Marco Ferrández-Jiménez, Irene Calabuig, María-Luisa Peral-Garrido, Miguel Gómez-Garberí, Mariano Andrés
OBJECTIVES: Osteoporosis causes significant morbidity and mortality by the development of fragility fractures, including vertebral fractures. Patients with gout may show an increased risk of osteoporotic fractures, as accelerated bone resorption is likely linked to urate crystal-led inflammatory state. This study aims to evaluate the risk of osteoporotic dorsal vertebral fractures associated with gout. METHODS: Cross-sectional study carried out in patients admitted for cardiovascular events...
February 25, 2021: Reumatología Clinica
Julián Torres-Vázquez, Martín Uriel Vázquez-Medina, David Alberto Comoto-Santacruz, Mariano Emilio Pradillo-Macias, Omar Eloy Muñoz-Monroy, Adriana Martínez-Cuazitl
OBJECTIVES: To evaluate IP-10 gene expression in patients with SLE, and its possible relationship with disease activity. PATIENTS AND METHODS: This study included 120 patients diagnosed with SLE and 30 healthy controls. The relative gene expression of IP-10 was investigated with the Fold Change method, which was correlated with the level of lupus activity evaluated with the SLEDAI 2-K instrument. RESULTS: Different levels of gene expression were found according to the SLE activity (p =<0...
February 24, 2021: Reumatología Clinica
Fernando Villalobos, Carla Matellan, Gabriel Sequeira, Eduardo Kerzberg
BACKGROUND: Off-label (OL) drug use is the prescription of a drug for indications other than those authorised in its technical datasheet. The objective of this study was to identify drugs recommended in rheumatology but considered for off-label use in Argentina. METHODS: A list of medications for certain selected rheumatic conditions was compiled. A drug was considered recommended if it was endorsed by a) at least one Argentine or Pan-American treatment guideline or consensus, or b) two international treatment guidelines, or c) one international treatment guideline and one selected textbook...
February 24, 2021: Reumatología Clinica
Paolo Falsetti, Edoardo Conticini, Caterina Baldi, Marco Bardelli, Luca Cantarini, Bruno Frediani
OBJECTIVES: To investigate peripheral enthesitis with power Doppler ultrasound (PDUS) in patients presenting low back pain (LBP) and metabolic syndrome (MetS) in comparison with patients with only LBP, to correlate US scores with clinical-anthropometric characteristics, and to define any relationship between enthesitis and concurrent diffuse idiopathic hyperostosis syndrome (DISH). METHODS: Sixty outpatients with LBP and MetS, evaluated with multi-site entheseal PDUS, scoring inflammatory and structural damage changes, were retrospectively analyzed...
February 24, 2021: Reumatología Clinica
Camilla de Almeida Martins, Ana Elisa Rabe Caon, Carolina Bortolozzo Graciolli Facanali, Carlos Walter Sobrado, Sergio Carlos Nahas, Rosa Maria Rodrigues Pereira, Reuma Margalit-Yehuda, Uri Kopylov, Natalia Sousa Freitas Queiroz
Background: Takayasu's arteritis (TA) and inflammatory bowel disease (IBD) are chronic inflammatory granulomatous disorders that have rarely been concomitantly reported in case reports and small case series. Objective: We report a series of seven cases of TA and IBD association in two referral centers with a comprehensive review of literature. Methods: We analyzed retrospectively the electronic medical charts of TA-IBD patients at the University Hospital of São Paulo, Brazil, and at the Sheba Medical Center at Tel Aviv University, Israel...
2021: Gastroenterology Research and Practice
María Laura Alberti, Verónica Wolff, Felipe Reyes, Ernesto Juárez-León, Leandro Fassola, Gabriel Carballo, Ivette Buendía-Roldán, Jorge Rojas-Serrano, Fabián Caro, Matías Florenzano, Francisco Paulín
BACKGROUND AND OBJECTIVES: ILD patients can be positive to highly specific autoantibodies of connective tissue diseases (CTD). Among them stand out myositis-specific and associated autoantibodies (MSA/MAA). There is limited knowledge about treatment response and prognosis of ILD patients positive to MSA/MAA (MSA/MAA-ILD). Our aim was to describe clinical, radiological and pulmonary function (PF) of MSA/MAA-ILD Latin-American patients and risk factors associated to PF at onset and long term follow up...
February 15, 2021: Reumatología Clinica
Sreoshy Saha, Latika Gupta
No abstract text is available yet for this article.
February 10, 2021: Reumatología Clinica
Gabriel Horta-Baas
OBJECTIVE: To evaluate the validity, reliability, and performance of the Health Assessment Questionnaire-II(HAQ-II) Spanish version questionnaire to measure physical function. METHODS: A cross-sectional study of 496 patients with rheumatoid arthritis, distributed in 2 samples. The construct validity was evaluated employing the confirmatory factor analysis and the validity based on the relationship with other variables. Cronbach's alpha (α) and McDonald's omega (ω) coefficient were used to determine reliability...
