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JOURNAL ARTICLE
Eric Saloux, Morgane Le Garrec, Nina Menet, Ludovic Dillon, Christophe Simard, Christophe Fraschini, Alain Manrique
OBJECTIVE: The purpose of this study was to assess cardiac shear wave imaging implemented in a new MACH 30 ultrasound machine (SuperSonic Imaging, Aix-en-Provence, France) and interfaced with a linear probe and a phased array probe, in comparison with a previously validated Aixplorer system connected to a linear probe (SuperSonic Imaging) using Elasticity QA phantoms (Models 039 and 049, CIRS Inc., Norfolk, VA, USA). METHODS: Quantile-quantile plots were used for distribution agreement...
March 11, 2024: Ultrasound in Medicine & Biology
#22
JOURNAL ARTICLE
Florence Fournet, Frédéric Simard, Didier Fontenille
Aligned with the Sustainable Development Goals, nature-based solutions such as urban greening e.g. public gardens, urban forests, parks and street trees, which aim to protect, sustainably manage or restore an ecosystem, have emerged as a promising tool for improving the health and well-being of an ever-increasing urban population. While urban greening efforts have undeniable benefits for human health and the biological communities inhabiting these green zones, disease vector populations may also be affected, possibly promoting greater pathogen transmission and the emergence of infectious diseases such as dengue, West Nile fever, malaria, leishmaniosis and tick-borne diseases...
March 2024: Euro Surveillance
#23
JOURNAL ARTICLE
Husein Moloo, Mathilde Gaudreau-Simard, Claire Kendall, Gordon Best, Nieve Seguin, Bernard J Jasmin, Mark Walker
No abstract text is available yet for this article.
March 2024: Lancet. Planetary Health
#24
JOURNAL ARTICLE
Sarah Provost, Solène Fourdain, Phetsamone Vannasing, Julie Tremblay, Kassandra Roger, Laura Caron-Desrochers, Alejandra Hüsser, Natacha Paquette, Amélie Doussau, Nancy Poirier, Marie-Noëlle Simard, Anne Gallagher
Neurodevelopmental disabilities affect up to 50% of survivors of congenital heart disease (CHD). Language difficulties are frequently identified during preschool period and can lead to academic, social, behavioral, and emotional difficulties. Structural brain alterations are associated with poorer neurodevelopmental outcomes in patients with CHD during infancy, childhood, and adolescence. However, evidence is lacking about the functional brain activity in children with CHD and its relationship with neurodevelopment...
February 27, 2024: Neuropsychologia
#25
Kristia Yiangou, Nasim Mavaddat, Joe Dennis, Maria Zanti, Qin Wang, Manjeet K Bolla, Mustapha Abubakar, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Adinda Baten, Sabine Behrens, Marina Bermisheva, Amy Berrington de Gonzalez, Katarzyna Białkowska, Nicholas Boddicker, Clara Bodelon, Natalia V Bogdanova, Stig E Bojesen, Kristen D Brantley, Hiltrud Brauch, Hermann Brenner, Nicola J Camp, Federico Canzian, Jose E Castelao, Melissa H Cessna, Jenny Chang-Claude, Georgia Chenevix-Trench, Wendy K Chung, Sarah V Colonna, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Alison M Dunning, Diana M Eccles, A Heather Eliassen, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Manuela Gago-Dominguez, Aleksandra Gentry-Maharaj, Anna González-Neira, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Ute Hamann, Jaana M Hartikainen, Vikki Ho, James Hodge, Antoinette Hollestelle, Ellen Honisch, Maartje J Hooning, Reiner Hoppe, John L Hopper, Sacha Howell, Anthony Howell, Simona Jakovchevska, Anna Jakubowska, Helena Jernström, Nichola Johnson, Rudolf Kaaks, Elza K Khusnutdinova, Cari M Kitahara, Stella Koutros, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Flavio Lejbkowicz, Annika Lindblom, Michael Lush, Arto Mannermaa, Dimitrios Mavroudis, Usha Menon, Rachel A Murphy, Heli Nevanlinna, Nadia Obi, Kenneth Offit, Tjoung-Won Park-Simon, Alpa V Patel, Cheng Peng, Paolo Peterlongo, Guillermo Pita, Dijana Plaseska-Karanfilska, Katri Pylkäs, Paolo Radice, Muhammad U Rashid, Gad Rennert, Eleanor Roberts, Juan Rodriguez, Atocha Romero, Efraim H Rosenberg, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Rita K Schmutzler, Christopher G Scott, Xiao-Ou Shu, Melissa C Southey, Jennifer Stone, Jack A Taylor, Lauren R Teras, Irma van de Beek, Walter Willett, Robert Winqvist, Wei Zheng, Celine M Vachon, Marjanka K Schmidt, Per Hall, Robert J MacInnis, Roger L Milne, Paul D P Pharoah, Jacques Simard, Antonis C Antoniou, Douglas F Easton, Kyriaki Michailidou
The 313-variant polygenic risk score (PRS 313 ) provides a promising tool for breast cancer risk prediction. However, evaluation of the PRS 313 across different European populations which could influence risk estimation has not been performed. Here, we explored the distribution of PRS 313 across European populations using genotype data from 94,072 females without breast cancer, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 225,105 female participants from the UK Biobank...
