Sinan Bekmez, Harun Cakmak, Tolga Kocaturk, Fulden Cantas, Sema Dundar
OBJECTIVE: To evaluate intraocular pressure (IOP) and corneal biomechanical properties changes after intravitreal ranibizumab injection (IVRI). METHODS: One hundred twenty eyes of 120 patients who underwent IVRI between January and March 2018 in Adnan Menderes University Ophthalmology Clinic were included in study. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) were measured by Ocular Response Analyzer (ORA) by the same specialist preoperatively (preop), postoperative 1st (postop-1st), postoperative 3rd (postop-3rd), and postoperative 24th hours (postop-24th) after single-dose IVRI...
November 9, 2020: Graefe's Archive for Clinical and Experimental Ophthalmology
Shing Chuen Chow, Barry Yat Ming Yeung
This paper aims to review different tonometers for intraocular pressure measurement in eyes after photorefractive keratectomy or small incision lenticule extraction. An Entrez Pubmed search was performed on July 19th, 2020. There were 32 eligible articles investigated in the use of tonometers or biomechanical properties of cornea in post photorefractive keratectomy eyes and 11 articles investigated in post small incision lenticule extraction eyes. Corvis ST and dynamic contour tonometry were found to be accurate for intraocular pressure measurement in post photorefractive keratectomy eyes...
2020: Clinical Ophthalmology
S M Bauer, L A Venatovskaya, L A Avershina, S M Pikusova
Modern tonometers (Ocular Response Analyzer) can only show the presence of biomechanical disorders of the fibrous membrane, while elastotonometry reacts not only to their presence, but also to their type. PURPOSE: To build a mathematical model that would use elastotonometry to assess biomechanical properties of the eye in treatment of hyperopia with LASIK and FemtoLASIK surgeries. MATERIAL AND METHODS: The study included 64 operations: 34 FemtoLASIK surgeries, and 31 LASIK surgeries...
2020: Vestnik Oftalmologii
Gabrielle Lapeyre, Pierre Fournie, Raphaël Vernet, Stéphanie Roseng, François Malecaze, Emmanuelle Bouzigon, David Touboul
PURPOSE: To assess the keratoconus (KC) prevalence among first-degree relatives of affected subjects. METHODS: We performed large epidemiological, prospective, and observational cohort, which took place in the French KC National Reference Centre, in Bordeaux. We studied data from 94 unrelated patients with KC and at least 2 first-degree relatives assessable. Each subject had a thorough ocular examination including visual acuity, refraction, slitlamp biomicroscopy, indirect ophthalmoscopy, keratometry, corneal topography and tomographer (Topographic Modeling System; Tomey Corporation, Japan; and Galilei G4, Ziemer, Switzerland, respectively), pachymetry, and biomechanical properties of cornea (Ocular Response Analyzer; Reichert, Depew, NY)...
September 21, 2020: Cornea
Francisco Cavas, David Piñero, José S Velázquez, Jorge Mira, Jorge L Alió
The morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The current study investigated the relationship of corneal morphogeometry and volume with two biomechanical parameters: corneal hysteresis (CH) and corneal resistance factor (CRF), both provided by an Ocular Response Analyzer (Reichert)...
August 27, 2020: Diagnostics
Raluca Claudia Iancu, Inna Adriana Bujor, Cătălina Iliuță, Ștefania Tudor, Emil Ungureanu, Irena Gabriela Pașca, Sînziana Istrate
This study aimed to analyze the connection between corneal biomechanics (corneal hysteresis, CH) and endothelial cell density of cornea (mean endothelial cell density, MCD) in patients diagnosed with cataract. This retrospective, observational study was performed in the Ophthalmology Clinic of the University Emergency Hospital in Bucharest. Of 60 patients (120 eyes) with cataract, who were included in this study, we analyzed the CH values obtained using with the Ocular Response Analyzer (ORA) and the MCD values obtained using the specular microscopy...
April 2020: Romanian Journal of Ophthalmology
Elsayed Elbasiony, Sharad K Mittal, William Foulsham, WonKyung Cho, Sunil K Chauhan
PURPOSE: Neutrophils play a critical role in defending against threats such as microbial infection, yet their activation during innate immune response incites collateral damage to healthy tissues. We have previously shown that corneal injury induces mast cells to express the neutrophil chemoattractant CXCL2. Here we delineate the mechanism of injury-induced, non-IgE-mediated mast cell activation at the ocular surface. METHODS: Corneal injury was induced by mechanical removal of the epithelium and anterior stroma in mast cell deficient (cKitW-sh ) and C57BL/6 mice using Algerbrush II...
