Luciano Polonelli, Tecla Ciociola, Walter Magliani, Pier Paolo Zanello, Tiziana D'Adda, Serena Galati, Flavia De Bernardis, Silvia Arancia, Elena Gabrielli, Eva Pericolini, Anna Vecchiarelli, Denise C Arruda, Marcia R Pinto, Luiz R Travassos, Thelma A Pertinhez, Alberto Spisni, Stefania Conti
Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro...
2012: PloS One