February 9, 2021: Reumatología Clinica
Fredeswinda Romero-Bueno, María Jesús Rodríguez-Nieto, Esperanza Naredo
INTRODUCTION: Lung ultrasound (LUS) is a clinical and research tool with great potential in the diagnosis and monitoring of diffuse interstitial lung disease (ILD) present in systemic autoimmune diseases (SAD). Appropriate training in LUS is essential for the correct and safe use of this technique. OBJECTIVE: To document the current state of LUS education and use among Spanish rheumatologists and pneumologists. MATERIAL AND METHODS: A national online survey was designed for members of the Spanish Society of Rheumatology and the ILD Area of the Spanish Society of Pneumology and Thoracic Surgery...
January 22, 2021: Reumatología Clinica
Julia Martínez-Barrio, Juan Antonio Martínez López, María Galindo, Arantza Ais, Nuria Martínez Sánchez, Laura Cano
BACKGROUND AND OBJECTIVES: Family planning in women with immune-mediated inflammatory diseases is a challenge for healthcare teams, highlighting the need for standardized available evidence to provide patients with objective and agreed information. This study reflects the work performed by a multidisciplinary team in reviewing available scientific evidence, and the strategy agreed for family planning, pregnancy, postpartum, and breastfeeding in patients with immune-mediated inflammatory diseases...
January 19, 2021: Reumatología Clinica
Tatiana Barbich, Osvaldo Luis Cerda, Emilce Edith Schneeberger, Gustavo Citera
OBJECTIVES: To evaluate the adherence to treatment with tofacitinib in patients with rheumatoid arthritis (RA) using two versions of the self-questionnaire Compliance Questionnaire Rheumatology, CQR19 and CQR5, to determine the variables associated with adherence to tofacitinib and to compare the performance of both questionnaires. MATERIAL AND METHODS: A cross-sectional study was carried out. We included patients ≥18years old, with RA (ACR/EULAR criteria 2010) under treatment with tofacitinib...
January 15, 2021: Reumatología Clinica
Andrea María Smichowski, Victor Daniel Caputo, Cecilia Romeo, Estela Rivero, Natalia Soledad Morales, Gustavo Casado
OBJECTIVE: To analyse the clinical / epidemiological data, the management and the treatments established in patients with ocular cicatricial pemphigoid in a Rheumatology Service. MATERIAL AND METHODS: Review of clinical histories of patients with ocular cicatricial pemphigoid referred by ophthalmology between 2008 and 2019. RESULTS: In our series of 27 patients, 67% were diagnosed and referred in the last 2 years. Most in Foster stage 1. Of the patients, 18...
January 13, 2021: Reumatología Clinica
Fatma Nur Korkmaz, Gulsen Ozen, Ali Ugur Unal, Asli Odabasi, Meryem Can, Ebru Asıcıoglu, Serhan Tuglular, Haner Direskeneli
OBJECTIVES: To determine the prevalence of vitamin D deficiency in patients with small and medium vessel systemic vasculitis. METHODS: In this cross-sectional study, 25-hydroxy (OH) vitamin D3 levels were measured in adult patients with systemic small and medium vessel vasculitis including antineutrophil cytoplasmic antibody-associated vasculitis (AAV), cryoglobulinaemic vasculitis (CryV), IgA vasculitis (IgAV) and polyarteritis nodosa (PAN), and age- and sex-matched healthy subjects (HS) and patients with rheumatoid arthritis (RA) as control groups...
January 13, 2021: Reumatología Clinica
Sara Ganhão, Raquel Lucas, João Eurico Fonseca, Maria José Santos, Diana Rosa Gonçalves, Nathalie Madeira, Cândida Silva, Eduardo Dourado, Raquel Freitas, Joana Rodrigues, Soraia Azevedo, Teresa Martins Rocha, Raquel Miriam Ferreira, Salomé Garcia, Bruno Miguel Fernandes, Ana Rita Prata, Maura Couto, Rita Pinheiro Torres, Inês Cunha, Lúcia Costa, Miguel Bernardes
BACKGROUND: Remission/ low disease activity (LDA) are the main treatment goals in rheumatoid arthritis (RA) patients. Two tools showing the ability to predict golimumab treatment outcomes in patients with RA were published. OBJECTIVES: To estimate the real-world accuracy of two quantitative tools created to predict RA remission and low disease activity. METHODS: Multicenter, observational study, using data from the Rheumatic Diseases Portuguese Register (Reuma...
