C Martinez-Múgica, G Manso
OBJECTIVE: New treatments in rheumatoid arthritis (RA) have been developed to improve patient outcomes, raise their quality of life, and reduce joint damage, but long-term responses and remission remain low. This study aimed to analyse the Spanish prescribing patterns and the effectiveness of biological (b) disease-modifying anti-rheumatic drugs (DMARDs) available for RA in clinical practice. PATIENTS AND METHODS: An observational retrospective study was performed in a teaching hospital, analysing the different combinations of drugs prescribed, real-life effectiveness and reasons for withdrawal...
August 2020: European Review for Medical and Pharmacological Sciences
L-Q Zhi, Q Zhong, J-B Ma, L Xiao, S-X Yao, X Wang
The article "LncRNA H19 inhibitor represses synovial cell proliferation and apoptosis in rats with rheumatoid arthritis via Notch signaling pathway, by L.-Q. Zhi, Q. Zhong, J.-B. Ma, L. Xiao, S.-X. Yao, X. Wang, published in Eur Rev Med Pharmacol Sci 2020; 24 (8): 4088-4094-DOI: 10.26355/eurrev_202004_20985-PMID: 32373945" has been withdrawn from the authors. The Publisher apologizes for any inconvenience this may cause.
August 2020: European Review for Medical and Pharmacological Sciences
Gary R Lichtenstein, Gerhard Rogler, Matthew A Ciorba, Chinyu Su, Gary Chan, Ronald D Pedersen, Nervin Lawendy, Daniel Quirk, Chudy I Nduaka, Andrew J Thorpe, Julian Panés
BACKGROUND: Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Here, we performed an integrated analysis of malignancy events from the tofacitinib phase 3 UC clinical development program (excluding nonmelanoma skin cancer [NMSC]). METHODS: Data (up to May 2019) were pooled from two phase 3 induction studies, a phase 3 maintenance study, and an ongoing, open-label, long-term extension (OLE) study, and analyzed as 3 cohorts: induction (N = 1139), maintenance (N = 592), and overall (induction, maintenance, and ongoing OLE study; N = 1124)...
August 7, 2020: Inflammatory Bowel Diseases
Ertuğrul Karataş, Ayhan Kul, Ebru Tepecik
Objective: The present cross-sectional study aimed to investigate possible association between Rheumatoid Arthritis (RA) and Apical Periodontitis (AP). Methods: In table one it is mentioned 48 patients diagnosed with RA were included in the experimental group. Another 48 healthy age- and gender-matched participants who reported no history of any systemic disease were selected to form the control group. All the patients were examined radiographically and clinically to diagnose the presence of AP...
2020: European Endodontic Journal
Long-Shan Ji, Xue-Hua Sun, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, Xiao-Jun Zhu, Ling-Ying Huang, Miao Fang, Ya-Ting Gao, Man Li, Yue-Qiu Gao
Helping B cells and antibody responses is a major function of CD4+ T helper cells. Follicular helper T (Tfh) cells are identified as a subset of CD4+ T helper cells, which is specialized in helping B cells in the germinal center reaction. Tfh cells express high levels of CXCR5, PD-1, IL-21, and other characteristic markers. Accumulating evidence has demonstrated that the dysregulation of Tfh cells is involved in infectious, inflammatory, and autoimmune diseases, including lymphocytic choriomeningitis virus (LCMV) infection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), IgG4-related disease (IgG4-RD), Sjögren syndrome (SS), and type 1 diabetes (T1D)...
2020: Journal of Immunology Research
Jianhong Wu, Jianling Dong, Shilin Li, Jiaang Luo, Yu Zhang, Hong Liu, Yuanpiao Ni, Xue Li, Jun Zhou, Hang Yang, Qianrong Xie, Xuejun Jiang, Tingting Wang, Pingxi Wang, Fanwei Zeng, Yanpeng Chu, Jing Yang, Fanxin Zeng
Background: The aim of this study is to evaluate the clinical efficacy of vitamin D (VitD) supplementation in terms of response to treatment and improvement of disease activity in rheumatoid arthritis (RA). Methods: This study analyzed 1180 RA patients' records treated at Mianyang Central Hospital from February 2015 to July 2019. The patients were allocated into VitD group and control group based on their medical regimens. The outcome measures were primary efficacy, defined as treatment response-based EULAR response criteria in RA, and secondary efficacy, defined as improvement in disease activity indicators...
