinos Vlachos, Antonio Frontera, Panagiotis Mililis, Athanasios Saplaouras, Andromahi Zygouri, Maria Erato Zymatoura, Marianthi Kontonika, Nikolaos Kafkas, Michael Efremidis, Konstantinos P Letsas
Outflow tract (OT) premature ventricular complexes (PVCs) are being recognized as a common and often troubling, clinical electrocardiographic finding. The OT areas consist of the Right Ventricular Outflow Tract (RVOT), the Left Ventricular Outflow Tract (LVOT), the Aortomitral Continuity (AMC), the aortic cusps and the Left Ventricular (LV) summit. By definition, all OT PVCs will exhibit an inferior QRS axis, defined as positive net forces in leads II, III and aVF. Activation mapping using the contemporary 3D mapping systems followed by pace mapping is the cornerstone strategy of every ablation procedure in these patients...
March 16, 2022: Reviews in Cardiovascular Medicine
#38
Konstantinos Vlachos, Charis Gkalapis, Michael Efremidis, George Bazoukis, Aggeliki Gouziouta, Pierre Jaïs, Konstantinos P Letsas
A 61-year-old man with highly symptomatic palpitations presented 13 months after undergoing pulmonary vein isolation for paroxysmal atrial fibrillation. A 12-lead electrocardiogram revealed atrial tachycardia, and the patient was scheduled for mapping, which revealed two regions of reconnection along the posterior part of the region of the left inferior pulmonary vein.
January 2022: Journal of Innovations in Cardiac Rhythm Management
#39
JOURNAL ARTICLE
George Bazoukis, Ioannis Liatakis, Vassilios S Vassiliou, Gary Tse, Pantelis Gounopoulos, Athanasios Saplaouras, Konstantinos P Letsas, Konstantinos Vlachos, Stamatis S Papadatos, Eleni Konstantinidou, Ioannis Lakoumentas, Antonios Sideris, Michael Efremidis
Sarcoidosis is a multisystem inflammatory disorder with an unknown origin. Symptomatic cardiac involvement is rare and occurs in about 5% of patients with sarcoidosis. Fatal ventricular arrhythmias are the most severe clinical presentation of the disease. Cardiac magnetic resonance (CMR) is a useful non-invasive tool for the risk stratification of ventricular arrhythmias and sudden cardiac death (SCD) in patients with cardiac sarcoidosis (CS). More specifically, late gadolinium enhancement (LGE), a CMR tool for scar detection, has been found to be significantly associated with arrhythmic events in CS patients...
January 28, 2022: Acta Cardiologica
#40
MULTICENTER STUDY
Sylvester Yao Lokpo, Ellis Owusu-Dabo, John Gameli Deku, Verner Ndudiri Orish, Gideon Kye-Duodu, Francis Abeku Ussher, Thomas Boakye, Daniel Adigbli, Louis Selassie Ameke, William Klutse Fianko, Robert Adedze-Kpodo, Henry Komla Letsa, Worlanyo Tashie, Noble Selorm Gbormittah, Godsway Edem Kpene, James Osei-Yeboah
Treponemal infections can be blood-borne with great public health consequences. This study is aimed at comparatively describing the five-year (2013-2017) regional epidemiology of treponemal infection using pregnant women in the sentinel survey and apparently healthy blood donors as a proxy for the general population at four sentinel sites in the Volta and Oti Regions of Ghana. We analyzed retrospective data from 17,744 prospective blood donors aged 18 to 58 years and 7,817 pregnant women in a sentinel survey with ages from 15 to 49 years at Hohoe, Ho, Tongu, and Krachi West sentinel sites in the Volta and Oti Regions...
2021: BioMed Research International
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