Miguel Ángel Saavedra, Dafhne Miranda-Hernández, Alejandra Lara-Mejía, Antonio Sánchez, Sara Morales, Claudia Cruz-Reyes, Pilar Cruz-Domínguez, Gabriela Medina, Luis Javier Jara
INTRODUCTION: Several factors have been associated with the development of preeclampsia in women with systemic lupus erythematosus (SLE). OBJECTIVE: To identify risk factors associated with preeclampsia in patients with SLE and its impact on fetal outcomes. PATIENTS AND METHODS: We studied a prospective cohort of pregnancies in women with SLE from January 2009 to December 2018. Demographic, clinical, serological and drug use characteristics were compared between patients who developed preeclampsia and those who did not, as well as the main neonatal outcomes...
March 30, 2020: International Journal of Rheumatic Diseases
Joshua A Ronen, Armugam Mekala, Catherine Wiechmann, Sai Mungara
Enteritis associated with systemic lupus erythematosus (SLE) is a rare and unusual manifestation of the gastrointestinal (GI) consequences of SLE itself. Complications of the enteritis component include mesenteric vasculitis, intestinal pseudo-obstruction, and protein-losing enteropathy. Lupus enteritis is very responsive to treatment with pulse steroids in almost 70% of the patients, but it is critical to diagnose it early to prevent devastating organ damage. The case describes a 21-year-old Caucasian female with a past medical history of uncomplicated laparoscopic appendectomy (one month prior to the time of presentation), major depressive disorder, asthma, iron deficiency anemia, pelvic inflammatory disease secondary to sexually transmitted Chlamydia trachomatis infection, and SLE (diagnosed two weeks prior to presentation)...
February 21, 2020: Curēus
Alicia J Little, Matthew D Vesely
Cutaneous lupus erythematosus (CLE) is an autoimmune disease of the skin with significant morbidity. Current treatments are often inadequate to control disease and there are no Food and Drug Administration (FDA)-approved therapies for this potentially debilitating disease, underscoring an unmet medical need. Recent insights into disease pathogenesis have implicated innate and adaptive immune components, including type I and type III interferons in the development of CLE. Promising clinical trials based on these insights are now underway...
March 2020: Yale Journal of Biology and Medicine
Leslie Carstensen Floren, Jennifer Mandal, Maria Dall'Era, Jaekyu Shin, David M Irby, Olle Ten Cate, Bridget C O'Brien
Objective. To develop and evaluate a mobile learning module to support knowledge construction between medical and pharmacy students through structured dialogue prompts. Methods. Rheumatologists and pharmacists collaboratively developed a two-week, case-based, asynchronous interprofessional learning module that was delivered via a mobile app and focused on collaborative medication management of a complex case involving a patient with systemic lupus erythematosus. The clinical case evolved over three phases: diagnosis, initial treatment, and medication-related complications...
February 2020: American Journal of Pharmaceutical Education
Seungwon Ryu, Eun Young Lee, Dong Ki Kim, Yon Su Kim, Doo Hyun Chung, Ji Hyung Kim, Hajeong Lee, Hye Young Kim
BACKGROUND: Innate lymphoid cells (ILCs) play an essential role in maintaining homeostasis; however, they can also cause chronic inflammation and autoimmune disease. This study aimed to identify the role of ILCs in the pathogenesis of lupus nephritis (LN). METHODS: The percentage of ILCs within the peripheral blood mononuclear cell (PBMC) population and urine of patients with LN (n = 16), healthy controls (HC; n = 8), and disease controls (ANCA-associated vasculitis (AAV; n = 6), IgA nephropathy (IgAN; n = 9), and other glomerular diseases (n = 5)) was determined by flow cytometry analysis...
March 29, 2020: Arthritis Research & Therapy
Giulia Calabrese, Gaetano Licata, Alessio Gambardella, Alina De Rosa, Andrea Ronchi, Giuseppe Argenziano
No abstract text is available yet for this article.
March 29, 2020: Journal of Cutaneous Pathology
Hanxiao You, Dong Xu, Jiuliang Zhao, Jing Li, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng
The dysregulation of the JAK-STAT pathway is associated with various immune disorders. Four JAK inhibitors have been approved for rheumatoid arthritis (RA), and numerous JAK inhibitors are currently being tested in phase II and III trials for the treatment of various autoimmune inflammatory diseases. In this narrative review, we elucidate the involvement of the JAK-STAT signaling pathway in the pathogenesis of connective tissue diseases (CTDs). We also discuss the efficacy of the first- and second-generation JAK inhibitors (tofacitinib, baricitinib, ruxolitinib, peficitinib, filgotinib, upadacitinib, solcitinib, itacitinib, decernotinib, R333, and pf-06651600) for CTDs including RA, systemic lupus erythematosus, dermatomyositis, systemic sclerosis, Sjögren's syndrome, and vasculitis, based on laboratory and clinical research findings...
