Ted R Mikuls, Quint Soto, Alison Petro, Lindsay Helget, Punyasha Roul, Harlan Sayles, Brendan Cope, Tuhina Neogi, Brian LaMoreaux, James R O'Dell, Bryant R England
Importance: Cardiometabolic and other risk factors could render patients with gout more likely to undergo lower extremity amputation (LEA). Objective: To examine the rate of and factors associated with LEA in patients with gout. Design, Setting, and Participants: In this matched cohort study using national administrative data, multivariable Cox proportional hazards regression models were used to examine the associations of gout with LEA. In analyses limited to patients with gout, attributes of serum urate control and treatment with urate-lowering therapy were examined as factors associated with LEA...
January 4, 2022: JAMA Network Open