October 2020: Acta Reumatológica Portuguesa
Reuma Gadassi Polack, Jutta Joormann, Meital Orbach, Wendy K Silverman, Eli R Lebowitz
The neuropeptide oxytocin (OT) plays a central role in the regulation of affiliative bonds and anxiety. However, the degree to which its levels are synchronized between interaction partners has not yet been assessed. Physiological synchrony assessed using other peripheral measures (e.g., heart rate, etc.) has been tied to positive outcomes for the individual and the dyad. The present study examined OT synchrony in the context of child anxiety and maternal depression by examining mother-child dyads. Mothers and their children with anxiety disorders participated in a behavioral interaction task...
January 6, 2021: Research on child and adolescent psychopathology
Fulya Ilhan, Rahime Aksoy, Hüseyin Tutkak
BACKGROUND: The autoinflammatory character of Behçet's Disease has led researchers to investigate the role of autoantibodies. However, no significant positive result has been reported for autoantibody tests for the disease. AIMS: To investigate the specific and nonspecific staining patterns of Behçet's Disease (BD) patients. METHODS: 140 patients (87 females, 53 males) with an average of 41.9±3 years who were being followed up for Behçet's Disease, and a control group consisting of a total of 736 (464 females, 272 males) healthy volunteers made up of blood donors without any disease whose average age was 50...
December 29, 2020: Reumatología Clinica
Lucía Mayordomo, Juan Molina Collada, Félix M Francisco Hernández, Ángel Bueno, Santos A Insua Vilariño, Francisco Gabriel Jiménez-Núñez, Rosalía Martínez Pérez, Ingrid Möller, Jacqueline Usón Jaeger, José Francisco García-Llorente, José M Álvaro-Gracia, Eduardo Aparicio Ruiz, Liliana Asaro Daverio, Esperanza Naredo
Ultrasound is a widely implemented imaging modality in rheumatology practice that implies a great interaction between patient and professional. The COVID-19 pandemic requires a change in our clinical practice, through the adoption of new strategies that allow comprehensive care for our patients, guaranteeing the safety of both patients and healthcare professionals. OBJETIVE: Our objective was to develop practical recommendations, agreed among a panel of experts, on the use and safety of rheumatological ultrasound during the COVID-19 pandemic...
December 2, 2020: Reumatología Clinica
José Rosas, Francisco Pasquau Liaño, Mónica Llombart Cantó, José María Carrasco Barea, Amparo Raga Beser, José Tomás Algado Rabasa, Francisco Martínez Adsuar, Brian Vila Auli, Isabel Fernández López, Ana María Garijo Sainz, Pere Esquerdo Ramis, Laura Ruiz Pérez, Mª Luisa Navarrete Rebollo, Raquel Hernández Lorido, Laura Gómez Escolar
OBJECTIVE: To describe the experience of treatment with baricitinib (BARI) and/or tocilizumab (TCZ), in monotherapy or combined, in patients admitted for interstitial pneumonia secondary to COVID19, and for 30 days after discharge. METHODS: Medical records of patients admitted with COVID19 and IP with PaO2 /FiO2 <300, treated with BARI and/or TCZ, and compared with patients who did not, were retrospectively reviewed. RESULTS: Sixty patients were included; 43 (72%) are males, mean age 67 (SD: 14) years (<50 years: 17%; 51-70: 30%; >70: 53%), with 8...
November 28, 2020: Reumatología Clinica
Paloma Álvarez Hernández, José de la Mata Llord
OBJECTIVE: To analyse the efficacy and safety of intra-articular injection of expanded Mesenchymal Stromal Cells (MSCs) in knee osteoarthritis. METHODS: Systematic Literature Review. A pre-defined search strategy was run in Medline, Embase and Cochrane Library until February 2018. INCLUSION CRITERIA: knee osteoarthritis (grades II-IV Kellgren-Lawrence); intra-articular injection of MSCs (without surgical co-treatments); Randomized Controlled Trials (RCTs) or Quasi-experimental Clinical Trials (QCTs) N≥10 and ≥6 months of follow-up were included...
December 10, 2020: Reumatología Clinica
Santos Castañeda, Carlos González, Virginia Villaverde, Cristina Lajas Petisco, María Carmen Castro, Fernando Jirout, Juan Carlos Obaya, Juan Carlos Hermosa, Carmen Suárez, Silvia García, María Rodero, Leticia León, Amparo López Esteban, Milena Gobbo, Laly Alcaide, Juan Carlos Torre-Alonso
OBJECTIVE: To develop and assess the feasibility in daily practice of four comorbidity checklists, for common use in rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). METHODS: A multidisciplinary panel of experts on comorbidity was established. Data from the GECOAR, GECOAX and GECOAP projects were analysed and a narrative literature review in Medline on RA, axSpA and PsA comorbidity was performed in order to select the most relevant and common comorbidities across the three diseases...
December 5, 2020: Reumatología Clinica
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