Shorouk M El-Sayyad, Mennatallah A Ali, Lamia S Kandil, Ghada M Ragab, Sherihan S Abdelhamid Ibrahim
OBJECTIVE: Rheumatoid arthritis is a progressive inflammatory disease with multiple dysfunctional intracellular signaling pathways that necessitate new approaches for its management. Hence, the study aimed to inspect the ability of the combination therapy of metformin and omega-3 to modulate different signaling pathways and micro RNAs such as (miR-155, miR-146a and miR-34) as new targets in order to mitigate adjuvant-induced arthritis and compare their effect to that of methotrexate. METHODS: Fourteen days post adjuvant injection, Sprague-Dawley rats were treated orally with metformin (200 mg/kg/day) and/or omega-3 (300 mg/kg/day) or intraperitoneally with methotrexate (2 mg/kg/week) for 4 weeks...
January 13, 2021: International Immunopharmacology
Shin Eui Kang, Jin Kyun Park, Hyun Jung Yoo, Young Woo Park, Bum-Chan Park, Jae-Eun Park, Eun Young Lee, Eun Bong Lee, Yeong Wook Song
This study was aimed at generating and investigating the efficacy of a novel monoclonal bispecific antibody (BsAb) for the combined inhibition of tumor necrosis factor-α (TNF-α) and CXCL10 as a treatment option for rheumatoid arthritis (RA). A novel BsAb targeting TNF-α and CXCL10 was generated by conjugating a single-chain variable fragment (scFv) of the anti-CXCL10 monoclonal antibody to the Fc region of adalimumab (ADA). The effects of the BsAb on the inflammatory response in the in vitro and in vivo development of arthritis and joint destruction were evaluated in human TNF transgenic (hTNF-Tg) mice, and K/BxN serum transfer arthritis models...
January 13, 2021: Translational Research: the Journal of Laboratory and Clinical Medicine
Fatemeh Moadab, Hossein Khorramdelazad, Mitra Abbasifard
Evidence suggests that uncontrolled immune system responses and their components play a significant role in developing rheumatoid arthritis (RA), which is considered an autoimmune disease (AD). Among immune system mediators, cytokines and chemokines are involved in numerous physiological and pathological processes. CCL2 or monocyte chemoattractant protein-1 (MCP-1) is known as a CC chemokine that can induce the locomotion and recruitment of monocytes and macrophages to the site of injury. When CCL2 binds to its receptors, the most important of which is CCR2, various signaling pathways are triggered, eventually leading to various immunological events such as inflammation...
January 13, 2021: Life Sciences
G Esther A Habers, Annette H M van der Helm-van Mil, Dieuwke S Veldhuijzen, Cornelia F Allaart, Erno Vreugdenhil, Daniëlle E J Starreveld, Tom W J Huizinga, Andrea W M Evers
OBJECTIVES: Rheumatoid arthritis (RA) patients show an earlier circadian rhythm (i.e. serum melatonin peaks earlier during the night, indicating an earlier timing of the internal circadian pacemaker). In the current study, we examined whether the chronotype, which is influenced by the circadian rhythm, is also earlier. In addition, we explored whether chronotype is related to disease activity and patient-reported outcomes. METHODS: The chronotype (Munich Chronotype Questionnaire) of patients with RA (n = 121; mean age 60 years, 73% female) was compared with that of subjects from the general population (norm group; n = 1695) with a one-sample t test...
January 16, 2021: Clinical Rheumatology
Jae-In Ryu, Ha-Young Kim, Yong-Dae Kwon
OBJECTIVES: This study aimed to investigate the association between dental implant therapy and osteonecrosis of the jaw (ONJ) in osteoporotic patients and the relationship between tooth extraction, dental implantation, and ONJ. MATERIAL AND METHODS: This retrospective cohort study used the Customized Health Information Data from the National Health Insurance Corporation in South Korea. The study population included patients older than 70 years with a history of osteoporosis; the cases included patients who had undergone dental implant surgery between July 2014 and July 2016 with specific procedure codes...
January 16, 2021: Clinical Oral Implants Research
Farzaneh Yazdi, Mohammad Reza Shakibi, Ehda Gharavi Roudsari, Nozar Nakhaee, Pouria Salajegheh
OBJECTIVE: Sexual functioning is an important component of life quality and musculoskeletal disorders may effect sexual functioning, so, the present study was conducted to evaluate sexual functioning in patients suffering from back pain, rheumatoid arthritis, and systemic lupus erythematosus (SLE). METHODS: This study was conducted on 102 patients with rheumatoid arthritis, 103 patients with back pain, 103 patients with SLE, and 210 people in the control group by the consecutive sampling method...