March 28, 2020: Clinical Reviews in Allergy & Immunology
Laura Batlle-Masó, Anna Mensa-Vilaró, Manuel Solís-Moruno, Tomàs Marquès-Bonet, Juan I Arostegui, Ferran Casals
Autoinflammatory diseases comprise a wide range of syndromes caused by dysregulation of the innate immune response. They are difficult to diagnose due to their phenotypic heterogeneity and variable expressivity. Thus, the genetic origin of the disease remains undetermined for an important proportion of patients. We aim to identify causal genetic variants in patients with suspected autoinflammatory disease and to test the advantages and limitations of the clinical exome gene panels for molecular diagnosis. Twenty-two unrelated patients with clinical features of autoinflammatory diseases were analyzed using clinical exome sequencing (∼4800 genes), followed by bioinformatic analyses to detect likely pathogenic variants...
March 25, 2020: European Journal of Medical Genetics
Renaud Felten, Laurent Arnaud
No abstract text is available yet for this article.
March 25, 2020: Joint, Bone, Spine: Revue du Rhumatisme
Ee-Ling Lai, Wen-Nan Huang, Hsin-Hua Chen, Jun-Peng Chen, Der-Yuan Chen, Tsu-Yi Hsieh, Wei-Ting Hung, Kuo-Lung Lai, Ching-Tsai Lin, Kuo-Tung Tang, Yi-Ming Chen, Yi-Hsing Chen
PURPOSE: Recently, trabecular bone score (TBS) has emerged as an important supplementary assessment tool in osteoporosis diagnosis and management. The high incidence of fragility fracture within the non-osteoporotic range of bone mineral density (BMD), among systemic lupus erythematosus (SLE) patients, highlights the crucial role of bone microarchitecture in osteoporosis. This study aimed to evaluate whether TBS identified existing vertebral fractures (VF) more accurately than BMD in SLE patients...
March 27, 2020: Archives of Osteoporosis
H-M Lorenz, L Pieterse, T Rüter, F Lorenz
The differential diagnosis of fever, especially in the context of autoimmune diseases is broad. Accordingly, the spectrum of diagnostic procedures is extensive and the therapeutic consequences are partly contradictory. Fever is basically the manifestation of an increased cell proliferation, such as classically seen in tumors, infections or autoimmune inflammation. Systemic lupus erythematosus (SLE) is one of the most multifaceted rheumatological diseases. Fever is one component of the new classification criteria which help to classify and possibly diagnose SLE...
March 27, 2020: Zeitschrift Für Rheumatologie
David Eldeiry, Moe Zandy, Oshrat E Tayer-Shifman, Andrew Kwan, Sherief Marzouk, Jiandong Su, Kathleen Bingham, Zahi Touma
OBJECTIVES: To study the clinical phenotypes, determined based on cumulative disease activity manifestations, and sociodemographic factors associated with depression and anxiety in SLE. METHODS: Patients attending a single centre were assessed for depression and anxiety. SLE clinical phenotypes were based on the organ systems of cumulative 10-year SLE Disease Activity Index 2000 (SLEDAI-2K), prior to visit. Multivariable logistic regression analyses for depression, anxiety, and coexisting anxiety and depression were performed to study associated SLE clinical phenotypes and other factors...
March 28, 2020: Rheumatology
Adriana Maria Paixao De Sousa Da Silva, Maria Isabel De Moraes-Pinto, Regina Célia Menezes Succi, Maria Teresa Terreri, Daisy Maria Machado
BACKGROUND: HIV infection and juvenile systemic lupus erythematosus (jSLE) are risk factors for the development of herpes zoster (HZ) and its complications. Both diseases share similar immunological aspects, such as immunodeficiency and immune activation. Therefore, our objective was to evaluate and compare the frequency and characteristics of HZ episodes in pediatric patients with HIV infection and jSLE. METHODS: A retrospective cohort study was carried out with the evaluation of 2 pediatric cohorts: HIV patients who were followed from January 1987 to December 2014 and patients with jSLE followed up from January 1990 to December 2014 in outpatient clinics...
