Guoqi Dong, Hui Gao, Yingqi Chen, Huayuan Yang
Background: Although rheumatoid arthritis (RA) is a common autoimmune disease, the precise pathogenesis of the disease remains unclear. Recent research has unraveled the role of autophagy in the development of RA. This research aims to explore autophagy-related diagnostic biomarkers in the peripheral blood of RA patients. Methods: The gene expression profiles of GSE17755 were retrieved from the gene expression ontology (GEO) database. Differentially expressed autophagy-related genes (DE-ARGs) were identified for the subsequent research by inserting autophagy-related genes and differentially expressed genes (DEGs)...
2023: Frontiers in Genetics
Caden Carver, Mikole Kalesinskas, Ngawang Dheden, A Razzaque Ahmed
Pemphigus foliaceus (PF) is an autoimmune blistering disease limited to the superficial skin without mucosal involvement. It is clinically, histologically, and immunopathologically distinct from pemphigus vulgaris (PV). As data on pediatric PF is often merged with data on both pediatric and adult PV patients, isolating clinical outcomes in pediatric PF is not always possible. Therefore, the authors of this review analyzed clinical outcomes following therapy in pediatric PF patients only. A search of databases resulted in 33 pediatric patients with PF...
September 2023: Curēus
Tanya Meade, Caroline Joyce, Tania Perich T, Nicholas Manolios, Phillip G Conaghan, Patricia Katz
OBJECTIVES: Many studies have reported high rates of anxiety in adults with Rheumatoid Arthritis (RA). The aim of this systematic review was to examine those findings and determine the overall prevalence, severity, and commonly used measures of anxiety in individuals with RA. METHODS: Six databases were searched from January 2000 without restrictions on language/location, study design, or grey literature. All identified studies that examined anxiety prevalence and severity in adults with RA, as assessed with clinical diagnostic interview and/or standardised self-report measures, were considered for inclusion...
October 2, 2023: Arthritis Care & Research
Carmel J W Stock, William G Bray, Vasilis Kouranos, Joseph Jacob, Maria Kokosi, Peter M George, Felix Chua, Athol U Wells, Piersante Sestini, Elisabetta A Renzoni
BACKGROUND AND OBJECTIVE: The acute-phase protein C-reactive protein (CRP) is known to be associated with poor outcomes in cancer and cardiovascular disease, but there is limited evidence of its prognostic implications in interstitial lung diseases (ILDs). We therefore set out to test whether baseline serum CRP levels are associated with mortality in four different ILDs. METHODS: In this retrospective study, clinically measured CRP levels, as well as baseline demographics and lung function measures, were collected for ILD patients first presenting to the Royal Brompton Hospital between January 2010 and December 2019...
October 1, 2023: Respirology: Official Journal of the Asian Pacific Society of Respirology
Ayaka Umetsu, Katsumi Eguchi, Tomohiro Koga, Takeshi Araki, Ayuko Takatani, Toshiyuki Aramaki, Kaoru Terada, Naoki Iwamoto, Kenji Miyahara, Nobuhisa Yonemitsu, Hideki Nakamura, Atsushi Kawakami, Yukitaka Ueki
We herein report a 27-year-old woman who presented with recurrent knee pain. Laboratory findings revealed minimal inflammation. Arthrography revealed structures resembling adipose tissues. Magnetic resonance imaging showed a high signal intensity of these structures, leading to the diagnosis of lipoma arborescens (LA). Synovectomy was performed. Pathology revealed adipocyte proliferation and B-cell clusters but no T-cell infiltration. A serum cytokine analysis revealed low levels of interleukin-6 and tumor necrosis factor-α compared with patients with rheumatoid arthritis...
September 29, 2023: Internal Medicine
Hyeok Chan Kwon, Mi Il Kang, So Mi Kim
OBJECTIVE: Methotrexate (MTX) is an anchor drug for most patients with rheumatoid arthritis (RA); its use may be limited depending on renal function. Therefore, this study aimed to examine the discrepancy in the estimated GFR (eGFR) using conventional serum creatinine (Cr)-, cystatin C-, and MTX-associated toxicities in patients with RA. METHODS: In total, 436 patients were enrolled, and eGFR was evaluated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation based on both cystatin C and serum Cr levels...
