Yusuke Kashiwado, Yasutaka Kimoto, Shiro Ohshima, Takuya Sawabe, Kensuke Irino, Shota Nakano, Junki Hiura, Akiko Yonekawa, Qiaolei Wang, Goro Doi, Masahiro Ayano, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Hiroaki Niiro, Taeko Hotta, Dongchon Kang, Nobuyuki Shimono, Koichi Akashi, Tsutomu Takeuchi, Takahiko Horiuchi
OBJECTIVES: To evaluate the long-term impact of immunosuppressive therapeutic agents on antibody response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) mRNA vaccination in patients with autoimmune rheumatic diseases (AIRD) in order to propose a strategy for annual vaccination. METHODS: This prospective multicentre cohort study evaluated the humoral response to second and third BNT162b2 and/or mRNA-1273 vaccines in 382 Japanese AIRD patients classified into 12 different medication groups and in 326 healthy controls (HCs)...
June 8, 2023: Rheumatology
Raphael Micheroli, Seraphina Kissling, Kristina Bürki, Burkhard Möller, Axel Finckh, Michael J Nissen, Pascale Exer, René Bräm, Diego Kyburz, Andrea Rubbert-Roth, Michael Andor, Xenofon Baraliakos, Manouk de Hooge, Oliver Distler, Almut Scherer, Adrian Ciurea
OBJECTIVE: As anaemia represents a biomarker for increased radiographic damage in rheumatoid arthritis, we aimed to investigate whether it independently predicts spinal radiographic progression in axial spondyloarthritis (axSpA). METHODS: AxSpA patients with available haemoglobin levels from the prospective Swiss Clinical Quality Management Registry were included for comparison of patients with and without anaemia. Spinal radiographic progression was assessed according to the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) in patients with ankylosing spondylitis (AS) if ≥ 2 sets of spinal radiographs were available every 2 years...
June 8, 2023: Clinical Rheumatology
Filip Machaj, Jakub Rosik, Bartosz Szostak, Damian Malinowski, Krzysztof Safranow, Gabriela Olędzka, Emilia Wiechec, Andrzej Pawlik
INTRODUCTION/OBJECTIVES: Rheumatoid arthritis (RA) is a disease affecting around 1% of the population in developed countries and can be treated with leflunomide. The higher prevalence of RA among women and numerous previous studies suggested the crucial role of sex hormones. Cytochrome CYB5A regulates the synthesis of androgens. Therefore, the aim of this study was to determine the association between common CYB5A gene polymorphism and the response to leflunomide in women with RA. METHODS: This study included 111 patients...
June 8, 2023: Clinical Rheumatology
Naz Elahi, Abraish Ali, Rahma Idrees
No abstract text is available yet for this article.
June 8, 2023: International Journal of Clinical Pharmacology and Therapeutics
Megumi Kishimoto, Mayumi Komine, Hirofumi Okada, Atsuko Sato, Koji Kamiya, Takeo Maekawa, Satoru Murata, Mamitaro Ohtsuki
Subcorneal pustular dermatosis, a rare, benign skin disease, is a type of neutrophilic dermatosis. The authors reported three cases of subcorneal pustular dermatosis. In case 1, a 9-year-old girl developed a skin rash with blisters following a mycoplasma infection and had a flare-up due to a common cold. She was successfully treated with a topical corticosteroid. In case 2, a 70-year-old woman who had been treated for rheumatoid arthritis with adalimumab, salazosulfapyridine, and leflunomide developed 3- to 5-mm pustules on her trunk and thighs 4 days after flu vaccination...
June 8, 2023: Journal of Dermatology
Min Wang, Kun Mei, Ce Chao, Dongmei Di, Yongxiang Qian, Bin Wang, Xiaoying Zhang
BACKGROUND: Numerous studies have demonstrated that rheumatoid arthritis (RA) is related to increased incidence of heart failure (HF), but the underlying association remains unclear. In this study, the potential association of RA and HF was clarified using Mendelian randomization analysis. METHODS: Genetic tools for RA, HF, autoimmune disease (AD), and NT-proBNP were acquired from genome-wide studies without population overlap. The inverse variance weighting method was employed for MR analysis...
