Yuxuan Zheng, Siyuan Wang, Xingyu Zhou, Shitong Qiao, Xin Zhao, Yuan Chen, Zijun Li, Zhanguo Li, Xiaolin Sun, Shuguang Tan, Jing He, George F Gao
No abstract text is available yet for this article.
May 29, 2024: Science Bulletin
Riwanti Estiasari, Syairah Banu, Alvina Widhani, Fitri Octaviana, Kartika Maharani, Tiara Aninditha, Muthia Huda Islami, Darma Imran, Diatri Nari Lastri
OBJECTIVE: Neuropsychiatric SLE (NPSLE) has a broad spectrum and to date, there is no gold-standard biomarker. The diagnosis relies on clinical assessment, supporting examinations and exclusion of other possible aetiologies. One method that can be used to establish NPSLE is to conduct a re-evaluation by involving several fields of medical science. This study aims to reassess SLE cases with neuropsychiatric (NP) manifestations through multidisciplinary re-evaluation and determine the final diagnosis of NPSLE or non-NPSLE...
June 8, 2024: Lupus Science & Medicine
Xin He, Xiaochen Zhu, Zhiliu Tang, Kerry Gairy, Patricia Juliao, Zongxi Wu, Sheng Han
OBJECTIVES: Assess hospital healthcare resource utilization (HCRU) and associated hospital costs of patients with lupus nephritis (LN) in China and compare these outcomes with a systemic lupus erythematosus (SLE) cohort (SLE with/without LN) as well as exploring the effect of end-stage kidney disease (ESKD). METHODS: This retrospective administrative claims-based analysis identified patients with SLE and SLE with LN from China using diagnosis codes and keywords...
June 7, 2024: Value in Health Regional Issues
Joanna Kosałka-Węgiel, Renata Pacholczak-Madej, Radosław Dziedzic, Andżelika Siwiec-Koźlik, Magdalena Spałkowska, Mamert Milewski, Lech Zaręba, Stanisława Bazan-Socha, Mariusz Korkosz
OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a variable clinical manifestation, potentially leading to death. Importantly, patients with SLE have an increased risk of neoplastic disorders. Thus, this study aimed to comprehensively evaluate the clinical and laboratory characteristics of patients with SLE and with or without malignancy. METHODS: We conducted a retrospective analysis of medical records of 932 adult Caucasian patients with SLE treated at the University Hospital in Kraków, Poland, from 2012 to 2022...
June 8, 2024: Rheumatology International
(no author information available yet)
The 78th Annual Meeting of the Canadian Rheumatology Association was held at the RBC Convention Centre in Winnipeg, Manitoba, Canada, and virtually on February 28-March 2, 2024. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2024 Award Winners: Distinguished Rheumatologist, John M. Esdaile; Distinguished Investigator, Ann Clarke; Distinguished Teacher-Educator, Nicole Johnson; Emerging Investigator, Tom Appleton; Emerging Teacher-Educator, Pari Basharat; Ian Watson Award for the Best Abstract on SLE Research by a Trainee, Eugene Krustev; Phil Rosen Award for the Best Abstract on Clinical or Epidemiology Research by a Trainee, Derin Karacabeyli; Best Abstract on Research by a Rheumatology Resident, Shane Cameron; Best Abstract on Basic Science Research by a Trainee, Kaien Gu; Best Abstract by a Post-Graduate Research Trainee, Zoha Faheem; Best Abstract on Quality Care Initiatives in Rheumatology, Jean-Charles Mourot; Best Abstract by a Medical Student, Angel Gao; Best Abstract by an Undergraduate Student, Nicholas Chan; Best Abstract by a Rheumatology Post-Graduate Research Trainee, Carolina Munoz-Grajales; Best Abstract on Research by Young Faculty, Lauren King; Best Abstract on Pediatric Research by Young Faculty, Ruud Verstegen; Best Abstract on Spondyloarthritis Research, Fadi Kharouf...
June 7, 2024: Journal of Rheumatology
Shushu Du, Lili Zhao, Jiaming Wu, Xiaofei Shi, Rongzeng Liu
BACKGROUND: FOXP3 is a transcription factor that regulates the development and function of Treg, playing an essential role in preventing autoimmune diseases. Variation in FOXP3 can impair the function of Treg cells, thus destroying their inhibitory capacity and leading to autoimmune diseases. This paper investigated whether the three SNPs in the FOXP3 gene (-3279 C/A, -924 A/G and -6054 del/ATT) are associated with systemic lupus erythematosus (SLE) susceptibility in the Han Chinese population...
December 2024: Annals of Medicine
Tingyu Lang, Shaoqi Hua, Junhong Du, Xi Chen, Xiaowei Liu, Xing Ma, Xiaolei Liang, Yongxiu Yang
POI is a multifactorial disease due to lack of estrogen resulting in symptoms such as insomnia, osteoporosis, and voiding disorders. For most women, fertility is affected. Autoimmune diseases are chronic diseases caused by disorders of immune regulation that often harm the ovaries. Recent epidemiological studies have reported a correlation between autoimmune diseases (AIDs) and premature ovarian insufficiency (POI). This study aims to explore the causal relationship between AIDs and POI using bidirectional two-sample Mendelian randomization (MR)...