October 1, 2023: Journal of Rheumatology
Jennifer J Y Lee, Sasha Bernatsky, Jeffrey C Kwong, Qing Li, Timothy S H Kwok, Jessica Widdifield
OBJECTIVE: To determine if COVID-19 vaccines were associated with adverse events of special interest (AESIs) and health care use among adults with rheumatoid arthritis (RA). METHODS: Among adults with RA who received at least 1 COVID-19 vaccine, a self-controlled case series (SCCS) analysis was conducted to evaluate relative incidence (RI) rates of AESIs (Bell's Palsy, Idiopathic Thrombocytopenia, Acute Disseminated Encephalomyelitis, Pericarditis/Myocarditis, Guillain-Barre syndrome, Transverse Myelitis, Myocardial Infarction, Anaphylaxis, Stroke, Deep Vein Thrombosis, Pulmonary Embolism, Narcolepsy, Appendicitis, and Disseminated Intravascular Coagulation) in any 21-day period following vaccination compared to control periods...
October 1, 2023: Journal of Rheumatology
Remi Sumiyoshi, Tomohiro Koga, Shoichi Fukui, Kaori Furukawa, Mamiko Momoki, Kunihiro Ichinose, Shingo Yano, Atsushi Kawakami
OBJECTIVE: To determine the molecular differences between iMCD-thrombocytopenia, anasarca, fevers, reticulin myelofibrosis, organomegaly (TAFRO), and iMCD-not otherwise specified (NOS). METHODS: CD4-positive T cells were isolated from two iMCD-TAFRO and two iMCD-NOS patients for RNA sequencing comparison. Serum proteins of two iMCD-TAFRO and four iMCD-NOS patients were comprehensively analyzed to identify pathogenesis-associated proteins. IGFBP-1 protein, extracted from serum analysis, was compared to healthy controls, iMCD, systemic lupus erythematosus, and rheumatoid arthritis patients...
September 29, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
A S Rebak, I A Hendriks, M L Nielsen
Citrullination is an important post-translational modification (PTM) of arginine, known to play a role in autoimmune disorders, innate immunity response and maintenance of stem cell potency. However, citrullination remains poorly characterized and not as comprehensively understood compared to other PTMs, such as phosphorylation and ubiquitylation. High-resolution mass spectrometry (MS)-based proteomics offers a valuable approach for studying citrullination in an unbiased manner, allowing confident identification of citrullination modification sites and distinction from deamidation events on asparagine and glutamine...
November 20, 2023: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Indira Neeli, Maryam Moarefian, Jayalakshmi Kuseladass, Nishant Dwivedi, Caroline Jones, Marko Radic
Neutrophil adhesion to endothelia, entry into tissues and chemotaxis constitute essential steps in the immune response to infections that drive inflammation. Neutrophils bind to other cells and migrate via adhesion receptors, notably the α M β 2 integrin dimer (also called Mac-1, CR3 or CD11b/CD18). Here, the response of neutrophils to integrin engagement was examined by monitoring the activity of peptidylarginine deiminase 4 (PAD4). Histone H3 deimination was strongly stimulated by manganese, an integrin-activating divalent cation, even in the absence of additional inflammatory stimuli...
November 20, 2023: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Cynthia de Bont, Ger J M Pruijn
One of the main strategies of neutrophils in responding to microbial infections is the formation of neutrophil extracellular traps (NETs). NETs are web-like structures of decondensed chromatin associated with antimicrobial proteins. Citrullination plays an important role during NET formation and a substantial fraction of NET-associated proteins appeared to be citrullinated. The release of citrullinated intracellular proteins from netting neutrophils led to the hypothesis that the production of anti-citrullinated protein autoantibodies by autoimmune patients, in particular patients with rheumatoid arthritis, might be initiated when citrullinated NET components are not properly cleared and are exposed to the immune system...
November 20, 2023: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Leonard Barasa, Paul R Thompson
Protein citrullination is a post-translational modification (PTM) that is catalysed by the protein arginine deiminase (PAD) family of enzymes. This PTM involves the transformation of an arginine residue into citrulline. Protein citrullination is associated with several physiological processes, including the epigenetic regulation of gene expression, neutrophil extracellular trap formation and DNA damage-induced apoptosis. Aberrant protein citrullination is relevant to several autoimmune and neurodegenerative diseases and certain forms of cancer...
November 20, 2023: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Xian Lin, Tengyu Lin, Xiaocheng Wang, Jiaxin He, Xu Gao, Shuyan Lyu, Qingwen Wang, Jian Chen
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease known as a leading cause of disability with considerable mortality. Developing alternative drugs and targets for RA treatment is an urgent issue. Sesamol is a phenolic compound isolated from natural food sesame (Sesamum indicum L.) with various biological activities. PURPOSE: The current research intended to illuminate the bioactivity and mechanisms of sesamol in RA fibroblast-like synoviocytes (FLS), and aimed to estimate the potential clinical application value of sesamol in RA treatment...
