Wendy Y Chen, Karla V Ballman, Ann H Partridge, Olwen M Hahn, Frederick M Briccetti, William J Irvin, Banu Symington, Kala Visvanathan, Paula R Pohlmann, Thomas H Openshaw, Anna Weiss, Eric P Winer, Lisa A Carey, Michelle D Holmes
IMPORTANCE: Observational studies of survivors of breast cancer and prospective trials of aspirin for cardiovascular disease suggest improved breast cancer survival among aspirin users, but prospective studies of aspirin to prevent breast cancer recurrence are lacking. OBJECTIVE: To determine whether aspirin decreases the risk of invasive cancer events among survivors of breast cancer. DESIGN, SETTING, AND PARTICIPANTS: A011502, a phase 3, randomized, placebo-controlled, double-blind trial conducted in the United States and Canada with 3020 participants who had high-risk nonmetastatic breast cancer, enrolled participants from 534 sites from January 6, 2017, through December 4, 2020, with follow-up to March 4, 2023...
April 29, 2024: JAMA