Jianting Wen, Jian Liu, Bing Wang, Hui Jiang, Lei Wan, Ling Xin, Yue Sun, Yanqiu Sun, Ying Zhang, Xinlei Du, Xin Wang, Jie Wang
Self-perception in patients is their self-response to sensory stimuli. It is an important aspect of the existence and quality of life among patients. However, the inherent relationship between self-perception and the cellular activity at the molecular level is elusive. In this study, we aimed to explore the association of self-perception with RNA expression profile in patients with rheumatoid arthritis (RA) through computational analysis. We recruited 30 patients clinically diagnosed with RA and to age- and sex-matched controls without previous clinical history...
2020: Frontiers in Medicine
Lisa Shah, Abeer O Elshaikh, Robert Lee, Christopher Joy Mathew, Merin Tresa Jose, Ivan Cancarevic
Rheumatoid arthritis and systemic lupus erythematosus (SLE) are autoimmune diseases that are commonly seen in the female population. Rheumatoid arthritis mainly consists of distal symmetrical deforming polyarthritis. SLE patients have immune complexes that damage the organs and systems of the body, and this can present with one or more symptoms including the characteristic malar rash, serositis, lupus nephritis, photosensitivity, and arthritis of large joints. The onset and progression of the diseases are affected by physiological processes that occur in the body such as menopause and aging...
October 14, 2020: Curēus
Wen-Cheng Wu, Sheng-Jiao Song, Yuan Zhang, Xing Li
Autoimmune diseases are conditions that emerge from abnormal immune responses to natural parts of the body. Extracellular vesicles (EVs) are membranous structures found in almost all types of cells. Because EVs often transport "cargo" between cells, their ability to crosstalk may be an important communication pathway within the body. The pathophysiological role of EVs is increasingly recognized in autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, Type 1 diabetes, and autoimmune thyroid disease...
2020: Frontiers in Immunology
Xunyao Wu
Inflammatory arthritis (IA) refers to a group of chronic diseases, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and other spondyloarthritis (SpA). IA is characterized by autoimmune-mediated joint inflammation and is associated with inflammatory cytokine networks. Innate lymphocytes, including innate-like lymphocytes (ILLs) expressing T or B cell receptors and innate lymphoid cells (ILCs), play important roles in the initiation of host immune responses against self-antigens and rapidly produce large amounts of cytokines upon stimulation...
2020: Frontiers in Immunology
Guilherme Gusmao-Silva, Sarah Leão Fiorini Aguiar, Mariana Camila Gonçalves Miranda, Mauro Andrade Guimarães, Juliana Lima Alves, Angélica Thomaz Vieira, Denise Carmona Cara, Anderson Miyoshi, Vasco Ariston Azevedo, Rafael Pires Oliveira, Ana Maria Caetano Faria
Oral tolerance is the physiological process that enables the immune system to differentiate between harmless dietary and microbiota antigens from pathogen derived antigens. It develops at the mucosal surfaces and can result in local and systemic regulatory and anti-inflammatory effects. Translation of these benefits to the clinical practice faces limitations involving specificity and doses of antigen as well as regimens of feeding. To circumvent these problems, we developed a recombinant Hsp65 delivered by the acid lactic bacteria Lactococcus lactis NCDO 2118 directy in the intestinal mucosa...
2020: Frontiers in Immunology
Isadora M Villas-Boas, Giselle Pidde, Flavio Lichtenstein, Ana Tung Ching Ching, Inácio de Loiola Meirelles Junqueira-de-Azevedo, Carlos DeOcesano-Pereira, Carlos Eduardo Madureira Trufen, Ana Marisa Chudzinski-Tavassi, Kátia Luciano Pereira Morais, Denise V Tambourgi
Pararamosis is a disease that occurs due to contact with the hairs of the larval stage of the Brazilian moth Premolis semirufa . Envenomation induces osteoarticular alterations with cartilage impairment that resembles joint synovitis. Thus, the toxic venom present in the caterpillar hairs interferes with the phenotype of the cells present in the joints, resulting in inflammation and promoting tissue injury. Therefore, to address the inflammatory mechanisms triggered by envenomation, we studied the effects of P ...
2020: Frontiers in Immunology
Laura Van Moortel, Kris Gevaert, Karolien De Bosscher
Exogenous glucocorticoids are widely used in the clinic for the treatment of inflammatory disorders and hematological cancers. Unfortunately, their use is associated with debilitating side effects, including hyperglycemia, osteoporosis, mood swings, and weight gain. Despite the continued efforts of pharma as well as academia, the search for so-called selective glucocorticoid receptor modulators (SEGRMs), compounds with strong anti-inflammatory or anti-cancer properties but a reduced number or level of side effects, has had limited success so far...