January 15, 2021: International Journal of Rheumatic Diseases
Claire E H Barber, Karen L Then, Victoria Bohm, Marc Hall, Deborah A Marshall, James A Rankin, Cheryl Barnabe, Glen S Hazlewood, Linda C Li, Dianne Mosher, Joanne Homik, Paul MacMullan, Karen Tsui, Kelly English, Diane Lacaille
OBJECTIVE: The aim of this study was to develop a patient-centered quality measurement framework to address a predefined vision statement and 7 strategic objectives for rheumatoid arthritis (RA) care that was developed in prior qualitative work with arthritis stakeholders. METHODS: One hundred forty-seven RA-related performance measures (PMs) were identified from a systematic review. A candidate list of 26 PMs meeting predefined criteria and addressing the strategic objectives previously defined was then assessed during a 3-round (R) modified Delphi...
September 1, 2020: Journal of Rheumatology
Ahmed A Sorour, Reto D Kurmann, Youssef E Shahin, Cynthia S Crowson, Sara J Achenbach, Rekha Mankad, Elena Myasoedova
OBJECTIVE: To examine the relationship between the use of Hydroxychloroquine (HCQ) and risk of developing Heart Failure (HF) in Rheumatoid Arthritis (RA). METHODS: In this nested case-control study, cases were Olmsted county, Minnesota residents with incident RA (based on 1987 ACR criteria) from 1980-2013 who developed HF after RA incidence. Each case was matched on year of birth, sex and year of RA incidence with an RA control who did not develop HF. Data on HCQ use including start and stop dates and dose changes was reviewed, and used to calculate HCQ duration and cumulative dose...
January 15, 2021: Journal of Rheumatology
Katelynn M Wilton, Sara J Achenbach, John M Davis, Elena Myasoedova, Eric L Matteson, Cynthia S Crowson
OBJECTIVE: Both erectile dysfunction (ED) and rheumatoid arthritis (RA) are associated with increased cardiovascular risk. It is unknown if these diagnoses are associated or if their combination confers additional cardiovascular risk. We aim to define the incidence of ED in RA, and determine if ED correlates with increased cardiovascular risk in RA. METHODS: Medical information concerning RA, ED and cardiovascular diagnoses for men with RA (n=260) diagnosed in Olmsted county, Minnesota and age-matched male comparators was extracted from a comprehensive medical record system...
January 15, 2021: Journal of Rheumatology
Ketian Li, Wenxiu Mo, Lijun Wu, Xunyao Wu, Cainan Luo, Xinyue Xiao, Xinmiao Jia, Huaxia Yang, Yunyun Fei, Hua Chen, Fengchun Zhang, Yongzhe Li, Lidan Zhao, Xuan Zhang
OBJECTIVES: Lack of effective biomarkers in anti-citrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA) impedes early diagnosis and treatment. This study aimed to identify novel autoantibodies in RA and verify their diagnostic values in ACPA-negative RA based on protein microarray technology. METHODS: A total of 1011 sera from 559 RA (276 ACPA-positive and 283 ACPA-negative), 239 disease controls (DCs) and 213 healthy controls (HCs) were collected and sampled on two sequential microarrays and ELISA and western blot (WB) detection, for novel autoantibodies discovery, validation and verification, respectively...
January 15, 2021: Annals of the Rheumatic Diseases
René Westhovens, William F C Rigby, Désirée van der Heijde, Daniel W T Ching, William Stohl, Jonathan Kay, Arvind Chopra, Beatrix Bartok, Franziska Matzkies, Zhaoyu Yin, Ying Guo, Chantal Tasset, John S Sundy, Angelika Jahreis, Neelufar Mozaffarian, Osvaldo Daniel Messina, Robert Bm Landewé, Tatsuya Atsumi, Gerd R Burmester
OBJECTIVES: To investigate efficacy and safety of the Janus kinase-1 inhibitor filgotinib in patients with active rheumatoid arthritis (RA) with limited or no prior methotrexate (MTX) exposure. METHODS: This 52-week, phase 3, multicentre, double-blind clinical trial (NCT02886728) evaluated once-daily oral filgotinib in 1252 patients with RA randomised 2:1:1:2 to filgotinib 200 mg with MTX (FIL200 +MTX), filgotinib 100 mg with MTX (FIL100 +MTX), filgotinib 200 mg monotherapy (FIL200), or MTX...
January 15, 2021: Annals of the Rheumatic Diseases
J Cajamarca-Baron, E Calvo Páramo, J L Morales Manrique, L V Vanegas Jiménez, J C Sarmiento-Monroy, A Rojas-Villarraga
BACKGROUND AND AIMS: Digital tomosynthesis has proven useful in the evaluation of damage to joints. This study aims to describe the most common digital tomosynthesis findings for four rheumatological entities and to compare the usefulness of this technique with that of other imaging techniques. MATERIALS AND METHODS: Following the PRISMA guidelines, we systematically searched the literature for articles about the use of digital tomosynthesis in rheumatoid arthritis, osteoarthritis, spondyloarthritis, and gout...
