Bingwen Eugene Fan, Jensen Ng, Stephrene Seok Wei Chan, Dheepa Christopher, Allison Ching Yee Tso, Li Min Ling, Barnaby Edward Young, Lester Jun Long Wong, Christina Lai Lin Sum, Hwee Tat Tan, Mui Kia Ang, Gek Hsiang Lim, Kiat Hoe Ong, Ponnudurai Kuperan, Yew Woon Chia
Patients with COVID-19 are known to be at risk of developing both venous, arterial and microvascular thrombosis, due to an excessive immuno-thrombogenic response to the SARS-CoV-2 infection. Overlapping syndromes of COVID-19 associated coagulopathy with consumptive coagulopathy and microangiopathy can be seen in critically ill patients as well. Blood was collected from 12 Intensive Care Unit (ICU) patients with severe COVID-19 who were on either mechanical ventilation or on high flow oxygen with a PaO2/FiO2 ratio of <300 mmHg...
October 24, 2020: Journal of Thrombosis and Thrombolysis
Alisha Gupta, Kelly J Shields, Susan Manzi, Mary Chester Wasko, Tarun S Sharma
OBJECTIVE: To study the relationship between hydroxychloroquine (HCQ) use and new onset atrial fibrillation in patients with systemic lupus erythematosus (SLE). METHODS: A retrospective cohort of adult SLE patients from Dec 1, 2014 to May 30, 2017 was constructed. Patients were categorized as either HCQ users or non-users. The primary outcome was incident atrial fibrillation; secondary outcomes included incident ventricular arrhythmias (composite of ventricular tachycardia (VT), ventricular fibrillation (VF), or torsades de pointes)...
October 23, 2020: Arthritis Care & Research
Yushiro Endo, Tomohiro Koga, Atsushi Kawakami
No abstract text is available yet for this article.
October 24, 2020: Rheumatology
Christopher D Scharer, Karen A Fortner, Julie A Dragon, Scott Tighe, Jeremy M Boss, Ralph C Budd
Systemic lupus erythematosus (SLE) is characterized by increased DNA demethylation in T cells, although it is unclear whether this occurs primarily in a subset of SLE T cells. The process driving the DNA demethylation and the consequences on overall gene expression are also poorly understood and whether this represents a secondary consequence of SLE or a primary contributing factor. Lupus-prone lpr mice accumulate large numbers of T cells with age because of a mutation in Fas (CD95). The accumulating T cells include an unusual population of CD4- CD8- TCR-αβ+ (DN) T cells that arise from CD8+ precursors and are also found in human SLE...
October 23, 2020: ImmunoHorizons
Juliana P Ocanha-Xavier, Camila O Cola-Senra, Jose Candido C Xavier-Junior
Reticular erythematous mucinosis (REM) was first described 50 years ago, but only around 100 case reports in English have been published. Its relation with other inflammatory skin disorders is still being debated. We report a case of REM, including the clinical and histopathological findings. Also, a systematic review of 94 English-language reported cases is provided. The described criteria for clinical and histopathological diagnosis are highlighted in order to REM can be confidently diagnosed.
October 23, 2020: Lupus
Xiaorong Han, Cheng Li, Shuai Zhang, Xiaojie Hou, Zhongbo Chen, Jin Zhang, Ying Zhang, Jian Sun, Yonggang Wang
Platelets play such an important role in the process of thrombosis that patients with thrombocytopenia generally have an increased risk of bleeding. However, abnormal thrombotic events can sometimes occur in patients with thrombocytopenia, which is unusual and inexplicable. The treatments for thrombocytopenia and thromboembolism are usually contradictory. This review introduces the mechanisms of thromboembolism in patients with different types of thrombocytopenia and outlines treatment recommendations for the prevention and treatment of thrombosis...
October 8, 2020: Thrombosis Research
Zara Izadi
No abstract text is available yet for this article.