2020: Frontiers in Endocrinology
Alessandra Della Porta, Kasha Bornstein, Austin Coye, Tim Montrief, Brit Long, Mehruba Anwar Parris
BACKGROUND: Acute chloroquine and hydroxychloroquine toxicity is characterized by a combination of direct cardiovascular effects and electrolyte derangements with resultant dysrhythmias and is associated with significant morbidity and mortality. OBJECTIVE: This review describes acute chloroquine and hydroxychloroquine toxicity, outlines the complex pathophysiologic derangements, and addresses the emergency department (ED) management of this patient population. DISCUSSION: Chloroquine and hydroxychloroquine are aminoquinoline derivatives widely used in the treatment of rheumatologic diseases including systemic lupus erythematosus and rheumatoid arthritis as well as for malaria prophylaxis...
July 19, 2020: American Journal of Emergency Medicine
Sinan Kardeş, Ali Suat Kuzu, Rahul Raiker, Haig Pakhchanian, Mine Karagülle
To evaluate the public interest in rheumatic diseases during the coronavirus disease 2019 (COVID-19) pandemic. Google Trends was queried to analyze search trends in the United States for numerous rheumatic diseases and also the interest in a rheumatologist. Three 8-week periods in 2020 ((March 15-May 9), (May 10-July 4), and (July 5-August 29)) were compared to similar periods of the prior 4 years (2016-2019). Compared to a similar time period between 2016 and 2019, a significant decrease was found in the relative search volume for more than half of the search terms during the initial March 15-May 9, 2020 period...
October 18, 2020: Rheumatology International
Sakae Tanaka, Yoshiya Tanaka
Rheumatoid arthritis (RA) is an inflammatory disorder characterized by progressive joint destruction. Recent studies have demonstrated that osteoclasts are responsible for bone destruction in RA. Receptor activator of nuclear factor kappa B ligand (RANKL), an osteoclast differentiation factor, belongs to the tumor necrosis factor superfamily and plays a critical role in osteoclast differentiation. RANKL is highly expressed in the synovial tissues in patients with RA and is involved in osteoclast development and thus bone destruction in RA...
October 18, 2020: Journal of Bone and Mineral Metabolism
Yvette Meissner, Martin Schäfer, Matthias Schneider, Elke Wilden, Silke Zinke, Angela Zink, Anja Strangfeld
No abstract text is available yet for this article.
October 2020: RMD Open
Faezeh Ajama, Mehrdad Aghaei, Saeed Mohammadi, Hadise Samiei, Nasser Behnampour, Ali Memarian
Defect in T lymphocyte homeostasis could implicate initiation and development of rheumatoid arthritis (RA). Since PD-1 plays a key role in the regulation of T lymphocytes, its expression pattern in various CD8 + T cell subsets could be so effective in RA pathogenesis. Here, we investigated the expression of PD-1 and CXCR3 on CD8+CD28- T cells in association with the IFN-γ levels in patients with RA. A total of 42 RA patients, including 10 newly-diagnosed (ND) and 32 relapsed (RL) cases and also 20 healthy donors were enrolled...
October 15, 2020: Immunology Letters
B Bernier, J-C Gallois, G Cadelis
INTRODUCTION: Methotrexate-induced pneumonitis is a rare but potentially fatal side effect. It is a diagnosis of exclusion. There are early and late forms and different cell patterns in the bronchoalveolar lavage (BAL). CASE REPORT: We present a case of acute interstitial lung disease in a 54-year-old patient who had been taking methotrexate for a year and a half for rheumatoid arthritis. After excluding other causes and based on the diagnostic criteria of Searles and McKendry, we could reasonably identify methotrexate as the cause of the lung disease...
October 14, 2020: Revue des Maladies Respiratoires
Seiji Shibasaki, Miki Karasaki, Kiyoshi Matsui, Tsuyoshi Iwasaki
BACKGROUND: An affibody molecule obtained from a bioengineered staphylococcal protein was previously shown to act as an affinity binder for a wide range of targets and to develop tumour necrosis factor α (TNF-α-binding clones). METHODS: In this study, we demonstrated that affibody molecules against TNF-α could bind to recombinant TNF- on the membrane for a biochemical detection. In addition, we examined whether the affibody molecules could block binding between recombinant TNF-α and its receptor on MH7A synovial cells...
October 16, 2020: Current Pharmaceutical Biotechnology
Milena Despotovic, Tatjana Jevtovic Stoimenov, Sonja Stojanovic, Jelena Basic, Jasen Kundalic, Branka Djordjevic, Milica Randjelovic, Dusica Pavlovic
BACKGROUND AND AIMS: Vitamin D receptor (VDR) genetic variants are considered to have a role in the pathogenesis of rheumatoid arthritis (RA). This study examines an association of FokI, BsmI, ApaI and TaqI with RA, as well as with bone mineral density (RA with normal bone mineral density, RA-NBMD; RA with associated osteopenia, RA-OSTP; and RA with associated osteoporosis, RA-OP) and inflammatory markers. MATERIALS AND METHODS: VDR genetic variants were tested in 248 subjects using the PCR-RFLP method...