2020: Frontiers in Medicine
Doaa Mohamed El-Tedawy, Mohammad Mahmoud Abd-Alhaseeb, Maged Wasfy Helmy, Asser Ibrahim Ghoneim
Bee venom (BV) is widely used as a traditional China medicine to treat various conditions, including rheumatoid arthritis (RA). The aim of the present study was to evaluate the effects of systemic BV (60 mg/kg) as an anti-arthritic natural product, compare it with Methotrexate and determine the possible underlying mechanisms of BV action using complete Freund's adjuvant-induced arthritic rats. The development of signs of RA signs (knee joint circumference and arthritis scoring index) was evaluated. Erythrocyte sedimentation rate, serum tumor necrosis factor-α (TNF-α) and serum interleukin-1β (IL-1β) levels were measured at the end of the study...
October 2020: Biomedical Reports
Xiaoxia Ren, Ting Yang, Jianmei Li, Jing Zhang, Jing Geng, Huaping Dai
Idiopathic pulmonary hemosiderosis (IPH) is a rare interstitial lung disease, usually occurring in children or young adults. Although several studies reported on the coexistence of IPH and immune system diseases, the association between these conditions has not been well described. The present study reports on the case of a 21-year-old female patient who presented with bilateral lung abnormalities. The patient was admitted due to a 2-year history of progressive exertional dyspnea, as well as arthralgia and joint swelling in the recent 2 months...
September 2020: Experimental and Therapeutic Medicine
Caroline Wasén, Caroline Ospelt, Alessandro Camponeschi, Malin C Erlandsson, Karin M E Andersson, Sofia Töyrä Silfverswärd, Steffen Gay, Maria I Bokarewa
Objective: Smoking suppresses PD-1 expression in patients with rheumatoid arthritis (RA). In this study, we assess if smoking changed the epigenetic control over CD8+ T cell memory formation through a microRNA (miR) dependent mechanism. Methods: Phenotypes of CD8+ T cells from smokers and non-smokers, RA and healthy, were analyzed by flow cytometry. A microarray analysis was used to screen for differences in miR expression. Sorted CD8+ cells were in vitro stimulated with nicotine and analyzed for transcription of miRs and genes related to memory programming by qPCR...
2020: Frontiers in Immunology
Theresa L Wampler Muskardin, Wei Fan, Zhongbo Jin, Mark A Jensen, Jessica M Dorschner, Yogita Ghodke-Puranik, Betty Dicke, Danielle Vsetecka, Kerry Wright, Thomas Mason, Scott Persellin, Clement J Michet, John M Davis, Eric Matteson, Timothy B Niewold
Previously, we demonstrated in test and validation cohorts that type I IFN (T1IFN) activity can predict non-response to tumor necrosis factor inhibitors (TNFi) in rheumatoid arthritis (RA). In this study, we examine the biology of non-classical and classical monocytes from RA patients defined by their pre-biologic treatment T1IFN activity. We compared single cell gene expression in purified classical (CL, n = 342) and non-classical (NC, n = 359) monocytes. In our previous work, RA patients who had either high IFNβ/α activity (>1...