October 2020: Arthritis Care & Research
Silvia Rosina, Jessica Tibaldi, Marta Mazzoni, Cecilia Bava, Valentina Natoli, Angelo Ravelli
No abstract text is available yet for this article.
October 2020: Arthritis Care & Research
Erin B Treemarcki, Aimee O Hersh
No abstract text is available yet for this article.
October 2020: Arthritis Care & Research
Shilpa Arora, David A Isenberg, Isabel Castrejon
No abstract text is available yet for this article.
October 2020: Arthritis Care & Research
Caleb Liles, Chase Warner, Ronald Warwar
Purpose: Systemic sclerosis (SSc) is characterized by multi-system inflammation and fibrosis. Ophthalmologists must be aware of the uncommon ocular features of SSc to secure the diagnosis. Observations: Here we report the rare occurrence of bilateral cotton wool spots in an 86-year-old woman with SSc/lupus overlap syndrome presenting with a history of chronic obstructive pulmonary disease, gastroesophageal reflux disease, polymyalgia rheumatica, scalp tenderness, and right jaw pain on chewing...
December 2020: American Journal of Ophthalmology Case Reports
Ichiro Kobayashi, Shunichiro Takezaki, Yusuke Tozawa, Masahiro Ueki, Asako Hayashi, Takeshi Yamazaki, Yasuyuki Sato, Takayuki Okamoto, Masafumi Yamada, Tadashi Ariga
Although acute poststreptococcal glomerulonephritis (APSGN) and acute rheumatic fever (ARF) are well-known complications of group A streptococcus infection, concomitant occurrence of both diseases is rare. We report an 11-year-old Japanese girl with primary Sjögren's syndrome complicated by acute renal failure about 2 weeks after the onset of pharyngitis. Although histopathological findings of the kidney were not confirmative, APSGN was suggested by the spontaneous recovery of her renal function, typical latent period with high levels of antistreptolysin O and low serum levels of C3 but not of C4...
July 2020: Modern rheumatology case reports
Masashi Funada, Kazuhisa Nakano, Ippei Miyagawa, Masanobu Ueno, Yoshiya Tanaka
Protein-losing enteropathy (PLE) is a rare organ disorder that can develop as a complication of systemic lupus erythematosus (SLE). Here, we report the case of a 59-year-old woman with SLE who experienced recurrent PLE resulting from different pathological conditions. The patient was diagnosed with SLE in X-14. In X-12, she was hospitalised due to persistent diarrhoea, generalised oedema, abdominal distension, dyspnoea on exertion, and hypoalbuminemia. A thrombus was noted in the superior mesenteric vein extending from the main trunk of the portal vein...
July 2020: Modern rheumatology case reports
Adam Scott-Charlton, Gemma Reynolds
A 21-year-old female with a history of systemic lupus erythematosus (SLE) presented to the emergency department with septic shock. She had been maintained on 5 mg prednisolone daily and hydroxychloroquine 400 mg once daily and been investigated three years prior for recurrent left upper quadrant chest pain. Her previous SLE complications included pericardial effusion and high-risk pregnancy. Intensive care support was required due to septic shock, and a diagnosis of primary invasive S treptococcus pneumoniae bacteraemia was made following positive blood cultures...
July 2020: Modern rheumatology case reports
Yoshihiko Tomofuji, Yuichi Ishikawa, Koto Hattori, Michio Fujiwara, Yasuhiko Kita
Systemic lupus erythematosus (SLE)-associated haemophagocytic lymphohistiocytosis (HLH) is called acute lupus haemophagocytic syndrome (ALHS), which is relatively rare but life-threatening. We present the case of a 43-year-old woman diagnosed with SLE with panniculitis, pleuritis, and autoimmune hepatitis. She was treated with high-dose glucocorticoids. Although disease activity temporarily improved, she developed fever, elevation of liver enzymes, hyperferritinemia, severe inflammatory response, and thrombocytopenia a month after starting glucocorticoids...
