Aishwarya Ravindran, Marta Casal Moura, Fernando C Fervenza, Samih H Nasr, Mariam P Alexander, Mary E Fidler, Loren P Herrera Hernandez, Pingchuan Zhang, Joseph P Grande, Lynn D Cornell, Lou Ann Gross, Vivian Negron, Grace E Jenson, Benjamin J Madden, M Cristine Charlesworth, Sanjeev Sethi
BACKGROUND: In patients with secondary (autoimmune) membranous nephropathy, two novel proteins, Exostosin 1 and Exostosin 2 (EXT1/EXT2), are potential disease antigens, biomarkers, or both. In this study, we validate the EXT1/EXT2 findings in a large cohort of membranous lupus nephritis. METHODS: We conducted a retrospective cohort study of patients with membranous lupus nephritis, and performed immunohistochemistry studies on the kidney biopsy specimens against EXT1 and EXT2...
January 21, 2021: Journal of the American Society of Nephrology: JASN