June 29, 2020: Ocular Surface
Rie Takahashi, Kanno Okamura, Tomoko Tsukahara-Kawamura, Kazuhiro Harada, Yusuke Saeki, Hiroaki Ozaki, Eiichi Uchio
Purpose: We have carried out three-dimensional finite element analysis (FEA) to determine the physical and mechanical response in several ocular injuries. We applied this FEA model to evaluate an airsoft gun impact on an eye and the deformation rate of eyes of various axial lengths at various velocities. Methods: This study was carried out on a human eye model using an FEA program created by Nihon, ESI Group. The airsoft gun pellet was set to impact the eye at initial velocities of 45, 60 and 75 m/s with the addition of variation in axial length of 20 mm (hyperopia), 22 mm (emmetropia), 24 mm (myopia) and 26 mm (high myopia)...
2020: Clinical Ophthalmology
Nitika Pandey, Apjit Kaur Chhabra
PURPOSE: The study evaluates the corneal biomechanical properties on Ocular Response Analyzer (ORA) and aims to establish their correlation with the clinical profile of patients with TAO. METHODS: A tertiary care centre-based cross-sectional observational study was conducted. Eighty patients with stage I and II TAO (EUGOGO classification), categorized as group A, were age and sex matched with 85 controls constituting group B. The disease activity was assessed using clinical activity score (CAS)...
June 9, 2020: Orbit
Sadık Etka Bayramoğlu, Nihat Sayın, Dilbade Yıldız Ekinci, Nuray Aktay Ayaz, Mustafa Çakan
Objectives: To compare anterior segment parameters and biomechanical analysis of the cornea in children with joint hypermobility (JH) and healthy children. Materials and Methods: Cross-sectional case-control study. Fifty eyes of 25 children with JH were compared with 74 eyes of 37 healthy age- and sex-matched controls in terms of refractive, anterior segment topographic, and corneal biomechanical measurements. Axial length (AL) was measured with a Nidek AL-Scan biometry device; corneal-compensated intraocular pressure (IOPcc), Goldmann-correlated IOP (IOPg), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured with a Reichert ocular response analyzer (ORA)...
April 29, 2020: Turkish Journal of Ophthalmology
Anna Perazzi, Chiara Gomiero, Livio Corain, Ilaria Iacopetti, Enrico Grisan, Marco Lombardo, Giuseppe Lombardo, Gianni Salvalaio, Roberta Contin, Marco Patruno, Tiziana Martinello, Antonella Peruffo
The purpose of this study was to investigate the response of porcine corneal organ cultures to riboflavin/UV-A phototherapy in the injury healing of induced lesions. A porcine corneal organ culture model was established. Corneal alterations in the stroma were evaluated using an assay system, based on an automated image analysis method able to (i) localize the holes and gaps within the stroma and (ii) measure the brightness values in these patches. The analysis has been performed by dividing the corneal section in 24 regions of interest (ROIs) and integrating the data analysis with a "multi-aspect approach...
April 23, 2020: Animals: An Open Access Journal From MDPI
Sudha Neelam, Jerry Y Niederkorn
Purpose: Severing corneal nerves during orthotopic corneal transplantation elicits the elaboration of the neuropeptide substance P (SP), which induces the generation of CD11c+ contrasuppressor (CS) cells. CS cells disable T regulatory cells (Tregs) that are induced when antigens enter the anterior chamber (AC), either by direct injection or by orthotopic corneal transplantation. This study examined the crucial cell surface molecules on Tregs that are adversely affected by CS cells that are generated by severing corneal nerves...
April 9, 2020: Investigative Ophthalmology & Visual Science
Leonardo Taroni, Federico Bernabei, Marco Pellegrini, Matilde Roda, Pier Giorgio Toschi, Ashraf M Mahmoud, Costantino Schiavi, Giuseppe Giannaccare, Cynthia J Roberts
PURPOSE: To compare corneal biomechanics of eyes that underwent scleral buckle (SB) for rhegmatogenous retinal detachment (RRD) with fellow eyes (FEs) and to further investigate its effect on intraocular pressure (IOP) values. DESIGN: Retrospective, fellow-eye matched cohort study. METHODS: Eighteen (11 males and 7 females) consecutive patients treated with SB for RRD in one eye were enrolled. Goldmann applanation tonometry (GAT) was used to measure IOP...
April 10, 2020: American Journal of Ophthalmology
Dan Fu, Meiyan Li, Michael C Knorz, Shengsheng Wei, Jianmin Shang, Xingtao Zhou
BACKGROUND: We aimed to compare the intraocular pressure (IOP) measurements by a dynamic Scheimpflug analyzer (Corvis ST), a non-contact tonometer, and an ocular response analyzer after hyperopic small-incision lenticule extraction (SMILE). METHODS: Thirteen patients who underwent hyperopic SMILE in one eye were enrolled prospectively. IOP and corneal biomechanical parameters were measured preoperatively and at 1 week, 1 month, and 3 months postoperatively with a non-contact tonometer (IOPNCT ), Corvis ST (biomechanical corrected IOP [bIOP]), and ocular response analyzer (Goldmann-correlated intraocular pressure [IOPg] and cornea compensated IOP [IOPcc])...