March 20, 2020: Pediatric Infectious Disease Journal
Antonis Fanouriakis, Myrto Kostopoulou, Kim Cheema, Hans-Joachim Anders, Martin Aringer, Ingeborg Bajema, John Boletis, Eleni Frangou, Frederic A Houssiau, Jane Hollis, Adexandre Karras, Francesca Marchiori, Stephen D Marks, Gabriella Moroni, Marta Mosca, Ioannis Parodis, Manuel Praga, Matthias Schneider, Josef S Smolen, Vladimir Tesar, Maria Trachana, Ronald F van Vollenhoven, Alexandre E Voskuyl, Y K Onno Teng, Bernadette van Leew, George Bertsias, David Jayne, Dimitrios T Boumpas
OBJECTIVE: To update the 2012 EULAR/ERA-EDTA recommendations for the management of lupus nephritis (LN). METHODS: Following the EULAR standardised operating procedures, a systematic literature review was performed. Members of a multidisciplinary Task Force voted independently on their level of agreeement with the formed statements. RESULTS: The changes include recommendations for treatment targets, use of glucocorticoids and calcineurin inhibitors (CNIs) and management of end-stage kidney disease (ESKD)...
March 27, 2020: Annals of the Rheumatic Diseases
Masaud Shah, Gi-Young Kim, Asma Achek, Eun-Young Cho, Wook-Young Baek, Yang Seon Choi, Wang Hee Lee, Dong-Jin Kim, Sang Ho Lee, Wook Kim, Soon Sun Kim, Jae Youn Cheong, Chang-Hee Suh, Sangdun Choi
Despite being crucial for combating microbes, paradoxical Toll-like receptors (TLRs) signaling have been associated with the aggravation of multiple immune disorders such as systemic lupus erythematosus, psoriasis, rheumatoid arthritis, and nonalcoholic steatohepatitis. The stoichiometry and precise arrangement of the interaction of adapters (via their Toll/interleukin-1 receptor [TIR] domains) are indispensable for the activation of TLRs and of downstream signaling cascades. Among adapters, plasma membrane-anchored MyD88 adaptor-like (MAL) has the potential for BB-loop-mediated self-oligomerization and interacts with other TIR domain-containing adaptors through αC and αD helices...
March 17, 2020: Biomaterials
Samir V Parikh, Salem Almaani, Sergey Brodsky, Brad H Rovin
Systemic lupus erythematosus is a multisystem autoimmune disease that commonly affects the kidneys. Lupus nephritis (LN) is the most common cause of kidney injury in systemic lupus erythematosus and a major risk factor for morbidity and mortality. The pathophysiology of LN is heterogeneous. Genetic and environmental factors likely contribute to this heterogeneity. Despite improved understanding of the pathogenesis of LN, treatment advances have been few and risk for kidney failure remains unacceptably high...
March 24, 2020: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
S Mokhtari, A Benzirar, O El Mahi
The diversity of juvenile arterial disease aetiologies requires a systematic investigation when limb critical ischemia is diagnosed before the age of 50. We would like to share a rare case of a young woman who was diagnosed with Lupus disease revealed by distal ischemia of the foot.
March 24, 2020: Annales de Cardiologie et D'angéiologie
R Alten, M Mischkewitz, A-L Stefanski, T Dörner
BACKGROUND: Cytokines and associated intracellular signal cascades play a major role in the pathogenesis of autoimmune diseases. Janus kinases (JAK) are part of these intracellular signal transduction processes. A relatively new drug group of targeted synthetic disease-modifying antirheumatic drugs (tsDMARD) are JAK inhibitors (JAKi) and are a promising treatment approach for autoimmune diseases. EFFICACY: Hitherto, three JAKis, Tofacitinib, Baricitinib and Upadacitinib, have been approved for treatment of Rheumatoid Arthritis (RA) in the USA, Switzerland and the EU...
March 26, 2020: Zeitschrift Für Rheumatologie
Yan Zhang, Ming Hu, Dong Wei, Hui Zhang, Bao Chu, Hao-Ming Xu, Tao Wang
Both the herpes zoster virus and suid herpesvirus type 1 (SuHV-1) belong to the Varicellovirus genus of the α-herpesviridae subfamily. They may cause opportunistic infections especially in patients with kidney diseases, varying from latent illness to overt lethality. Under these circumstances, impaired renal function is both the culprit for and victim of the infection. However, fulminant eruption of severe skin herpes zoster in lupus nephritis (LN) patients under prolonged immunosuppressive therapy is rare and even more rarely seen is the SuHV-1 encephalitis in human...
2020: International Journal of Medical Sciences
Nikolaus Kögl, Martin Dostal, Alexander Örley, Claudius Thomé, Sebastian Hartmann
Pedicle fractures are rare and usually associated with repetitive stress, high-speed trauma, osteoporosis, unilateral spondylolysis, or instrumentation surgery. A review of the current literature on bilateral pedicle fractures of the lumbar spine revealed only a few cases listed as a complication of instrumentation or excessive decompression surgery. The authors present the clinical case of a 49-year-old man with exacerbating low-back pain and intermittent L5 radicular pain. The known comorbidities were rather remarkable for systemic lupus erythematosus and osteopenia...
March 27, 2020: Journal of Neurosurgery. Spine
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