February 13, 2024: medRxiv
#26
JOURNAL ARTICLE
Mathilde Gaudreau-Simard, Tana Saiyin, Matthew D F Mcinnes, Sydney Ruller, Edward G Clark, Krista Wooller, Elaine Kilabuk, Alan J Forster, Michael Y Woo
BACKGROUND: Acute kidney injury is a common disorder that is associated with significant morbidity and mortality. Point-of-care ultrasonography (PoCUS) is an imaging modality performed at the bedside and is used to assess for obstructive causes of acute kidney injury. Little is known about the test characteristics of PoCUS in patients with acute kidney injury. OBJECTIVE: Our primary objective was to describe the test characteristics of PoCUS for the detection of hydronephrosis in patients presenting with acute kidney injury at our centre...
February 22, 2024: The ultrasound journal
#27
JOURNAL ARTICLE
Hasan S Alarouri, Gerardo V Lo Russo, Alejandra Chavez Ponce, Abdul-Rahman Akkawi, Abdulah Mahayni, Agata Sularz, Ammar M Killu, Trevor Simard, Gurpreet Singh, William R Miranda, Mohamad Alkhouli
BACKGROUND: The hemodynamic effects of transcatheter left atrial appendage occlusion (LAAO) remain unclear. OBJECTIVE: We sought to assess the effect of LAAO on invasive hemodynamics and their correlation with clinical outcomes. METHODS: We recorded mean left atrial pressure (mLAP) before and after device deployment. We assessed: (a) the prevalence and predictors of mLAP increase post-deployment; (b) the association between significant mLAP increase post-deployment and 45-day peridevice leak (PDL); (c) the association between mLAP increase and heart failure (HF) hospitalization...
February 14, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#28
JOURNAL ARTICLE
Jean-Philippe C Lavoie, Mélissa Simard, Hilal Kalkan, Volatiana Rakotoarivelo, Sandrine Huot, Vincenzo Di Marzo, Andréanne Côté, Marc Pouliot, Nicolas Flamand
Prostaglandin (PG) E2 is a recognized inhibitor of granulocyte functions. However, most of the data supporting this was obtained when available pharmacological tools mainly targeted the EP2 receptor. Herein, we revisited the inhibitory effect of PGE2 on reactive oxygen species production, leukotriene biosynthesis and migration in human neutrophils. Our data confirm the inhibitory effect of PGE2 on these functions and unravel that the effect of PGE2 on human neutrophils is obtained by the combined action of EP2 and EP4 agonism...
February 12, 2024: Journal of Leukocyte Biology
#29
JOURNAL ARTICLE
Acute Development of Traumatic Intracranial Aneurysms Following Civilian Gunshot Wounds to the Head.
Riccardo Serra, Bradley Wilhelmy, Chixiang Chen, Jeffrey Daniel Oliver, Jesse A Stokum, Uttam K Bodanapally, J Marc Simard, Gary Schwartzbauer, Bizhan Aarabi
In previous studies, the incidence of traumatic intracranial aneurysms (TICAs) after civilian gunshot wound to the head (cGSWH) was approximately 3%. Given the use of delayed vessel imaging, we hypothesize that a significant fraction of TICAs is missed on initial non-contrasted scans. This study was designed to characterize acute TICAs using admission CT angiography (aCTA) in cGSWH. Over the 2017-22 period, 341 patients were admitted to Shock Trauma Center with cGSWH. 136 subjects had aCTA ~3 (SD 3.5) hours post-injury...