January 12, 2021: Radiología
María Galindo-Izquierdo, José Luis Pablos Alvarez
The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis...
January 13, 2021: Cells
Piotr Wójcik, Agnieszka Gęgotek, Neven Žarković, Elżbieta Skrzydlewska
Autoimmune diseases, including psoriasis, systemic lupus erythematosus (SLE), and rheumatic arthritis (RA), are caused by a combination of environmental and genetic factors that lead to overactivation of immune cells and chronic inflammation. Since oxidative stress is a common feature of these diseases, which activates leukocytes to intensify inflammation, antioxidants could reduce the severity of these diseases. In addition to activating leukocytes, oxidative stress increases the production of lipid mediators, notably of endocannabinoids and eicosanoids, which are products of enzymatic lipid metabolism that act through specific receptors...
January 13, 2021: International Journal of Molecular Sciences
Jianting Wen, Jian Liu, Xin Wang, Jie Wang
The aim of this study was to investigate the changes in and clinical significance of circular RNAs (circRNAs) expression related to immunity and inflammation in patients with rheumatoid arthritis (RA). We analyzed the circRNAs related to immunity and inflammation in peripheral blood mononuclear cells (PBMCs) from three RA patients and three healthy controls using high-throughput sequencing and bioinformatics analysis. Subsequently, four differentially expressed circRNAs were verified by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR)...
January 12, 2021: International Immunopharmacology
Xiaolong Lv, Jiuqin Huang, Hongqi Wang
The downregulation of miR-30a-3p has been reported in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS); however, it is poorly understood its possible involvement and the underlying mechanism. The effects of miR-30a-3p overexpression on the proliferation and apoptosis as well as oxidative stress injury were evaluated in rats RA-FLS. The targeting relationship between miR-30a-3p and Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) or cullin3 (cul3) was assessed by luciferase reporter assays...
January 12, 2021: Immunology Letters
Hui Jiang, Jian Liu, Chang Fan, Jing Wang, Weiping Li
Rheumatoid arthritis (RA) is an autoimmune disease that occurs in approximately 1.0% of the general population. In RA patients, physical disability and joint damage are the major prognostic factors, which are associated with a reduction in the quality of life and early mortality. At present, the exact molecular mechanism of RA remains elusive. Long noncoding RNAs (lncRNAs) have been revealed to play a regulatory role in the pathogenesis of RA. To reveal the function of lncRNAs in rheumatoid arthritis, lncRNAS56464...
March 2021: International Journal of Molecular Medicine
Qiang Zou, Linnan Wang, Xi Yang, Yueming Song, Limin Liu, Lei Wang, Zhongjie Zhou, Bowen Hu, Hao Liu, Taiyong Chen
Objective: To compare the predictive abilities of O-C2 angle (O-C2a), O-EA angle (O-EAa), and Oc-Ax angle (Oc-Axa) for development of dysphagia in patients after occipitocervical fusion (OCF). Methods: Between April 2010 and May 2019, 114 patients who underwent OCF and met the selection criteria were selected as the research objects. Among them, 54 were males and 60 were females; they were 14-76 years old, with an average of 50.6 years old. The follow-up time was 13-122 months (median, 60...
January 15, 2021: Chinese Journal of Reparative and Reconstructive Surgery
Matthew R Claxton, Matthew B Shirley, Richard F Nauert, Mark E Morrey, Joaquin Sanchez-Sotelo, Matthew T Houdek
PURPOSE: Total elbow arthroplasty (TEA) is associated with a relatively high complication rate, and exceptionally catastrophic complications might lead to amputation. The purpose of this study was to determine the incidence and aetiology of amputation performed at our institution in upper extremity limbs with a prior TEA. METHODS: Between 1973 and 2018, 1906 consecutive TEAs were performed at our institution. Upper extremity amputation was performed in seven (0...
January 15, 2021: International Orthopaedics
Rabia Agca, Annelies B Blanken, Alper M van Sijl, Yvo M Smulders, Alexandre E Voskuyl, Conny van der Laken, Ronald Boellaard, Michael T Nurmohamed
OBJECTIVE: RA is associated with higher risk of cardiovascular (CV) disease. Ongoing systemic inflammation is presumed to accelerate atherosclerosis by increasing inflammation in the arterial wall. However, evidence supporting this hypothesis is limited. We aimed to investigate arterial wall inflammation in RA vs OA, and its association with markers of inflammation and CV risk factors. METHODS: 18-fluorodeoxyglucose PET combined with CT (18F-FDG-PET/CT) was performed in RA (n = 61) and OA (n = 28) to investigate inflammatory activity in the wall of large arteries...
January 14, 2021: Rheumatology
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