2020: Frontiers in Immunology
Valéria Valim, Ketty Lysie Libardi Lira Machado, Samira Tatiyama Miyamoto, Arthur Dalmaso Pinto, Priscila Costa Martins Rocha, Erica Vieira Serrano, Valquiria Garcia Dinis, Sônia Alves Gouvêa, João Gabriel Fragoso Dias, Ana Carolina Campi-Azevedo, Andréa Teixeira-Carvalho, Vanessa Peruhype-Magalhães, Ismael Artur da Costa-Rocha, Sheila Maria Barbosa de Lima, Emily Hime Miranda, Gisela Freitas Trindade, Maria de Lourdes de Sousa Maia, Maria Bernadete Renoldi de Oliveira Gavi, Lidia Balarini da Silva, Ruben Horst Duque, Ana Paula Espíndula Gianordoli, Thays Zanon Casagrande, Karine Gadioli Oliveira, Bruna Costa da Mata Moura, Fernanda Nicole-Batista, Luiza Correa Rodrigues, Thalles Brandão Clemente, Enan Sales Magalhães, Maria de Fatima Bissoli, Maria da Penha Gomes Gouvea, Lauro Ferreira da Silva Pinto-Neto, Carolina Zorzanelli Costa, Raquel Altoé Giovelli, Leticia Resende Brandão, Elizandra Tomazela Laurenti Polito, Ingrid de Oliveira Koehlert, Brunela Passos Borjaille, Daniela Bergamim Pereira, Laiza Hombre Dias, Daniela Linhares Merlo, Luiz Fellipe Favoreto Genelhu, Flavia Zon Pretti, Maryella Dos Santos Giacomin, Ana Paula Neves Burian, Francieli Fontana Sutile Tardetti Fantinato, Gecilmara Salviato Pileggi, Lícia Maria Henrique da Mota, Olindo Assis Martins-Filho
Yellow Fever (YF) vaccination is suggested to induce a large number of adverse events (AE) and suboptimal responses in patients with autoimmune diseases (AID); however, there have been no studies on 17DD-YF primary vaccination performance in patients with AID. This prospective non-interventional study conducted between March and July, 2017 assessed the safety and immunogenicity of planned 17DD-YF primary vaccination in patients with AID. Adult patients with AID (both sexes) were enrolled, along with healthy controls, at a single hospital (Vitória, Brazil)...
2020: Frontiers in Immunology
Alessio Romerio, Francesco Peri
Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by Pathogen- and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers pro-inflammatory responses that belong to the repertoire of innate immune responses, consequently protecting against infectious challenges and boosting adaptive immunity. Mild TLR4 stimulation by non-toxic molecules resembling its natural agonist (lipid A) provided efficient vaccine adjuvants. The non-toxic TLR4 agonist monophosphoryl lipid A (MPLA) has been approved for clinical use...
2020: Frontiers in Immunology
Denes Toth, Edina Szabo, Andrea Tamas, Tamas Juhasz, Gabriella Horvath, Eszter Fabian, Balazs Opper, Dora Szabo, Grazia Maugeri, Agata G D'Amico, Velia D'Agata, Viktoria Vicena, Dora Reglodi
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is also expressed in peripheral organs but its peripheral protective effects have not been summarized so far. Therefore, the aim of the present paper is to review the existing literature regarding the cytoprotective effects of PACAP in non-neuronal cell types, peripheral tissues, and organs. Among others, PACAP has widespread expression in the digestive system, where it shows protective effects in various intestinal pathologies, such as duodenal ulcer, small bowel ischemia, and intestinal inflammation...
2020: Frontiers in Endocrinology
Atta Abbas Naqvi, Mohamed Azmi Hassali, Mehwish Rizvi, Ale Zehra, Zeb-Un- Nisa, Md Ashraful Islam, Muhammad Shahid Iqbal, Maryam Farooqui, Mohammad Tarique Imam, Mohammad Akbar Hossain, Irfanullah Khan, Muhammad Zahid Iqbal, Majid Ali, Abdul Haseeb
Objective: The aim was to validate the Urdu version of General Medication Adherence Scale (GMAS) in patients with rheumatoid arthritis disease. Methods: A 2-month (March-April 2019) cross-sectional study was conducted in randomly selected out-patients with rheumatoid arthritis. The sample size was calculated using item-subject ratio of 1:20. The scale was evaluated for factorial, concrete, concurrent, and known group validities. Concrete validity was established by correlating scores of EQ-5D quality of life scale and GMAS adherence score...