February 3, 2024: Journal of Neurotrauma
#30
JOURNAL ARTICLE
Amadeia Rector, Ivana Marić, Yashaar Chaichian, Eliza Chakravarty, Miranda Cantu, Michael H Weisman, Gary M Shaw, Maurice L Druzin, Julia F Simard
OBJECTIVE: Systemic lupus erythematosus (SLE) disproportionately affects women during childbearing years, and hydroxychloroquine (HCQ) is the standard first-line treatment. Preeclampsia complicates up to one-third of pregnancies in lupus patients, although reports vary by parity and multifetal gestation. We investigated whether taking HCQ early in pregnancy may reduce the risk of preeclampsia. METHODS: We studied 1,068 live birth singleton pregnancies among 1,020 privately insured patients with SLE (2007-2016)...
January 25, 2024: Arthritis & Rheumatology
#31
REVIEW
Matthew Ades, Camille Simard, Thomas Vanassche, Peter Verhamme, John Eikelboom, Thomas A Mavrakanas
Patients with end-stage kidney disease (ESKD) experience a high thrombotic risk but are also at increased risk of bleeding. There is an unmet need for safer antithrombotic therapy in patients with ESKD on hemodialysis. Factor XI (FXI) represents an attractive therapeutic target for anticoagulation because of the potential to mitigate the bleeding risks associated with currently approved anticoagulants, especially in patients at high risk of bleeding. FXI inhibition is also an attractive option in settings where coagulation is activated by exposure of the blood to artificial surfaces, including the extracorporeal circuit during hemodialysis...
January 24, 2024: Seminars in Nephrology
#32
JOURNAL ARTICLE
Geraud Galvaing, Jean Bussières, Serge Simard, Etienne J Couture, Catherine Cournoyer, Massimo Conti, Yves Lacasse, Anne Sophie Laliberté
OBJECTIVE: The aim of this study was to evaluate the impact of the ipsilateral arm position on ipsilateral shoulder pain after lung cancer resection by video-assisted thoracic surgery. DESIGN: A prospective randomized controlled trial. SETTING: A single academic center study. PARTICIPANTS: Patients undergoing video-assisted thoracic surgery pulmonary resection for cancer at the Institut Universitaire de Cardiologie et de Pneumologie de Québec from May 2020 to May 2022 were included...
December 22, 2023: Journal of Cardiothoracic and Vascular Anesthesia
#33
JOURNAL ARTICLE
Sarah Alsubhi, Saoussen Berrahmoune, Roy W R Dudley, David Dufresne, Elisabeth Simard Tremblay, Myriam Srour, Kenneth A Myers
We evaluated the utility of genetic testing in the pre-surgical evaluation of pediatric patients with drug-resistant focal epilepsy. This single-center retrospective study reviewed the charts of all pediatric patients referred for epilepsy surgery evaluation over a 5-year period. We extracted and analyzed results of genetic testing as well as clinical, EEG, and neuroimaging data. Of 125 patients referred for epilepsy surgical evaluation, 86 (69%) had some form of genetic testing. Of these, 18 (21%) had a pathogenic or likely pathogenic variant identified...
January 23, 2024: Journal of Neurology
#34
REVIEW
Jiantao Zhang, Kellie Hom, Chenyu Zhang, Mohamed Nasr, Volodymyr Gerzanich, Yanjin Zhang, Qiyi Tang, Fengtian Xue, J Marc Simard, Richard Y Zhao
The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due to its rapid transmission, ability to mutate, high mortality and morbidity, and enduring health complications. Vaccines have exhibited effectiveness, but their efficacy diminishes over time while new variants continue to emerge. Antiviral medications offer a viable alternative, but their success has been inconsistent. Therefore, there remains an ongoing need to identify innovative antiviral drugs for treating COVID-19 and its post-infection complications...
