Michael E O'Brien, James Londino, Marcus McGinnis, Nathaniel Weathington, Jessica Adair, Tomeka Suber, Valerian Kagan, Kong Chen, Chunbin Zou, Bill Chen, Jessica Bon, Rama K Mallampalli
FBXL2 is an important ubiquitin E3 ligase component that modulates inflammatory signaling and cell cycle progression, but its molecular regulation is largely unknown. Here we show that TNFα, a critical cytokine linked to the inflammatory response during skeletal muscle regeneration, suppressed Fbxl2 mRNA expression in C2C12 myoblasts and triggered significant alterations in cell cycle, metabolic, and protein translation processes. Gene silencing of Fbxl2 in skeletal myoblasts resulted in increased proliferative responses characterized by activation of mitogen activated protein (MAP) kinases and nuclear factor kappa B and decreased myogenic differentiation as reflected by reduced expression of myogenin and impaired myotube formation...
March 23, 2020: Molecular and Cellular Biology
Ricardo Costa, Ana Lourenço, Vanda Oliveira, Helena Pereira
[This corrects the article DOI: 10.1016/j.heliyon.2019.e02910.].
March 2020: Heliyon
Edward C Lulai, Linda L Olson, Karen K Fugate, Jonathan D Neubauer, Larry G Campbell
The mechanisms regulating, and modulating potato wound-healing processes are of great importance in reducing tuber infections, reducing shrinkage and maintaining quality and nutritional value for growers and consumers. Wound-induced changes in tuber polyamine metabolism have been linked to the modulation of wound healing (WH) and in possibly providing the crucial amount of H2 O2 required for suberization processes. In this investigation we determined the effect of inhibition of specific steps within the pathway of polyamine metabolism on polyamine content and the initial accumulation of suberin polyphenolics (SPP) during WH...
December 17, 2019: Journal of Plant Physiology
Rebecca Ravotti, Oliver Fellmann, Ludger J Fischer, Jörg Worlitschek, Anastasia Stamatiou
Esters present several advantages when compared to traditional materials used for thermal energy storage, amongst which are better sustainability and greater chemical stability. However, at present, their thermal properties remain mostly unknown or not well documented. In this study, 12 diesters from four dicarboxylic acids (oxalic, succinic, suberic, sebacic) and three alcohols (methanol, 1-pentanol, 1-decanol) have been assessed as bio-based phase change materials for thermal energy storage. All diesters have been synthesized via Fischer esterification to high purities, and their chemical structures, as well as thermal properties, have been fully characterized...
February 11, 2020: Materials
Hagai Cohen, Vadim Fedyuk, Chunhua Wang, Shuang Wu, Asaph Aharoni
Root endodermis, the innermost cortical layer surrounding the root vasculature, serves as the foremost barrier to water, solutes, and nutrients taken up from soil. Endodermis barrier functionality is achieved via its hydrophobic coating of lignified Casparian strips and the suberin lamellae; nonetheless the regulatory mechanisms underlying endodermis suberization are still elusive. Here, we discovered that the Arabidopsis SUBERMAN (SUB) transcription factor controls establishment of the root suberin lamellae...
February 6, 2020: Plant Journal
Shashi Kant Bhatia, Ranjit Gurav, Tae-Rim Choi, Hyun Joong Kim, Soo-Yeon Yang, Hun-Suk Song, Jun Young Park, Ye-Lim Park, Yeong-Hoon Han, Yong-Keun Choi, Sang-Hyoun Kim, Jeong-Jun Yoon, Yung-Hun Yang
In this study, a heterogeneous catalyst prepared by pyrolysis of waste cork (Quercus suber) was used for the transesterification of waste cooking oil (WCO). Physicochemical properties of the synthesized biochar catalyst were studied using BET, SEM, FTIR, and XRD. The experiment results demonstrate that heterogeneous catalyst synthesized at 600 °C showed maximum fatty acids methyl esters (FAMEs) conversion (98%) at alcohol:oil (25:1), catalyst loading (1.5% w/v) and temperature 65 °C. Biodiesel produced from WCO (Canola oil) mainly composed of FAMEs in following order C18:1 > C18:2 > C16:0 > C18:0 > C20:0...
January 23, 2020: Bioresource Technology
Youssef Chebli, Samira El Otmani, Mouad Chentouf, Jean-Luc Hornick, Jérôme Bindelle, Jean-François Cabaraux
Mediterranean forest rangelands offer an important feed source for goats. Concerns about grazing strategies and management schemes in order to ensure the rangeland sustainability of Southern Mediterranean forest have revived interest in the foraging behavior of goats. This study was conducted to investigate the seasonal changes of feeding behavior of grazing goats in the Southern Mediterranean forest rangeland of Northern Morocco during two consecutive years beginning in 2016. The direct observation method was used to compare diet composition, intake rate, and diet selectivity of goats during three seasons (spring, summer, and fall)...
