Nikolay O Kamenshchikov, Mariia L Diakova, Yuri K Podoksenov, Elena A Churilina, Tatiana Yu Rebrova, Shamil D Akhmedov, Leonid N Maslov, Alexander V Mukhomedzyanov, Elena B Kim, Ekaterina S Tokareva, Igor V Kravchenko, Alexander M Boiko, Maxim S Kozulin, Boris N Kozlov
Performing cardiac surgery under cardiopulmonary bypass (CPB) and circulatory arrest (CA) provokes the development of complications caused by tissue metabolism, microcirculatory disorders, and endogenous nitric oxide (NO) deficiency. This study aimed to investigate the potential mechanisms for systemic organoprotective effects of exogenous NO during CPB and CA based on the assessment of dynamic changes in glycocalyx degradation markers, deformation properties of erythrocytes, and tissue metabolism in the experiment...
March 23, 2024: Biomedicines