January 14, 2024: Pathogens
#35
JOURNAL ARTICLE
Moustapha Djite, Juan Manuel Chao de la Barca, Cinzia Bocca, Ndiaga Matar Gaye, Néné Oumou Kesso Barry, Mame Ndoumbé Mbacke, Ousmane Cissé, Pape Matar Kandji, Ndèye Marème Thioune, Najah Fatou Coly-Gueye, El Hadji Malick Ndour, Fatou Gueye-Tall, Amadou Gallo Diop, Gilles Simard, Delphine Mirebeau-Prunier, Papa Madieye Gueye, Pascal Reynier
Metabolomics is a powerful data-driven tool for in-depth biological phenotyping that could help identify the specific metabolic profile of cryptogenic strokes, for which no precise cause has been identified. We performed a targeted quantitative metabolomics study in West African patients who had recently suffered an ischemic stroke, which was either cryptogenic ( n = 40) or had a clearly identified cause ( n = 39), compared to a healthy control group ( n = 40). Four hundred fifty-six metabolites were accurately measured...
December 29, 2023: Antioxidants (Basel, Switzerland)
#36
JOURNAL ARTICLE
Mikaël Simard, Daniel G Robertson, Ryan Fullarton, Gary J Royle, Sam Beddar, Charles-Antoine Collins-Fekete
Integrated-mode proton radiography leading to water equivalent thickness (WET) maps is an avenue of interest for motion management, patient positioning, and in vivo range verification. Radiographs can be obtained using a pencil beam scanning setup with a large 3D monolithic scintillator coupled with optical cameras. Established reconstruction methods either (1) involve a camera at the distal end of the scintillator, or (2) use a lateral view camera as a range telescope. Both approaches lead to limited image quality...
January 19, 2024: Physics in Medicine and Biology
#37
JOURNAL ARTICLE
Julia F Simard, Emily F Liu, Eliza Chakravarty, Amadeia Rector, Miranda Cantu, Daniel Z Kuo, Gary M Shaw, Maurice L Druzin, Michael H Weisman, Monique M Hedderson
OBJECTIVE: Although the systemic lupus (SLE) patient population is racially and ethnically diverse, many study populations are homogeneous. Further, data are often lacking on critical factors such as antiphospholipid (aPL) antibodies. We investigated livebirth rates in patients with SLE at Kaiser Permanente Northern California including race/ethnicity and aPL data. METHODS: Electronic health records of pregnancies with outcomes observed from 2011-2020 were identified among patients with SLE...
January 14, 2024: Arthritis Care & Research
#38
REVIEW
Xavier Deschênes-Simard, Mohan Malleshaiah, Gerardo Ferbeyre
This comprehensive review delves into the multifaceted aspects of ERK signaling and the intricate mechanisms underlying distinct cellular fates. ERK1 and ERK2 (ERK) govern proliferation, transformation, epithelial-mesenchymal transition, differentiation, senescence, or cell death, contingent upon activation strength, duration, and context. The biochemical mechanisms underlying these outcomes are inadequately understood, shaped by signaling feedback and the spatial localization of ERK activation. Generally, ERK activation aligns with the Goldilocks principle in cell fate determination...
December 24, 2023: Cancers
#39
JOURNAL ARTICLE
Jarred Garfinkle, May Khairy, Marie-Noelle Simard, Jonathan Wong, Prakesh S Shah, Thuy Mai Luu, Marc Beltempo
BACKGROUND AND OBJECTIVES: Research on outcomes of prematurity frequently examines neurodevelopment in the toddler years as an end point, but the age range at examination varies. We aimed to evaluate whether the corrected age (CA) at Bayley-III assessment is associated with rates of developmental delay in extremely preterm children. METHODS: This retrospective cohort study included children born at <29 weeks' gestation who were admitted in the Canadian Neonatal Network between 2009 and 2017...
January 1, 2024: Pediatrics
#40
JOURNAL ARTICLE
Tamir Klein, Ido Rog, Stav Livne-Luzon, Marcel G A van der Heijden, Christian Körner
The mycorrhizal symbiosis between fungi and plants is among the oldest, ubiquitous and most important interactions in terrestrial life on Earth. Carbon (C) transfer across a common mycorrhizal network (CMN) was demonstrated over half a century ago in the lab ( Reid & Woods, 1969), and later in the field ( Simard et al ., 1997a). Recent years have seen ample progress in this research direction, including evidence for ecological significance of carbon transfer ( Klein et al ., 2016). Furthermore, specific cases where the architecture of mycorrhizal networks have been mapped ( Beiler et al ...
2023: Open Res Eur
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