June 7, 2024: Reproductive Sciences
Bernard Rubin, Yan Chen, Karen Worley, Brendan Rabideau, Benson Wu, Rose Chang, Maral DerSarkissian
INTRODUCTION: Patients with systemic lupus erythematosus (SLE) have variable treatment pathways, including antimalarials, glucocorticoids, immunosuppressants, and/or biologics. This study describes differences in clinical outcomes when initiating belimumab (BEL) before and after immunosuppressant use. METHODS: This real-world, retrospective cohort study (GSK Study 217536) used de-identified administrative claims data from January 2015 to December 2022 in the Komodo Health Database...
June 7, 2024: Rheumatology and Therapy
Jing Zhang, Ruoshan Lian, Yi Chen, Jianxin Wan
OBJECTIVE: To investigate the correlations between serum antineutrophil cytoplasmic antibody (ANCA) and clinicopathological features, induction treatment response, and prognosis of lupus nephritis (LN) patients. METHODS: In this retrospective study, biopsy-proven LN patients from October 2010 to September 2020 were tested for serum ANCA by indirect immunofluorescence and ELISA and were divided into ANCA-positive group and ANCA-negative group. The clinicopathological data of the two groups were analyzed and compared...
December 2024: Renal Failure
Rasmus Søgaard Hansen, Julie Brogaard Larsen, Pernille Just Vinholt, Anne Voss, Anders Abildgaard
Individuals with antiphospholipid syndrome (APS) have antibodies directed against phospholipid-binding proteins (aPL). The condition is most associated with an increased risk of thromboembolism and obstetric complications. The 2023 classification criteria for APS include six clinical domains (venous thromboembolism, arterial thrombosis, microvascular events, obstetric events, cardiac valve, thrombocytopaenia) and two laboratory domains (lupus anticoagulant, and anti-cardiolipin or anti-β2-glycoprotein-I antibodies)...
May 20, 2024: Ugeskrift for Laeger
Arpita Singh, Shilpi Sahu, Neha R Jadhav, Navdeep Kaur
BACKGROUND: Connective tissue disorders (CTD's) are a group of autoimmune disorders having multifactorial etiology, multisystem involvement and overlapping clinical features. Their prevalence has been increasing in India, with Systemic lupus erythematosus (SLE) being the most common CTD, affecting mostly females. Antinuclear Antibodies (ANA) directed against a variety of nuclear antigens detectable in the serum are used for screening, diagnoses, and monitoring of autoimmune diseases, with immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) being the most widely used methods...
June 4, 2024: Indian Journal of Pathology & Microbiology
Fatimaezzahra Bensalek, Hajar Joulal, Jaouad Yousfi, Mouna Zahlane, Leila Benjilali, Lamiaa Essaadouni
BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, characterised by multi-organ affections. Haematological involvement is a common manifestation of SLE, consisting of autoimmune peripheral cytopenia. Autoimmune myelofibrosis (AIMF) is a rare cause of cytopenia in SLE; it could precede or be concurrent with the diagnosis of SLE. There are few studies that describe this association. CASE DESCRIPTION: We report a case of AIMF revealing the diagnosis of SLE in 34-year-old female, presented with episodes of gingival bleeding associated with peripheral inflammatory polyarthralgia, photosensitivity and deterioration of general condition...
2024: European Journal of Case Reports in Internal Medicine
Sandhya Kumari, Ghanshyam K Verma, Ajeet K Negi, Aakanksha Sharma
Leprosy is a silent disease with protean manifestations, especially during lepra reactions (LRs). Cases with atypical leprosy or LR simulate a number of conditions misdiagnosed frequently. Here, three classical cases of leprosy are reported for their complex presentation. Leprosy was hidden in Case 1 due to co-existing diabetes. COVID vaccination induced LR unmasked all leprosy lesions, which were extensive, large, bizarre and spreading to various immune zones. Case 2 presented with high-grade fever, tachycardia, generalized erythema and body aches...
2024: Indian Dermatology Online Journal
Paytra A Klein, Rose Parisi, Jency M Daniel, Roy S Rogers
The bond between humans and dogs is precious and has been treasured since ancient times. Dog ownership is linked to numerous health benefits, such as increased physical activity and social functioning and decreased depression and cardiovascular events. However, dogs can transmit zoonotic diseases to humans, many of which present with cutaneous findings. This review summarizes the dermatologic manifestations, transmission routes, diagnosis, and treatment of zoonotic diseases transmitted by dogs, including vector-borne, bacterial, viral, fungal, and parasitic infections...