2023: Frontiers in Endocrinology
Abdulmalek Y Abdullah, Rihab A Yousif, Awadia G Suliman, Amel A Ibn Idris, Sujood A Hassan, Shima I Ali, Sultan A Alshoabi, Eman M Algorashi, Bassam N Mohammed, Maisa Elzaki
Background Rheumatoid arthritis (RA) is one cause of carpal tunnel syndromes (CTS); due to increased intracarpal pressure in the rheumatoid wrist, synovial enlargement, joint erosions, and ligamentous laxity cause the compression of the median nerve (MN). Materials and methods A case-control study was conducted to assess the measurement of median nerve areas in RA using high-frequency ultrasound (US) and to correlate the measurement with the disease duration. Forty patients with rheumatoid arthritis (RA) and 40 with non-rheumatoid arthritis (RA) as a control group were referred to the radiology department of Yastabshiron Hospital, Khartoum, Sudan, from June to August 2022...
May 2023: Curēus
Jasmit Walia, Rehan Mujahid
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is a protein encoded by the NOD2 gene and plays an important role in the immune system. NOD2 is an intracellular pattern recognition receptor (PRR) responsible for the recognition of pathogens as well as the activation of many biochemical processes within cells of the host immune system. Mutations of the NOD2 gene can significantly impact the host's immune response against a variety of pathogens. In addition to immunodeficiency, mutations of the NOD2 gene have also been linked with several atopic diseases and autoimmune conditions such as rheumatoid arthritis and Crohn's disease (CD)...
May 2023: Curēus
Qi Chen, Chengyuan Wu, Siwei Wang, Qiang Wang, Peiyun Wu, Lei Wang, Peiyu Yan, Ying Xie
Introduction: Rheumatoid arthritis is an autoimmune disease characterized by chronic joint inflammation. Methotrexate is one of the most effective drugs for rheumatoid arthritis, but the adverse reactions caused by oral methotrexate greatly limit its clinical application. Transdermal drug delivery system is an ideal alternative to oral methotrexate by absorbing drugs into the human body through the skin. However, methotrexate in the existing methotrexate microneedles is mostly used alone, and there are few reports of combined use with other anti-inflammatory drugs...
2023: Frontiers in Chemistry
Marta Juliana Mantilla, Juan José Chaves, Juan Camilo Santacruz, Gustavo Rodríguez-Salas, Igor Rueda, Ana Maria Santos, John Londoño, Julio Cesar Mantilla
INTRODUCTION: the autopsy is an essential medical procedure; however, its use has declined over the decades. In autoimmune and rheumatological diseases, anatomical and microscopic diagnosis is critical to diagnose of the cause of death. For this reason, our objective is to describe the cause of death in patients diagnosed with autoimmune and rheumatic diseases who underwent an autopsy in a Pathology reference center in Colombia. MATERIALS AND METHODS: a retrospective and descriptive study of autopsy reports...
2023: Autopsy & Case Reports
Andriko Palmowski, Zhivana Boyadzhieva, Sabrina M Nielsen, Burkhard Muche, Sandra Hermann, Maarten Boers, Henning Bliddal, Robin Christensen, Edgar Wiebe, Frank Buttgereit
BACKGROUND: It is unclear whether sex or age modify the association of glucocorticoid (GC) use with reduced bone mineral density (BMD) in patients with rheumatoid arthritis (RA). METHODS: We studied cross-sectional data of RA patients with current or previous GC treatment in a single center cohort study (Rh-GIOP cohort). Our primary outcome was the minimum T-score (measured by DXA) of either lumbar spine, total femur, or femoral neck. Current GC dose was the main exposure; cumulative GC dose and cumulative duration of GC use were also assessed...