April 5, 2020: BMC Ophthalmology
Mehmet Orcun Akdemir, Banu Torun Acar, Suphi Acar
PURPOSE: The present study's aim was to compare the biomechanical properties of corneal tissue in patients who underwent deep anterior lamellar keratoplasty (DALK) surgery, with successful big bubble formation and manual lamellar dissection, during failed big bubble formation. METHODS: This retrospective comparative study included 60 eyes from 60 keratoconus patients who previously underwent DALK surgery. These patients were categorized as big bubble (+) or big bubble (-) based on the success or failure of big bubble formation during the surgery...
March 2020: Arquivos Brasileiros de Oftalmologia
Nisha R Dhanushkodi, Ruchi Srivastava, Swayam Prakash, Soumyabrata Roy, Pierre-Gregoire A Coulon, Hawa Vahed, Angela M Nguyen, Stephanie Salazar, Lan Nguyen, Cassandra Amezquita, Caitlin Ye, Vivianna Nguyen, Lbachir BenMohamed
The invariant natural killer (iNKT) cells are among the first innate immune cells to elicit early protective immunity that control invading viral pathogens. The role of iNKT cell subsets, iNKT1, iNKT2, and iNKT17, in herpes immunity remains to be fully elucidated. In this study, we examined the protective role of corneal-resident iNKT cell subsets, using the mouse model of ocular herpes infection and disease. Wild type (WT) C57BL/6 mice and CD1d knockout (KO) mice were infected ocularly with HSV-1 (strain McKrae)...
February 26, 2020: Journal of Virology
Bakoliarisoa Nivomalala Voahangy Rasoanirina, Mohamed Ali Lassoued, Amel Kamoun, Badr Bahloul, Karim Miladi, Souad Sfar
The aim of this study was to develop self- nanoemulsifying drug delivery system (SNEDDS) as to improve the transcorneal permeability of voriconazole. A "mixture design around a reference mixture" approach was applied. This latter included four components, namely, isopropyl myristate, PEG 400, Tween® 80 and Span® 80 as oil, co-solvent, surfactant and co-surfactant,respectively. Droplet size was selected as response. The effect of mixture components on droplet size was analyzed by means of response trace method...
February 17, 2020: Pharmaceutical Development and Technology
Louise Pellegrino Gomes Esporcatte, Marcella Q Salomão, Bernardo T Lopes, Paolo Vinciguerra, Riccardo Vinciguerra, Cynthia Roberts, Ahmed Elsheikh, Daniel G Dawson, Renato Ambrósio
Corneal biomechanics has been a hot topic for research in contemporary ophthalmology due to its prospective applications in diagnosis, management, and treatment of several clinical conditions, including glaucoma, elective keratorefractive surgery, and different corneal diseases. The clinical biomechanical investigation has become of great importance in the setting of refractive surgery to identify patients at higher risk of developing iatrogenic ectasia after laser vision correction. This review discusses the latest developments in the detection of corneal ectatic diseases...
2020: Eye and Vision (London, England)
Pooja Khamar, Krishnatej Nishtala, Rohit Shetty, Trailokyanath Panigrahi, Keerthi Shetty, Natasha Pahuja, Vrushali Deshpande, Arkasubhra Ghosh
We studied the early protein profile in the ocular tissue extracted after LASIK and SMILE surgery. SMILE and LASIK was performed in contralateral eyes and stromal tissue samples were collected from 10 eyes of 5 donors. The stromal tissue samples were analyzed using label free quantification approach and ITRAQ labelling approach in LC-MS/MS. Combined functional analysis revealed many differentially expressed proteins which were involved in important biological processes. About 117 unique differentially expressed proteins were identified using two different proteomic approaches...
March 2020: Experimental Eye Research
Dinesh Thapa, Elizabeth A Cairns, Anna-Maria Szczesniak, Pushkar M Kulkarni, Alex J Straiker, Ganesh A Thakur, Melanie E M Kelly
Cannabinoid receptor 1 (CB1) activation has been reported to reduce transient receptor potential cation channel subfamily V member 1 (TRPV1)-induced inflammatory responses and is anti-nociceptive and anti-inflammatory in corneal injury. We examined whether allosteric ligands, can modulate CB1 signaling to reduce pain and inflammation in corneal hyperalgesia. Corneal hyperalgesia was generated by chemical cauterization of cornea in wildtype and CB2 knockout (CB2-/- ) mice. The novel racemic CB1 allosteric ligand GAT211 and its enantiomers GAT228 and GAT229 were examined alone or in combination with the orthosteric CB1 agonist Δ8 -tetrahydrocannabinol (Δ8 -THC)...
January 20, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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