January 23, 2020: Animals: An Open Access Journal From MDPI
Stanislao Rizzo, Pierre-Olivier Barale, Sarah Ayello-Scheer, Robert G Devenyi, Marie-Noëlle Delyfer, Jean-François Korobelnik, Aleksandra Rachitskaya, Alex Yuan, K Thiran Jayasundera, David N Zacks, James T Handa, Sandra R Montezuma, Dara Koozekanani, Paulo E Stanga, Lyndon da Cruz, Peter Walter, Albert J Augustin, Marzio Chizzolini, Lisa C Olmos de Koo, Allen C Ho, Bernd Kirchhof, Paul Hahn, Lejla Vajzovic, Raymond Iezzi, David Gaucher, J Fernando Arevalo, Ninel Z Gregori, Salvatore Grisanti, Emin Özmert, Young Hee Yoon, Gregg T Kokame, Jennifer I Lim, Peter Szurman, Eugene de Juan, Flavio A Rezende, Joël Salzmann, Gisbert Richard, Suber S Huang, Francesco Merlini, Uday Patel, Cynthia Cruz, Robert J Greenberg, Sally Justus, Laura Cinelli, Mark S Humayun
PURPOSE: To analyze and provide an overview of the incidence, management, and prevention of conjunctival erosion in Argus II clinical trial subjects and postapproval patients. METHODS: This retrospective analysis followed the results of 274 patients treated with the Argus II Retinal Prosthesis System between June 2007 and November 2017, including 30 subjects from the US and European clinical trials, and 244 patients in the postapproval phase. Results were gathered for incidence of a serious adverse event, incidence of conjunctival erosion, occurrence sites, rates of erosion, and erosion timing...
February 2020: Retina
Marçal Soler, Roger Verdaguer, Sandra Fernández-Piñán, Dolors Company-Arumí, Pau Boher, Elsa Góngora-Castillo, Marc Valls, Enriqueta Anticó, Marisa Molinas, Olga Serra, Mercè Figueras
Both suberin and its associated waxes contribute to the formation of apoplastic barriers that protect plants from the environment. Some transcription factors have emerged as regulators of the suberization process. The potato StNAC103 gene was reported as a repressor of suberin polyester and suberin-associated waxes deposition because its RNAi-mediated downregulation (StNAC103-RNAi) over-accumulated suberin and associated waxes in the tuber phellem concomitantly with the induction of representative biosynthetic genes...
February 2020: Plant Science: An International Journal of Experimental Plant Biology
Nabil Amimi, Stéphane Dussert, Virginie Vaissayre, Hana Ghouil, Sylvie Doulbeau, Carlo Costantini, Youssef Ammari, Thierry Joët
BACKGROUND AND AIMS: Oaks are the foundation and dominant tree species of most Mediterranean forests. As climate models predict dramatic changes in the Mediterranean basin, a better understanding of the ecophysiology of seed persistence and germination in oaks could help define their regeneration niches. Tunisian oaks occupy distinct geographical areas, which differ in their rainfall and temperature regimes, and are thus a valuable model to investigate relationships between seed traits and species ecological requirements...
January 6, 2020: Annals of Botany
Carla Sappino, Ludovica Primitivo, Martina De Angelis, Marzia Oneto Domenici, Andrea Mastrodonato, Ilaria Ben Romdan, Chiara Tatangelo, Lorenza Suber, Luciano Pilloni, Alessandra Ricelli, Giuliana Righi
With the aim to easily recover and reuse the catalyst, an efficient amino alcohol catalyst previously tested in the asymmetric addition of diethylzinc to several aromatic aldehydes has been immobilized on proper functionalized superparamagnetic core-shell magnetite-silica nanoparticles and employed in the Henry reaction in the semi-homogeneous phase. The nanocatalyst exhibits a promising catalytic activity that remains unchanged in the three catalytic cycles performed. The results prove that highly efficient catalysts, by being immobilized on suitable magnetic nanosupports, can be easily recovered and reused, maintaining their catalytic behavior...
December 24, 2019: ACS Omega
Radhika Gudi, Jada Suber, Robert Brown, Benjamin M Johnson, Chenthamarakshan Vasu
BACKGROUND: β-Glucans (BGs), a group of complex dietary polysaccharides (CDPs), are available as dietary supplements. However, the effects of orally administered highly purified BGs on gut inflammation are largely unknown. OBJECTIVES: The aim of this study was to investigate the impact of orally administering highly purified, yeast-derived BG (YBG; β-1,3/1,6-d-glucan) on susceptibility to colitis. METHODS: Eight-week-old C57BL/6 (B6) mice were used in a series of experiments...