June 7, 2023: Arthritis Research & Therapy
Gi Heon Jeong, Min-Kyung Nam, Wonhee Hur, Seolhee Heo, Saseong Lee, Eunbyeol Choi, Jae Hyung Park, Youngjae Park, Wan-Uk Kim, Hyangshuk Rhim, Seung-Ah Yoo
BACKGROUND: High-temperature requirement serine protease A 2 (HtrA2) is known to be involved in growth, unfolded protein response to stress, apoptosis, and autophagy. However, whether HtrA2 controls inflammation and immune response remains elusive. METHODS: Expression of HtrA2 in the synovial tissue of patients was examined using immunohistochemistry and immunofluorescence staining. Enzyme-linked immunosorbent assay was used to determine the concentrations of HtrA2, interleukin-6 (IL-6), interleukin-8 (IL-8), chemokine (C-C motif) ligand 2 (CCL2), and tumor necrosis factor α (TNFα)...
June 7, 2023: Arthritis Research & Therapy
Manuel Pombo-Suárez, Daniel Seoane-Mato, Federico Díaz-González, Fernando Sánchez-Alonso, Marta Sánchez-Jareño, Luis Cea-Calvo, Isabel Castrejón
BACKGROUND: In patients with rheumatic diseases, the use of biological (b) or targeted synthetic (ts) disease-modifying antirheumatic drugs (DMARDs) after discontinuation of tumor necrosis factor inhibitors (TNFi) is known to be effective. However, data on the use of TNFi after discontinuation of non-TNFi bDMARDs or tsDMARDs (non-TNFi) are scarce. This study assessed the 4-years golimumab retention in patients with rheumatic diseases when used after discontinuation of non-TNFi. METHODS: Adults with rheumatoid arthritis (RA; n = 72), psoriatic arthritis (PsA; n = 30) or axial spondyloarthritis (axSpA; n = 23) who initiated golimumab after discontinuation of non-TNFi from the Spanish registry of biological drugs (BIOBADASER) were analyzed retrospectively...
June 7, 2023: Advances in Rheumatology
Dinah Rzepka, Hannah Schenker, Hans Geinitz, Elisabeth Silberberger, Dorothee Kaudewitz, Barbara Schuster, Lukas Kuhlmann, Miriam Schonath, Horacio Ayala Gaona, Bernhard Aschacher, Rainer Fietkau, Georg Schett, Luitpold Distel
BACKGROUND: The risk of developing late radiotoxicity after radiotherapy in patients with high chromosomal radiosensitivity after radiotherapy could potentially be higher compared to the risk in patients with average radiosensitivity. In case of extremely high radiosensitivity, dose reduction may be appropriate. Some rheumatic diseases (RhD), including connective tissue diseases (CTDs) appear to be associated with higher radiosensitivity. The question arises as to whether patients with rheumatoid arthritis (RA) also generally have a higher radiosensitivity and whether certain parameters could indicate clues to high radiosensitivity in RA patients which would then need to be further assessed before radiotherapy...
June 7, 2023: Radiation Oncology
Janni Maria Pedersen, Aida Solhøj Hansen, Cæcilie Skejø, Kristian Juul-Madsen, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Bjarne Kuno Møller, Lene Dreyer, Ellen-Margrethe Hauge, Malene Hvid, Stinne Greisen, Bent Deleuran
BACKGROUND: Lymphocyte activation gene-3 (LAG-3) inhibits T cell activation and interferes with the immune response by binding to MHC-II. As antigen presentation is central in rheumatoid arthritis (RA) pathogenesis, we studied aspects of LAG-3 as a serological marker and mediator in the pathogenesis of RA. Since Galectin-3 (Gal-3) is described as an additional binding partner for LAG-3, we also aimed to study the functional importance of this interaction. METHODS: Plasma levels of soluble (s) LAG-3 were measured in early RA patients (eRA, n = 99) at baseline and after 12 months on a treat-to-target protocol, in self-reportedly healthy controls (HC, n = 32), and in paired plasma and synovial fluid (SF) from chronic RA patients (cRA, n = 38)...