September 21, 2023: Phytomedicine
Mette Louise Andersen, Floor Dijkstra Zegers, Line Riis Jølving, Torben Knudsen, Egon Stenager, Bente Mertz Nørgård
BACKGROUND: It has not previously been clarified if COVID-19 triggers disease activity and increases the risk of hospitalisation with COVID-19 in patients with multiple sclerosis. We examined the association between COVID-19 and the use of systemic corticosteroids prescriptions and hospital contacts at neurological departments as proxies of disease activity among patients with multiple sclerosis. Furthermore, we examined whether patients with multiple sclerosis were more likely to be hospitalised with COVID-19 compared to references...
September 25, 2023: Multiple Sclerosis and related Disorders
M J Alam, M R Choudhury, S A Haq, N Islam, S Ahmed, A Shahin, S M Ali, T Mahmood, A K Azad, M N Shazzad, M G Rabbani
Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting 0.5-1.0% of the general population worldwide and although RA is properly considered a disease of the joints, it can cause a variety of extra-articular manifestations. This study was performed to find out any discrepancy in fracture risk estimates with and without bone mineral density (BMD) in rheumatoid arthritis (RA) patients. This observational cross-sectional study was carried out in the Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh from July 2013 to July 2015...
October 2023: Mymensingh Medical Journal: MMJ
Wuyue Zhang, Jiawei Sun, Jinyao Li, Yanyan Wang, Weiyao Liu, Weili Xue, Yan Yuan, Xiaolei Wang
RATIONALE AND OBJECTIVES: The purpose of this study is to conduct a comparison between the newly introduced Angio PLanewave UltraSensitive (AngioPLUS) method and the power Doppler ultrasound (PDUS) technique, evaluating the efficacy of these two methods in detecting synovial blood flow in wrist and finger joints of rheumatoid arthritis (RA) patients. Furthermore, the study aimed to investigate the potential associations between the observed blood flow patterns and various symptoms and indicators associated with RA...
September 28, 2023: Academic Radiology
An-Ren Zhang, Qing-Hao Cheng, Yong-Ze Yang, Xin Yang, Zhuang-Zhuang Zhang, Hong-Zhang Guo
The purpose of this study was to compare the difference in functional scores and the incidence of complications after TKA between RA and osteoarthritis. The PubMed, MedLine, The Cochrane Library, Embase and Web of Science databases were searched for all clinical studies up to 15 March 2023 comparing outcomes after total knee replacement in patients with RA and OA, with two review authors independently screening the literature. A total of 7,820,115 (knee-counted) cases were included in 34 studies. The results of meta-analysis showed that the scores of the RA group were lower than that of the osteoarthritis group in the postoperative knee joint score [MD=-2...
September 28, 2023: Asian Journal of Surgery
Allison Fitoussi, Julien Dartus, Roger Erivan, Gilles Pasquier, Henri Migaud, Sophie Putman, Emmanuel Chazard
INTRODUCTION: Unicompartmental knee arthroplasty (UKA) and valgus high tibial osteotomy (HTO) are two options for isolated medial femorotibial osteoarthritis in genu varum. In the absence of registries for osteotomies and for arthroplasty in the knee, epidemiological data are hard to obtain in France. We therefore performed a retrospective study, with the aims of 1) estimating UKA and HTO survival without revision by total knee arthroplasty (TKA), and 2) assessing risk factors for revision according to treatment group...
September 28, 2023: Orthopaedics & Traumatology, Surgery & Research: OTSR
Stefka Neycheva, Emilia Naseva, Zguro Batalov, Rositsa Karalilova, Anastas Batalov
Rheumatoid arthritis is an inflammatory joint disease that causes progressive joint damage, leading to severe disability. Early diagnosis, optimal therapy, and strict adherence to the prescribed medication are key factors that allow for the cessation of the disease progression and the preserving of the patient's quality of life. The objective of this study was to estimate the compliance to and persistence of biologic disease-modifying anti-rheumatic drugs (bDMARDs) among the Bulgarian population with RA. This retrospective observational cohort study included 179 patients, who were tracked over a 36-month period...
September 30, 2023: Rheumatology International
Carly Conran, Jason Kolfenbach, Kristine Kuhn, Christopher Striebich, Larry Moreland
PURPOSE OF REVIEW: A subset of patients with rheumatoid arthritis (RA) who fail multiple biologic therapies are deemed to have "difficult-to-treat" (D2T) RA. In 2021, a European Alliance of Associations for Rheumatology (EULAR) task force proposed a clinical definition of D2T RA. Here we review RA phenotypes and clinical assessment of RA, propose a different definition of D2T RA, discuss possible D2T RA risk factors, and summarize existing literature on the management of D2T RA. RECENT FINDINGS: High disease activity at the time of diagnosis or prior to treatment with a biologic is associated with the development of D2T RA...
September 30, 2023: Current Rheumatology Reports
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