October 15, 2020: Clinical Biochemistry
Carlos Fernández-Díaz, Santos Castañeda, Rafael B Melero-González, Francisco Ortiz-Sanjuán, Antonio Juan-Mas, Carmen Carrasco-Cubero, Ivette Casafont-Solé, Alejandro Olivé, Samantha Rodríguez-Muguruza, Raquel Almodóvar-González, Raul Castellanos-Moreira, Sebastian C Rodríguez-García, Clara Aguilera-Cros, Ignacio Villa, Sergio Ordóñez-Palau, Erique Raya-Alvarez, Pilar Morales-Garrido, Clara Ojeda-García, Manuel J Moreno-Ramos, María Gema Bonilla Hernán, Iñigo Hernández Rodríguez, Mireia López-Corbeto, José L Andreu, Juan R D Jiménez de Aberásturi, Ana Ruibal-Escribano, Rosa Expósito-Molinero, Trinidad Pérez-Sandoval, Ana María López-Robles, Patricia Carreira-Delgado, Natalia Mena-Vázquez, Ana Urruticoechea-Arana, Cilia Peralta-Ginés, Luis Arboleya-Rodríguez, F Javier Narváez García, Deseada Palma-Sánchez, Evelin C Cervantes Pérez, Olga Maiz-Alonso, María N Alvarez-Rivas, Julia Fernández-Melón, Paloma Vela Casasempere, Ivan Cabezas-Rodríguez, Iván Castellvi-Barranco, Carmen González-Montagut, Juan Blanco-Madrigal, Natividad Del Val-Del Amo, María C Fito, Manuel Rodríguez-Gómez, Eva Salgado-Pérez, Blanca García-Magallón, Cristina Hidalgo-Calleja, Ruben López-Sánchez, Sabela Fernández-Aguado, Jesús C Fernández-López, Sonia Castro-Oreiro, Isabel Serrano-García, Andrea García-Valle, Susana Romero-Yuste, Lorena Expósito-Pérez, Lorena Pérez-Albadalejo, Angel García-Aparicio, Neus Quillis-Marti, José A Bernal-Vidal, Javier Loricera-García, José L Hernández, Miguel A González-Gay, Ricardo Blanco
OBJECTIVE: To assess the efficacy of abatacept (ABA) in RA patients with interstitial lung disease (ILD) (RA-ILD). METHODS: This was an observational, multicentre study of RA-ILD patients treated with at least one dose of ABA. ILD was diagnosed by high-resolution CT (HRCT). We analysed the following variables at baseline (ABA initiation), 12 months and at the end of the follow-up: Modified Medical Research Council (MMRC) scale (1-point change), forced vital capacity (FVC) or diffusion lung capacity for carbon monoxide (DLCO) (improvement or worsening ≥10%), HRCT, DAS on 28 joints evaluated using the ESR (DAS28ESR) and CS-sparing effect...
October 17, 2020: Rheumatology
Richard Conway, Elena Nikiphorou
No abstract text is available yet for this article.
October 17, 2020: Rheumatology
Avinash Jain, Amita Aggarwal, Jo Adams, Rachel E Jordan, Steven Sadhra, Shirish Dubey, Kerry Allen, Kanta Kumar
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease with varied articular and extra-articular manifestations. In developing countries such as India patients with RA often delay seeking medical advice which may impact prognosis and disease burden. AIM: To explore perceptions and experiences of patients living in India in seeking medical help for their RA symptoms. METHODS: Clinician-diagnosed RA participants from different socioeconomic backgrounds were interviewed using a semi-structured topic guide...
October 17, 2020: International Journal of Rheumatic Diseases
Junko Toyoshima, Mai Shibata, Atsunori Kaibara, Yuichiro Kaneko, Hiroyuki Izutsu, Tetsuya Nishimura
AIMS: To analyze the population pharmacokinetics (PK) of peficitinib in patients with rheumatoid arthritis (RA) and assess the potential PK covariates to identify the requirement for dose adjustment in RA patients. METHODS: The analysis incorporated 2464 observations from 98 healthy volunteers and 4919 observations from 989 RA patients. A population PK model for peficitinib in RA patients was constructed by a non-linear mixed effect model using NONMEM® with prior information from a healthy volunteer model...
October 17, 2020: British Journal of Clinical Pharmacology
Celia Cartagena García, Alexandra Lefèvre, Jean-Marc R Busnel
TNF is a key cytokine in autoimmune diseases like rheumatoid arthritis, and TNF antagonists are commonly prescribed therapeutics. Although anti-TNF drugs have enabled a very significant progress in this field, disease heterogeneity remains and causes diversity in patient response. These challenges increase the need for anti-TNF characterization tools that may open perspectives toward the development of personalized medicine. In this study, we present a novel whole blood-based flow cytometry functional assay that allows, within a given whole blood sample, the characterization of an anti-TNF molecule mechanisms of action...
October 16, 2020: ImmunoHorizons
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