December 27, 2019: Journal of Nutrition
Guzel R Akhiyarova, Ekaterina I Finkina, Tatiana V Ovchinnikova, Dmitry S Veselov, Guzel R Kudoyarova
Lipid transfer proteins (LTPs) are a class of small, cationic proteins that bind and transfer lipids and play an important role in plant defense. However, their precise biological role in plants under adverse conditions including salinity and possible regulation by stress hormone abscisic acid (ABA) remains unknown. In this work, we studied the localization of LTPs and ABA in the roots of pea plants using specific antibodies. Presence of LTPs was detected on the periphery of the cells mainly located in the phloem...
December 20, 2019: Biomolecules
Ricardo Costa, Ana Lourenço, Vanda Oliveira, Helena Pereira
Sustainability of cork oak ( Quercus suber ) forests is threatened by biotic and abiotic factors and characterization of potentially differing genetic resources has therefore gained importance. This work addresses the chemical variation of the three tissues of cork oak stems - cork, phloem and wood - in relation to tree and provenance, looking for genetic chemical diversity and for physiological derived differences. The three tissues differ with cork clearly differentiating regarding summative composition, component ratios and monomeric composition...
December 2019: Heliyon
Mario Khalil, Sylvain Lerat, Nathalie Beaudoin, Carole Beaulieu
The outer potato periderm layer consists of dead suberized cells. Suberin, a protective biopolymer, is made of a polyaliphatic portion covalently linked to polyaromatic moieties. Evidence accumulates that Streptomyces scabies , the main causal agent of potato common scab, can degrade the suberin aliphatic part but its ability to degrade the aromatic portion has not been documented. This polyaromatic portion is mainly composed of cinnamic acids. In this study, two cinnamates ( trans -ferulic or p -coumaric acids) were added to the culture medium of S...
2019: Frontiers in Microbiology
Susana T Lopes, Daniel Sobral, Bruno Costa, Pedro Perdiguero, Inês Chaves, Augusta Costa, Célia M Miguel
Cork cambium (or phellogen) is a secondary meristem, responsible for the formation of phelloderm and phellem/cork, which together compose the periderm. In Quercus suber, the phellogen is active throughout the entire life of the tree, producing a continuous and renewable outer bark of cork. To identify specific candidate genes associated with cork cambium activity and phellem differentiation, we performed a comparative transcriptomic study of Q. suber secondary growth tissues (xylem and phellogen/phellem), using RNA-seq...
December 19, 2019: Tree Physiology
Eugenio Zoni, Martina Minoli, Cédric Bovet, Anne Wehrhan, Salvatore Piscuoglio, Charlotte K Y Ng, Peter C Gray, Martin Spahn, George N Thalmann, Marianna Kruithof-de Julio
BACKGROUND: Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence, with the aim of improving patient stratification. METHODS: We conducted a case-control study within a cohort of PCa patients recruited between 1996 and 2015...
December 16, 2019: BMC Cancer
Amish Patel, Mariana R N Lima, Hyeon-Yeol Cho, Ki Bum Lee, N Sanjeeva Murthy, Joachim Kohn
Polymeric nanospheres have the ability to encapsulate drugs, and are therefore widely used in drug delivery applications. Structural transformations that affect drug release from nanospheres are governed by the surrounding environment. To understand these effects, we investigated the adsorption behavior of three types of nanospheres onto model surfaces using quartz crystal microbalance with dissipation (QCM-D) and by atomic force microscopy (AFM). Substrates were prepared from polymers with different degree of PEGylation (0, 1 and 15%)...
December 11, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Wesuk Kang, Dabin Choi, Taesun Park
Ultraviolet (UV) radiation is a major cause of skin photoaging, which is mainly characterized by dryness and wrinkle formation. In the current study, we investigated the anti-photoaging effects of dietary suberic acid, a naturally occurring photochemical, using UVB-irradiated hairless mice. Mice were exposed to UVB three times weekly and fed diets containing three different suberic acid concentrations (0.05%, 0.1% and 0.2%) for 10 weeks. It was found that suberic acid inhibited UVB-induced skin dryness, wrinkle formation, and epidermal thickness in hairless mice...
December 4, 2019: Nutrients
Tino Kreszies, Stella Eggels, Victoria Kreszies, Alina Osthoff, Nandhini Shellakkutti, Jutta A Baldauf, Viktoria V Zeisler-Diehl, Frank Hochholdinger, Kosala Ranathunge, Lukas Schreiber
Wild barley, Hordeum vulgare spp. spontaneum, has a wider genetic diversity than its cultivated progeny, Hordeum vulgare spp. vulgare. Osmotic stress leads to a series of different responses in wild barley seminal roots, ranging from no changes in suberization to enhanced endodermal suberization of certain zones and the formation of a suberized exodermis, which was not observed in the modern cultivars studied so far. Further, as a response to osmotic stress, the hydraulic conductivity of roots was not affected in wild barley, but it was 2...
November 24, 2019: Plant, Cell & Environment
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