July 2020: Modern rheumatology case reports
Shiau Li Lim, Ping Seung Ong, Chiew Gek Khor
Tuberculosis (TB) and its association with rheumatic diseases have been widely recognised. Occurrence of multifocal skeletal involvement constitutes <5% of all skeletal TB cases. We present a Malay patient with multifocal osteoarticular TB (OATB). A 35 year-old SLE woman with background usage of corticosteroid therapy and Azathioprine presented with lupus nephritis flare. Renal biopsy revealed diffuse proliferative lupus nephritis and intravenous (IV) Cyclophosphamide 0.5 g/m2 (850 mg) was initiated...
July 2020: Modern rheumatology case reports
Kojiro Sato, Yoshimi Aizaki, Yoshihiro Yoshida, Toshihide Mimura
Psoriasis is a chronic disease of the skin that often affects the joints (psoriatic arthritis, PsA). Biologic agents such as TNF-α, IL-23 and IL-17 blockers have been proven to be quite effective against psoriasis and PsA, indicating the importance of those cytokines in the pathogenesis of the diseases. The importance of the IL-23/IL-17 axis has also been reported in systemic lupus erythematosus (SLE), but the safety and effectiveness of IL-17 blockers in SLE remain largely unknown. We encountered a patient with PsA and SLE...
July 2020: Modern rheumatology case reports
Syoko Tsubouchi, Haeru Hayashi, Koichiro Tahara, Kayo Ishii, Takuya Yasuda, Yusuke Yamamoto, Takahiro Mizuuchi, Hiroaki Mori, Mayu Tago, Eri Kato, Tetsuji Sawada
Neuropsychiatric (NP) manifestations of systemic lupus erythematosus (SLE) are diverse, but involvement of basal ganglia is rare. We describe here a 28-year-old woman with NPSLE presenting aseptic meningitis accompanied by elevated interleukin-6 levels in the cerebrospinal fluid, who developed symmetrical basal ganglia lesions, containing a cytotoxic oedematous core, surrounded by vasogenic oedema upon magnetic resonance imaging. We were able to observe these lesions from a de novo appearance during the disease onset to its disappearance during immunosuppressive treatment...
January 2020: Modern rheumatology case reports
Takayasu Ando, Yoshioki Yamasaki, Yukiko Takakuwa, Harunobu Iida, Yusa Asari, Kanako Suzuki, Marina Uchida, Nozomi Kotoku, Yasuhiro Tanabe, Motohiro Chosokabe, Masahide Takahashi, Kengo Suzuki, Yoshihiro J Akashi, Hidehiro Yamada, Kimito Kawahata
Acute lupus myocarditis and pulmonary arterial hypertension (PAH) are rare complications associated with systemic lupus erythematosus (SLE). No previous reports have shown the coexistence of these disorders. Here we present a 41-year-old patient with SLE who concurrently developed severe acute lupus myocarditis and PAH with digital gangrene as an initial manifestation. Acute lupus myocarditis and PAH were successfully treated with prednisolone and intravenous cyclophosphamide pulse therapy (600-700 mg × 6) along with anticoagulant therapy...
January 2020: Modern rheumatology case reports
Yoichi Nakayama, Daisuke Taura, Kimitaka Shibue, Nobuo Kuramoto, Tsuneyo Mimori, Nobuya Inagaki
An 18-year-old female was diagnosed with subclinical Cushing's syndrome (CS) due to a left adrenal adenoma. When she was 20 years old, she developed lupus nephritis. She was treated with high-dose prednisolone (PSL) and soon developed the symptoms of CS. When she was 25 years old, we evaluated her serum glucocorticoid level while she continued to take oral PSL. The result suggested her CS was affected by both the oral PSL and the endogenous cortisol secreted by the adrenocortical adenoma, which was therefore resected...
January 2020: Modern rheumatology case reports
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