Yujiao Wang, Xiao Wang, Tiantian Tang, Yundong Xie, Jia Li, Wenfei Wang, Taotao Li, Ding Liu, Kai Yang, Yajun Shi, Jing Sun, Dongyan Guo, Junbo Zou, Fengyun Bai, Ying Sun, Xiaofei Zhang, Changli Wang
PURPOSE: Frankincense has been shown in studies to have healing benefits for people with ulcerative colitis (UC). However, its underlying mechanisms have not been fully investigated. The objective of this study was to explore the potential molecular mechanisms of Frankincense essential oil (FREO) in improving dextran sodium sulfate (DSS)-induced UC from multiple perspectives. METHODS: The FREO components were analyzed by GC-MS, and the interactions between the key active components and the mechanism of FREO were determined based on RNA-seq, "quantity-effect" weighting coefficient network pharmacology, WGCNA and pharmacodynamic experiments...
November 10, 2023: Fitoterapia