2020: Frontiers in Pharmacology
Soohyun Kim, Siun Kim, Howard Lee
We evaluated the appropriateness of various equivalence margins for CT-P13, an infliximab biosimilar, in the PLANETRA clinical trial. The 95-95% method was used to independently determine an equivalence margin by pooling the historical clinical trials with original infliximab versus placebo, identified in a systematic literature search. The constancy assumption with the PLANETRA trial was assessed for each identified historical clinical trial to decide which study was scientifically justifiable to be pooled...
2020: Drug Design, Development and Therapy
Dalia Miltinienė, Giedrė Deresevičienė, Birutė Nakčerienė, Valerija Edita Davidavičienė, Edvardas Danila, Irena Butrimienė, Jolanta Dadonienė
Background and objective: With an increase in survival rates among rheumatic patients, comorbidities and infections, in particular, have gained more importance, especially after the introduction of biologicals to the treatment algorithms. Tuberculosis (TB) infection has always been given a special attention in patients with rheumatic diseases (RD). Although Lithuanian population has one of the highest TB incidence rates among European countries, the incidence of TB in the rheumatic patients' population is still unknown...
August 5, 2020: Medicina
Keisuke Ono, Mitsumasa Kishimoto, Teppei Shimasaki, Hiroko Uchida, Daisuke Kurai, Gautam A Deshpande, Yoshinori Komagata, Shinya Kaname
Reactive arthritis (ReA) is typically preceded by sexually transmitted disease or gastrointestinal infection. An association has also been reported with bacterial and viral respiratory infections. Herein, we report the first case of ReA after the he severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This male patient is in his 50s who was admitted with COVID-19 pneumonia. On the second day of admission, SARS-CoV-2 PCR was positive from nasopharyngeal swab specimen. Despite starting standard dose of favipiravir, his respiratory condition deteriorated during hospitalisation...
August 2020: RMD Open
Alireza Paniri, Mohammad Mahdi Hosseini, Ahmad Rasoulinejad, Haleh Akhavan-Niaki
Antimalaria drugs such as chloroquine (CQ) and hydroxychloroquine (HCQ) have been administered to several inflammatory diseases including rheumatoid arthritis and systemic lupus erythematosus, and infectious diseases such as acquired immune deficiency syndrome and influenza. Recently, several patients infected with novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were given HCQ, and showed a discrepant response. HCQ inhibits SARS-CoV-2 cell entry, and inflammatory cascade by interfering with lysosomal and endosomal activities, and autophagy, impeding virus-membrane fusion, and inhibiting cytokine production resulted from inflammatory pathways activation...
August 4, 2020: European Journal of Pharmacology
Hülya Peynirci Cerşit, İlker Yağcı, Sinan Cerşit
Objectives: This study aims to evaluate the effect of cardiac rehabilitation (CR) on disease activity, functional status, fitness, and modified cardiovascular disease (CVD) risk factors in patients with rheumatoid arthritis (RA) with a moderate disease activity. Patients and methods: This single-center, controlled study included a total of 60 female RA patients (mean age 57.5 years; range, 50 to 64 years) with moderate disease activity according to the Disease Activity Score-28 (DAS28) between January 2014 and June 2015...
June 2020: Turkish journal of physical medicine and rehabilitation
Felice Rivellese, Francesca W Rossi, Giovanni Giorli, Filomena Napolitano, Amato de Paulis, Costantino Pitzalis
Mast cells (MCs) are immune cells infiltrating the synovial membrane and implicated in the pathogenesis of Rheumatoid Arthritis (RA). Their infiltration in the synovia of early RA patients has been shown to be associated with systemic inflammation, disease activity and autoantibody positivity. Here, we analyzed their presence in matched synovial samples obtained by ultrasound-guided synovial biopsies pre- and post-treatment with conventional synthetic Disease Modifying Anti-Rheumatic Drugs (csDMARDs) (n=20)...
2020: Frontiers in Pharmacology
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