June 6, 2024: International Journal of Dermatology
Stanley Cohen, Jean S Beebe, Vishala Chindalore, Shunjie Guan, Mina Hassan-Zahraee, Madhurima Saxena, Li Xi, Craig Hyde, Sarita Koride, Robert Levin, Shannon Lubaczewski, Mikhail Salganik, Abigail Sloan, Erin Stevens, Elena Peeva, Michael S Vincent, David A Martin, Myron Chu
BACKGROUND: The objective of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl immunoglobulin G1 antibody targeting C-X-C chemokine receptor type 5 (CXCR5) that potentially depletes B cells, follicular T helper (Tfh) cells, and circulating Tfh-like (cTfh) cells, in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). METHODS: This first-in-human, multicenter, double-blind, sponsor-open, placebo-controlled Phase 1 study recruited patients aged 18-70 years with SLE or RA...
June 6, 2024: Arthritis Research & Therapy
Anna Radziszewska, Hannah Peckham, Nina M de Gruijter, Restuadi Restuadi, Wing Han Wu, Elizabeth C Jury, Elizabeth C Rosser, Coziana Ciurtin
While adaptive immune responses have been studied extensively in SLE (systemic lupus erythematosus), there is limited and contradictory evidence regarding the contribution of natural killer (NK) cells to disease pathogenesis. There is even less evidence about the role of NK cells in the more severe phenotype with juvenile-onset (J)SLE. In this study, analysis of the phenotype and function of NK cells in a large cohort of JSLE patients demonstrated that total NK cells, as well as perforin and granzyme A expressing NK cell populations, were significantly diminished in JSLE patients compared to age- and sex-matched healthy controls...
June 6, 2024: Scientific Reports
Emmanuel Campos-Tinajero, Maria Fernanda Ortiz-Nuño, Diana Paola Flores-Gutierrez, Jorge Antonio Esquivel-Valerio, Gisela Garcia-Arellano, Jesus Alberto Cardenas-de la Garza, Estefania Aguilar-Rivera, Dionicio A Galarza-Delgado, Griselda Serna-Peña
OBJECTIVE: Stress and trauma are psychosocial factors with an impact on the course of systemic lupus erythematosus (SLE). The influence of violence on SLE has not been entirely explored, even though women (including patients with rheumatic diseases) are a vulnerable population to any form of violence. This study aims to assess the prevalence and impact of intimate partner violence (IPV) on health-related quality of life in women with SLE. METHODS: An observational, cross-sectional, and analytical study was conducted at a rheumatology clinic of a university hospital from September 2022 and September 2023...
June 6, 2024: Lupus
Mahdieh Naghavi Alhosseini, Padideh Ebadi, Mohammad Hossein Karimi, Graziella Migliorati, Luigi Cari, Giuseppe Nocentini, Mozhdeh Heidari, Saeede Soleimanian
In the last decade, cell therapies have revolutionized the treatment of some diseases, earning the definition of being the "third pillar" of therapeutics. In particular, the infusion of regulatory T cells (Tregs) is explored for the prevention and control of autoimmune reactions and acute/chronic allograft rejection. Such an approach represents a promising new treatment for autoimmune diseases to recover an immunotolerance against autoantigens, and to prevent an immune response to alloantigens. The efficacy of the in vitro expanded polyclonal and antigen-specific Treg infusion in the treatment of a large number of autoimmune diseases has been extensively demonstrated in mouse models...
June 4, 2024: Transplant Immunology
Taejoon Won, Evelyn J Song, Hannah M Kalinoski, Javid J Moslehi, Daniela Čiháková
Autoimmunity significantly contributes to the pathogenesis of myocarditis, underscored by its increased frequency in autoimmune diseases such as systemic lupus erythematosus and polymyositis. Even in cases of myocarditis caused by viral infections, dysregulated immune responses contribute to pathogenesis. However, whether triggered by existing autoimmune conditions or viral infections, the precise antigens and immunologic pathways driving myocarditis remain incompletely understood. The emergence of myocarditis associated with immune checkpoint inhibitor therapy, commonly used for treating cancer, has afforded an opportunity to understand autoimmune mechanisms in myocarditis, with autoreactive T cells specific for cardiac myosin playing a pivotal role...
June 7, 2024: Circulation Research
Jiho Park, Jongeun Lee, Yunjung Hur, Chan-Johng Kim, Han Bit Kim, Dahun Um, Da Som Kim, June-Yong Lee, Sungjun Park, Youngjae Park, Tae-Kyung Kim, Sin-Hyeog Im, Sung Won Kim, Seung-Ki Kwok, Yoontae Lee
Follicular helper T (TFH ) cells mediate germinal center reactions to generate high affinity antibodies against specific pathogens, and their excessive production is associated with the pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE). ETV5, a member of the ETS transcription factor family, promotes TFH cell differentiation in mice. In this study, we examined the role of ETV5 in the pathogenesis of lupus in mice and humans. T cell-specific deletion of Etv5 alleles ameliorated TFH cell differentiation and autoimmune phenotypes in lupus mouse models...
June 11, 2024: Proceedings of the National Academy of Sciences of the United States of America
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