June 7, 2023: Arthritis Research & Therapy
J M Reyes, M V Gutierrez, H Madariaga, W Otero, R Guzman, J Izquierdo, M Abello, P Velez, D Castillo, D Ponce de Leon, T Lukic, L Amador
OBJECTIVE: To describe efficacy, safety, and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) with an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) treated with tofacitinib or biological DMARDs (bDMARDs) in real-life conditions. METHODS: A noninterventional study was performed between March 2017 and September 2019 at 13 sites in Colombia and Peru. Outcomes measured at baseline and at the 6-month follow-up were disease activity (RAPID3 [Routine Assessment of Patients Index Data] score), functional status (HAQ-DI [Health Assessment Questionnaire] score), and quality of life (EQ-5D-3L [EuroQol Questionnaire])...
2023: Reumatología clinica
Ryan Cheng, Ethan C Krell, Yu-Fen Chiu, Jeffrey D Stimac, Thomas J Heyse, Matthew P Abdel, Mark P Figgie, Jason L Blevins
BACKGROUND: Total knee arthroplasties (TKA) for patients 35 years of age and younger are rare, but necessary for patients who have diseases such as juvenile idiopathic arthritis, osteonecrosis, osteoarthritis, and rheumatoid arthritis. Few studies have examined the 10- and 20-year survivorship and clinical outcomes of TKAs for young patients. METHODS: A retrospective registry review identified 185 TKAs in 119 patients ≤ 35 years old between 1985 and 2010 performed at a single institution...
June 5, 2023: Journal of Arthroplasty
Chang-Le Liu, Meng-Qi Yang, Zhi-Shu Tang, Yan-Ru Liu, Zhong-Xing Song, Xin Zhang, Xing-Jing Yang, Yan-Ting Zhao
OBJECTIVE: To investigate the therapeutic effect and mechanism of the traditional Chinese medicine Saposhnikovia divaricata (Trucz.) Schischk in rats with complete Freund's adjuvant-induced rheumatoid arthritis (RA). METHODS: The chemical targets and RA targets of Saposhnikovia divaricata (Trucz.) Schischk were acquired by the network pharmacological method. The complete Freund's adjuvant-induced rat RA model was used to further explore the mechanism of Saposhnikovia divaricata (Trucz...
June 5, 2023: Analytical Biochemistry
Shao-Liang Jiang, Zhe-Ying Hu, Wan-Jun Wang, Lu Hu, Li Li, Song-Bo Kou, Jie-Hua Shi
Baricitinib is a Janus Kinase (JAK) inhibitor that is primarily used to treat moderately to severely active rheumatoid arthritis in adults and has recently been reported for the treatment of patients with severe COVID-19. This paper describes the investigation of the binding behavior of baricitinib to human α1-acid glycoprotein (HAG) employing a variety of spectroscopic techniques, molecular docking and dynamics simulations. Baricitinib can quench the fluorescence from amino acids in HAG through a mix of dynamic and static quenching, according to steady-state fluorescence and UV spectra observations, but it is mainly static quenching at low concentration...
June 5, 2023: International Journal of Biological Macromolecules
Jiahua Zhang, Wang Jie, Guofeng Cheng, Zhaojun Gu, Xingguo Liu
In this study, we analyzed the hepatopancreas tissues of Asian Clam (Corbicula fluminea) exposed to three different adverse environmental conditions from the same batch using RNA-seq. The four treatment groups included the Asian Clam group treated with Microcystin-LR (MC), the Microplastics-treated group (MP), the Microcystin-LR and Microplastics-treated group (MP-MC), and the Control group. Our Gene Ontology analysis revealed 19,173 enriched genes, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis identified 345 related pathways...
June 5, 2023: Fish & Shellfish Immunology
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