Hanneke W M van Laarhoven, Giulio Gambarota, Jasper Lok, Martin Lammens, Yvonne L M Kamm, Theo Wagener, Cornelis J A Punt, Albert J van der Kogel, Arend Heerschap
For the systemic treatment of colorectal cancer, 5-fluorouracil (FU)-based chemotherapy is the standard. However, only a subset of patients responds to chemotherapy. Breathing of carbogen (95% O2 and 5% CO2) may increase the uptake of FU through changes in tumor physiology. This study aims to monitor in animal models in vivo the effects of carbogen breathing on tumor blood plasma volume, pH, and energy status, and on FU uptake and metabolism in two colon tumor models C38 and C26a, which differ in their vascular structure and hypoxic status...
June 2006: Neoplasia: An International Journal for Oncology Research